CY1119818T1 - Χρηση του αναστολεα c1 για την προληψη βλαβης ισχαιμιας-επαναιματωσης - Google Patents

Χρηση του αναστολεα c1 για την προληψη βλαβης ισχαιμιας-επαναιματωσης

Info

Publication number
CY1119818T1
CY1119818T1 CY20181100029T CY181100029T CY1119818T1 CY 1119818 T1 CY1119818 T1 CY 1119818T1 CY 20181100029 T CY20181100029 T CY 20181100029T CY 181100029 T CY181100029 T CY 181100029T CY 1119818 T1 CY1119818 T1 CY 1119818T1
Authority
CY
Cyprus
Prior art keywords
inhibitor
reperfusion
ischemical
prevent
recurrent
Prior art date
Application number
CY20181100029T
Other languages
English (en)
Inventor
Maurice Mannesse
Johannes Henricus Nuijens
Frank Pieper
Maria Grazia De Simoni
Gijsbertus Johannes Ziere
Original Assignee
Pharming Intellectual Property B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharming Intellectual Property B.V. filed Critical Pharming Intellectual Property B.V.
Publication of CY1119818T1 publication Critical patent/CY1119818T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με τη θεραπευτική και προφυλακτική χρήση του αναστολέα C1 για την πρόληψη, μείωση και θεραπεία της βλάβης ισχαιμίας και επαναιμάτωσης. Ο αναστολέας C1 της παρούσας εφεύρεσης εξακολουθεί να είναι θεραπευτικώς αποτελεσματικός, όταν χορηγείται μετά από μια ισχαιμική περίοδο και επαναιμάτωση και επομένως είναι ιδιαίτερα χρήσιμος για απρόβλεπτες εμφανίσεις ισχαιμικής επαναιμάτωσης, όπως π.χ. ένα εγκεφαλικό επεισόδιο.
CY20181100029T 2005-12-21 2018-01-10 Χρηση του αναστολεα c1 για την προληψη βλαβης ισχαιμιας-επαναιματωσης CY1119818T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05112630 2005-12-21
US76094406P 2006-01-23 2006-01-23
EP11172880.4A EP2380587B1 (en) 2005-12-21 2006-12-19 Use of C1 inhibitor for the prevention of ischemia-reperfusion injury
EP06824316A EP1965831B1 (en) 2005-12-21 2006-12-19 Use of c1 inhibitor for the prevention of ischemia-reperfusion injury

Publications (1)

Publication Number Publication Date
CY1119818T1 true CY1119818T1 (el) 2018-06-27

Family

ID=38016640

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20111100950T CY1112452T1 (el) 2005-12-21 2011-10-05 Χρηση του αναστολεα c1 για την προληψη της βλαβης εξ ισχαιμιας-επαναιματωσης
CY20181100029T CY1119818T1 (el) 2005-12-21 2018-01-10 Χρηση του αναστολεα c1 για την προληψη βλαβης ισχαιμιας-επαναιματωσης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20111100950T CY1112452T1 (el) 2005-12-21 2011-10-05 Χρηση του αναστολεα c1 για την προληψη της βλαβης εξ ισχαιμιας-επαναιματωσης

Country Status (15)

Country Link
US (3) US8071532B2 (el)
EP (2) EP1965831B1 (el)
JP (2) JP5394748B2 (el)
KR (1) KR101508668B1 (el)
AT (1) ATE516043T1 (el)
AU (1) AU2006327989B2 (el)
CA (1) CA2632400C (el)
CY (2) CY1112452T1 (el)
DK (1) DK2380587T3 (el)
HR (2) HRP20110622T1 (el)
IL (2) IL192180A (el)
NZ (1) NZ568749A (el)
PL (2) PL2380587T3 (el)
SI (1) SI2380587T1 (el)
WO (1) WO2007073186A2 (el)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2502539A1 (en) * 2002-10-17 2004-04-29 Pharming Intellectual Property B.V. Protein modification
ATE516043T1 (de) 2005-12-21 2011-07-15 Pharming Intellectual Pty Bv Verwendung von c1-inhibitor zur prävention von ischämischen reperfusionsschäden
JP2010505946A (ja) * 2006-10-10 2010-02-25 アカデミシュ ジーケンハウス ビイ デ ユニヴェアズィテート ファン アムステルダム 神経再生改善のための補体阻害
JP5423266B2 (ja) * 2009-09-14 2014-02-19 富士電機株式会社 デジタル制御スイッチング電源装置
CA2829037C (en) * 2011-03-09 2022-05-17 Csl Behring Gmbh Factor xii inhibitors for the administration with medical procedures comprising contact with artificial surfaces
EP2497489A1 (en) * 2011-03-09 2012-09-12 CSL Behring GmbH Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs
CA2848510A1 (en) 2011-09-24 2013-03-28 Csl Behring Gmbh Combination therapy using immunoglobulin and c1-inhibitor
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
US9452203B2 (en) 2011-12-22 2016-09-27 Csl Behring Gmbh Use of C1-inhibitor for the treatment of secondary edema of the central nervous system
WO2014008242A1 (en) * 2012-07-03 2014-01-09 The Trustees Of Columbia University In The City Of New York The use of interleukin-11 to protect against ischemia and reperfusion injury
CN110818798A (zh) 2012-10-25 2020-02-21 美国比奥维拉迪维股份有限公司 抗补体C1s抗体和其用途
EP2914291B1 (en) 2012-11-02 2022-02-23 Bioverativ USA Inc. Anti-complement c1s antibodies and uses thereof
US10441631B2 (en) 2013-02-28 2019-10-15 Csl Behring Gmbh Therapeutic agent for amniotic fluid embolism
US10286047B2 (en) * 2013-03-08 2019-05-14 Csl Behring Gmbh Treatment and prevention of remote ischemia-reperfusion injury
KR102430453B1 (ko) 2013-03-15 2022-08-05 바이로파마 바이오로직스 엘엘씨 C1 에스터라제 억제제 결핍과 관련된 장애의 예방 및 치료를 위한 c1-inh 조성물 및 방법
JP2017501968A (ja) 2013-06-28 2017-01-19 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 第ｘｉｉ因子インヒビターおよびｃ１−インヒビターを使用する組合せ療法
DK3215221T3 (da) * 2014-11-03 2020-05-11 Thrombolytic Science Llc Fremgangsmåder og sammensætninger til sikker og effektiv trombolyse
HRP20230093T1 (hr) 2015-04-06 2023-03-31 Bioverativ Usa Inc. Humanizirana anti-c1s protutijela i postupci njihove primjene
EP3302529A4 (en) 2015-06-03 2019-02-06 The Children's Hospital Medical Center COMPOSITIONS AND METHODS FOR TREATING GALLENA GANGATRESIA IN NEWBORNS
WO2017087882A1 (en) * 2015-11-19 2017-05-26 Shire Human Genetic Therapies, Inc. Recombinant human c1 esterase inhibitor and uses thereof
WO2018024873A1 (en) 2016-08-05 2018-02-08 Csl Behring Gmbh Pharmaceutical formulations of c1 esterase inhibitor
CN109641031A (zh) 2016-08-23 2019-04-16 德国杰特贝林生物制品有限公司 预防与c1酯酶抑制剂缺乏相关的遗传性血管性水肿急性发作的方法
US11154596B2 (en) 2017-06-16 2021-10-26 Thrombolytic Science, Llc Methods for thrombolysis
US20200276283A1 (en) 2017-09-15 2020-09-03 Cedars-Sinai Medical Center Methods for improving organ function in organ transplant patients
AU2019226355A1 (en) 2018-02-28 2020-09-17 Pharming Intellectual Property B.V. Treatment and prevention of pre-eclampsia
WO2019166572A1 (en) 2018-02-28 2019-09-06 Pharming Intellectual Property B.V. Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor
AU2019361252A1 (en) 2018-10-17 2021-06-03 Csl Behring Gmbh Process for purifying C1-INH
AU2020299425A1 (en) 2019-07-04 2022-03-03 Csl Behring Gmbh Process for purifying C1-INH
KR102191500B1 (ko) 2020-03-30 2020-12-15 국립낙동강생물자원관 초석잠 추출물을 포함하는 기억력 및 인지기능 개선, 허혈 재관류 손상 예방 및 개선용 조성물
EP3895726A1 (en) 2020-04-17 2021-10-20 Pharming Intellectual Property BV Using c1 esterase inhibitor to treat viral infection-related acute respiratory distress
KR102217607B1 (ko) 2020-06-01 2021-02-18 국립낙동강생물자원관 석창포 추출물을 포함하는 기억력 및 인지기능 개선, 허혈 재관류 손상 예방 및 개선용 조성물
KR102191452B1 (ko) 2020-06-30 2020-12-15 주식회사 에이치비헬스케어 곶감 추출물을 포함하는 기억력 및 인지기능 개선, 허혈 재관류 손상 예방 및 개선용 조성물
KR20230110563A (ko) 2020-11-20 2023-07-24 체에스엘 베링 게엠베하 항체 매개 거부 반응의 치료 방법
EP4366761A1 (en) 2021-07-09 2024-05-15 Pharming Intellectual Property B.V. Using c1 esterase inhibitor to treat viral infection-related symptoms

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1181038T3 (da) 1999-05-14 2004-08-09 Steffen Thiel Hidtil ukendte indikationer af mannanbindende lectin (MBL) til behandling af immunkompromitterede individer
US7067713B2 (en) 2000-01-31 2006-06-27 Pharming Intellectual Property B.V. C1 Inhibitor produced in the milk of transgenic non-human mammals
CA2398707C (en) * 2000-01-31 2010-10-26 Pharming Intellectual Property B.V. C1 inhibitor produced in the milk of transgenic mammals
JP2004100982A (ja) * 2002-09-05 2004-04-02 Denso Corp 熱交換器
CA2502539A1 (en) 2002-10-17 2004-04-29 Pharming Intellectual Property B.V. Protein modification
US7544853B2 (en) 2003-05-16 2009-06-09 Pharming Intellectual Property B.V. C1 inhibitor with short half-life transient treatment
ATE516043T1 (de) 2005-12-21 2011-07-15 Pharming Intellectual Pty Bv Verwendung von c1-inhibitor zur prävention von ischämischen reperfusionsschäden

Also Published As

Publication number Publication date
WO2007073186A3 (en) 2007-08-09
EP1965831B1 (en) 2011-07-13
PL1965831T3 (pl) 2011-12-30
EP2380587A1 (en) 2011-10-26
ATE516043T1 (de) 2011-07-15
US8415288B2 (en) 2013-04-09
JP5394748B2 (ja) 2014-01-22
IL192180A0 (en) 2009-02-11
CY1112452T1 (el) 2015-12-09
WO2007073186A2 (en) 2007-06-28
CA2632400C (en) 2016-06-07
DK2380587T3 (en) 2017-12-04
NZ568749A (en) 2011-05-27
AU2006327989A1 (en) 2007-06-28
EP1965831A2 (en) 2008-09-10
US9211318B2 (en) 2015-12-15
JP2009520815A (ja) 2009-05-28
HRP20171738T1 (hr) 2018-01-26
KR20080098001A (ko) 2008-11-06
CA2632400A1 (en) 2007-06-28
EP2380587B1 (en) 2017-10-25
SI2380587T1 (en) 2018-03-30
IL228954A (en) 2016-10-31
US8071532B2 (en) 2011-12-06
IL192180A (en) 2013-10-31
HRP20110622T1 (hr) 2011-09-30
JP2013126992A (ja) 2013-06-27
KR101508668B1 (ko) 2015-04-06
US20080305993A1 (en) 2008-12-11
US20120088728A1 (en) 2012-04-12
IL228954A0 (en) 2013-12-31
AU2006327989B2 (en) 2012-06-07
PL2380587T3 (pl) 2018-03-30
US20130244941A1 (en) 2013-09-19

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