CY1119389T1 - Μεθοδος για τη θεραπευτικη αγωγη της πολλαπλης σκληρυνσης - Google Patents

Μεθοδος για τη θεραπευτικη αγωγη της πολλαπλης σκληρυνσης

Info

Publication number
CY1119389T1
CY1119389T1 CY20171100999T CY171100999T CY1119389T1 CY 1119389 T1 CY1119389 T1 CY 1119389T1 CY 20171100999 T CY20171100999 T CY 20171100999T CY 171100999 T CY171100999 T CY 171100999T CY 1119389 T1 CY1119389 T1 CY 1119389T1
Authority
CY
Cyprus
Prior art keywords
treatment
subject
treating
multiple sclerosis
multiple science
Prior art date
Application number
CY20171100999T
Other languages
English (en)
Inventor
Roland Martin
Henry F Mcfarland
Bibiana Bielekova
Original Assignee
The Government Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health & Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Government Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health & Human Services filed Critical The Government Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health & Human Services
Publication of CY1119389T1 publication Critical patent/CY1119389T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

Εδώ αποκαλύπτεται μια μέθοδος για τη θεραπεία ενός υποκειμένου με πολλαπλή σκλήρυνση. Σε μια ενσωμάτωση, παρέχεται μια μέθοδος για τη θεραπεία ενός υποκειμένου με πολλαπλή σκλήρυνση που περιλαμβάνει τη χορήγηση στο υποκείμενο μιας θεραπευτικώς αποτελεσματικής ποσότητας από έναν ανταγωνιστή του υποδοχέα της IL-21, όπου το υποκείμενο έχει αποτύχει να αποκριθεί σε θεραπευτική αγωγή με βήτα ιντερφερόνη, θεραπεύοντας έτσι το υποκείμενο.
CY20171100999T 2002-06-28 2017-09-21 Μεθοδος για τη θεραπευτικη αγωγη της πολλαπλης σκληρυνσης CY1119389T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39302102P 2002-06-28 2002-06-28
PCT/US2002/038290 WO2004002500A1 (en) 2002-06-28 2002-11-27 Method of treating autoimmune diseases with interferon-beta and il-2r antagonist
EP03762181.0A EP1539200B1 (en) 2002-06-28 2003-06-27 Method for the treatment of multiple sclerosis

Publications (1)

Publication Number Publication Date
CY1119389T1 true CY1119389T1 (el) 2018-02-14

Family

ID=30000962

Family Applications (2)

Application Number Title Priority Date Filing Date
CY2016043C CY2016043I2 (el) 2002-06-28 2016-12-09 Μεθοδος για τη θεραπευτικη αγωγη της πολλαπλης σκληρυνσης
CY20171100999T CY1119389T1 (el) 2002-06-28 2017-09-21 Μεθοδος για τη θεραπευτικη αγωγη της πολλαπλης σκληρυνσης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY2016043C CY2016043I2 (el) 2002-06-28 2016-12-09 Μεθοδος για τη θεραπευτικη αγωγη της πολλαπλης σκληρυνσης

Country Status (15)

Country Link
US (11) US7575742B2 (el)
EP (3) EP1539200B1 (el)
JP (8) JP2005535636A (el)
AU (3) AU2002368055B2 (el)
CA (3) CA2490804C (el)
CY (2) CY2016043I2 (el)
DK (2) DK2314627T3 (el)
ES (2) ES2474718T3 (el)
HK (2) HK1074769A1 (el)
HU (2) HUE036677T2 (el)
IL (2) IL165973A (el)
LU (1) LU93315I2 (el)
PT (2) PT1539200E (el)
SI (2) SI2314627T1 (el)
WO (2) WO2004002500A1 (el)

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Also Published As

Publication number Publication date
AU2003247813A1 (en) 2004-01-19
JP2013139478A (ja) 2013-07-18
CY2016043I1 (el) 2017-04-05
ES2637011T3 (es) 2017-10-10
IL241920A0 (en) 2015-11-30
US20040109859A1 (en) 2004-06-10
EP1539200A4 (en) 2007-11-07
US20170190779A1 (en) 2017-07-06
ES2474718T3 (es) 2014-07-09
EP1539200A2 (en) 2005-06-15
US20090175823A1 (en) 2009-07-09
HUE036677T2 (hu) 2018-07-30
US20050249704A1 (en) 2005-11-10
EP2314627A2 (en) 2011-04-27
JP2011157378A (ja) 2011-08-18
AU2002368055A1 (en) 2004-01-19
DK2314627T3 (en) 2017-10-23
LU93315I2 (fr) 2017-01-26
JP2014221813A (ja) 2014-11-27
HUS1600050I1 (hu) 2017-06-28
WO2004002421A2 (en) 2004-01-08
EP2314627A3 (en) 2011-05-11
JP2005535636A (ja) 2005-11-24
JP2016145220A (ja) 2016-08-12
HK1249850A1 (zh) 2018-11-16
JP2013032372A (ja) 2013-02-14
HK1074769A1 (en) 2005-11-25
AU2003247813C1 (en) 2010-07-22
IL165973A0 (en) 2006-01-15
JP5905534B2 (ja) 2016-04-20
EP1539200B1 (en) 2014-05-28
CA2844639A1 (en) 2004-01-08
CY2016043I2 (el) 2017-04-05
IL165973A (en) 2015-10-29
CA2490804C (en) 2016-12-06
AU2008212004A1 (en) 2008-09-25
CA2490186A1 (en) 2004-01-08
US20130095069A1 (en) 2013-04-18
US20130017152A1 (en) 2013-01-17
US20190002575A1 (en) 2019-01-03
WO2004002500A1 (en) 2004-01-08
US8298525B2 (en) 2012-10-30
US8454965B2 (en) 2013-06-04
SI2314627T1 (sl) 2017-10-30
EP2314627B1 (en) 2017-07-26
JP2006508039A (ja) 2006-03-09
EP3269377A1 (en) 2018-01-17
SI1539200T1 (sl) 2014-09-30
US7575742B2 (en) 2009-08-18
DK1539200T3 (da) 2014-06-30
US20080038275A1 (en) 2008-02-14
CA2490804A1 (en) 2004-01-08
US8636997B2 (en) 2014-01-28
PT1539200E (pt) 2014-08-25
JP2010132660A (ja) 2010-06-17
US20150010477A1 (en) 2015-01-08
US20150337044A1 (en) 2015-11-26
PT2314627T (pt) 2017-08-29
AU2008212004B2 (en) 2010-10-21
CA2490186C (en) 2014-04-15
AU2003247813B2 (en) 2008-06-05
WO2004002421A3 (en) 2004-09-02
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