CY1119818T1 - Χρηση του αναστολεα c1 για την προληψη βλαβης ισχαιμιας-επαναιματωσης - Google Patents

Χρηση του αναστολεα c1 για την προληψη βλαβης ισχαιμιας-επαναιματωσης

Info

Publication number
CY1119818T1
CY1119818T1 CY20181100029T CY181100029T CY1119818T1 CY 1119818 T1 CY1119818 T1 CY 1119818T1 CY 20181100029 T CY20181100029 T CY 20181100029T CY 181100029 T CY181100029 T CY 181100029T CY 1119818 T1 CY1119818 T1 CY 1119818T1
Authority
CY
Cyprus
Prior art keywords
inhibitor
reperfusion
ischemical
prevent
recurrent
Prior art date
Application number
CY20181100029T
Other languages
English (en)
Inventor
Maurice Mannesse
Johannes Henricus Nuijens
Frank Pieper
Maria Grazia De Simoni
Gijsbertus Johannes Ziere
Original Assignee
Pharming Intellectual Property B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharming Intellectual Property B.V. filed Critical Pharming Intellectual Property B.V.
Publication of CY1119818T1 publication Critical patent/CY1119818T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με τη θεραπευτική και προφυλακτική χρήση του αναστολέα C1 για την πρόληψη, μείωση και θεραπεία της βλάβης ισχαιμίας και επαναιμάτωσης. Ο αναστολέας C1 της παρούσας εφεύρεσης εξακολουθεί να είναι θεραπευτικώς αποτελεσματικός, όταν χορηγείται μετά από μια ισχαιμική περίοδο και επαναιμάτωση και επομένως είναι ιδιαίτερα χρήσιμος για απρόβλεπτες εμφανίσεις ισχαιμικής επαναιμάτωσης, όπως π.χ. ένα εγκεφαλικό επεισόδιο.
CY20181100029T 2005-12-21 2018-01-10 Χρηση του αναστολεα c1 για την προληψη βλαβης ισχαιμιας-επαναιματωσης CY1119818T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05112630 2005-12-21
US76094406P 2006-01-23 2006-01-23
EP06824316A EP1965831B1 (en) 2005-12-21 2006-12-19 Use of c1 inhibitor for the prevention of ischemia-reperfusion injury
EP11172880.4A EP2380587B1 (en) 2005-12-21 2006-12-19 Use of C1 inhibitor for the prevention of ischemia-reperfusion injury

Publications (1)

Publication Number Publication Date
CY1119818T1 true CY1119818T1 (el) 2018-06-27

Family

ID=38016640

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20111100950T CY1112452T1 (el) 2005-12-21 2011-10-05 Χρηση του αναστολεα c1 για την προληψη της βλαβης εξ ισχαιμιας-επαναιματωσης
CY20181100029T CY1119818T1 (el) 2005-12-21 2018-01-10 Χρηση του αναστολεα c1 για την προληψη βλαβης ισχαιμιας-επαναιματωσης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20111100950T CY1112452T1 (el) 2005-12-21 2011-10-05 Χρηση του αναστολεα c1 για την προληψη της βλαβης εξ ισχαιμιας-επαναιματωσης

Country Status (15)

Country Link
US (3) US8071532B2 (el)
EP (2) EP2380587B1 (el)
JP (2) JP5394748B2 (el)
KR (1) KR101508668B1 (el)
AT (1) ATE516043T1 (el)
AU (1) AU2006327989B2 (el)
CA (1) CA2632400C (el)
CY (2) CY1112452T1 (el)
DK (1) DK2380587T3 (el)
HR (2) HRP20110622T1 (el)
IL (2) IL192180A (el)
NZ (1) NZ568749A (el)
PL (2) PL1965831T3 (el)
SI (1) SI2380587T1 (el)
WO (1) WO2007073186A2 (el)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2502539A1 (en) * 2002-10-17 2004-04-29 Pharming Intellectual Property B.V. Protein modification
PL1965831T3 (pl) 2005-12-21 2011-12-30 Pharming Intellectual Property B V Zastosowanie inhibitora C1 do profilaktyki uszkodzenia niedokrwienno-reperfuzyjnego
EP3028716B1 (en) * 2006-10-10 2020-09-16 Regenesance B.V. Complement inhibition for improved nerve regeneration
JP5423266B2 (ja) * 2009-09-14 2014-02-19 富士電機株式会社 デジタル制御スイッチング電源装置
EP2497489A1 (en) * 2011-03-09 2012-09-12 CSL Behring GmbH Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs
CA2829037C (en) * 2011-03-09 2022-05-17 Csl Behring Gmbh Factor xii inhibitors for the administration with medical procedures comprising contact with artificial surfaces
ES2714999T3 (es) 2011-09-24 2019-05-31 Csl Behring Gmbh Terapia de combinación que usa inmunoglobulina e inhibidor de C1
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
JP6127063B2 (ja) * 2011-12-22 2017-05-10 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 中枢神経系の続発性浮腫の治療のためのｃ１インヒビターの使用
WO2014008242A1 (en) * 2012-07-03 2014-01-09 The Trustees Of Columbia University In The City Of New York The use of interleukin-11 to protect against ischemia and reperfusion injury
WO2014066744A2 (en) 2012-10-25 2014-05-01 True North Therapeutics, Inc. Anti-complement c1s antibodies and uses thereof
GB2509260B (en) 2012-11-02 2016-05-04 True North Therapeutics Inc Anti-complement C1s antibodies and uses thereof
ES2609070T3 (es) * 2013-02-28 2017-04-18 Csl Behring Gmbh Agente terapéutico para el embolismo de líquido amniótico
EP2964255B1 (en) * 2013-03-08 2020-11-04 CSL Behring GmbH Treatment and prevention of remote ischemia-reperfusion injury
EP2968434B1 (en) 2013-03-15 2017-06-28 Shire Viropharma Incorporated C1-inh compositions for use in the prevention and treatment of hereditary angioedema (hae).
EP3013366B1 (en) * 2013-06-28 2021-08-25 CSL Behring GmbH Combination therapy using a factor xii inhibitor and a c1-inhibitor
ES2788697T3 (es) * 2014-11-03 2020-10-22 Thrombolytic Science Llc Métodos y composiciones para trombólisis segura y eficaz
US10729767B2 (en) 2015-04-06 2020-08-04 Bioverativ Usa Inc. Humanized anti-C1s antibodies and methods of inhibiting C1s cleavage
WO2016196070A1 (en) 2015-06-03 2016-12-08 Children's Hospital Medical Center Compositions and methods for treating neonatal biliary atresia
JP7189767B2 (ja) * 2015-11-19 2022-12-14 武田薬品工業株式会社 組換えヒトｃ１エステラーゼインヒビター及びその使用
CN109562149A (zh) 2016-08-05 2019-04-02 德国杰特贝林生物制品有限公司 C1酯酶抑制剂的药物制剂
AU2017316513A1 (en) 2016-08-23 2019-03-28 Csl Behring Gmbh Method of preventing acute attacks of hereditary angioedema associated with C1 esterase inhibitor deficiency
US11154596B2 (en) 2017-06-16 2021-10-26 Thrombolytic Science, Llc Methods for thrombolysis
CA3075686A1 (en) 2017-09-15 2019-03-21 Cedars-Sinai Medical Center Methods for improving organ function in organ transplant patients
WO2019166572A1 (en) 2018-02-28 2019-09-06 Pharming Intellectual Property B.V. Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor
EP3758739B1 (en) 2018-02-28 2024-05-15 Pharming Intellectual Property B.V. Treatment and prevention of pre-eclampsia
JP2022505307A (ja) 2018-10-17 2022-01-14 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー Ｃ１－ｉｎｈを精製する方法
US20220363715A1 (en) 2019-07-04 2022-11-17 Csl Behring Gmbh Process for Purifying C1-INH
KR102191500B1 (ko) 2020-03-30 2020-12-15 국립낙동강생물자원관 초석잠 추출물을 포함하는 기억력 및 인지기능 개선, 허혈 재관류 손상 예방 및 개선용 조성물
EP3895726A1 (en) 2020-04-17 2021-10-20 Pharming Intellectual Property BV Using c1 esterase inhibitor to treat viral infection-related acute respiratory distress
KR102217607B1 (ko) 2020-06-01 2021-02-18 국립낙동강생물자원관 석창포 추출물을 포함하는 기억력 및 인지기능 개선, 허혈 재관류 손상 예방 및 개선용 조성물
KR102191452B1 (ko) 2020-06-30 2020-12-15 주식회사 에이치비헬스케어 곶감 추출물을 포함하는 기억력 및 인지기능 개선, 허혈 재관류 손상 예방 및 개선용 조성물
CA3198740A1 (en) 2020-11-20 2022-05-27 John Roberts Method for treating antibody-mediated rejection
EP4366761A1 (en) 2021-07-09 2024-05-15 Pharming Intellectual Property B.V. Using c1 esterase inhibitor to treat viral infection-related symptoms

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1402897E (pt) 1999-05-14 2007-01-31 Jens Christian Jensenius Novas indicações de lectina de ligação a manana (mbl) no tratamento de indivíduos imunocomprometidos
US7067713B2 (en) * 2000-01-31 2006-06-27 Pharming Intellectual Property B.V. C1 Inhibitor produced in the milk of transgenic non-human mammals
JP2003521914A (ja) * 2000-01-31 2003-07-22 ファーミング インテレクチュアル プロパティー ベー．フェー． トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター
JP2004100982A (ja) * 2002-09-05 2004-04-02 Denso Corp 熱交換器
CA2502539A1 (en) * 2002-10-17 2004-04-29 Pharming Intellectual Property B.V. Protein modification
PL1626736T3 (pl) * 2003-05-16 2021-05-04 Pharming Intellectual Property B.V. Inhibitor c1 o krótkim okresie półtrwania do leczenia przejściowego
PL1965831T3 (pl) 2005-12-21 2011-12-30 Pharming Intellectual Property B V Zastosowanie inhibitora C1 do profilaktyki uszkodzenia niedokrwienno-reperfuzyjnego

Also Published As

Publication number Publication date
EP2380587A1 (en) 2011-10-26
PL1965831T3 (pl) 2011-12-30
US8071532B2 (en) 2011-12-06
SI2380587T1 (en) 2018-03-30
EP1965831B1 (en) 2011-07-13
US9211318B2 (en) 2015-12-15
JP2009520815A (ja) 2009-05-28
EP1965831A2 (en) 2008-09-10
HRP20110622T1 (hr) 2011-09-30
AU2006327989A1 (en) 2007-06-28
JP5394748B2 (ja) 2014-01-22
US20080305993A1 (en) 2008-12-11
IL192180A0 (en) 2009-02-11
IL228954A (en) 2016-10-31
PL2380587T3 (pl) 2018-03-30
NZ568749A (en) 2011-05-27
WO2007073186A3 (en) 2007-08-09
US8415288B2 (en) 2013-04-09
AU2006327989B2 (en) 2012-06-07
CA2632400C (en) 2016-06-07
CA2632400A1 (en) 2007-06-28
IL228954A0 (en) 2013-12-31
EP2380587B1 (en) 2017-10-25
KR20080098001A (ko) 2008-11-06
HRP20171738T1 (hr) 2018-01-26
IL192180A (en) 2013-10-31
ATE516043T1 (de) 2011-07-15
DK2380587T3 (en) 2017-12-04
CY1112452T1 (el) 2015-12-09
JP2013126992A (ja) 2013-06-27
US20120088728A1 (en) 2012-04-12
KR101508668B1 (ko) 2015-04-06
US20130244941A1 (en) 2013-09-19
WO2007073186A2 (en) 2007-06-28

Similar Documents

Publication Publication Date Title
CY1119818T1 (el) Χρηση του αναστολεα c1 για την προληψη βλαβης ισχαιμιας-επαναιματωσης
MX2009005185A (es) Analogos de tiofeno para el tratamiento o prevencion de infecciones de flavivirus.
SMP200900013B (it) Peptidomimetici smac utili come inibitori di iap
NO20072665L (no) Rapamycinderivater og deres anvendelse i behandling av nevrologiske lidelser
UA101943C2 (ru) Биарилзамещенные гетероциклические ингибиторы lta4h для лечения воспаления
IN2014DN08578A (el)
GEP20125683B (en) Serine proteases inhibitors for hcv infections treatment
NO20081846L (no) Bifenylderivater og deres anvendelse ved behandling av hepatitt C
NO20083032L (no) Anvendelse av benzofuserte heterocykliske sulfamidderivater for behandling av mani og bipolar forstyrrelse
NO20083036L (no) Anvendelse av benzofuserte heterocykliske sulfamidderivater for behandling av depresjon
EA200602220A1 (ru) Новое применение пептидных соединений для лечения амиотрофического бокового склероза
NO20074275L (no) 2- (4-okso-4H-kinazolin-3-yl) acetamider og deres anvendelse som Vasopressin-V3-antagonister
NZ716598A (en) Anthelmintic compounds and compositions and method of using thereof
MY145823A (en) Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
CO5570674A2 (es) Derivados de 4-(4-alcoxi-3-hidroxifenil)-2-pirrolidona como inhibidores de pde-4 para el tratamiento de sindromes neurologicos
WO2009055335A3 (en) Hcv protease inhibitors
MY149175A (en) Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents
ATE384058T1 (de) Thiazolderivate
ATE531377T1 (de) Purin-derivate und anwendungsverfahren
NZ598750A (en) Therapeutic agent for mood disorders
TN2011000204A1 (en) Cycloundecadepsipeptide compounds and use of said compounds as a medicament
WO2009148600A3 (en) Deuterated lysine-based compounds
NZ598754A (en) Therapeutic agent for anxiety disorders
WO2009041026A1 (ja) Ｃｘｃｌ１０産生抑制剤
WO2008130632A3 (en) Methods of increasing camp levels and uses thereof