CY1118694T1 - Μεθοδοι διαχωρισμου σωματιδιων χρησιμοποιωντας μια συσκευη με ενα στοιχειο διαχωρισμου με διακριση μεγεθους που εχει μια επιμηκη αιχμη - Google Patents

Μεθοδοι διαχωρισμου σωματιδιων χρησιμοποιωντας μια συσκευη με ενα στοιχειο διαχωρισμου με διακριση μεγεθους που εχει μια επιμηκη αιχμη

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Publication number
CY1118694T1
CY1118694T1 CY20171100298T CY171100298T CY1118694T1 CY 1118694 T1 CY1118694 T1 CY 1118694T1 CY 20171100298 T CY20171100298 T CY 20171100298T CY 171100298 T CY171100298 T CY 171100298T CY 1118694 T1 CY1118694 T1 CY 1118694T1
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CY
Cyprus
Prior art keywords
size
distribution
cells
methods
subject
Prior art date
Application number
CY20171100298T
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English (en)
Inventor
Georgi Hvichia
Original Assignee
Angle North America, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angle North America, Inc. filed Critical Angle North America, Inc.
Publication of CY1118694T1 publication Critical patent/CY1118694T1/el

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0694—Cells of blood, e.g. leukemia cells, myeloma cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0272—Investigating particle size or size distribution with screening; with classification by filtering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N2015/0288—Sorting the particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Ecology (AREA)
  • Hospice & Palliative Care (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Combined Means For Separation Of Solids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Η εφεύρεση αναφέρεται στον διαχωρισμό των μεγαλύτερων σωματιδίων των κυττάρων που επιλέγονται από τα κύτταρα όγκου κυκλοφορίας και τα ενδοθηλιακά κύτταρα κυκλοφορίας από τα κύτταρα αίματος σε ένα δείγμα υγρού π.χ. δείγμα ανθρώπινου αίματος, με βάση την αδυναμία μεγαλύτερων σωματιδίων των κυττάρων να διασχίσουν αυτό το βήμα διαχωρισμού μιας συσκευής που προορίζεται για τον συγκεκριμένο σκοπό.
CY20171100298T 2013-03-15 2017-03-07 Μεθοδοι διαχωρισμου σωματιδιων χρησιμοποιωντας μια συσκευη με ενα στοιχειο διαχωρισμου με διακριση μεγεθους που εχει μια επιμηκη αιχμη CY1118694T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361794468P 2013-03-15 2013-03-15
US14/077,811 US9631179B2 (en) 2013-03-15 2013-11-12 Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge
EP14159725.2A EP2790020B9 (en) 2013-03-15 2014-03-14 Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge

Publications (1)

Publication Number Publication Date
CY1118694T1 true CY1118694T1 (el) 2017-07-12

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CY20161100434T CY1117533T1 (el) 2013-03-15 2016-05-20 Μεθοδοι διαχωρισμου σωματιδιων χρησιμοποιωντας μια συσκευη με ενα στοιχειο διαχωρισμου με διακριση μεγεθους που εχει μια επιμηκη αιχμη
CY20171100298T CY1118694T1 (el) 2013-03-15 2017-03-07 Μεθοδοι διαχωρισμου σωματιδιων χρησιμοποιωντας μια συσκευη με ενα στοιχειο διαχωρισμου με διακριση μεγεθους που εχει μια επιμηκη αιχμη

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Country Status (20)

Country Link
US (6) US9631179B2 (el)
EP (2) EP2790020B9 (el)
JP (2) JP6066950B2 (el)
CN (3) CN107991476B (el)
AU (2) AU2014201576B2 (el)
BR (1) BR102014006329A2 (el)
CA (1) CA2845390C (el)
CY (2) CY1117533T1 (el)
DK (2) DK3029465T3 (el)
ES (2) ES2618511T3 (el)
HK (1) HK1247667A1 (el)
HR (2) HRP20160395T1 (el)
HU (2) HUE028597T2 (el)
LT (1) LT3029465T (el)
MX (2) MX356042B (el)
PL (2) PL2790020T3 (el)
PT (1) PT3029465T (el)
RS (2) RS54749B1 (el)
SI (2) SI3029465T1 (el)
SM (1) SMT201600152B (el)

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Also Published As

Publication number Publication date
EP2790020B9 (en) 2016-05-18
ES2573120T3 (es) 2016-06-06
EP2790020A2 (en) 2014-10-15
HRP20160395T1 (hr) 2016-07-01
DK2790020T3 (en) 2016-04-25
US10279349B2 (en) 2019-05-07
US9851344B2 (en) 2017-12-26
BR102014006329A2 (pt) 2015-01-13
MX356042B (es) 2018-05-09
MX362661B (es) 2019-01-28
EP2790020A3 (en) 2014-12-24
EP3029465B1 (en) 2017-01-11
HUE033689T2 (en) 2017-12-28
LT3029465T (lt) 2017-03-27
AU2016238956A1 (en) 2016-11-03
US20190217294A1 (en) 2019-07-18
JP6067917B1 (ja) 2017-01-25
US10583437B2 (en) 2020-03-10
US20170157609A1 (en) 2017-06-08
HRP20170360T1 (hr) 2017-04-21
CA2845390C (en) 2019-02-12
JP6066950B2 (ja) 2017-01-25
ES2618511T3 (es) 2017-06-21
DK3029465T3 (en) 2017-03-06
PL2790020T3 (pl) 2016-08-31
AU2016238956B2 (en) 2016-11-17
SI2790020T1 (sl) 2016-08-31
AU2014201576A1 (en) 2014-10-02
CN104147853B (zh) 2018-01-12
HUE028597T2 (hu) 2016-12-28
PT3029465T (pt) 2017-03-10
JP2014224800A (ja) 2014-12-04
CN107991476B (zh) 2020-03-03
US20180126378A1 (en) 2018-05-10
RS54749B1 (sr) 2016-10-31
US20140271909A1 (en) 2014-09-18
SMT201600152B (it) 2016-07-01
SI3029465T1 (sl) 2017-04-26
US20180045708A1 (en) 2018-02-15
CN107991476A (zh) 2018-05-04
PL3029465T3 (pl) 2017-06-30
JP2017046696A (ja) 2017-03-09
MX2014003296A (es) 2015-02-10
EP2790020B1 (en) 2016-03-09
US9631179B2 (en) 2017-04-25
EP3029465A1 (en) 2016-06-08
AU2014201576B2 (en) 2016-10-13
CN104147853A (zh) 2014-11-19
RS55796B1 (sr) 2017-08-31
US9939425B2 (en) 2018-04-10
US20170160263A1 (en) 2017-06-08
CA2845390A1 (en) 2014-09-15
CY1117533T1 (el) 2017-04-26
HK1247667A1 (zh) 2018-09-28
CN106834423A (zh) 2017-06-13
US9861983B2 (en) 2018-01-09

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