BRPI0512893B8 - métodos de determinação da eficácia da terapia no tratamento da amiloidose e de identificação de paciente como prodrômico para doença associada com a deposição amilóide e respectivos compostos - Google Patents
métodos de determinação da eficácia da terapia no tratamento da amiloidose e de identificação de paciente como prodrômico para doença associada com a deposição amilóide e respectivos compostosInfo
- Publication number
- BRPI0512893B8 BRPI0512893B8 BRPI0512893A BRPI0512893A BRPI0512893B8 BR PI0512893 B8 BRPI0512893 B8 BR PI0512893B8 BR PI0512893 A BRPI0512893 A BR PI0512893A BR PI0512893 A BRPI0512893 A BR PI0512893A BR PI0512893 B8 BRPI0512893 B8 BR PI0512893B8
- Authority
- BR
- Brazil
- Prior art keywords
- patient
- therapy
- effectiveness
- determining
- amyloid deposition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Radiology & Medical Imaging (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58448704P | 2004-07-02 | 2004-07-02 | |
PCT/US2005/023617 WO2006014381A2 (en) | 2004-07-02 | 2005-07-01 | Use of thioflavin radiolabeled derivatives in amyloid imaging gor assessing anti-amyloid therapies |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0512893A BRPI0512893A (pt) | 2008-04-15 |
BRPI0512893B1 BRPI0512893B1 (pt) | 2019-12-24 |
BRPI0512893B8 true BRPI0512893B8 (pt) | 2021-07-27 |
Family
ID=35504952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0512893A BRPI0512893B8 (pt) | 2004-07-02 | 2005-07-01 | métodos de determinação da eficácia da terapia no tratamento da amiloidose e de identificação de paciente como prodrômico para doença associada com a deposição amilóide e respectivos compostos |
Country Status (16)
Country | Link |
---|---|
US (4) | US8147798B2 (pt) |
EP (1) | EP1771208B1 (pt) |
JP (1) | JP2008505115A (pt) |
CN (2) | CN101137397A (pt) |
AU (1) | AU2005270026A1 (pt) |
BR (1) | BRPI0512893B8 (pt) |
CA (2) | CA2830939C (pt) |
CY (1) | CY1114644T1 (pt) |
DK (1) | DK1771208T3 (pt) |
ES (1) | ES2427963T3 (pt) |
NO (1) | NO339187B1 (pt) |
PL (1) | PL1771208T3 (pt) |
PT (1) | PT1771208E (pt) |
RU (1) | RU2007104107A (pt) |
SI (1) | SI1771208T1 (pt) |
WO (1) | WO2006014381A2 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
PT2264018E (pt) * | 2000-08-24 | 2015-06-03 | Univ Pittsburgh | Derivados de tioflavina para uso no diagnóstico da doença de alzheimer |
US7270800B2 (en) * | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
PL378571A1 (pl) * | 2003-02-01 | 2006-05-02 | Neuralab Limited | Czynna immunizacja dla wytworzenia przeciwciał przeciw rozpuszczalnemu A-ß |
US8236282B2 (en) | 2003-08-22 | 2012-08-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Benzothiazole derivative compounds, compositions and uses |
US8916165B2 (en) | 2004-12-15 | 2014-12-23 | Janssen Alzheimer Immunotherapy | Humanized Aβ antibodies for use in improving cognition |
GB0516564D0 (en) * | 2005-08-12 | 2005-09-21 | Ge Healthcare Ltd | Fluorination process |
US20080305040A1 (en) * | 2005-09-16 | 2008-12-11 | University Of Pittsburgh | In Vivo or in Vitro Method For Detecting Amyloid Deposits Having at Least One Amyloidogenic Protein |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
EP2023919A4 (en) | 2006-05-08 | 2010-12-22 | Molecular Neuroimaging Llc | COMPOUNDS AND AMYLOID PROBES FOR THERAPY AND IMAGING USES |
TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
CN101293878B (zh) * | 2007-04-25 | 2010-12-15 | 中国科学院上海应用物理研究所 | 苯并噻唑苯胺类化合物及其制备方法和应用 |
PL2182983T3 (pl) * | 2007-07-27 | 2014-10-31 | Janssen Alzheimer Immunotherap | Leczenie chorób amyloidowych z wykorzystaniem humanizowanych przeciwciał specyficznych względem Abeta |
MX2010002196A (es) * | 2007-08-30 | 2010-03-18 | Ge Healthcare Ltd | Composicion radiofarmaceutica. |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
JP5603855B2 (ja) | 2008-04-04 | 2014-10-08 | アビッド レディオファーマシューティカルズ、インク. | 神経変成疾患の放射性薬剤による画像化 |
DK2338059T3 (en) * | 2008-09-23 | 2015-06-15 | Wista Lab Ltd | Ligands for aggregated tau molecules |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
KR101155403B1 (ko) * | 2008-11-06 | 2013-12-20 | 서울대학교산학협력단 | 플루오린이 도입된 벤조타이아졸 유도체, 이의 제조방법 및 이를 이용한 알츠하이머 질환 진단용 영상화제 |
WO2011106732A1 (en) * | 2010-02-25 | 2011-09-01 | Wyeth Llc | Pet monitoring of ab-directed immunotherapy |
WO2014004664A2 (en) * | 2012-06-27 | 2014-01-03 | Mayo Foundation For Medical Education And Research | Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives |
US9422286B2 (en) | 2014-01-27 | 2016-08-23 | Washington University | Metal-binding bifunctional compounds as diagnostic agents for Alzheimer's disease |
US10478513B2 (en) * | 2015-08-18 | 2019-11-19 | The Regents Of The University Of Califonia | Nitroxide containing amyloid binding agents for imaging and therapeutic uses |
CN116953008A (zh) * | 2023-06-14 | 2023-10-27 | 汕头大学医学院第二附属医院 | 基于磁共振成像的β淀粉样蛋白浓度检测方法及系统 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030092003A1 (en) * | 1999-12-29 | 2003-05-15 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for the treatment of Alzheimer's disease |
PT2264018E (pt) | 2000-08-24 | 2015-06-03 | Univ Pittsburgh | Derivados de tioflavina para uso no diagnóstico da doença de alzheimer |
US7270800B2 (en) * | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
WO2002085903A2 (en) | 2001-04-23 | 2002-10-31 | The Trustees Of The University Of Pennsylvania | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
GB0130305D0 (en) | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
AU2003212490A1 (en) * | 2002-02-13 | 2003-09-04 | Amersham Plc | Benzothiazole derivatives for in vivo imaging of amyloid plaques |
CA2438032C (en) * | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
GB0307855D0 (en) | 2003-04-04 | 2003-05-14 | Novartis Ag | Organic compounds |
EP1768709A1 (en) * | 2004-07-02 | 2007-04-04 | University of Pittsburgh | A method of diagnosing prodromal forms of diseases associated with amyloid deposition |
-
2005
- 2005-07-01 WO PCT/US2005/023617 patent/WO2006014381A2/en active Application Filing
- 2005-07-01 BR BRPI0512893A patent/BRPI0512893B8/pt active IP Right Grant
- 2005-07-01 RU RU2007104107/04A patent/RU2007104107A/ru not_active Application Discontinuation
- 2005-07-01 EP EP05787557.7A patent/EP1771208B1/en active Active
- 2005-07-01 CA CA2830939A patent/CA2830939C/en active Active
- 2005-07-01 US US11/666,083 patent/US8147798B2/en active Active
- 2005-07-01 CN CNA2005800263010A patent/CN101137397A/zh active Pending
- 2005-07-01 AU AU2005270026A patent/AU2005270026A1/en not_active Abandoned
- 2005-07-01 PL PL05787557T patent/PL1771208T3/pl unknown
- 2005-07-01 ES ES05787557T patent/ES2427963T3/es active Active
- 2005-07-01 CN CN2012104014697A patent/CN102973954A/zh active Pending
- 2005-07-01 JP JP2007519500A patent/JP2008505115A/ja active Pending
- 2005-07-01 DK DK05787557.7T patent/DK1771208T3/da active
- 2005-07-01 CA CA2587248A patent/CA2587248C/en active Active
- 2005-07-01 SI SI200531765T patent/SI1771208T1/sl unknown
- 2005-07-01 PT PT57875577T patent/PT1771208E/pt unknown
-
2007
- 2007-01-31 NO NO20070593A patent/NO339187B1/no unknown
-
2012
- 2012-03-06 US US13/412,823 patent/US8343457B2/en active Active
- 2012-10-23 US US13/658,483 patent/US8580229B2/en active Active
-
2013
- 2013-09-10 CY CY20131100776T patent/CY1114644T1/el unknown
- 2013-10-09 US US14/050,018 patent/US20140105820A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20120177572A1 (en) | 2012-07-12 |
CN102973954A (zh) | 2013-03-20 |
SI1771208T1 (sl) | 2013-10-30 |
RU2007104107A (ru) | 2008-08-10 |
DK1771208T3 (da) | 2013-09-02 |
WO2006014381A3 (en) | 2007-01-18 |
AU2005270026A1 (en) | 2006-02-09 |
US20140105820A1 (en) | 2014-04-17 |
JP2008505115A (ja) | 2008-02-21 |
US8580229B2 (en) | 2013-11-12 |
CA2587248A1 (en) | 2006-02-09 |
WO2006014381A2 (en) | 2006-02-09 |
NO20070593L (no) | 2007-03-27 |
US20080219931A1 (en) | 2008-09-11 |
US8147798B2 (en) | 2012-04-03 |
NO339187B1 (no) | 2016-11-14 |
BRPI0512893A (pt) | 2008-04-15 |
US8343457B2 (en) | 2013-01-01 |
CY1114644T1 (el) | 2016-10-05 |
BRPI0512893B1 (pt) | 2019-12-24 |
CA2587248C (en) | 2014-01-07 |
CN101137397A (zh) | 2008-03-05 |
ES2427963T3 (es) | 2013-11-05 |
PT1771208E (pt) | 2013-09-24 |
EP1771208A2 (en) | 2007-04-11 |
EP1771208B1 (en) | 2013-06-19 |
US20130045164A1 (en) | 2013-02-21 |
PL1771208T3 (pl) | 2013-11-29 |
WO2006014381A9 (en) | 2006-04-13 |
CA2830939A1 (en) | 2006-02-09 |
CA2830939C (en) | 2017-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0512893B8 (pt) | métodos de determinação da eficácia da terapia no tratamento da amiloidose e de identificação de paciente como prodrômico para doença associada com a deposição amilóide e respectivos compostos | |
RU2018110647A (ru) | Арильные, гетероарильные и гетероциклические соединения для лечения заболеваний | |
RU2012118974A (ru) | Комбинации ингибитора pi3k и ингибитора мек | |
BRPI0512213A (pt) | método para tratamento, prevenção ou melhora de uma doença ou distúrbio; composição farmacêutica; processo para a preparação de um composto; e uso de um composto | |
BRPI0512220A (pt) | método para tratamento, prevenção ou melhora de uma doença ou distúrbio; composição farmacêutica; processo para a preparação de um composto; e uso de um composto | |
ATE499934T1 (de) | Verwendung von (3.2.0) heterocyclischen verbindungen und ihren analoga zur behandlung von krebs | |
BRPI0510274B8 (pt) | uso de um agente para tratar ou prevenir doença celíaca, composição farmacêutica compreendendo dito agente, método de diagnóstico de doença celíaca, ou suscetibilidade à doença celíaca, uso do dito agente para a preparação de um meio de diagnóstico e kit para realizar o dito método de diagnóstico | |
ECSP17000643A (es) | Combinación farmacéutica que comprende 3-(3-dimetilamino-1etil-2-metil-propil)-fenol y Paracetamol. | |
EA200870254A1 (ru) | Способ лечения воспалительных заболеваний | |
RU2012124268A (ru) | Бензимидазольные соединения и их применения | |
ATE470151T1 (de) | Diagnose, behandlung und prävention von gefässerkrankungen mittels il-1alpha- autoantikörpern | |
ECSP088762A (es) | Tratamiento del dolor | |
EA201270144A1 (ru) | Комбинированная терапия при лечении диабета | |
RU2008135131A (ru) | Лечение туберозного склероза | |
EA200870088A1 (ru) | Применение бензоконденсированных гетероциклических сульфамидных производных для понижения уровней липидов и глюкозы в крови | |
JP2014525465A5 (pt) | ||
JP2009544585A5 (pt) | ||
EA201401231A1 (ru) | Фармацевтические комбинации, предназначенные для лечения метаболических нарушений | |
MX2020001342A (es) | Uso de gaboxadol en el tratamiento contra diabetes y afecciones relacionadas. | |
ATE536178T1 (de) | Therapeutische anwendung von methionin zur behandlung oder prävention von mucositis | |
BRPI0519036A2 (pt) | mÉtodo para o tratamento de um paciente acometido por uma doenÇa neuro-degenerativa; composiÇço farmacÊutica para tratar uma doenÇa neuro-degenerativa; e uso de um agonista 5-ht6 ou de um agonista 5-ht6 | |
RU2005135428A (ru) | Поглощение макромолекул | |
WO2015024420A1 (zh) | 局麻药止痛延时剂 | |
BRPI0416591A (pt) | métodos e reagentes para o tratamento de distúrbios inflamatórios | |
DE602004024221D1 (de) | Behandlung von entzündlichen darmerkrankungen mit 2-methylen-19-nor-vitamin d verbindungen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
|
B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: COMPLEMENTAR TAXA DE EXPEDICAO DA CARTA PATENTE REFERENTE PETICAO NO 800160229695 DE 15/08/2016. |
|
B15G | Petition not considered as such [chapter 15.7 patent gazette] | ||
B12F | Appeal: other appeals | ||
B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/12/2019, OBSERVADAS AS CONDICOES LEGAIS. |
|
B25D | Requested change of name of applicant approved |
Owner name: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) |
|
B25G | Requested change of headquarter approved |
Owner name: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) |
|
B16C | Correction of notification of the grant |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/07/2005, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |