CY1114644T1 - Χρηση ραδιοεπισημασμενων παραγωγων θειοφλαβινης στην απεικονιση αμυλοειδους για την αξιολογηση αντι-αμυλοειδικων θεραπειων - Google Patents

Χρηση ραδιοεπισημασμενων παραγωγων θειοφλαβινης στην απεικονιση αμυλοειδους για την αξιολογηση αντι-αμυλοειδικων θεραπειων

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Publication number
CY1114644T1
CY1114644T1 CY20131100776T CY131100776T CY1114644T1 CY 1114644 T1 CY1114644 T1 CY 1114644T1 CY 20131100776 T CY20131100776 T CY 20131100776T CY 131100776 T CY131100776 T CY 131100776T CY 1114644 T1 CY1114644 T1 CY 1114644T1
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Cyprus
Prior art keywords
amyloid
patient
thioplavine
formula
radiated
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CY20131100776T
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English (en)
Inventor
William E Klunk
Chester A Mathis Jr
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University Of Pittsburgh - Of The Commonwealth System Of Higher Education
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Publication of CY1114644T1 publication Critical patent/CY1114644T1/el

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    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
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Abstract

Η παρούσα μέθοδος για προσδιορισμό της αποτελεσματικότητας θεραπείας στην αγωγή αμυλοείδωσης ενέχει χορήγηση -σε ασθενή που την έχει ανάγκη- ένωσης του τύπου (Ι) ή τύπου (II) ή των δομών 1-45 και απεικόνιση του ασθενούς. Μετά την εν λόγω απεικόνιση, στον εν λόγω ασθενή χορηγείται τουλάχιστον ένας αντι-αμυλοειδικός παράγοντας. Στη συνέχεια, αποτελεσματική ποσότητα ένωσης του τύπου (Ι) ή τύπου (II) ή των δομών 1-45 χορηγείται στον ασθενή και ο ασθενής υπόκειται πάλι σε απεικόνιση. Τέλος, τα επίπεδα γραμμής βάσης απόθεσης αμυλοειδούς στον ασθενή πριν την αγωγή με τον αντι-αμυλοειδικό παράγοντα συγκρίνονται με επίπεδα απόθεσης αμυλοειδούς στον ασθενή μετά την αγωγή με τον αντι-αμυλοειδικό παράγοντα.
CY20131100776T 2004-07-02 2013-09-10 Χρηση ραδιοεπισημασμενων παραγωγων θειοφλαβινης στην απεικονιση αμυλοειδους για την αξιολογηση αντι-αμυλοειδικων θεραπειων CY1114644T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58448704P 2004-07-02 2004-07-02
EP05787557.7A EP1771208B1 (en) 2004-07-02 2005-07-01 Use of thioflavin radiolabeled derivatives in amyloid imaging for assessing anti-amyloid therapies

Publications (1)

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CY1114644T1 true CY1114644T1 (el) 2016-10-05

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CY20131100776T CY1114644T1 (el) 2004-07-02 2013-09-10 Χρηση ραδιοεπισημασμενων παραγωγων θειοφλαβινης στην απεικονιση αμυλοειδους για την αξιολογηση αντι-αμυλοειδικων θεραπειων

Country Status (16)

Country Link
US (4) US8147798B2 (el)
EP (1) EP1771208B1 (el)
JP (1) JP2008505115A (el)
CN (2) CN102973954A (el)
AU (1) AU2005270026A1 (el)
BR (1) BRPI0512893B8 (el)
CA (2) CA2830939C (el)
CY (1) CY1114644T1 (el)
DK (1) DK1771208T3 (el)
ES (1) ES2427963T3 (el)
NO (1) NO339187B1 (el)
PL (1) PL1771208T3 (el)
PT (1) PT1771208E (el)
RU (1) RU2007104107A (el)
SI (1) SI1771208T1 (el)
WO (1) WO2006014381A2 (el)

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ES2536449T3 (es) * 2000-08-24 2015-05-25 University Of Pittsburgh Of The Commonwealth System Of Higher Education Derivados de tioflavina para uso en diagnosis de la enfermedad de Alzheimer
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CN101137397A (zh) 2008-03-05
PL1771208T3 (pl) 2013-11-29
US20130045164A1 (en) 2013-02-21
CN102973954A (zh) 2013-03-20
EP1771208A2 (en) 2007-04-11
US8343457B2 (en) 2013-01-01
CA2587248C (en) 2014-01-07
US20120177572A1 (en) 2012-07-12
NO20070593L (no) 2007-03-27
SI1771208T1 (sl) 2013-10-30
BRPI0512893A (pt) 2008-04-15
CA2587248A1 (en) 2006-02-09
WO2006014381A3 (en) 2007-01-18
US8580229B2 (en) 2013-11-12
EP1771208B1 (en) 2013-06-19
CA2830939C (en) 2017-02-28
CA2830939A1 (en) 2006-02-09
JP2008505115A (ja) 2008-02-21
US20080219931A1 (en) 2008-09-11
NO339187B1 (no) 2016-11-14
BRPI0512893B1 (pt) 2019-12-24
AU2005270026A1 (en) 2006-02-09
RU2007104107A (ru) 2008-08-10
WO2006014381A9 (en) 2006-04-13
BRPI0512893B8 (pt) 2021-07-27
WO2006014381A2 (en) 2006-02-09
DK1771208T3 (da) 2013-09-02
US8147798B2 (en) 2012-04-03
US20140105820A1 (en) 2014-04-17
PT1771208E (pt) 2013-09-24
ES2427963T3 (es) 2013-11-05

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