CY1117938T1 - Συνθεσεις και μεθοδοι χρησης φορβολικων εστερων - Google Patents
Συνθεσεις και μεθοδοι χρησης φορβολικων εστερωνInfo
- Publication number
- CY1117938T1 CY1117938T1 CY20161100709T CY161100709T CY1117938T1 CY 1117938 T1 CY1117938 T1 CY 1117938T1 CY 20161100709 T CY20161100709 T CY 20161100709T CY 161100709 T CY161100709 T CY 161100709T CY 1117938 T1 CY1117938 T1 CY 1117938T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hiv
- diseases
- methods
- compositions
- cytopathic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/46—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom rings with more than six members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Παρέχονται μέθοδοι και συνθέσεις που περιέχουν φορβολικό εστέρα ή παράγωγο φορβολικού εστέρα για την θεραπευτική αγωγή κυτταροπαθολογικών ασθενειών. Κυτταροπαθολογικές ασθένειες μπορούν να προκληθούν από ποικιλία μέσων όπως ιικές λοιμώξεις όπως HIV και AIDS, ή από ανάπτυξη νεοπλασμάτων σε θηλαστικό υποκείμενο. Οι μέθοδοι και συνθέσεις της εφεύρεσης είναι αποτελεσματικές για αναστολή de novo λοίμωξης HIV, αυξορρύθμιση ιικής έκφρασης από λανθάνοντα προϊόν, αναστολή HIV-επαγόμενων κυτταροπαθολογικών φαινομένων, μειορρύθμιση του υποδοχέα HIV, αύξηση έκφρασης κυτοκινών Th1, μείωση έκφρασης κυτοκινών Th2, αύξηση φωσφορυλίωσης ERK, επαγωγή απόπτωσης σε κακοήθη κύτταρα, επαγωγή ύφεσης, διατήρηση ύφεσης, ως χημειοθεραπευτικοί παράγοντες, όπως επίσης και για μείωση συμπτωμάτων κυτταροπαθολογικών ασθενειών και περιστασιακών μολύνσεων που μπορούν να συνοδεύουν τέτοιες ασθένειες. Παρέχονται επιπρόσθετες συνθέσεις και μέθοδοι που χρησιμοποιούν φορβολικό εστέρα ή παράγωγη ένωση σε συνδυασμό με τουλάχιστον έναν επιπρόσθετο παράγοντα όπως αυτούς που χρησιμοποιούνται σε πρωτόκολλα HAART, θεραπευτικούς παράγοντες που χρησιμοποιούνται σε θεραπευτική αγωγή περιστασιακών μολύνσεων λόγω HIV, ή χημειοθεραπευτικούς παράγοντες για να αποκτηθούν αποτελεσματικότερα μέσα θεραπείας εναντίον κυτταροπαθολογικών ασθενειών σε θηλαστικά υποκείμενα.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89881007P | 2007-01-31 | 2007-01-31 | |
| EP08725016A EP2170053A4 (en) | 2007-01-31 | 2008-01-30 | COMPOSITIONS AND METHODS FOR THE USE OF PHILOSOPHERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117938T1 true CY1117938T1 (el) | 2017-05-17 |
Family
ID=39674428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100709T CY1117938T1 (el) | 2007-01-31 | 2016-07-19 | Συνθεσεις και μεθοδοι χρησης φορβολικων εστερων |
Country Status (24)
| Country | Link |
|---|---|
| US (8) | US20080226589A1 (el) |
| EP (2) | EP2368555B1 (el) |
| JP (5) | JP2010516813A (el) |
| KR (2) | KR20120091267A (el) |
| CN (1) | CN101677542B (el) |
| AU (1) | AU2008211081A1 (el) |
| BR (1) | BRPI0806863B8 (el) |
| CA (1) | CA2676551C (el) |
| CY (1) | CY1117938T1 (el) |
| ES (1) | ES2584327T3 (el) |
| HR (1) | HRP20160902T1 (el) |
| HU (1) | HUE029954T2 (el) |
| IL (1) | IL200141A0 (el) |
| LT (1) | LT2368555T (el) |
| MX (1) | MX2009008179A (el) |
| MY (2) | MY186986A (el) |
| PH (1) | PH12017502257A1 (el) |
| PL (1) | PL2368555T3 (el) |
| PT (1) | PT2368555T (el) |
| RS (1) | RS54988B1 (el) |
| RU (1) | RU2472511C2 (el) |
| SI (1) | SI2368555T1 (el) |
| WO (1) | WO2008094657A1 (el) |
| ZA (1) | ZA200905273B (el) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10369222B2 (en) | 2012-01-18 | 2019-08-06 | Biosuccess Biotech Co., Ltd. | Compositions and methods of use of phorbol esters for the treatment of stroke |
| US9974764B2 (en) | 2007-01-31 | 2018-05-22 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters in the treatment of neoplasms |
| US9636317B2 (en) | 2007-01-31 | 2017-05-02 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters |
| US11564901B2 (en) | 2007-01-31 | 2023-01-31 | Biosuccess Biotech Co., Ltd. | Compositions and methods of use of phorbol esters |
| US9533938B2 (en) | 2007-01-31 | 2017-01-03 | Biosuccess Biotech Co., Ltd. | Compositions and methods of use of phorbol esters for the treatment of stroke |
| US11696908B2 (en) | 2007-01-31 | 2023-07-11 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters |
| EP2368555B1 (en) | 2007-01-31 | 2016-04-20 | Biosuccess Biotech Company | Compositions and methods of use of phorbolesters |
| WO2010065721A1 (en) | 2008-12-03 | 2010-06-10 | The Scripps Research Institute | Stem cell cultures |
| US8575216B2 (en) * | 2009-08-04 | 2013-11-05 | Rutgers, The State University Of New Jersey | Method of treatment for acute myelogenous leukemia |
| US10099996B2 (en) | 2012-01-18 | 2018-10-16 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters in the treatment of neoplasms |
| TWI619494B (zh) * | 2013-01-18 | 2018-04-01 | 華鴻新藥股份有限公司 | 巴豆酯之組成物及使用方法 |
| CA2861459C (en) * | 2012-01-18 | 2020-08-25 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters |
| US9550722B2 (en) | 2012-01-18 | 2017-01-24 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbal esters for the treatment of stroke |
| RU2488400C1 (ru) * | 2012-03-12 | 2013-07-27 | Вячеслав Владимирович Чеботарёв | Способ превентивного дифференцированного лечения лиц, контактных с больными заразной формой сифилиса |
| US9517224B2 (en) | 2012-11-15 | 2016-12-13 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Methods of treating patients infected with HIV and HTLV |
| TWI630909B (zh) * | 2013-01-18 | 2018-08-01 | 華鴻新藥股份有限公司 | 用於中風治療之巴豆酯組成物及使用方法 |
| MA40904A (fr) * | 2014-11-03 | 2017-09-12 | Hygeia Tech Inc | Compositions d'ester de phorbol et procédés pour traiter ou réduire la durée d'une cytopénie |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB427857A (en) | 1934-08-02 | 1935-05-01 | Newsum Sons & Company Ltd H | A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames |
| US6080784A (en) * | 1986-06-11 | 2000-06-27 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators N |
| ES2120962T3 (es) | 1990-05-30 | 1998-11-16 | Us Health | Composicion antivirica. |
| DE69131667D1 (de) * | 1990-07-30 | 1999-11-04 | Procyon Pharm Inc | Proteinkinase-c-modulatoren mit entzündungshemmender und antiviraler aktivität |
| RU2197964C2 (ru) * | 1995-04-12 | 2003-02-10 | Дзе Проктер Энд Гэмбл Компани | Фармацевтическая композиция, композиция стандартной лекарственной формы и способ лечения злокачественных новообразований, опухолей и вирусных инфекций |
| US6184248B1 (en) | 1996-09-05 | 2001-02-06 | Robert K. K. Lee | Compositions and methods for treatment of neurological disorders and neurodegenerative diseases |
| GB9620390D0 (en) | 1996-09-30 | 1996-11-13 | Eisai London Res Lab Ltd | Substances and their uses |
| US6063814A (en) * | 1997-04-14 | 2000-05-16 | Chang; Richard L. | Phorbol esters as anti-neoplastic and white blood cell elevating agents |
| CA2237877A1 (en) | 1998-06-26 | 1999-12-26 | Anthony Paolitto | Chest retractor for performing cardiac surgery |
| JP4110347B2 (ja) | 1999-11-05 | 2008-07-02 | 大鵬薬品工業株式会社 | 抗ｈｉｖ剤 |
| JP2001139468A (ja) * | 1999-11-11 | 2001-05-22 | Lead Chemical Co Ltd | 抗ウイルス作用を有するホルボール誘導体 |
| AU4317500A (en) * | 2000-05-02 | 2001-11-12 | Lead Chemical Co., Ltd. | Antibiral compositions containing phorbol derivatives as the main active ingredient |
| JP2004505047A (ja) | 2000-07-28 | 2004-02-19 | キャンサー・リサーチ・テクノロジー・リミテッド | 複合治療による癌治療 |
| US20070009529A1 (en) | 2002-03-26 | 2007-01-11 | New York University | Agents that dissolve arterial thrombi |
| US20080004332A1 (en) | 2002-03-07 | 2008-01-03 | Alkon Daniel L | Methods for alzheimer's disease treatment and cognitive enhancement |
| DE10244453A1 (de) | 2002-09-24 | 2004-04-01 | Phenomiques Gmbh | Hemmung der Proteinkinase C-alpha zur Behandlung von Krankheiten |
| US7662852B2 (en) | 2003-05-22 | 2010-02-16 | Lead Chemical Co., Ltd. | Compounds and preparations having antiviral effect |
| JP4006645B2 (ja) * | 2003-08-27 | 2007-11-14 | トヨタ自動車株式会社 | 排ガス浄化装置 |
| JP2005179201A (ja) * | 2003-12-16 | 2005-07-07 | Japan Science & Technology Agency | 抗ｈｉｖ化合物とその利用 |
| CA2502109C (en) * | 2004-03-24 | 2010-02-23 | Yamasa Corporation | 4'-c-substituted-2-haloadenosine derivative |
| JP2008069182A (ja) | 2004-03-24 | 2008-03-27 | Yamasa Shoyu Co Ltd | ４’−ｃ−置換−２−ハロアデノシン誘導体 |
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| WO2008024490A2 (en) | 2006-08-24 | 2008-02-28 | Theraquest Biosciences, Inc. | Oral pharmaceutical formulations of abuse deterrent cannabinoids and method of use |
| EP2368555B1 (en) | 2007-01-31 | 2016-04-20 | Biosuccess Biotech Company | Compositions and methods of use of phorbolesters |
| EP2030631A1 (en) | 2007-08-31 | 2009-03-04 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Means and methods for treating peripheral and cardiovascular diseases via modulation of arteriogenesis |
| US8575216B2 (en) | 2009-08-04 | 2013-11-05 | Rutgers, The State University Of New Jersey | Method of treatment for acute myelogenous leukemia |
| KR101144327B1 (ko) | 2010-04-02 | 2012-05-11 | 한국과학기술연구원 | Ｐｋｃ 작용 활성제를 유효성분으로 함유하는 압상스 간질의 예방 및 치료용 조성물 |
| WO2011127288A2 (en) | 2010-04-07 | 2011-10-13 | La Jolla Institute For Allergy And Immunology | Methods and uses of nur77 and nur77 agonists to modulate macrophages and monocytes, and treat inflammation, inflammatory disease and cardiovascular disease |
| WO2011144901A1 (en) | 2010-05-20 | 2011-11-24 | The University Of Newcastle Upon Tyne | Expansion and directed differentiation of epidermal neural crest stem cells |
| CA2861459C (en) | 2012-01-18 | 2020-08-25 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters |
| JP5738207B2 (ja) * | 2012-01-27 | 2015-06-17 | 三菱電機株式会社 | 圧縮機、冷蔵庫、機器 |
-
2008
- 2008-01-30 EP EP10015894.8A patent/EP2368555B1/en active Active
- 2008-01-30 EP EP08725016A patent/EP2170053A4/en not_active Withdrawn
- 2008-01-30 LT LTEP10015894.8T patent/LT2368555T/lt unknown
- 2008-01-30 MY MYPI2017001013A patent/MY186986A/en unknown
- 2008-01-30 ES ES10015894.8T patent/ES2584327T3/es active Active
- 2008-01-30 RS RS20160571A patent/RS54988B1/sr unknown
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