CY1113994T1 - Πολυμορφικες δομες της φωσφορικης οσελταμιβιρης - Google Patents

Πολυμορφικες δομες της φωσφορικης οσελταμιβιρης

Info

Publication number
CY1113994T1
CY1113994T1 CY20131100398T CY131100398T CY1113994T1 CY 1113994 T1 CY1113994 T1 CY 1113994T1 CY 20131100398 T CY20131100398 T CY 20131100398T CY 131100398 T CY131100398 T CY 131100398T CY 1113994 T1 CY1113994 T1 CY 1113994T1
Authority
CY
Cyprus
Prior art keywords
osltamivir
phosphoric
polymorphic structures
polymorphic
structures
Prior art date
Application number
CY20131100398T
Other languages
English (en)
Inventor
André Bubendorf
Pierre Goldbach
Olaf Grassmann
Michael Hennig
Ines Sauer
RENé TRUSSARDI
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of CY1113994T1 publication Critical patent/CY1113994T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με πολυμορφικές δομές της φωσφορικής οσελταμιβίρης, ειδικότερα με τον φωσφορικό αιθυλεστέρα του (3R,4R,5S)-5-αμινο-4-ακετυλαμινο-3-(1-αιθυλο-προποξυ)-κυκλοεξ-1-ενοκαρβοξυλικού οξέος, ο οποίος είναι ισχυρός αναστολέας της ιογενούς νευραμινιδάσης.
CY20131100398T 2008-01-04 2013-05-16 Πολυμορφικες δομες της φωσφορικης οσελταμιβιρης CY1113994T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08150057 2008-01-04
EP08869959A EP2240433B1 (en) 2008-01-04 2008-12-23 Polymorphic forms of oseltamivir phosphate

Publications (1)

Publication Number Publication Date
CY1113994T1 true CY1113994T1 (el) 2016-07-27

Family

ID=40527455

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100398T CY1113994T1 (el) 2008-01-04 2013-05-16 Πολυμορφικες δομες της φωσφορικης οσελταμιβιρης

Country Status (13)

Country Link
US (1) US8334319B2 (el)
EP (1) EP2240433B1 (el)
JP (1) JP5543368B2 (el)
CN (1) CN101910118B (el)
CA (1) CA2710484C (el)
CY (1) CY1113994T1 (el)
DK (1) DK2240433T3 (el)
ES (1) ES2408232T3 (el)
HR (1) HRP20130507T1 (el)
PL (1) PL2240433T3 (el)
PT (1) PT2240433E (el)
SI (1) SI2240433T1 (el)
WO (1) WO2009087062A2 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088648A1 (zh) * 2010-12-31 2012-07-05 Kang Yanlong 奥司他韦的氘代酸加成盐
US10350188B2 (en) 2011-11-04 2019-07-16 Myron R. Szewczuk Use of Neu1 sialidase inhibitors in the treatment of cancer
WO2018004261A1 (ko) * 2016-06-30 2018-01-04 한미약품 주식회사 오셀타미비어 함유 경구용 고형제제 및 그 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0759917T3 (da) * 1995-02-27 2000-07-31 Gilead Sciences Inc Hidtil ukendte selektive inhibitorer af virale eller bakterielle neuraminidaser
ATE215062T1 (de) * 1996-08-23 2002-04-15 Gilead Sciences Inc Verfahren zur herstellung von cyclohexen- carboxylatderivate
US5859284A (en) * 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
IL134691A0 (en) * 1997-09-17 2001-04-30 Gilead Sciences Inc Compounds containing six-membered rings, processes for their preparation, and their use as medicaments
US7732632B2 (en) * 2006-01-02 2010-06-08 Hetero Drugs Limited Process for obtaining pure oseltamivir
US7981930B2 (en) * 2007-03-13 2011-07-19 Adamas Pharmaceuticals, Inc. Compositions and kits for treating influenza

Also Published As

Publication number Publication date
CA2710484A1 (en) 2009-07-16
JP2011510914A (ja) 2011-04-07
PT2240433E (pt) 2013-04-18
ES2408232T3 (es) 2013-06-19
CN101910118A (zh) 2010-12-08
JP5543368B2 (ja) 2014-07-09
EP2240433A2 (en) 2010-10-20
SI2240433T1 (sl) 2013-05-31
WO2009087062A2 (en) 2009-07-16
HRP20130507T1 (en) 2013-07-31
PL2240433T3 (pl) 2013-08-30
US20090176886A1 (en) 2009-07-09
WO2009087062A3 (en) 2010-01-14
CN101910118B (zh) 2014-07-30
US8334319B2 (en) 2012-12-18
CA2710484C (en) 2016-04-05
DK2240433T3 (da) 2013-04-15
EP2240433B1 (en) 2013-03-20

Similar Documents

Publication Publication Date Title
CY1125155T1 (el) Κρυσταλλικες μορφες αναστολεα προλυλο υδροξυλασης
SMT201700092B (it) Processo per la preparazione di composti utili come inibitori di sglt
BR112014018756A8 (pt) Processo para preparo de etil éster de ácido n-(4-ciclo-hexil-3-trifluorometil-benziloxi)-acetimídico
CY1122670T1 (el) Παρασκευη παρασκευασματος και παρασκευασμα που περιλαμβανει αναστολεα μεκ
BRPI0920834A2 (pt) processo para preparação de derivados protegidos de l-alanina
IT1401911B1 (it) Processo per la sintesi di acido 2,5-furandicarbossilico
BR112012006031A2 (pt) processo para preparação de compostos azabicíclicos.
CL2009000503A1 (es) Proceso de preparacion de compuestos derivados de acido 2-amino-5-cianobenzoico-3-sustituidos o 1h-pirazol-5-carboxamida.
BRPI1012638B8 (pt) métodos e intermediários para preparar agentes farmacêuticos
BR112013001267A2 (pt) métodos para a preparação de pró-fármacos de fosforamidato diasteromericamente puro
BRPI1006031A2 (pt) processo de síntese de um ômega-aminoácido(éster)
CY1109766T1 (el) Παραγωγα αζαπεπτιδιου ως αναστολεις πρωτεασης hiv
CR20140510A (es) Nucleósidos de espirooxetano de uracilo
BR112012032244A2 (pt) processo para preparar derivados de antranilamida com tetrazole-substituído e polimorfos cristalinos novos e derivados destes
UY33735A (es) Compuestos antivirales
ME01618B (me) Novi proces za dobijanje derivata aminokiselina
EA200702614A1 (ru) Способы получения 4-(бифенилил)азетидин-2-оналкилфосфиновых кислот
UA111142C2 (uk) Одержання заміщених похідних 2-фторакрилової кислоти
CR20140554A (es) Compuestos de acido dimetil-benzoico
DK2285765T3 (da) Fremgangsmåde til fremstilling af derivater af 1-(2-halobiphenyl-4-yl)-cyclopropancarboxylsyre
UY30682A1 (es) Nueva difenilazetidinona sustituida con acido piperazina-1-sulfonico con propiedades farmacologicas mejoradas
CR20150084A (es) 2-oxo-2,3-dihidro-indoles
CY1114493T1 (el) Διαδικασια για την παρασκευη μιας ενωσης χρησιμης ως αναστολεα της tafia
CR20120515A (es) Heterobiaril-ciclohexil-tetraazabenzo[e] azulenos
CY1113994T1 (el) Πολυμορφικες δομες της φωσφορικης οσελταμιβιρης