MX362661B - Métodos para segregar partículas usando un aparato con un elemento de separación por discriminación de tamaño que tiene un borde delantero alargado. - Google Patents

Métodos para segregar partículas usando un aparato con un elemento de separación por discriminación de tamaño que tiene un borde delantero alargado.

Info

Publication number
MX362661B
MX362661B MX2017008116A MX2017008116A MX362661B MX 362661 B MX362661 B MX 362661B MX 2017008116 A MX2017008116 A MX 2017008116A MX 2017008116 A MX2017008116 A MX 2017008116A MX 362661 B MX362661 B MX 362661B
Authority
MX
Mexico
Prior art keywords
particles
leading edge
segregating
methods
size
Prior art date
Application number
MX2017008116A
Other languages
English (en)
Inventor
George Hvichia
Original Assignee
Angle North America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angle North America Inc filed Critical Angle North America Inc
Publication of MX362661B publication Critical patent/MX362661B/es

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0694—Cells of blood, e.g. leukemia cells, myeloma cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0272—Investigating particle size or size distribution with screening; with classification by filtering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N2015/0288—Sorting the particles

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ecology (AREA)
  • Hospice & Palliative Care (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Combined Means For Separation Of Solids (AREA)
  • Sorting Of Articles (AREA)

Abstract

La descripción se relaciona a un aparato para segregar partículas con base en su capacidad de fluir por un pasaje escalonado; por lo menos algunas de las partículas pueden no pasar por un pasaje más estrecho unido por una etapa de segregación, teniendo como resultado la segregación de las partículas; el ancho del borde delantero de por lo menos una etapa del aparato es apreciablemente mayor que la anchura total del pasaje en el que el ocurre la etapa, permitiendo un rendimiento alto y rápido de la muestra; el aparato y los métodos descritos en la presente pueden ser utilizados para segregar partículas de una gran variedad de tipos; a manera de ejemplo, ellos pueden ser utilizados para segregar células de tumor circulantes de una muestra de sangre humana.
MX2017008116A 2013-03-15 2014-03-18 Métodos para segregar partículas usando un aparato con un elemento de separación por discriminación de tamaño que tiene un borde delantero alargado. MX362661B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361794468P 2013-03-15 2013-03-15
US14/077,811 US9631179B2 (en) 2013-03-15 2013-11-12 Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge

Publications (1)

Publication Number Publication Date
MX362661B true MX362661B (es) 2019-01-28

Family

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Family Applications (2)

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MX2017008116A MX362661B (es) 2013-03-15 2014-03-18 Métodos para segregar partículas usando un aparato con un elemento de separación por discriminación de tamaño que tiene un borde delantero alargado.
MX2014003296A MX356042B (es) 2013-03-15 2014-03-18 Métodos para segregar partículas usando un aparato con un elemento de separación por discriminación de tamaño que tiene un borde delantero alargado.

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MX2014003296A MX356042B (es) 2013-03-15 2014-03-18 Métodos para segregar partículas usando un aparato con un elemento de separación por discriminación de tamaño que tiene un borde delantero alargado.

Country Status (20)

Country Link
US (6) US9631179B2 (es)
EP (2) EP2790020B9 (es)
JP (2) JP6066950B2 (es)
CN (3) CN107991476B (es)
AU (2) AU2014201576B2 (es)
BR (1) BR102014006329A2 (es)
CA (1) CA2845390C (es)
CY (2) CY1117533T1 (es)
DK (2) DK3029465T3 (es)
ES (2) ES2618511T3 (es)
HK (1) HK1247667A1 (es)
HR (2) HRP20160395T1 (es)
HU (2) HUE028597T2 (es)
LT (1) LT3029465T (es)
MX (2) MX362661B (es)
PL (2) PL3029465T3 (es)
PT (1) PT3029465T (es)
RS (2) RS54749B1 (es)
SI (2) SI2790020T1 (es)
SM (1) SMT201600152B (es)

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US9631179B2 (en) * 2013-03-15 2017-04-25 Angle North America, Inc. Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge
KR102528348B1 (ko) * 2015-03-16 2023-05-03 루미넥스 코포레이션 다중-단차부 채널 에멀젼화를 위한 디바이스 및 방법
GB201617722D0 (en) 2016-10-19 2016-11-30 Univ London Queen Mary Method for determining prognosis of cancer
GB201617723D0 (en) 2016-10-19 2016-11-30 Univ London Queen Mary Method for predicting prostate cancer metastasis
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CN111526932B (zh) * 2017-12-28 2022-02-11 株式会社村田制作所 分离回收系统以及分离回收方法
FR3087792B1 (fr) * 2018-10-29 2023-09-29 Inovotion Modele animal pour amplifier des cellules tumorales circulantes humaines ou animales
US20220062317A1 (en) 2018-12-20 2022-03-03 Universität Basel Na+/k+ atpase inhibitors for use in the prevention or treatment of metastasis
CN109557304A (zh) * 2019-01-11 2019-04-02 广州万孚生物技术股份有限公司 免疫层析检测装置
WO2020178951A1 (en) * 2019-03-04 2020-09-10 Enplas Corporation Fluid handling device
KR102569747B1 (ko) * 2020-04-27 2023-08-25 고려대학교 산학협력단 유동채널 및 체액 내 입자 분리 장치
CN114397141B (zh) * 2021-12-10 2022-11-29 连云港市东方医院 一种神经内科临床用取液装置

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US9631179B2 (en) 2013-03-15 2017-04-25 Angle North America, Inc. Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge

Also Published As

Publication number Publication date
RS54749B1 (sr) 2016-10-31
US10279349B2 (en) 2019-05-07
HUE033689T2 (en) 2017-12-28
CY1118694T1 (el) 2017-07-12
CN107991476A (zh) 2018-05-04
SI2790020T1 (sl) 2016-08-31
AU2016238956B2 (en) 2016-11-17
CN107991476B (zh) 2020-03-03
AU2014201576A1 (en) 2014-10-02
HRP20170360T1 (hr) 2017-04-21
ES2573120T3 (es) 2016-06-06
CN104147853A (zh) 2014-11-19
US9861983B2 (en) 2018-01-09
LT3029465T (lt) 2017-03-27
SI3029465T1 (sl) 2017-04-26
EP2790020A3 (en) 2014-12-24
US20140271909A1 (en) 2014-09-18
EP3029465B1 (en) 2017-01-11
CY1117533T1 (el) 2017-04-26
JP6066950B2 (ja) 2017-01-25
EP2790020B9 (en) 2016-05-18
CN106834423A (zh) 2017-06-13
DK2790020T3 (en) 2016-04-25
AU2016238956A1 (en) 2016-11-03
RS55796B1 (sr) 2017-08-31
HRP20160395T1 (hr) 2016-07-01
JP2014224800A (ja) 2014-12-04
MX2014003296A (es) 2015-02-10
US10583437B2 (en) 2020-03-10
HUE028597T2 (hu) 2016-12-28
US9939425B2 (en) 2018-04-10
JP2017046696A (ja) 2017-03-09
CN104147853B (zh) 2018-01-12
SMT201600152B (it) 2016-07-01
US20170157609A1 (en) 2017-06-08
EP2790020A2 (en) 2014-10-15
EP2790020B1 (en) 2016-03-09
BR102014006329A2 (pt) 2015-01-13
EP3029465A1 (en) 2016-06-08
HK1247667A1 (zh) 2018-09-28
PT3029465T (pt) 2017-03-10
US20190217294A1 (en) 2019-07-18
PL3029465T3 (pl) 2017-06-30
PL2790020T3 (pl) 2016-08-31
US20170160263A1 (en) 2017-06-08
CA2845390A1 (en) 2014-09-15
ES2618511T3 (es) 2017-06-21
MX356042B (es) 2018-05-09
CA2845390C (en) 2019-02-12
US20180045708A1 (en) 2018-02-15
AU2014201576B2 (en) 2016-10-13
US9631179B2 (en) 2017-04-25
DK3029465T3 (en) 2017-03-06
US20180126378A1 (en) 2018-05-10
JP6067917B1 (ja) 2017-01-25
US9851344B2 (en) 2017-12-26

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