CY1116757T1 - Πεπτιδια που προσδενουν υποδοχεα αυξητικου παραγοντα 1 ομοιαζοντος με ινσουλινη - Google Patents
Πεπτιδια που προσδενουν υποδοχεα αυξητικου παραγοντα 1 ομοιαζοντος με ινσουλινηInfo
- Publication number
- CY1116757T1 CY1116757T1 CY20151100883T CY151100883T CY1116757T1 CY 1116757 T1 CY1116757 T1 CY 1116757T1 CY 20151100883 T CY20151100883 T CY 20151100883T CY 151100883 T CY151100883 T CY 151100883T CY 1116757 T1 CY1116757 T1 CY 1116757T1
- Authority
- CY
- Cyprus
- Prior art keywords
- insulin
- polypeptides
- factor
- growth factor
- peptides
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000009465 Growth Factor Receptors Human genes 0.000 title 1
- 108010009202 Growth Factor Receptors Proteins 0.000 title 1
- 230000002608 insulinlike Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 230000008499 blood brain barrier function Effects 0.000 abstract 2
- 210000001218 blood-brain barrier Anatomy 0.000 abstract 2
- 102000004584 Somatomedin Receptors Human genes 0.000 abstract 1
- 108010017622 Somatomedin Receptors Proteins 0.000 abstract 1
- 210000004671 cell-free system Anatomy 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Αποκαλυπτόμενα είναι πεπτίδια που προσδένουν τον υποδοχέα ομοιάζοντος με ινσουλίνη αυξητικού παράγοντα 1, και τα πολυνουκλεοτίδια που κωδικεύουν τα πολυπεπτίδια. Αποκαλυπτόμενες ακόμη είναι μέθοδοι για παραγωγή των πολυπεπτιδίων χρησιμοποιώντας συστήματα κυτταρικής έκφρασης και συστήματα άνευ κυττάρων και μέθοδοι χρήσης των πολυπεπτιδίων για παραγωγή πρωτεϊνών σύντηξης. Τα πολυπεπτίδια που αποκαλύπτονται μπορούν να παρέχουν μέσα για παράδοση θεραπευτικών παραγόντων διαμέσου του αιματοεγκεφαλικού φραγμού (ΒΒΒ).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34893710P | 2010-05-27 | 2010-05-27 | |
EP11787324.0A EP2575846B1 (en) | 2010-05-27 | 2011-05-25 | Insulin-like growth factor 1 receptor binding peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1116757T1 true CY1116757T1 (el) | 2017-03-15 |
Family
ID=45004356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100883T CY1116757T1 (el) | 2010-05-27 | 2015-10-05 | Πεπτιδια που προσδενουν υποδοχεα αυξητικου παραγοντα 1 ομοιαζοντος με ινσουλινη |
Country Status (28)
Country | Link |
---|---|
US (1) | US8415306B2 (el) |
EP (1) | EP2575846B1 (el) |
JP (1) | JP5864556B2 (el) |
KR (1) | KR101898502B1 (el) |
CN (1) | CN103025341B (el) |
AU (1) | AU2011258301B2 (el) |
BR (1) | BR112012030084B1 (el) |
CA (1) | CA2800744C (el) |
CY (1) | CY1116757T1 (el) |
DK (1) | DK2575846T3 (el) |
EA (1) | EA023541B1 (el) |
ES (1) | ES2550040T3 (el) |
HK (1) | HK1183234A1 (el) |
HR (1) | HRP20151084T1 (el) |
HU (1) | HUE026269T2 (el) |
IL (1) | IL223030A (el) |
ME (1) | ME02206B (el) |
MX (1) | MX337134B (el) |
NZ (1) | NZ603611A (el) |
PL (1) | PL2575846T3 (el) |
PT (1) | PT2575846E (el) |
RS (1) | RS54278B1 (el) |
SG (1) | SG186068A1 (el) |
SI (1) | SI2575846T1 (el) |
SM (1) | SMT201500222B (el) |
UA (1) | UA107596C2 (el) |
WO (1) | WO2011150061A1 (el) |
ZA (1) | ZA201209689B (el) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102355310B1 (ko) * | 2014-03-06 | 2022-01-24 | 내셔날 리서치 카운실 오브 캐나다 | 인슐린-유사 성장 인자 1 수용체-특이적 항체 및 그의 용도 |
UA120047C2 (uk) * | 2014-03-06 | 2019-09-25 | Нешнл Рісеч Каунсіл Оф Канада | Антигензв'язуючий фрагмент антитіла, який специфічно зв'язується з рецептором інсуліноподібного фактора росту 1 (igf1r) |
MX2016011560A (es) | 2014-03-06 | 2017-04-13 | Nat Res Council Canada | Anticuerpos especificos para el receptor del factor de crecimiento similar a insulina 1 y usos de los mismos. |
RU2694064C1 (ru) | 2015-12-21 | 2019-07-09 | Браинон Инк. | Композиция для улучшения памяти, способности к обучению и когнитивных способностей |
KR101706296B1 (ko) | 2015-12-21 | 2017-02-13 | 주식회사 브레인온 | 기억력, 학습력, 인지력 향상용 조성물 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US6329508B1 (en) | 1989-09-07 | 2001-12-11 | Alkermes, Inc. | Transferrin receptor reactive chimeric antibodies |
JPH06228199A (ja) * | 1992-11-27 | 1994-08-16 | Takeda Chem Ind Ltd | 血液脳関門通過可能なペプチド結合体 |
EP1006184A1 (en) * | 1998-12-03 | 2000-06-07 | F. Hoffmann-La Roche Ag | IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof |
US20100293669A2 (en) | 1999-05-06 | 2010-11-18 | Jingdong Liu | Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement |
US20090087878A9 (en) | 1999-05-06 | 2009-04-02 | La Rosa Thomas J | Nucleic acid molecules associated with plants |
AU6607100A (en) | 1999-07-23 | 2001-02-13 | Regents Of The University Of California, The | Anti-growth factor receptor avidin fusion proteins as universal vectors for drugdelivery |
CA2385533C (en) | 1999-10-04 | 2008-03-25 | Shearwater Corporation | Polymer stabilized neuropeptides |
US20020009491A1 (en) | 2000-02-14 | 2002-01-24 | Rothbard Jonathan B. | Compositions and methods for enhancing drug delivery across biological membranes and tissues |
CA2420475A1 (en) * | 2000-09-26 | 2002-04-04 | Genentech, Inc. | Ige receptor antagonists |
US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
AU2003220557A1 (en) * | 2002-03-26 | 2003-10-13 | Centocor, Inc. | Multiple sclerosis-related immunoglobulin derived proteins, compositions, methods and uses |
US7388079B2 (en) * | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
US20050026823A1 (en) | 2003-06-20 | 2005-02-03 | Biomarin Pharmaceutical Inc. | Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues |
US8017151B2 (en) | 2004-09-07 | 2011-09-13 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Amphiphilic polymer-protein conjugates and methods of use thereof |
NZ564098A (en) * | 2005-06-15 | 2010-04-30 | Schering Corp | Anti-IGF1R antibody formulations |
US8053569B2 (en) * | 2005-10-07 | 2011-11-08 | Armagen Technologies, Inc. | Nucleic acids encoding and methods of producing fusion proteins |
WO2008143679A2 (en) * | 2006-06-01 | 2008-11-27 | Verenium Corporation | Nucleic acids and proteins and methods for making and using them |
WO2009032782A2 (en) * | 2007-08-28 | 2009-03-12 | Biogen Idec Ma Inc. | Compositions that bind multiple epitopes of igf-1r |
ES2564523T3 (es) | 2007-12-19 | 2016-03-23 | Janssen Biotech, Inc. | Diseño y generación de bibliotecas de presentación en fago por pIX de novo humanas mediante fusión con pIX o pVII, vectores, anticuerpos y métodos |
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2011
- 2011-05-25 EA EA201291416A patent/EA023541B1/ru unknown
- 2011-05-25 SI SI201130557T patent/SI2575846T1/sl unknown
- 2011-05-25 US US13/115,523 patent/US8415306B2/en active Active
- 2011-05-25 HU HUE11787324A patent/HUE026269T2/en unknown
- 2011-05-25 AU AU2011258301A patent/AU2011258301B2/en active Active
- 2011-05-25 KR KR1020127033486A patent/KR101898502B1/ko active IP Right Grant
- 2011-05-25 MX MX2012013710A patent/MX337134B/es active IP Right Grant
- 2011-05-25 CN CN201180025866.2A patent/CN103025341B/zh active Active
- 2011-05-25 EP EP11787324.0A patent/EP2575846B1/en active Active
- 2011-05-25 DK DK11787324.0T patent/DK2575846T3/en active
- 2011-05-25 PT PT117873240T patent/PT2575846E/pt unknown
- 2011-05-25 ME MEP-2015-146A patent/ME02206B/me unknown
- 2011-05-25 UA UAA201214969A patent/UA107596C2/ru unknown
- 2011-05-25 RS RS20150591A patent/RS54278B1/en unknown
- 2011-05-25 BR BR112012030084A patent/BR112012030084B1/pt active IP Right Grant
- 2011-05-25 WO PCT/US2011/037904 patent/WO2011150061A1/en active Application Filing
- 2011-05-25 NZ NZ603611A patent/NZ603611A/en unknown
- 2011-05-25 JP JP2013512202A patent/JP5864556B2/ja not_active Expired - Fee Related
- 2011-05-25 PL PL11787324T patent/PL2575846T3/pl unknown
- 2011-05-25 SG SG2012086617A patent/SG186068A1/en unknown
- 2011-05-25 ES ES11787324.0T patent/ES2550040T3/es active Active
- 2011-05-25 CA CA2800744A patent/CA2800744C/en active Active
-
2012
- 2012-11-14 IL IL223030A patent/IL223030A/en active IP Right Grant
- 2012-12-20 ZA ZA2012/09689A patent/ZA201209689B/en unknown
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2013
- 2013-09-13 HK HK13110609.7A patent/HK1183234A1/zh unknown
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2015
- 2015-09-22 SM SM201500222T patent/SMT201500222B/xx unknown
- 2015-10-05 CY CY20151100883T patent/CY1116757T1/el unknown
- 2015-10-13 HR HRP20151084TT patent/HRP20151084T1/hr unknown
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