CY1118883T1 - Μεθοδος παρασκευης βορτιοξετινης - Google Patents

Μεθοδος παρασκευης βορτιοξετινης

Info

Publication number
CY1118883T1
CY1118883T1 CY20171100483T CY171100483T CY1118883T1 CY 1118883 T1 CY1118883 T1 CY 1118883T1 CY 20171100483 T CY20171100483 T CY 20171100483T CY 171100483 T CY171100483 T CY 171100483T CY 1118883 T1 CY1118883 T1 CY 1118883T1
Authority
CY
Cyprus
Prior art keywords
preparation
bortioxetine
formula
vortexetine
dimethylthiophenol
Prior art date
Application number
CY20171100483T
Other languages
Greek (el)
English (en)
Inventor
Thomas Ruhland
Kim Lasse Christensen
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of CY1118883T1 publication Critical patent/CY1118883T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02Iron compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
CY20171100483T 2013-02-22 2017-05-03 Μεθοδος παρασκευης βορτιοξετινης CY1118883T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361767883P 2013-02-22 2013-02-22
DKPA201300104 2013-02-22
PCT/EP2014/053313 WO2014128207A1 (en) 2013-02-22 2014-02-20 Vortioxetine manufacturing process

Publications (1)

Publication Number Publication Date
CY1118883T1 true CY1118883T1 (el) 2018-01-10

Family

ID=59215387

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100483T CY1118883T1 (el) 2013-02-22 2017-05-03 Μεθοδος παρασκευης βορτιοξετινης

Country Status (37)

Country Link
US (1) US9353073B2 (OSRAM)
EP (1) EP2958903B1 (OSRAM)
JP (1) JP6464098B2 (OSRAM)
KR (1) KR102230628B1 (OSRAM)
CN (1) CN104995181B (OSRAM)
AP (1) AP2015008640A0 (OSRAM)
AU (1) AU2014220735B2 (OSRAM)
BR (1) BR112015019268B1 (OSRAM)
CA (1) CA2901821A1 (OSRAM)
CL (1) CL2015002309A1 (OSRAM)
CR (1) CR20150423A (OSRAM)
CY (1) CY1118883T1 (OSRAM)
DK (1) DK2958903T3 (OSRAM)
DO (1) DOP2015000187A (OSRAM)
EA (1) EA027756B1 (OSRAM)
ES (1) ES2625380T3 (OSRAM)
GE (1) GEP201706749B (OSRAM)
HR (1) HRP20170607T1 (OSRAM)
IL (1) IL240501B (OSRAM)
LT (1) LT2958903T (OSRAM)
MA (1) MA38338B1 (OSRAM)
ME (1) ME02671B (OSRAM)
MX (1) MX362355B (OSRAM)
MY (1) MY172337A (OSRAM)
PE (1) PE20151589A1 (OSRAM)
PH (1) PH12015501807B1 (OSRAM)
PL (1) PL2958903T3 (OSRAM)
PT (1) PT2958903T (OSRAM)
RS (1) RS55932B1 (OSRAM)
RU (1) RU2652265C2 (OSRAM)
SG (1) SG11201506651SA (OSRAM)
SI (1) SI2958903T1 (OSRAM)
SM (1) SMT201700238T1 (OSRAM)
TN (1) TN2015000335A1 (OSRAM)
UA (1) UA116236C2 (OSRAM)
WO (1) WO2014128207A1 (OSRAM)
ZA (1) ZA201506050B (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX354133B (es) 2010-08-18 2018-02-14 Samumed Llc Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina.
MY176004A (en) 2013-02-22 2020-07-21 Samumed Llc Gamma-diketones as wnt/beta-catenin signaling pathway activators
EP3206686B1 (en) 2014-08-20 2019-10-09 Samumed, LLC Gamma-diketones for treatment and prevention of aging skin and wrinkles
WO2016125191A2 (en) 2015-02-04 2016-08-11 Mylan Laboratories Limited Processes for the preparation of vortioxetine hydrobromide
EP3274330A1 (en) 2015-03-26 2018-01-31 Cipla Limited Method for making serotonin reuptake inhibitors
CN106279065A (zh) * 2015-05-12 2017-01-04 北京深蓝海生物医药科技有限公司 一种氢溴酸沃替西汀的精制转晶方法
JO3456B1 (ar) 2015-05-13 2020-07-05 H Lundbeck As فيروتيوكسيتين بيروجلوتامات
ES2819831T3 (es) * 2016-02-08 2021-04-19 H Lundbeck As Síntesis de 1-[2-(2,4-dimetil-fenilsulfanil)-fenil]piperazina
US9820984B1 (en) 2016-07-01 2017-11-21 H. Lundbeck A/S Dosing regimens for fast onset of antidepressant effect
US10519121B2 (en) 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
CN109912538B (zh) * 2019-01-22 2021-03-12 安徽赛乐普制药有限公司 一种抗抑郁药沃替西汀的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
IL161966A0 (en) * 2001-12-20 2005-11-20 Lundbeck & Co As H Aryloxyphenyl and arylsulfanylphenyl
US8722684B2 (en) * 2006-06-16 2014-05-13 H. Lundbeck A/S 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
TW201033181A (en) * 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine

Also Published As

Publication number Publication date
US9353073B2 (en) 2016-05-31
RU2652265C2 (ru) 2018-04-27
PL2958903T3 (pl) 2017-08-31
SI2958903T1 (sl) 2017-09-29
UA116236C2 (uk) 2018-02-26
MA38338A1 (fr) 2016-09-30
TN2015000335A1 (en) 2017-01-03
CA2901821A1 (en) 2014-08-28
PE20151589A1 (es) 2015-12-03
HK1216098A1 (en) 2016-10-14
PH12015501807B1 (en) 2019-05-31
SG11201506651SA (en) 2015-09-29
JP6464098B2 (ja) 2019-02-06
MX362355B (es) 2019-01-14
EA027756B1 (ru) 2017-08-31
AU2014220735A1 (en) 2015-08-20
CN104995181A (zh) 2015-10-21
WO2014128207A1 (en) 2014-08-28
RS55932B1 (sr) 2017-09-29
PT2958903T (pt) 2017-05-26
MX2015010656A (es) 2015-12-17
HRP20170607T1 (hr) 2017-06-30
IL240501B (en) 2018-08-30
AP2015008640A0 (en) 2015-08-31
MY172337A (en) 2019-11-21
LT2958903T (lt) 2017-08-25
EA201591349A1 (ru) 2015-12-30
ES2625380T3 (es) 2017-07-19
EP2958903B1 (en) 2017-04-12
RU2015134407A (ru) 2017-03-28
AU2014220735B2 (en) 2017-06-22
GEP201706749B (en) 2017-10-10
ZA201506050B (en) 2017-08-30
BR112015019268B1 (pt) 2023-01-10
BR112015019268A2 (pt) 2020-01-28
CN104995181B (zh) 2017-03-08
DK2958903T3 (en) 2017-05-15
PH12015501807A1 (en) 2015-11-09
IL240501A0 (en) 2015-09-24
DOP2015000187A (es) 2015-11-30
US20160009670A1 (en) 2016-01-14
CR20150423A (es) 2015-10-20
KR20150118146A (ko) 2015-10-21
ME02671B (me) 2017-06-20
JP2016509042A (ja) 2016-03-24
MA38338B1 (fr) 2018-10-31
EP2958903A1 (en) 2015-12-30
KR102230628B1 (ko) 2021-03-22
CL2015002309A1 (es) 2016-03-04
SMT201700238T1 (it) 2017-07-18

Similar Documents

Publication Publication Date Title
CY1118883T1 (el) Μεθοδος παρασκευης βορτιοξετινης
CY1120635T1 (el) Βενζαμιδια αμινοετεροαρυλιου ως αναστολεις κινασης
UA113643C2 (xx) N-цикліламіди як нематоциди
EA201600091A1 (ru) 4-членные кольцевые карбоксамиды, применяемые в качестве нематоцидов
CR20140468A (es) Inhibidores de diacilglicerol aciltransferasa 2
BR112016029333A2 (pt) síntese de compostos de carbamoilpiridona policíclico
EA201690473A1 (ru) Комбинированный состав двух противовирусных соединений
MX378288B (es) Inhibidores de pirimidina del fgfr4.
UY34591A (es) Compuestos de imidazopirrolidinona
CY1118950T1 (el) Νεα παραγωγα πυραζολιου
EA201591634A1 (ru) Дигидропиридопиримидиновые соединения
EA201591805A1 (ru) Оксабицикло [2.2.2] кислоты - модуляторы gpr120
CR20140306A (es) Fluormetil -5,6-dihidro-4h-[1,3] oxazinas
CY1118593T1 (el) Πρωτοτυπα παραγωγα πυραζινης
PH12015502665A1 (en) Improvements in or relating to organic compounds
EA201691412A1 (ru) Гидроксиформамидные производные и их применение
CL2015002358A1 (es) Compuestos bicíclicos.
MX2015013365A (es) Derivados de urea y su uso como inhibidores de proteina de union de acidos grasos (puag).
MX386975B (es) Fármacos precursores de oxabicicloheptanos.
CR20160083A (es) Compuestos con actividad pesticida
UA111333C2 (uk) Спосіб одержання l-аргінінової солі периндроприлу
MX2015016332A (es) Inhibidores de alk biciclicos fusionados.
CY1121116T1 (el) Νεα μεθοδος για την συνθεση αγομελατινης
MX2015013374A (es) Derivados de urea y su uso como inhibidores de proteina de uniuon a acidos grasos (puag).
AR101951A1 (es) Síntesis de ent-progesterona e intermediarios de la misma