CY1116579T1 - Φαρμακευτικες μορφες δοσολογιας ελεγχομενης απελευθερωσης - Google Patents

Φαρμακευτικες μορφες δοσολογιας ελεγχομενης απελευθερωσης

Info

Publication number
CY1116579T1
CY1116579T1 CY20151100677T CY151100677T CY1116579T1 CY 1116579 T1 CY1116579 T1 CY 1116579T1 CY 20151100677 T CY20151100677 T CY 20151100677T CY 151100677 T CY151100677 T CY 151100677T CY 1116579 T1 CY1116579 T1 CY 1116579T1
Authority
CY
Cyprus
Prior art keywords
dosage
pharmaceutical forms
controlled
methods
layer
Prior art date
Application number
CY20151100677T
Other languages
English (en)
Inventor
Haiyong Hugh Huang
Original Assignee
Purdue Pharma L.P.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Pharma L.P. filed Critical Purdue Pharma L.P.
Publication of CY1116579T1 publication Critical patent/CY1116579T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε φαρμακευτικές μορφές δοσολογίας πολλαπλής στιβάδας, για παράδειγμα σε ανθεκτική σε παραβίαση μορφή δοσολογίας περιλαμβάνουσα μια πρώτη στιβάδα που περιλαμβάνει δραστικό παράγοντα και μια δεύτερη στιβάδα που δεν περιλαμβάνει τον εν λόγω δραστικό παράγοντα, και μεθόδους βιομηχανικής κατασκευής, χρήσεις και μεθόδους θεραπείας αυτών που παρέχουν ουσιαστικά απελευθέρωση μηδενικής τάξης.
CY20151100677T 2011-03-25 2015-08-03 Φαρμακευτικες μορφες δοσολογιας ελεγχομενης απελευθερωσης CY1116579T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161467824P 2011-03-25 2011-03-25
EP20120717468 EP2688556B1 (en) 2011-03-25 2012-03-22 Controlled release pharmaceutical dosage forms

Publications (1)

Publication Number Publication Date
CY1116579T1 true CY1116579T1 (el) 2017-03-15

Family

ID=46018006

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100677T CY1116579T1 (el) 2011-03-25 2015-08-03 Φαρμακευτικες μορφες δοσολογιας ελεγχομενης απελευθερωσης

Country Status (23)

Country Link
US (1) US20140056979A1 (el)
EP (1) EP2688556B1 (el)
JP (1) JP5964940B2 (el)
KR (1) KR101619579B1 (el)
CN (1) CN103547259A (el)
AU (1) AU2012235878B2 (el)
BR (1) BR112013024585A8 (el)
CA (1) CA2831218C (el)
CY (1) CY1116579T1 (el)
DK (1) DK2688556T3 (el)
ES (1) ES2544735T3 (el)
HR (1) HRP20150835T1 (el)
HU (1) HUE026981T2 (el)
IL (1) IL228441B (el)
ME (1) ME02189B (el)
MX (1) MX350875B (el)
PL (1) PL2688556T3 (el)
PT (1) PT2688556E (el)
RS (1) RS54152B1 (el)
SI (1) SI2688556T1 (el)
SM (1) SMT201500209B (el)
WO (1) WO2012131463A2 (el)
ZA (1) ZA201307862B (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2230556C2 (ru) 1999-10-29 2004-06-20 Эро-Селтик, С.А. Препаративные формы гидрокодона с контролируемым высвобождением
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
AU2002227383B2 (en) 2000-10-30 2004-07-08 Euro-Celtique S.A. Controlled release hydrocodone formulations
US20040253310A1 (en) 2001-09-21 2004-12-16 Gina Fischer Morphine polymer release system
EP2957281A1 (en) 2001-09-21 2015-12-23 Egalet Ltd. Polymer release system
EP2301526B1 (en) 2003-03-26 2016-03-23 Egalet Ltd. Morphine controlled release system
WO2008148798A2 (en) 2007-06-04 2008-12-11 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
WO2010089132A1 (en) 2009-02-06 2010-08-12 Egalet A/S Immediate release composition resistant to abuse by intake of alcohol
NZ597283A (en) 2009-06-24 2013-07-26 Egalet Ltd Controlled release formulations
CN103370058A (zh) 2010-12-22 2013-10-23 普渡制药公司 包覆的抗篡改控制释放剂型
CA2822769C (en) 2010-12-23 2016-10-04 Purdue Pharma L.P. Tamper resistant solid oral dosage forms
SG11201406025UA (en) 2012-04-17 2014-11-27 Purdue Pharma Lp Systems and methods for treating an opioid-induced adverse pharmacodynamic response
US9549899B2 (en) 2012-07-06 2017-01-24 Egalet Ltd. Abuse deterrent pharmaceutical compositions for controlled release
KR101840526B1 (ko) 2013-02-05 2018-03-20 퍼듀 퍼머 엘피 내변조성 제약 제제
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
CA2919892C (en) 2013-08-12 2019-06-18 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
WO2015095391A1 (en) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9707184B2 (en) 2014-07-17 2017-07-18 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
US9132096B1 (en) 2014-09-12 2015-09-15 Alkermes Pharma Ireland Limited Abuse resistant pharmaceutical compositions
US9849124B2 (en) 2014-10-17 2017-12-26 Purdue Pharma L.P. Systems and methods for treating an opioid-induced adverse pharmacodynamic response
EP3209282A4 (en) 2014-10-20 2018-05-23 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
US9839212B2 (en) 2015-04-16 2017-12-12 Bio-Lab, Inc. Multicomponent and multilayer compacted tablets
CA3073570A1 (en) 2017-08-31 2019-03-07 Purdue Pharma L.P. Opioid oral extended release formulations comprising an anionic surfactant and polyethylene oxide

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KR950007907B1 (ko) * 1992-09-01 1995-07-21 동국제약 주식회사 치주질환 치료용 막형 국소약물송달제제
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US5634702A (en) 1995-09-27 1997-06-03 Fistonich; Juraj Hands free waste container having a closed cover that automatically opens when the container is moved outside its cabinet enclosure
CA2396782A1 (en) * 2000-02-04 2001-08-09 Depomed, Inc. Shell-and-core dosage form approaching zero-order drug release
AU2002227383B2 (en) * 2000-10-30 2004-07-08 Euro-Celtique S.A. Controlled release hydrocodone formulations
FI1765303T4 (fi) * 2004-07-01 2023-01-31 Väärinkäytöltä suojattu oraalinen tabletti
US7434308B2 (en) * 2004-09-02 2008-10-14 International Business Machines Corporation Cooling of substrate using interposer channels
CA2605180A1 (en) * 2005-04-19 2006-10-26 Alza Corporation Controlled delivery dosage form of tramadol and gabapentin
WO2007133150A1 (en) * 2006-05-17 2007-11-22 Sandvik Intellectual Property Ab A top hammer rock-drilling tool, a drill rod and coupling sleeve
SA07280459B1 (ar) * 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
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Also Published As

Publication number Publication date
BR112013024585A8 (pt) 2018-01-09
PL2688556T3 (pl) 2015-10-30
EP2688556A2 (en) 2014-01-29
CA2831218C (en) 2017-01-17
KR20130135973A (ko) 2013-12-11
US20140056979A1 (en) 2014-02-27
SMT201500209B (it) 2015-10-30
MX2013010987A (es) 2014-10-13
IL228441B (en) 2019-05-30
DK2688556T3 (en) 2015-08-03
SI2688556T1 (sl) 2015-09-30
AU2012235878A1 (en) 2013-05-02
AU2012235878B2 (en) 2015-10-15
HRP20150835T1 (hr) 2015-09-11
CA2831218A1 (en) 2012-10-04
JP2014510094A (ja) 2014-04-24
KR101619579B1 (ko) 2016-05-10
JP5964940B2 (ja) 2016-08-03
WO2012131463A2 (en) 2012-10-04
NZ616600A (en) 2015-07-31
MX350875B (es) 2017-09-19
PT2688556E (pt) 2015-09-11
RS54152B1 (en) 2015-12-31
EP2688556B1 (en) 2015-05-06
ZA201307862B (en) 2014-06-25
WO2012131463A3 (en) 2012-11-29
CN103547259A (zh) 2014-01-29
IL228441A0 (en) 2013-12-31
ES2544735T3 (es) 2015-09-03
HUE026981T2 (en) 2016-08-29
ME02189B (me) 2016-02-20

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