CY1117227T1 - Αναλογα βουπρενορφινης - Google Patents

Αναλογα βουπρενορφινης

Info

Publication number
CY1117227T1
CY1117227T1 CY20161100187T CY161100187T CY1117227T1 CY 1117227 T1 CY1117227 T1 CY 1117227T1 CY 20161100187 T CY20161100187 T CY 20161100187T CY 161100187 T CY161100187 T CY 161100187T CY 1117227 T1 CY1117227 T1 CY 1117227T1
Authority
CY
Cyprus
Prior art keywords
formula
buprenorphine
analogues
compounds
buprenorphine analogues
Prior art date
Application number
CY20161100187T
Other languages
English (en)
Inventor
Donald J Kyle
Laykea Tafesse
Original Assignee
Purdue Pharma L.P.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44903285&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117227(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Purdue Pharma L.P. filed Critical Purdue Pharma L.P.
Publication of CY1117227T1 publication Critical patent/CY1117227T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η παρούσα εφεύρεση αφορά ενώσεις Αναλόγων Βουπρενορφίνης του Τύπου (I), Τύπου (ΙΑ) ή Τύπου (IB) που δεικνύονται κατωτέρω, όπου τα R1, R2, R8, R3a, R3b G, X, Ζ και Y είναι όπως ορίζεται εδώ. Οι Ενώσεις της Εφεύρεσης είναι χρήσιμες εις την θεραπευτική αγωγή του πόνου, της δυσκοιλιότητας και άλλων καταστάσεων οι οποίες τροποποιούνται δια της δράσης υποδοχέων οπιοειδών και ORL-1.
CY20161100187T 2010-09-21 2016-03-04 Αναλογα βουπρενορφινης CY1117227T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38491210P 2010-09-21 2010-09-21
US201161503674P 2011-07-01 2011-07-01
EP11776855.6A EP2619212B1 (en) 2010-09-21 2011-09-20 Buprenorphine analogs as opioid receptor agonists and/or antagonists

Publications (1)

Publication Number Publication Date
CY1117227T1 true CY1117227T1 (el) 2017-04-05

Family

ID=44903285

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100187T CY1117227T1 (el) 2010-09-21 2016-03-04 Αναλογα βουπρενορφινης

Country Status (34)

Country Link
US (1) US9221831B2 (el)
EP (1) EP2619212B1 (el)
JP (2) JP5977240B2 (el)
KR (2) KR20150027315A (el)
CN (2) CN103154000A (el)
AR (1) AR083062A1 (el)
AU (1) AU2011306644B2 (el)
CA (1) CA2810356C (el)
CL (1) CL2013000732A1 (el)
CO (1) CO6690803A2 (el)
CR (1) CR20130129A (el)
CY (1) CY1117227T1 (el)
DK (1) DK2619212T3 (el)
DO (1) DOP2013000060A (el)
EA (1) EA201390422A1 (el)
EC (1) ECSP13012543A (el)
ES (1) ES2566828T3 (el)
HK (1) HK1187045A1 (el)
HR (1) HRP20160281T1 (el)
HU (1) HUE027195T2 (el)
ME (1) ME02367B (el)
MX (1) MX2013003354A (el)
NI (1) NI201300032A (el)
NZ (1) NZ609200A (el)
PE (1) PE20140020A1 (el)
PL (1) PL2619212T3 (el)
RS (1) RS54579B1 (el)
SG (1) SG188300A1 (el)
SI (1) SI2619212T1 (el)
SM (1) SMT201600088B (el)
TW (2) TW201242968A (el)
UY (1) UY33618A (el)
WO (1) WO2012038813A1 (el)
ZA (1) ZA201301217B (el)

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CN101801415B (zh) 2007-05-25 2015-09-23 Rb医药品有限公司 利培酮化合物的持续递送制剂
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US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
DK2582366T3 (en) 2010-06-15 2015-12-07 Gruenenthal Gmbh A pharmaceutical combination for the treatment of pain.
JP5934787B2 (ja) 2011-05-10 2016-06-15 ギリアード サイエンシーズ， インコーポレイテッド イオンチャネルモジュレーターとしての縮合複素環式化合物
NO3175985T3 (el) 2011-07-01 2018-04-28
TW201837023A (zh) 2011-07-01 2018-10-16 美商基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
EP2788358B1 (en) 2011-12-08 2018-08-29 Purdue Pharma LP Quaternized buprenorphine analogs
US9315514B2 (en) * 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
EP2917182B1 (en) 2012-11-09 2018-01-03 Purdue Pharma LP Benzomorphan analogs and the use thereof
WO2014087226A1 (en) * 2012-12-07 2014-06-12 Purdue Pharma L.P. Buprenorphine analogs as opiod receptor modulators
EP2951160B1 (en) 2013-01-31 2019-04-24 Purdue Pharma LP Benzomorphan analogs and the use thereof
US8969358B2 (en) * 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
WO2015097545A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
US20160333020A1 (en) * 2013-12-26 2016-11-17 Purdue Pharma L.P. 7-beta analogs of orvinols
US9994571B2 (en) 2013-12-26 2018-06-12 Purdue Pharma L.P. 10-substituted morphinan hydantoins
JP6353543B2 (ja) 2013-12-26 2018-07-04 パーデュー、ファーマ、リミテッド、パートナーシップ 環縮小モルフィナン及びその使用
WO2015097548A1 (en) * 2013-12-26 2015-07-02 Purdue Pharma L.P. 7-beta-alkyl analogs of orvinols
US10550088B2 (en) 2013-12-27 2020-02-04 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
CA2950567A1 (en) 2014-05-27 2015-12-03 Purdue Pharma L.P. Spirocyclic morphinans and use thereof
US10202382B2 (en) 2014-06-13 2019-02-12 Purdue Pharma L.P. Azamorphinan derivatives and use thereof
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
KR20180080248A (ko) * 2015-10-26 2018-07-11 오르포메드, 인코포레이티드 부프레노르핀의 에틸렌 글리콜 에테르
CN108884026B (zh) * 2016-03-22 2021-05-25 赫尔森保健股份公司 苯磺酰基不对称尿素及其医学用途
US10745402B2 (en) 2017-01-02 2020-08-18 Purdue Pharma L.P. Morphinan derivatives and use thereof
CA3063975A1 (en) 2017-05-19 2018-11-22 River Stone Biotech Aps Preparation of buprenorphine
JP2021104932A (ja) * 2018-03-30 2021-07-26 日本ケミファ株式会社 モルヒナン誘導体の製造方法
WO2024044179A1 (en) * 2022-08-23 2024-02-29 Virginia Commonwealth University Multiple targeting opioid receptor ligands as novel analgesics with minimum abuse liability

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US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
US20160333020A1 (en) 2013-12-26 2016-11-17 Purdue Pharma L.P. 7-beta analogs of orvinols
WO2015097548A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 7-beta-alkyl analogs of orvinols
US9994571B2 (en) 2013-12-26 2018-06-12 Purdue Pharma L.P. 10-substituted morphinan hydantoins
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
US10550088B2 (en) 2013-12-27 2020-02-04 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
EP3089978B1 (en) 2013-12-30 2018-08-29 Purdue Pharma L.P. Pyridone-sulfone morphinan analogs as opioid receptor ligands

Also Published As

Publication number Publication date
CA2810356A1 (en) 2012-03-29
MX2013003354A (es) 2013-06-24
UY33618A (es) 2012-03-30
KR20130097210A (ko) 2013-09-02
KR101630912B1 (ko) 2016-06-15
ECSP13012543A (es) 2013-06-28
AU2011306644B2 (en) 2015-07-02
ME02367B (me) 2016-06-20
TW201422621A (zh) 2014-06-16
SG188300A1 (en) 2013-04-30
SI2619212T1 (sl) 2016-04-29
KR20150027315A (ko) 2015-03-11
EP2619212B1 (en) 2016-01-06
HK1187045A1 (en) 2014-03-28
HRP20160281T1 (hr) 2016-04-08
PL2619212T3 (pl) 2016-09-30
PE20140020A1 (es) 2014-01-31
CO6690803A2 (es) 2013-06-17
HUE027195T2 (en) 2016-10-28
CR20130129A (es) 2013-08-29
JP2016102115A (ja) 2016-06-02
EP2619212A1 (en) 2013-07-31
US9221831B2 (en) 2015-12-29
CN105399751A (zh) 2016-03-16
EA201390422A1 (ru) 2014-01-30
CA2810356C (en) 2016-06-14
NZ609200A (en) 2015-01-30
RS54579B1 (en) 2016-06-30
SMT201600088B (it) 2016-04-29
US20140057931A1 (en) 2014-02-27
AR083062A1 (es) 2013-01-30
CN103154000A (zh) 2013-06-12
AU2011306644A1 (en) 2013-04-11
NI201300032A (es) 2014-01-13
CL2013000732A1 (es) 2013-07-26
JP5977240B2 (ja) 2016-08-24
DK2619212T3 (en) 2016-03-21
DOP2013000060A (es) 2013-04-30
WO2012038813A1 (en) 2012-03-29
JP2013543488A (ja) 2013-12-05
TW201242968A (en) 2012-11-01
ES2566828T3 (es) 2016-04-15
ZA201301217B (en) 2013-09-25

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