CY1116697T1 - Συνδετες sigma για την προληψη ή τη θεραπεια πονου που εχει προκληθει απο χημειοθεραπεια - Google Patents
Συνδετες sigma για την προληψη ή τη θεραπεια πονου που εχει προκληθει απο χημειοθεραπειαInfo
- Publication number
- CY1116697T1 CY1116697T1 CY20151100618T CY151100618T CY1116697T1 CY 1116697 T1 CY1116697 T1 CY 1116697T1 CY 20151100618 T CY20151100618 T CY 20151100618T CY 151100618 T CY151100618 T CY 151100618T CY 1116697 T1 CY1116697 T1 CY 1116697T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pain caused
- prevention
- treatment
- sigma
- chemotherapy
- Prior art date
Links
- 230000002265 prevention Effects 0.000 title abstract 2
- 238000002512 chemotherapy Methods 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
- 229940123237 Taxane Drugs 0.000 abstract 1
- 229940122803 Vinca alkaloid Drugs 0.000 abstract 1
- 229940044683 chemotherapy drug Drugs 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382144A EP2292236A1 (en) | 2009-08-14 | 2009-08-14 | Sigma ligands for the prevention or treatment of pain induced by chemotherapy |
| EP10744560.3A EP2464356B1 (en) | 2009-08-14 | 2010-08-12 | Sigma ligands for the prevention or treatment of pain induced by chemotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116697T1 true CY1116697T1 (el) | 2017-03-15 |
Family
ID=41531868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100618T CY1116697T1 (el) | 2009-08-14 | 2015-07-15 | Συνδετες sigma για την προληψη ή τη θεραπεια πονου που εχει προκληθει απο χημειοθεραπεια |
Country Status (34)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| EP2426111A1 (en) * | 2010-08-09 | 2012-03-07 | Laboratorios Del. Dr. Esteve, S.A. | 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms |
| EP2524694A1 (en) * | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| EP2792352A1 (en) | 2013-04-16 | 2014-10-22 | Laboratorios Del. Dr. Esteve, S.A. | Alpha-2 adrenoreceptor and sigma receptor ligand combinations |
| MX2016002892A (es) * | 2013-09-12 | 2016-06-10 | Esteve Labor Dr | Combinaciones de ligando de receptores sigma y aine. |
| SG11201604480PA (en) | 2013-12-17 | 2016-07-28 | Esteve Labor Dr | SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS |
| MX2016007286A (es) | 2013-12-17 | 2016-08-04 | Esteve Labor Dr | Combinaciones de gabapentinoides y ligandos de receptores sigma. |
| AR108682A1 (es) * | 2016-06-06 | 2018-09-12 | Esteve Labor Dr | Derivados de pirazol-3-iloxi ligandos del receptor sigma |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2024105225A1 (en) * | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU11248A1 (ru) | 1927-03-29 | 1929-09-30 | В.С. Григорьев | Способ очистки антрацена |
| FR2301250A1 (fr) * | 1975-02-21 | 1976-09-17 | Bellon Labor Sa Roger | Nouveaux diaryl-1, 4o-aminoalcoxy-3 pyrazoles et leurs sels |
| MX2007002341A (es) * | 2004-08-27 | 2007-09-25 | Esteve Labor Dr | Inhibidores del receptor sigma. |
| KR101352012B1 (ko) * | 2004-08-27 | 2014-01-15 | 라보라토리오스 델 드라. 에스테브.에스.에이. | 시그마 수용체 저해제 |
| EP1634872A1 (en) * | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
| CN101395157A (zh) * | 2006-03-01 | 2009-03-25 | 伊斯特芬博士实验室有限公司 | 作为西格玛受体抑制剂的吡唑衍生物 |
| WO2007098953A1 (en) * | 2006-03-01 | 2007-09-07 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
-
2009
- 2009-08-14 EP EP09382144A patent/EP2292236A1/en not_active Withdrawn
-
2010
- 2010-08-10 TW TW099126632A patent/TWI529168B/zh not_active IP Right Cessation
- 2010-08-12 MX MX2012001877A patent/MX2012001877A/es active IP Right Grant
- 2010-08-12 RU RU2012109554/04A patent/RU2543382C2/ru not_active IP Right Cessation
- 2010-08-12 HU HUE10744560A patent/HUE025642T2/en unknown
- 2010-08-12 EP EP10744560.3A patent/EP2464356B1/en active Active
- 2010-08-12 BR BR112012003053A patent/BR112012003053A2/pt not_active IP Right Cessation
- 2010-08-12 KR KR1020177028558A patent/KR20170125951A/ko not_active Ceased
- 2010-08-12 KR KR1020127006715A patent/KR101605151B1/ko not_active Expired - Fee Related
- 2010-08-12 DK DK10744560.3T patent/DK2464356T3/en active
- 2010-08-12 IN IN2149DEN2012 patent/IN2012DN02149A/en unknown
- 2010-08-12 NZ NZ598213A patent/NZ598213A/en not_active IP Right Cessation
- 2010-08-12 PT PT107445603T patent/PT2464356E/pt unknown
- 2010-08-12 PL PL10744560T patent/PL2464356T3/pl unknown
- 2010-08-12 KR KR1020157034281A patent/KR20150140419A/ko not_active Ceased
- 2010-08-12 AU AU2010283761A patent/AU2010283761B2/en not_active Ceased
- 2010-08-12 SI SI201030977T patent/SI2464356T1/sl unknown
- 2010-08-12 SG SG2012009098A patent/SG178338A1/en unknown
- 2010-08-12 CA CA2770441A patent/CA2770441C/en not_active Expired - Fee Related
- 2010-08-12 MY MYPI2012000561A patent/MY157334A/en unknown
- 2010-08-12 JP JP2012524233A patent/JP5922575B2/ja active Active
- 2010-08-12 US US13/389,733 patent/US20120141606A1/en not_active Abandoned
- 2010-08-12 PH PH1/2012/500286A patent/PH12012500286A1/en unknown
- 2010-08-12 CN CN201080036098.6A patent/CN102497864B/zh active Active
- 2010-08-12 WO PCT/EP2010/061720 patent/WO2011018487A1/en not_active Ceased
- 2010-08-12 ES ES10744560.3T patent/ES2543645T3/es active Active
- 2010-08-12 HR HRP20150788TT patent/HRP20150788T1/hr unknown
- 2010-08-13 AR ARP100102983A patent/AR077876A1/es unknown
- 2010-12-08 UA UAA201202969A patent/UA108859C2/ru unknown
-
2012
- 2012-01-31 TN TNP2012000048A patent/TN2012000048A1/en unknown
- 2012-02-02 IL IL217911A patent/IL217911A0/en unknown
- 2012-02-03 ZA ZA2012/00843A patent/ZA201200843B/en unknown
- 2012-02-09 EC ECSP12011658 patent/ECSP12011658A/es unknown
- 2012-03-08 MA MA34669A patent/MA33569B1/fr unknown
- 2012-03-14 CO CO12044528A patent/CO6511240A2/es not_active Application Discontinuation
-
2015
- 2015-07-15 CY CY20151100618T patent/CY1116697T1/el unknown
- 2015-08-05 SM SM201500189T patent/SMT201500189T1/xx unknown
-
2016
- 2016-03-17 US US15/073,460 patent/US20160199380A1/en not_active Abandoned
- 2016-04-07 US US15/093,589 patent/US20160220575A1/en not_active Abandoned
- 2016-09-14 AU AU2016228207A patent/AU2016228207B2/en not_active Ceased
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1124068T1 (el) | Στερεες μορφες ενος εκλεκτικου αναστολεα cdk4/6 | |
| IN2012DN02149A (enExample) | ||
| EA201171493A1 (ru) | МОТИВЫ ХИМИЧЕСКИХ МОДИФИКАЦИЙ ДЛЯ ИНГИБИТОРОВ И МИМЕТИКОВ мкРНК | |
| EA201490891A1 (ru) | Пиридопиразины, обладающие противораковой активностью через ингибирование fgfr киназ | |
| UA107951C2 (xx) | Похідні імідазопіридину як інгібітори jak | |
| MA33803B1 (fr) | Inhibiteur de bromodomaine de benzodiazépine | |
| ATE473975T1 (de) | Chemische verbindungen | |
| ATE398613T1 (de) | Chemische verbindungen | |
| EA201170772A1 (ru) | Органические соединения | |
| CU20120042A7 (es) | (heteroarilmetil)tiohidantoínas sustituidas como drogas anticáncer | |
| CL2008001540A1 (es) | Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer. | |
| EA201491447A1 (ru) | Ендиины, их конъюгаты и способы их получения и применения | |
| UA111717C2 (uk) | Склад для перорального введення і ліпофільні солі метилналтрексону | |
| UY31065A1 (es) | Heterociclos ciclicos | |
| EA201071224A1 (ru) | Ингибиторы limk2, композиции, содержащие их, и способы их применения | |
| EA201190125A1 (ru) | Таблетки для комбинированной терапии | |
| EA201691032A1 (ru) | Производные изохромена в качестве ингибиторов фосфоинозитид-3-киназ | |
| EA201591698A1 (ru) | Макроциклические ингибиторы киназы lrrk2 | |
| BR112015026292A8 (pt) | composto dihidropirazino-pirazina, composição farmacêutica que o compreende, uso do composto, métodos para inibir ou medir a fosforilação e para inibir a atividade da dna-pk, bem como kit | |
| TW200738627A (en) | Trialkylsilyl-indoles | |
| EA201501187A1 (ru) | Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний | |
| CO6501171A2 (es) | Derivados de quinoxalina y su uso para el tratamiento de tumores benignos y malignos | |
| EA201171414A1 (ru) | Ингибиторы белков семейства iap | |
| ATE474574T1 (de) | Imidazoazephinonverbindungen | |
| TR201104008T1 (tr) | Bir antitümör ilacının oluşturulmasına ve stabilizasyonuna ilişkin yöntemler. |