AR077876A1 - Ligandos del receptor sigma para la prevencion o el tratamiento de dolor inducido por quimioterapia - Google Patents

Ligandos del receptor sigma para la prevencion o el tratamiento de dolor inducido por quimioterapia

Info

Publication number
AR077876A1
AR077876A1 ARP100102983A ARP100102983A AR077876A1 AR 077876 A1 AR077876 A1 AR 077876A1 AR P100102983 A ARP100102983 A AR P100102983A AR P100102983 A ARP100102983 A AR P100102983A AR 077876 A1 AR077876 A1 AR 077876A1
Authority
AR
Argentina
Prior art keywords
substituted
unsubstituted
nr8r9
heterocyclyl
aromatic
Prior art date
Application number
ARP100102983A
Other languages
English (en)
Spanish (es)
Inventor
Jose Manuel Baeyens-Cabrera
Helmut Heinrich Buschmann
Hernandez Jose Miguel Vela
Daniel Zamanillo-Castanedo
Francisco-Rafael Nieto-Lopez
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of AR077876A1 publication Critical patent/AR077876A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ARP100102983A 2009-08-14 2010-08-13 Ligandos del receptor sigma para la prevencion o el tratamiento de dolor inducido por quimioterapia AR077876A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09382144A EP2292236A1 (en) 2009-08-14 2009-08-14 Sigma ligands for the prevention or treatment of pain induced by chemotherapy

Publications (1)

Publication Number Publication Date
AR077876A1 true AR077876A1 (es) 2011-09-28

Family

ID=41531868

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102983A AR077876A1 (es) 2009-08-14 2010-08-13 Ligandos del receptor sigma para la prevencion o el tratamiento de dolor inducido por quimioterapia

Country Status (34)

Country Link
US (3) US20120141606A1 (enExample)
EP (2) EP2292236A1 (enExample)
JP (1) JP5922575B2 (enExample)
KR (3) KR101605151B1 (enExample)
CN (1) CN102497864B (enExample)
AR (1) AR077876A1 (enExample)
AU (2) AU2010283761B2 (enExample)
BR (1) BR112012003053A2 (enExample)
CA (1) CA2770441C (enExample)
CO (1) CO6511240A2 (enExample)
CY (1) CY1116697T1 (enExample)
DK (1) DK2464356T3 (enExample)
EC (1) ECSP12011658A (enExample)
ES (1) ES2543645T3 (enExample)
HR (1) HRP20150788T1 (enExample)
HU (1) HUE025642T2 (enExample)
IL (1) IL217911A0 (enExample)
IN (1) IN2012DN02149A (enExample)
MA (1) MA33569B1 (enExample)
MX (1) MX2012001877A (enExample)
MY (1) MY157334A (enExample)
NZ (1) NZ598213A (enExample)
PH (1) PH12012500286A1 (enExample)
PL (1) PL2464356T3 (enExample)
PT (1) PT2464356E (enExample)
RU (1) RU2543382C2 (enExample)
SG (1) SG178338A1 (enExample)
SI (1) SI2464356T1 (enExample)
SM (1) SMT201500189T1 (enExample)
TN (1) TN2012000048A1 (enExample)
TW (1) TWI529168B (enExample)
UA (1) UA108859C2 (enExample)
WO (1) WO2011018487A1 (enExample)
ZA (1) ZA201200843B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2116539A1 (en) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
EP2353591A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2353598A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for use in the prevention and/or treatment of postoperative pain
EP2388005A1 (en) * 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
EP2426111A1 (en) * 2010-08-09 2012-03-07 Laboratorios Del. Dr. Esteve, S.A. 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms
EP2524694A1 (en) * 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
EP2792352A1 (en) 2013-04-16 2014-10-22 Laboratorios Del. Dr. Esteve, S.A. Alpha-2 adrenoreceptor and sigma receptor ligand combinations
MX2016002892A (es) * 2013-09-12 2016-06-10 Esteve Labor Dr Combinaciones de ligando de receptores sigma y aine.
SG11201604478UA (en) 2013-12-17 2016-07-28 Esteve Labor Dr Gabapentinoids and sigma receptor ligands combinations
SG11201604480PA (en) 2013-12-17 2016-07-28 Esteve Labor Dr SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS
EP3463339B1 (en) 2016-06-06 2023-12-06 Esteve Pharmaceuticals, S.A. Use of sigma receptor ligands in cancer
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2024105225A1 (en) * 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU11248A1 (ru) 1927-03-29 1929-09-30 В.С. Григорьев Способ очистки антрацена
FR2301250A1 (fr) * 1975-02-21 1976-09-17 Bellon Labor Sa Roger Nouveaux diaryl-1, 4o-aminoalcoxy-3 pyrazoles et leurs sels
RU2417987C2 (ru) * 2004-08-27 2011-05-10 Лабораторьос Дель Др.Эстеве, С.А. Ингибиторы сигма-рецептора
AU2005276590B2 (en) 2004-08-27 2011-05-19 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
EP1634872A1 (en) * 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Pyrazole derivatives as sigma receptor inhibitors
JP2009528315A (ja) * 2006-03-01 2009-08-06 ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ シグマ受容体阻害剤としてのピラゾール誘導体
CN101395157A (zh) * 2006-03-01 2009-03-25 伊斯特芬博士实验室有限公司 作为西格玛受体抑制剂的吡唑衍生物

Also Published As

Publication number Publication date
EP2464356A1 (en) 2012-06-20
SMT201500189T1 (it) 2015-09-07
HK1171945A1 (en) 2013-04-12
HUE025642T2 (en) 2016-04-28
DK2464356T3 (en) 2015-07-13
KR20150140419A (ko) 2015-12-15
SG178338A1 (en) 2012-03-29
IN2012DN02149A (enExample) 2015-08-07
IL217911A0 (en) 2012-03-29
CA2770441A1 (en) 2011-02-17
RU2012109554A (ru) 2013-09-20
MY157334A (en) 2016-05-31
SI2464356T1 (sl) 2015-08-31
AU2010283761A1 (en) 2012-03-08
MA33569B1 (fr) 2012-09-01
WO2011018487A1 (en) 2011-02-17
CN102497864B (zh) 2015-07-22
US20160199380A1 (en) 2016-07-14
KR20120055692A (ko) 2012-05-31
BR112012003053A2 (pt) 2016-08-02
CO6511240A2 (es) 2012-08-31
PH12012500286A1 (en) 2015-06-26
CN102497864A (zh) 2012-06-13
NZ598213A (en) 2014-05-30
UA108859C2 (uk) 2015-06-25
HRP20150788T1 (hr) 2015-08-28
EP2292236A1 (en) 2011-03-09
JP5922575B2 (ja) 2016-05-24
AU2016228207B2 (en) 2017-09-07
AU2016228207A1 (en) 2016-11-03
TN2012000048A1 (en) 2013-09-19
ECSP12011658A (es) 2012-03-30
KR101605151B1 (ko) 2016-03-21
US20120141606A1 (en) 2012-06-07
CA2770441C (en) 2017-12-12
ZA201200843B (en) 2012-10-31
AU2010283761B2 (en) 2016-10-13
EP2464356B1 (en) 2015-05-06
CY1116697T1 (el) 2017-03-15
US20160220575A1 (en) 2016-08-04
TW201121959A (en) 2011-07-01
JP2013501754A (ja) 2013-01-17
RU2543382C2 (ru) 2015-02-27
KR20170125951A (ko) 2017-11-15
MX2012001877A (es) 2012-04-11
ES2543645T3 (es) 2015-08-20
PT2464356E (pt) 2015-08-31
PL2464356T3 (pl) 2015-10-30
TWI529168B (zh) 2016-04-11

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