CY1114079T1 - Μεθοδος για την παρασκευη ibodutant (μεν15596) και σχετικων ενδιαμεσων ουσιων - Google Patents
Μεθοδος για την παρασκευη ibodutant (μεν15596) και σχετικων ενδιαμεσων ουσιωνInfo
- Publication number
- CY1114079T1 CY1114079T1 CY20131100392T CY131100392T CY1114079T1 CY 1114079 T1 CY1114079 T1 CY 1114079T1 CY 20131100392 T CY20131100392 T CY 20131100392T CY 131100392 T CY131100392 T CY 131100392T CY 1114079 T1 CY1114079 T1 CY 1114079T1
- Authority
- CY
- Cyprus
- Prior art keywords
- ibodutant
- preparing
- alpha
- coupling
- related intermediate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Η εφεύρεση αυτή αφορά μία νέα μέθοδο για τη σύνθεση του προϊόντος ibodutant, η οποία δεικνύεται στο σχήμα κατωτέρω, η οποία αποτελείται από έναν μικρό αριθμό βημάτων μεγάλης απόδοσης, όπου συμπεριλαμβάνονται αντιδραστήρια και διαλύτες με μικρές περιβαλλοντικές επιπτώσεις, χαρακτηριζόμενη από τη σύζευξη δύο τμημάτων, των ενώσεων (3) και (4), μία από τις οποίες, η (3), συντίθεται δια σύζευξης 6-μεθυλο-2-βενζο[b]θειοφαινοκαρβοξυλικού οξέος (1) με 1-αμινο-αλφα-αλφα-κυκλοπεντανοκαρβοξυλικό οξύ και επακόλουθη κυκλοποίηση με οξαζολόνη, ενώ η άλλη ένωση (4) λαμβάνεται από κατάλληλες εξαιρετικά επιλεκτικές δραστικοποιήσεις της 4-αμινομεθυλοπιπεριδίνης (2).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2009A000897A IT1394304B1 (it) | 2009-05-21 | 2009-05-21 | Processo per la preparazione di ibodutant (men15596) e relativi intermedi |
| EP10721687A EP2432778B1 (en) | 2009-05-21 | 2010-05-11 | Process for the preparation of ibodutant (men15596) and related intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114079T1 true CY1114079T1 (el) | 2016-07-27 |
Family
ID=41264221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100392T CY1114079T1 (el) | 2009-05-21 | 2013-05-16 | Μεθοδος για την παρασκευη ibodutant (μεν15596) και σχετικων ενδιαμεσων ουσιων |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8431684B2 (el) |
| EP (1) | EP2432778B1 (el) |
| JP (1) | JP5645926B2 (el) |
| KR (1) | KR101695346B1 (el) |
| CN (1) | CN102428081B (el) |
| AR (1) | AR076785A1 (el) |
| AU (1) | AU2010251514B2 (el) |
| BR (1) | BRPI1013073A2 (el) |
| CA (1) | CA2762625A1 (el) |
| CY (1) | CY1114079T1 (el) |
| DK (1) | DK2432778T3 (el) |
| EA (1) | EA019777B1 (el) |
| EG (1) | EG27000A (el) |
| ES (1) | ES2409705T3 (el) |
| HK (1) | HK1169828A1 (el) |
| HR (1) | HRP20130380T1 (el) |
| IL (1) | IL216400A (el) |
| IT (1) | IT1394304B1 (el) |
| MA (1) | MA33375B1 (el) |
| MX (1) | MX2011012317A (el) |
| NZ (1) | NZ596523A (el) |
| PL (1) | PL2432778T3 (el) |
| PT (1) | PT2432778E (el) |
| SG (1) | SG176171A1 (el) |
| SI (1) | SI2432778T1 (el) |
| TW (1) | TWI424996B (el) |
| UA (1) | UA105523C2 (el) |
| WO (1) | WO2010133306A1 (el) |
| ZA (1) | ZA201108483B (el) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY130373A (en) * | 2001-10-29 | 2007-06-29 | Malesci Sas | Linear basic compounds having nk-2 antagonist activity and formulations thereof |
| ITFI20040221A1 (it) * | 2004-10-27 | 2005-01-27 | Guidotti & C Spa | Composizioni farmaceutiche a base di nk2 antagonisti per uso pediatrico |
| WO2007080884A1 (ja) * | 2006-01-11 | 2007-07-19 | Seikagaku Corporation | シクロアルキルカルボニルアミノ酸エステル誘導体及びその製造方法 |
-
2009
- 2009-05-21 IT ITMI2009A000897A patent/IT1394304B1/it active
-
2010
- 2010-05-11 EP EP10721687A patent/EP2432778B1/en active Active
- 2010-05-11 EA EA201190267A patent/EA019777B1/ru not_active IP Right Cessation
- 2010-05-11 MX MX2011012317A patent/MX2011012317A/es active IP Right Grant
- 2010-05-11 WO PCT/EP2010/002884 patent/WO2010133306A1/en active Application Filing
- 2010-05-11 JP JP2012511171A patent/JP5645926B2/ja not_active Expired - Fee Related
- 2010-05-11 NZ NZ596523A patent/NZ596523A/xx not_active IP Right Cessation
- 2010-05-11 ES ES10721687T patent/ES2409705T3/es active Active
- 2010-05-11 SG SG2011085545A patent/SG176171A1/en unknown
- 2010-05-11 DK DK10721687.1T patent/DK2432778T3/da active
- 2010-05-11 UA UAA201113614A patent/UA105523C2/uk unknown
- 2010-05-11 BR BRPI1013073A patent/BRPI1013073A2/pt not_active IP Right Cessation
- 2010-05-11 CN CN201080021722.5A patent/CN102428081B/zh not_active Expired - Fee Related
- 2010-05-11 MA MA34472A patent/MA33375B1/fr unknown
- 2010-05-11 US US13/321,501 patent/US8431684B2/en not_active Expired - Fee Related
- 2010-05-11 CA CA2762625A patent/CA2762625A1/en not_active Abandoned
- 2010-05-11 SI SI201030192T patent/SI2432778T1/sl unknown
- 2010-05-11 PT PT107216871T patent/PT2432778E/pt unknown
- 2010-05-11 PL PL10721687T patent/PL2432778T3/pl unknown
- 2010-05-11 KR KR1020117027585A patent/KR101695346B1/ko active IP Right Grant
- 2010-05-11 AU AU2010251514A patent/AU2010251514B2/en not_active Ceased
- 2010-05-20 AR ARP100101759A patent/AR076785A1/es unknown
- 2010-05-20 TW TW099116060A patent/TWI424996B/zh not_active IP Right Cessation
-
2011
- 2011-11-17 EG EG2011111951A patent/EG27000A/xx active
- 2011-11-17 IL IL216400A patent/IL216400A/en not_active IP Right Cessation
- 2011-11-18 ZA ZA2011/08483A patent/ZA201108483B/en unknown
-
2012
- 2012-10-24 HK HK12110578.5A patent/HK1169828A1/xx not_active IP Right Cessation
-
2013
- 2013-05-02 HR HRP20130380AT patent/HRP20130380T1/hr unknown
- 2013-05-16 CY CY20131100392T patent/CY1114079T1/el unknown
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