MX2011012317A - Procedimiento para la preparacion de ibodutant (men15596) e intermediarios relacionados. - Google Patents
Procedimiento para la preparacion de ibodutant (men15596) e intermediarios relacionados.Info
- Publication number
- MX2011012317A MX2011012317A MX2011012317A MX2011012317A MX2011012317A MX 2011012317 A MX2011012317 A MX 2011012317A MX 2011012317 A MX2011012317 A MX 2011012317A MX 2011012317 A MX2011012317 A MX 2011012317A MX 2011012317 A MX2011012317 A MX 2011012317A
- Authority
- MX
- Mexico
- Prior art keywords
- ibodutant
- alpha
- men15596
- preparation
- coupling
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Steroid Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Nuevo procedimiento para sintetizar el producto ibodutant que se muestra en el intermediario (3), que consiste en una cantidad reducida de pasos de alto rendimiento en los que se utilizan reactivos y solventes de bajo impacto ambiental, que se caracterizan por el acoplamiento de dos porciones, los compuestos (3) y (4), uno de los cuales (3) se sintetiza mediante acoplamiento de ácido 6-metil-2-benzo[b]tiofenocarboxílico (1) con ácido 1-amino-alfa-alfa-ciclopentano carboxílico y subsiguiente ciclado con oxazolona, mientras que el otro, el compuesto (4), se obtiene a partir de funcionalizaciones apropiadas altamente selectivas de 4-aminometilpiperidina (2) (ver fórmulas).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2009A000897A IT1394304B1 (it) | 2009-05-21 | 2009-05-21 | Processo per la preparazione di ibodutant (men15596) e relativi intermedi |
| PCT/EP2010/002884 WO2010133306A1 (en) | 2009-05-21 | 2010-05-11 | Process for the preparation of ibodutant (men15596) and related intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011012317A true MX2011012317A (es) | 2012-03-07 |
Family
ID=41264221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011012317A MX2011012317A (es) | 2009-05-21 | 2010-05-11 | Procedimiento para la preparacion de ibodutant (men15596) e intermediarios relacionados. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8431684B2 (es) |
| EP (1) | EP2432778B1 (es) |
| JP (1) | JP5645926B2 (es) |
| KR (1) | KR101695346B1 (es) |
| CN (1) | CN102428081B (es) |
| AR (1) | AR076785A1 (es) |
| AU (1) | AU2010251514B2 (es) |
| BR (1) | BRPI1013073A2 (es) |
| CA (1) | CA2762625A1 (es) |
| CY (1) | CY1114079T1 (es) |
| DK (1) | DK2432778T3 (es) |
| EA (1) | EA019777B1 (es) |
| EG (1) | EG27000A (es) |
| ES (1) | ES2409705T3 (es) |
| HK (1) | HK1169828A1 (es) |
| HR (1) | HRP20130380T1 (es) |
| IL (1) | IL216400A (es) |
| IT (1) | IT1394304B1 (es) |
| MA (1) | MA33375B1 (es) |
| MX (1) | MX2011012317A (es) |
| NZ (1) | NZ596523A (es) |
| PL (1) | PL2432778T3 (es) |
| PT (1) | PT2432778E (es) |
| SG (1) | SG176171A1 (es) |
| SI (1) | SI2432778T1 (es) |
| TW (1) | TWI424996B (es) |
| UA (1) | UA105523C2 (es) |
| WO (1) | WO2010133306A1 (es) |
| ZA (1) | ZA201108483B (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY130373A (en) * | 2001-10-29 | 2007-06-29 | Malesci Sas | Linear basic compounds having nk-2 antagonist activity and formulations thereof |
| ITFI20040221A1 (it) * | 2004-10-27 | 2005-01-27 | Guidotti & C Spa | Composizioni farmaceutiche a base di nk2 antagonisti per uso pediatrico |
| AU2007205578B2 (en) * | 2006-01-11 | 2012-06-28 | Seikagaku Corporation | Cycloalkylcarbonylamino acid ester derivative and process for producing the same |
-
2009
- 2009-05-21 IT ITMI2009A000897A patent/IT1394304B1/it active
-
2010
- 2010-05-11 EA EA201190267A patent/EA019777B1/ru not_active IP Right Cessation
- 2010-05-11 ES ES10721687T patent/ES2409705T3/es active Active
- 2010-05-11 JP JP2012511171A patent/JP5645926B2/ja not_active Expired - Fee Related
- 2010-05-11 AU AU2010251514A patent/AU2010251514B2/en not_active Ceased
- 2010-05-11 WO PCT/EP2010/002884 patent/WO2010133306A1/en active Application Filing
- 2010-05-11 SI SI201030192T patent/SI2432778T1/sl unknown
- 2010-05-11 KR KR1020117027585A patent/KR101695346B1/ko active IP Right Grant
- 2010-05-11 PL PL10721687T patent/PL2432778T3/pl unknown
- 2010-05-11 SG SG2011085545A patent/SG176171A1/en unknown
- 2010-05-11 NZ NZ596523A patent/NZ596523A/xx not_active IP Right Cessation
- 2010-05-11 BR BRPI1013073A patent/BRPI1013073A2/pt not_active IP Right Cessation
- 2010-05-11 US US13/321,501 patent/US8431684B2/en not_active Expired - Fee Related
- 2010-05-11 CA CA2762625A patent/CA2762625A1/en not_active Abandoned
- 2010-05-11 UA UAA201113614A patent/UA105523C2/uk unknown
- 2010-05-11 PT PT107216871T patent/PT2432778E/pt unknown
- 2010-05-11 CN CN201080021722.5A patent/CN102428081B/zh not_active Expired - Fee Related
- 2010-05-11 MX MX2011012317A patent/MX2011012317A/es active IP Right Grant
- 2010-05-11 DK DK10721687.1T patent/DK2432778T3/da active
- 2010-05-11 MA MA34472A patent/MA33375B1/fr unknown
- 2010-05-11 EP EP10721687A patent/EP2432778B1/en active Active
- 2010-05-20 TW TW099116060A patent/TWI424996B/zh not_active IP Right Cessation
- 2010-05-20 AR ARP100101759A patent/AR076785A1/es unknown
-
2011
- 2011-11-17 EG EG2011111951A patent/EG27000A/xx active
- 2011-11-17 IL IL216400A patent/IL216400A/en not_active IP Right Cessation
- 2011-11-18 ZA ZA2011/08483A patent/ZA201108483B/en unknown
-
2012
- 2012-10-24 HK HK12110578.5A patent/HK1169828A1/xx not_active IP Right Cessation
-
2013
- 2013-05-02 HR HRP20130380AT patent/HRP20130380T1/hr unknown
- 2013-05-16 CY CY20131100392T patent/CY1114079T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |