CY1114359T1 - Παραγοντας κατα ογκων περιλαμβανων τον αναστολεα αποακετυλασης ιστονης fk228 kai ton αναστολεα τοποϊσομερασης ιι δοξορουβικινη - Google Patents
Παραγοντας κατα ογκων περιλαμβανων τον αναστολεα αποακετυλασης ιστονης fk228 kai ton αναστολεα τοποϊσομερασης ιι δοξορουβικινηInfo
- Publication number
- CY1114359T1 CY1114359T1 CY20131100771T CY131100771T CY1114359T1 CY 1114359 T1 CY1114359 T1 CY 1114359T1 CY 20131100771 T CY20131100771 T CY 20131100771T CY 131100771 T CY131100771 T CY 131100771T CY 1114359 T1 CY1114359 T1 CY 1114359T1
- Authority
- CY
- Cyprus
- Prior art keywords
- destinator
- kai
- histone
- doxorubicin
- disaster
- Prior art date
Links
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 title 2
- 108010033040 Histones Proteins 0.000 title 1
- 229960004679 doxorubicin Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 229940124087 DNA topoisomerase II inhibitor Drugs 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000317 Topoisomerase II Inhibitor Substances 0.000 abstract 1
- VJZITPJGSQKZMX-XDPRQOKASA-N amrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC=C4C(=O)C=3C(O)=C21)(N)C(=O)C)[C@H]1C[C@H](O)[C@H](O)CO1 VJZITPJGSQKZMX-XDPRQOKASA-N 0.000 abstract 1
- 229960002550 amrubicin Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Ένωση τύπου Ι: ή ένα φαρμακευτικά αποδεκτό άλας αυτής, σε συνδυασμό με έναν αναστολέα τοποϊσομεράσης ΙΙ, εκτός της αμρουβικίνης και ενός φαρμακευτικά αποδεκτού άλατος αυτής, για χρήση στην αγωγή του καρκίνου.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003334340 | 2003-09-25 | ||
JP2003344315 | 2003-10-02 | ||
EP10163527.4A EP2263694B1 (en) | 2003-09-25 | 2004-09-24 | Antitumor agent comprising the histone deacetylase inhibitor FK228 and the topoisomerase II inhibitor doxorubicin |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114359T1 true CY1114359T1 (el) | 2016-08-31 |
Family
ID=34380371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100771T CY1114359T1 (el) | 2003-09-25 | 2013-09-09 | Παραγοντας κατα ογκων περιλαμβανων τον αναστολεα αποακετυλασης ιστονης fk228 kai ton αναστολεα τοποϊσομερασης ιι δοξορουβικινη |
Country Status (14)
Country | Link |
---|---|
US (1) | US7314862B2 (el) |
EP (2) | EP2263694B1 (el) |
JP (1) | JP4779971B2 (el) |
AT (1) | ATE471740T1 (el) |
CA (1) | CA2540108A1 (el) |
CY (1) | CY1114359T1 (el) |
DE (1) | DE602004027824D1 (el) |
DK (1) | DK2263694T3 (el) |
ES (2) | ES2344899T3 (el) |
MX (1) | MXPA06003222A (el) |
PL (2) | PL1670514T3 (el) |
PT (1) | PT2263694E (el) |
SI (1) | SI2263694T1 (el) |
WO (1) | WO2005030239A2 (el) |
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RU2298414C2 (ru) * | 2001-08-21 | 2007-05-10 | Астеллас Фарма Инк. | Медицинское применение ингибитора гистоновой дезацетилазы и способ оценки его противоопухолевого действия |
JP2005521737A (ja) * | 2002-04-05 | 2005-07-21 | 藤沢薬品工業株式会社 | 腎臓癌の治療のためのデプシペプチド |
CA2519320A1 (en) * | 2003-02-19 | 2004-09-02 | Astellas Pharma Inc. | Method of estimating antitumor effect of histone deacetylase inhibitor |
CA2518318A1 (en) * | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
ES2344899T3 (es) | 2003-09-25 | 2010-09-09 | Astellas Pharma Inc. | Agente antitumoral que comprende un inhibidor de histona desacetilasa y un inhibidor de topoisomerasa ii. |
WO2005065681A1 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer |
WO2005066151A2 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
US7951780B2 (en) * | 2004-02-25 | 2011-05-31 | Astellas Pharma Inc. | Antitumor agent |
WO2006066133A2 (en) * | 2004-12-16 | 2006-06-22 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
US7642253B2 (en) * | 2005-05-11 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
AU2006270322A1 (en) * | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
WO2007040522A1 (en) * | 2005-09-30 | 2007-04-12 | The Ohio State Research Foundation | Antitumor agents |
CA2630216A1 (en) * | 2005-11-18 | 2007-05-31 | Gloucester Pharmaceuticals, Inc. | Metabolite derivatives of the hdac inhibitor fk228 |
JP2009525955A (ja) * | 2006-01-13 | 2009-07-16 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
US9539303B2 (en) * | 2006-04-24 | 2017-01-10 | Celgene Corporation | Treatment of Ras-expressing tumors |
WO2007146730A2 (en) | 2006-06-08 | 2007-12-21 | Gloucester Pharmaceuticals | Deacetylase inhibitor therapy |
AU2007340129B2 (en) * | 2006-12-26 | 2012-02-02 | Pharmacyclics Llc | Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy |
US8691534B2 (en) | 2006-12-29 | 2014-04-08 | Celgene Corporation | Preparation of romidepsin |
WO2008083290A1 (en) * | 2006-12-29 | 2008-07-10 | Gloucester Pharmaceuticals, Inc. | Romidepsin-based treatments for cancer |
WO2009002941A1 (en) * | 2007-06-22 | 2008-12-31 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by histone deacetylase inhibitors |
US20110021517A1 (en) * | 2008-02-26 | 2011-01-27 | Nerviano Medical Sciences S.R.L. | Antitumor combination comprising a morpholinyl anthracycline derivative and demethylating agents |
SG10201505475XA (en) | 2010-07-12 | 2015-09-29 | Celgene Corp | Romidepsin solid forms and uses thereof |
US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
SG2014014419A (en) | 2011-09-13 | 2014-07-30 | Pharmacyclics Inc | Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof |
AU2013202506B2 (en) | 2012-09-07 | 2015-06-18 | Celgene Corporation | Resistance biomarkers for hdac inhibitors |
JP6253591B2 (ja) * | 2012-11-01 | 2017-12-27 | 公益財団法人微生物化学研究会 | 抗がん剤、及び併用抗がん剤 |
AU2013202507B9 (en) | 2012-11-14 | 2015-08-13 | Celgene Corporation | Inhibition of drug resistant cancer cells |
NZ630311A (en) | 2013-12-27 | 2016-03-31 | Celgene Corp | Romidepsin formulations and uses thereof |
CN116327887B (zh) * | 2023-04-24 | 2023-11-03 | 南京捷因诊断技术有限公司 | 一种lsd1抑制剂作为抗肿瘤药物的应用 |
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US4950755A (en) * | 1985-08-12 | 1990-08-21 | Ohio State University | Bis(morpholinomethyl) derivative of 1,2-bis(dioxopiperizinyl)propane |
US5242901A (en) * | 1988-01-27 | 1993-09-07 | New York University | Reduction of anthracycline induced cardiotoxicity |
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JP2005521737A (ja) | 2002-04-05 | 2005-07-21 | 藤沢薬品工業株式会社 | 腎臓癌の治療のためのデプシペプチド |
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US20040152632A1 (en) * | 2002-11-06 | 2004-08-05 | Wyeth | Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome |
US20050222013A1 (en) | 2003-01-16 | 2005-10-06 | Georgetown University | Methods for the use of inhibitors of histone deacetylase as synergistic agents in cancer therapy |
CN1791396A (zh) * | 2003-05-21 | 2006-06-21 | 诺瓦提斯公司 | 组蛋白脱乙酰基酶抑制剂与化疗剂的组合 |
PE20050206A1 (es) * | 2003-05-26 | 2005-03-26 | Schering Ag | Composicion farmaceutica que contiene un inhibidor de histona deacetilasa |
EP1638541B1 (en) | 2003-06-27 | 2010-05-19 | Astellas Pharma Inc. | Therapeutic agent for soft tissue sarcoma |
ES2344899T3 (es) | 2003-09-25 | 2010-09-09 | Astellas Pharma Inc. | Agente antitumoral que comprende un inhibidor de histona desacetilasa y un inhibidor de topoisomerasa ii. |
US7951780B2 (en) | 2004-02-25 | 2011-05-31 | Astellas Pharma Inc. | Antitumor agent |
-
2004
- 2004-09-24 ES ES04773539T patent/ES2344899T3/es active Active
- 2004-09-24 WO PCT/JP2004/014451 patent/WO2005030239A2/en active Application Filing
- 2004-09-24 PT PT101635274T patent/PT2263694E/pt unknown
- 2004-09-24 US US10/948,288 patent/US7314862B2/en active Active
- 2004-09-24 PL PL04773539T patent/PL1670514T3/pl unknown
- 2004-09-24 EP EP10163527.4A patent/EP2263694B1/en active Active
- 2004-09-24 SI SI200432064T patent/SI2263694T1/sl unknown
- 2004-09-24 AT AT04773539T patent/ATE471740T1/de active
- 2004-09-24 PL PL10163527T patent/PL2263694T3/pl unknown
- 2004-09-24 DK DK10163527.4T patent/DK2263694T3/da active
- 2004-09-24 MX MXPA06003222A patent/MXPA06003222A/es active IP Right Grant
- 2004-09-24 JP JP2006515402A patent/JP4779971B2/ja active Active
- 2004-09-24 CA CA002540108A patent/CA2540108A1/en not_active Abandoned
- 2004-09-24 DE DE602004027824T patent/DE602004027824D1/de active Active
- 2004-09-24 ES ES10163527T patent/ES2425083T3/es active Active
- 2004-09-24 EP EP04773539A patent/EP1670514B1/en active Active
-
2013
- 2013-09-09 CY CY20131100771T patent/CY1114359T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP2263694A1 (en) | 2010-12-22 |
JP4779971B2 (ja) | 2011-09-28 |
PL2263694T3 (pl) | 2013-11-29 |
WO2005030239A3 (en) | 2005-07-28 |
CA2540108A1 (en) | 2005-04-07 |
WO2005030239A2 (en) | 2005-04-07 |
US7314862B2 (en) | 2008-01-01 |
ES2344899T3 (es) | 2010-09-09 |
ATE471740T1 (de) | 2010-07-15 |
US20050070467A1 (en) | 2005-03-31 |
PT2263694E (pt) | 2013-08-27 |
DK2263694T3 (da) | 2013-08-26 |
PL1670514T3 (pl) | 2010-11-30 |
EP1670514B1 (en) | 2010-06-23 |
JP2007506647A (ja) | 2007-03-22 |
DE602004027824D1 (de) | 2010-08-05 |
SI2263694T1 (sl) | 2013-09-30 |
EP1670514A2 (en) | 2006-06-21 |
MXPA06003222A (es) | 2006-05-22 |
EP2263694B1 (en) | 2013-06-12 |
ES2425083T3 (es) | 2013-10-11 |
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