BR112012003053A2 - ligantes sigma para a prevenção ou tratamento de dor induzida pela quimioterapia - Google Patents

ligantes sigma para a prevenção ou tratamento de dor induzida pela quimioterapia

Info

Publication number
BR112012003053A2
BR112012003053A2 BR112012003053A BR112012003053A BR112012003053A2 BR 112012003053 A2 BR112012003053 A2 BR 112012003053A2 BR 112012003053 A BR112012003053 A BR 112012003053A BR 112012003053 A BR112012003053 A BR 112012003053A BR 112012003053 A2 BR112012003053 A2 BR 112012003053A2
Authority
BR
Brazil
Prior art keywords
chemotherapy
prevention
treatment
induced pain
sigma ligands
Prior art date
Application number
BR112012003053A
Other languages
English (en)
Inventor
Daniel Zamanillo-Castanedo
Francisco-Rafael Nieto-López
Helmut Heinrich Buschmann
José Manuel Baeyens-Cabrera
José Miguel Vela Hernández
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of BR112012003053A2 publication Critical patent/BR112012003053A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112012003053A 2009-08-14 2010-08-12 ligantes sigma para a prevenção ou tratamento de dor induzida pela quimioterapia BR112012003053A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09382144A EP2292236A1 (en) 2009-08-14 2009-08-14 Sigma ligands for the prevention or treatment of pain induced by chemotherapy
PCT/EP2010/061720 WO2011018487A1 (en) 2009-08-14 2010-08-12 Sigma ligands for the prevention or treatment of pain induced by chemotherapy

Publications (1)

Publication Number Publication Date
BR112012003053A2 true BR112012003053A2 (pt) 2016-08-02

Family

ID=41531868

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012003053A BR112012003053A2 (pt) 2009-08-14 2010-08-12 ligantes sigma para a prevenção ou tratamento de dor induzida pela quimioterapia

Country Status (34)

Country Link
US (3) US20120141606A1 (pt)
EP (2) EP2292236A1 (pt)
JP (1) JP5922575B2 (pt)
KR (3) KR101605151B1 (pt)
CN (1) CN102497864B (pt)
AR (1) AR077876A1 (pt)
AU (2) AU2010283761B2 (pt)
BR (1) BR112012003053A2 (pt)
CA (1) CA2770441C (pt)
CO (1) CO6511240A2 (pt)
CY (1) CY1116697T1 (pt)
DK (1) DK2464356T3 (pt)
EC (1) ECSP12011658A (pt)
ES (1) ES2543645T3 (pt)
HK (1) HK1171945A1 (pt)
HR (1) HRP20150788T1 (pt)
HU (1) HUE025642T2 (pt)
IL (1) IL217911A0 (pt)
IN (1) IN2012DN02149A (pt)
MA (1) MA33569B1 (pt)
MX (1) MX2012001877A (pt)
MY (1) MY157334A (pt)
NZ (1) NZ598213A (pt)
PL (1) PL2464356T3 (pt)
PT (1) PT2464356E (pt)
RU (1) RU2543382C2 (pt)
SG (1) SG178338A1 (pt)
SI (1) SI2464356T1 (pt)
SM (1) SMT201500189T1 (pt)
TN (1) TN2012000048A1 (pt)
TW (1) TWI529168B (pt)
UA (1) UA108859C2 (pt)
WO (1) WO2011018487A1 (pt)
ZA (1) ZA201200843B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2116539A1 (en) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
EP2353591A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2353598A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for use in the prevention and/or treatment of postoperative pain
EP2388005A1 (en) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
EP2426111A1 (en) * 2010-08-09 2012-03-07 Laboratorios Del. Dr. Esteve, S.A. 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms
EP2524694A1 (en) * 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
EP2792352A1 (en) 2013-04-16 2014-10-22 Laboratorios Del. Dr. Esteve, S.A. Alpha-2 adrenoreceptor and sigma receptor ligand combinations
EP3043795A1 (en) * 2013-09-12 2016-07-20 Laboratorios Del. Dr. Esteve, S.A. Nsaid and sigma receptor ligand combinations
MX2016007286A (es) 2013-12-17 2016-08-04 Esteve Labor Dr Combinaciones de gabapentinoides y ligandos de receptores sigma.
EP3082782A1 (en) 2013-12-17 2016-10-26 Laboratorios Del. Dr. Esteve, S.A. SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS
CN109310672B (zh) * 2016-06-06 2022-05-03 埃斯特韦制药有限公司 σ受体配体在癌症中的用途
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2024105225A1 (en) * 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU11248A1 (ru) 1927-03-29 1929-09-30 В.С. Григорьев Способ очистки антрацена
FR2301250A1 (fr) * 1975-02-21 1976-09-17 Bellon Labor Sa Roger Nouveaux diaryl-1, 4o-aminoalcoxy-3 pyrazoles et leurs sels
BRPI0514692A (pt) 2004-08-27 2008-06-17 Esteve Labor Dr inibidores do receptor sigma
PT1781618E (pt) * 2004-08-27 2012-12-18 Esteve Labor Dr Inibidores do receptor sigma
EP1634872A1 (en) * 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Pyrazole derivatives as sigma receptor inhibitors
MX2008011016A (es) * 2006-03-01 2008-09-08 Esteve Labor Dr Inhibidores de receptor sigma.
CN101395157A (zh) * 2006-03-01 2009-03-25 伊斯特芬博士实验室有限公司 作为西格玛受体抑制剂的吡唑衍生物

Also Published As

Publication number Publication date
WO2011018487A1 (en) 2011-02-17
HK1171945A1 (en) 2013-04-12
AU2010283761B2 (en) 2016-10-13
TN2012000048A1 (en) 2013-09-19
US20120141606A1 (en) 2012-06-07
TW201121959A (en) 2011-07-01
EP2464356A1 (en) 2012-06-20
CA2770441A1 (en) 2011-02-17
KR20150140419A (ko) 2015-12-15
TWI529168B (zh) 2016-04-11
MY157334A (en) 2016-05-31
US20160199380A1 (en) 2016-07-14
DK2464356T3 (en) 2015-07-13
ES2543645T3 (es) 2015-08-20
UA108859C2 (uk) 2015-06-25
AU2010283761A1 (en) 2012-03-08
HRP20150788T1 (hr) 2015-08-28
EP2292236A1 (en) 2011-03-09
PT2464356E (pt) 2015-08-31
EP2464356B1 (en) 2015-05-06
NZ598213A (en) 2014-05-30
ZA201200843B (en) 2012-10-31
PL2464356T3 (pl) 2015-10-30
SMT201500189T1 (it) 2015-09-07
AR077876A1 (es) 2011-09-28
SI2464356T1 (sl) 2015-08-31
MX2012001877A (es) 2012-04-11
CN102497864A (zh) 2012-06-13
CN102497864B (zh) 2015-07-22
CY1116697T1 (el) 2017-03-15
JP2013501754A (ja) 2013-01-17
HUE025642T2 (en) 2016-04-28
US20160220575A1 (en) 2016-08-04
KR20170125951A (ko) 2017-11-15
AU2016228207B2 (en) 2017-09-07
IN2012DN02149A (pt) 2015-08-07
MA33569B1 (fr) 2012-09-01
CO6511240A2 (es) 2012-08-31
RU2543382C2 (ru) 2015-02-27
SG178338A1 (en) 2012-03-29
KR20120055692A (ko) 2012-05-31
ECSP12011658A (es) 2012-03-30
CA2770441C (en) 2017-12-12
JP5922575B2 (ja) 2016-05-24
KR101605151B1 (ko) 2016-03-21
RU2012109554A (ru) 2013-09-20
AU2016228207A1 (en) 2016-11-03
IL217911A0 (en) 2012-03-29

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2595 DE 29-09-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.