CY1119689T1 - Μεθοδοι και συνθεσεις για την ανιχνευση του επιπεδου της δραστικοτητας της λυσοσωμικης εξωκυτταρωσης και μεθοδοι χρησης - Google Patents

Μεθοδοι και συνθεσεις για την ανιχνευση του επιπεδου της δραστικοτητας της λυσοσωμικης εξωκυτταρωσης και μεθοδοι χρησης

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CY1119689T1
CY1119689T1 CY20171101321T CY171101321T CY1119689T1 CY 1119689 T1 CY1119689 T1 CY 1119689T1 CY 20171101321 T CY20171101321 T CY 20171101321T CY 171101321 T CY171101321 T CY 171101321T CY 1119689 T1 CY1119689 T1 CY 1119689T1
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Cyprus
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methods
lysosomal
activity
disease
level
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CY20171101321T
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English (en)
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Ida ANNUNZIATA
Alessandra D’AZZO
Shai WHITE-GILBERTSON
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St. Jude Children's Research Hospital
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Publication of CY1119689T1 publication Critical patent/CY1119689T1/el

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Abstract

Παρέχονται μέθοδοι για την πρόγνωση, τη διάγνωση και την αντιμετώπιση διαφόρων παθολογικών καταστάσεων, περιλαμβανομένων του καρκίνου, της ανθεκτικότητας στη χημειοθεραπεία και της άνοιας που σχετίζεται με τη νόσο Alzheimer. Οι μέθοδοι που παρέχονται στο παρόν βασίζονται στην ανακάλυψη ότι διάφορες πρωτεΐνες με υψηλό βαθμό σιαλυλίωσης καταδεικνύεται στο παρόν ότι σχετίζονται με καταστάσεις νόσου, όπως ο καρκίνος, η ανθεκτικότητα στη χημειοθεραπεία και η άνοια που σχετίζεται με τη νόσο Alzheimer. Οι μέθοδοι αυτές παρέχουν ένα προφίλ δραστικότητας της λυσοσωμικής εξωκυττάρωσης που περιλαμβάνει μία ή περισσότερες τιμές που αντιπροσωπεύουν τη δραστικότητα της λυσοσωμικής εξωκυττάρωσης. Παρέχεται επίσης στο παρόν η ανακάλυψη ότι η χαμηλή δραστικότητα της λυσοσωμικής σιαλιδάσης σχετίζεται με διάφορες παθολογικές καταστάσεις. Κατ' αυτόν τον τρόπο, οι μέθοδοι παρέχουν επίσης ένα προφίλ δραστικότητας της λυσοσωμικής σιαλιδάσης, που περιλαμβάνει μία ή περισσότερες τιμές που αντιπροσωπεύουν τη δραστικότητα της λυσοσωμικής σιαλιδάσης. Ένα προφίλ δραστικότητας της λυσοσωμικής σιαλιδάσης αποτελεί ένα παράδειγμα προφίλ δραστικότητας της λυσοσωμικής εξωκυττάρωσης. Ως εκ τούτου, το επίπεδο της δραστικότητας της λυσοσωμικής εξωκυττάρωσης ή/και της δραστικότητας της λυσοσωμικής σιαλιδάσης είναι προγνωστικό τυχόν διάγνωσης ή/και πρόγνωσης καρκίνου, ανθεκτικότητας στη χημειοθεραπεία ή άνοιας που σχετίζεται με τη νόσο Alzheimer.
CY20171101321T 2011-08-31 2017-12-18 Μεθοδοι και συνθεσεις για την ανιχνευση του επιπεδου της δραστικοτητας της λυσοσωμικης εξωκυτταρωσης και μεθοδοι χρησης CY1119689T1 (el)

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PCT/US2012/052629 WO2013033074A2 (en) 2011-08-31 2012-08-28 Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use

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