CY1117006T1 - Ν-[4-(1Η-ΠΥΡΑΖΟΛΟ[3,4-b|ΠΥΡΑΖΙΝ-6-ΥΛ)-ΦΑΙΝΥΛ]-ΣΟΥΛΦΟΝΑΜΙΔΕΣ ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΦΑΡΜΑΚΕΥΤΙΚΑ ΜΕΣΑ - Google Patents

Ν-[4-(1Η-ΠΥΡΑΖΟΛΟ[3,4-b|ΠΥΡΑΖΙΝ-6-ΥΛ)-ΦΑΙΝΥΛ]-ΣΟΥΛΦΟΝΑΜΙΔΕΣ ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΦΑΡΜΑΚΕΥΤΙΚΑ ΜΕΣΑ

Info

Publication number
CY1117006T1
CY1117006T1 CY20151101035T CY151101035T CY1117006T1 CY 1117006 T1 CY1117006 T1 CY 1117006T1 CY 20151101035 T CY20151101035 T CY 20151101035T CY 151101035 T CY151101035 T CY 151101035T CY 1117006 T1 CY1117006 T1 CY 1117006T1
Authority
CY
Cyprus
Prior art keywords
sgk
formula
pyrazolo
sulfonamides
phenyl
Prior art date
Application number
CY20151101035T
Other languages
English (en)
Inventor
Marc Nazaré
Nis Halland
Friedemann Schmidt
Tilo Weiss
Uwe Dietz
Armin Hofmeister
Jean-Christophe Carry
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of CY1117006T1 publication Critical patent/CY1117006T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

H παρούσα εφεύρεση σχετίζεται με Ν-[4-(1 Η-πυραζολο[3,4-b]πυραζιν-6-υλ)-φαινυλ]-σουλφοναμίδες του τύπου I, όπου Ar, R1, R2 και n έχουν τις έννοιες που υποδεικνύονται στις αξιώσεις. Οι ενώσεις του τύπου I είναι πολύτιμες φαρμακολογικά ενεργές ενώσεις που ρυθμίζουν την δράση πρωτεϊνικής κινάσης, ειδικά την δράση της κινάσης ρυθμιζόμενης από τον ορό και τα γλυκοκορτικοειδή (SGK), ειδικότερα του ισόμορφου κινάσης ρυθμιζόμενης από τον ορό και τα γλυκοκορτικοειδή 1 (SGK-1, SGK1), και είναι κατάλληλες για την θεραπεία νόσων όπου η δράση SGK είναι ακατάλληλη, για παράδειγμα εκφυλιστικές νόσοι αρθρώσεων ή φλεγμονώδεις διαδικασίες όπως οστεοαρθρίτιδα ή ρευματισμός. Η εφεύρεση επιπλέον σχετίζεται με διαδικασίες για την παρασκευή των ενώσεων του τύπου I, την χρήση τους ως φαρμακευτικά μέσα, και φαρμακευτικές συνθέσεις που τις περιέχουν.
CY20151101035T 2011-09-19 2015-11-18 Ν-[4-(1Η-ΠΥΡΑΖΟΛΟ[3,4-b|ΠΥΡΑΖΙΝ-6-ΥΛ)-ΦΑΙΝΥΛ]-ΣΟΥΛΦΟΝΑΜΙΔΕΣ ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΦΑΡΜΑΚΕΥΤΙΚΑ ΜΕΣΑ CY1117006T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11306179.0A EP2570415B1 (en) 2011-09-19 2011-09-19 N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides and their use as pharmaceuticals

Publications (1)

Publication Number Publication Date
CY1117006T1 true CY1117006T1 (el) 2017-04-05

Family

ID=46875813

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151101035T CY1117006T1 (el) 2011-09-19 2015-11-18 Ν-[4-(1Η-ΠΥΡΑΖΟΛΟ[3,4-b|ΠΥΡΑΖΙΝ-6-ΥΛ)-ΦΑΙΝΥΛ]-ΣΟΥΛΦΟΝΑΜΙΔΕΣ ΚΑΙ Η ΧΡΗΣΗ ΤΟΥΣ ΩΣ ΦΑΡΜΑΚΕΥΤΙΚΑ ΜΕΣΑ

Country Status (17)

Country Link
US (1) US9174993B2 (el)
EP (2) EP2570415B1 (el)
AR (1) AR087907A1 (el)
BR (1) BR112014006207A2 (el)
CY (1) CY1117006T1 (el)
DK (1) DK2570415T3 (el)
EA (1) EA024295B1 (el)
ES (2) ES2552836T3 (el)
HR (1) HRP20151183T1 (el)
HU (1) HUE026072T2 (el)
MX (1) MX342869B (el)
MY (1) MY179987A (el)
PL (1) PL2570415T3 (el)
PT (1) PT2570415E (el)
SI (1) SI2570415T1 (el)
TW (1) TWI577679B (el)
WO (1) WO2013041502A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018106459A1 (en) 2016-12-07 2018-06-14 New Era Pharma, Inc. Compounds and pharmaceutical compositions for modulating sgk activity, and methods thereof
WO2018156401A1 (en) * 2017-02-24 2018-08-30 Indiana University Research And Technology Corporation Methods of inhibiting serum glucocorticoid induced kinase 1 (sgk1) as a treatment for salt and water balance diseases
BR112021023562A2 (pt) 2019-06-14 2022-01-04 Janssen Pharmaceutica Nv Carbamatos de pirazina e seus usos como moduladores do receptor de glun2b
KR20220024512A (ko) 2019-06-14 2022-03-03 얀센 파마슈티카 엔.브이. 치환된 헤테로방향족 피라졸로-피리딘 및 GluN2B 수용체 조절제로서의 이의 용도
AU2020292994A1 (en) * 2019-06-14 2022-01-06 Janssen Pharmaceutica Nv Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators
EP3983074A1 (en) 2019-06-14 2022-04-20 Janssen Pharmaceutica NV Pyridine carbamates and their use as glun2b receptor modulators
WO2020249792A1 (en) 2019-06-14 2020-12-17 Janssen Pharmaceutica Nv Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators
WO2024015055A1 (en) * 2022-07-13 2024-01-18 Thryv Therapeutics Inc. Pyrazolo[3,4-d]pyrimidin-6-yl-sulfonamide derivatives for the inhibition of sgk-1 and treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6690240B2 (en) 2002-01-10 2004-02-10 Cirrus Logic, Inc. Low-jitter loop filter for a phase-locked loop system
AU2004274403A1 (en) 2003-09-03 2005-03-31 Aventis Pharmaceuticals Inc. 5-aryl-Pyrazolo(4,3-d)pyrimidines, pyridines, and pyrazines and related compounds
DE102004059781A1 (de) 2004-12-10 2006-06-22 Sanofi-Aventis Deutschland Gmbh Verwendung der Serum-/Glucocorticoid regulierten Kinase
DE102005015255A1 (de) 2005-04-04 2006-10-05 Merck Patent Gmbh Acylhydrazide
DE102006043443A1 (de) 2006-09-15 2008-03-27 Bayer Healthcare Ag Neue aza-bicyclische Verbindungen und ihre Verwendung
DE102007002717A1 (de) 2007-01-18 2008-07-24 Merck Patent Gmbh Heterocyclische Indazolderivate
AU2011377409B2 (en) 2011-09-19 2017-05-25 Sanofi N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides and their use as pharmaceuticals
US20130072493A1 (en) 2011-09-19 2013-03-21 Sanofi N-[4-(1H-PYRAZOLO[3,4-b]PYRAZIN-6-YL)-PHENYL]-SULFONAMIDES AND THEIR USE AS PHARMACEUTICALS

Also Published As

Publication number Publication date
BR112014006207A2 (pt) 2017-04-11
MY179987A (en) 2020-11-19
EA024295B1 (ru) 2016-09-30
HUE026072T2 (en) 2016-05-30
EA201490662A1 (ru) 2014-07-30
ES2552836T3 (es) 2015-12-02
PT2570415E (pt) 2015-11-23
SI2570415T1 (sl) 2015-12-31
HRP20151183T1 (hr) 2015-12-04
EP2758399A1 (en) 2014-07-30
EP2570415B1 (en) 2015-08-26
EP2570415A8 (en) 2013-05-22
US20140357640A1 (en) 2014-12-04
MX2014002736A (es) 2014-05-01
TW201329079A (zh) 2013-07-16
PL2570415T3 (pl) 2016-01-29
WO2013041502A1 (en) 2013-03-28
DK2570415T3 (en) 2015-11-23
EP2758399B1 (en) 2017-11-15
US9174993B2 (en) 2015-11-03
MX342869B (es) 2016-10-17
EP2570415A1 (en) 2013-03-20
ES2659551T3 (es) 2018-03-16
AR087907A1 (es) 2014-04-23
TWI577679B (zh) 2017-04-11

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