CY1113965T1 - 4-[2-(4-μεθυλφαινυλσουλφανυλ) φαινυλ] πιπεριδινη με συνδυασμενη σεροτονινη και αναστολη της επαναπροσληψης νορεπινεφρινης για τη θεραπεια της adhd, μελαγχολιας, ανθισταμενης στην αγωγη καταθλιψης ή υπολειμματικων συμπτωματων καταθλιψης - Google Patents

4-[2-(4-μεθυλφαινυλσουλφανυλ) φαινυλ] πιπεριδινη με συνδυασμενη σεροτονινη και αναστολη της επαναπροσληψης νορεπινεφρινης για τη θεραπεια της adhd, μελαγχολιας, ανθισταμενης στην αγωγη καταθλιψης ή υπολειμματικων συμπτωματων καταθλιψης

Info

Publication number
CY1113965T1
CY1113965T1 CY20131100146T CY131100146T CY1113965T1 CY 1113965 T1 CY1113965 T1 CY 1113965T1 CY 20131100146 T CY20131100146 T CY 20131100146T CY 131100146 T CY131100146 T CY 131100146T CY 1113965 T1 CY1113965 T1 CY 1113965T1
Authority
CY
Cyprus
Prior art keywords
treatment
depression
methylphenylsulfanyl
adhd
piperidine
Prior art date
Application number
CY20131100146T
Other languages
English (en)
Inventor
Tine Bryan Stensbøl
Silke Miller
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of CY1113965T1 publication Critical patent/CY1113965T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Παρέχεται η χρήση της 4-[2-(4-μεθυλφαινυλσουλφανυλ) φαινυλ] πιπεριδίνης και αλάτων προσθήκης οξέος αυτής για τη θεραπεία της ADHD, μελαγχολίας, ανθιστάμενης στην αγωγή κατάθλιψης ή υπολειμματικών συμπτωμάτων κατάθλιψης.
CY20131100146T 2007-03-20 2013-02-15 4-[2-(4-μεθυλφαινυλσουλφανυλ) φαινυλ] πιπεριδινη με συνδυασμενη σεροτονινη και αναστολη της επαναπροσληψης νορεπινεφρινης για τη θεραπεια της adhd, μελαγχολιας, ανθισταμενης στην αγωγη καταθλιψης ή υπολειμματικων συμπτωματων καταθλιψης CY1113965T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200700423 2007-03-20
EP08715618A EP2139479B1 (en) 2007-03-20 2008-03-14 4-[2-(4-methylphenylsulfanyl)phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of adhd, melancholia, treatment resistent depression or residual symptoms in depression

Publications (1)

Publication Number Publication Date
CY1113965T1 true CY1113965T1 (el) 2016-07-27

Family

ID=39575680

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20131100146T CY1113965T1 (el) 2007-03-20 2013-02-15 4-[2-(4-μεθυλφαινυλσουλφανυλ) φαινυλ] πιπεριδινη με συνδυασμενη σεροτονινη και αναστολη της επαναπροσληψης νορεπινεφρινης για τη θεραπεια της adhd, μελαγχολιας, ανθισταμενης στην αγωγη καταθλιψης ή υπολειμματικων συμπτωματων καταθλιψης
CY20141100065T CY1114774T1 (el) 2007-03-20 2014-01-24 4- [2- (4-μεθυλφαινυλσουλφανυλ) φαινυλο]πιπεριδινη για την αγωγη του συνδρομου ευερεθιστου εντερου (ibs)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20141100065T CY1114774T1 (el) 2007-03-20 2014-01-24 4- [2- (4-μεθυλφαινυλσουλφανυλ) φαινυλο]πιπεριδινη για την αγωγη του συνδρομου ευερεθιστου εντερου (ibs)

Country Status (28)

Country Link
US (2) US20100144788A1 (el)
EP (2) EP2139479B1 (el)
JP (1) JP5388867B2 (el)
KR (1) KR20090125775A (el)
CN (2) CN101674830B (el)
AR (1) AR065798A1 (el)
AU (1) AU2008228639B2 (el)
BR (1) BRPI0808831A2 (el)
CA (1) CA2684556C (el)
CL (1) CL2008000796A1 (el)
CO (1) CO6220957A2 (el)
CY (2) CY1113965T1 (el)
DK (2) DK2139479T3 (el)
EA (1) EA017407B1 (el)
ES (2) ES2399305T3 (el)
HK (1) HK1142007A1 (el)
HR (1) HRP20130049T1 (el)
IL (1) IL200954A (el)
MX (1) MX2009009934A (el)
MY (1) MY163537A (el)
NZ (1) NZ579723A (el)
PL (2) PL2139479T3 (el)
PT (2) PT2139479E (el)
RS (2) RS52676B (el)
SI (1) SI2139479T1 (el)
TW (1) TWI432194B (el)
UA (2) UA99611C2 (el)
WO (1) WO2008113360A2 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA016054B1 (ru) * 2006-06-16 2012-01-30 Х. Лундбекк А/С Кристаллические формы 4-[2-(4-метилфенилсульфанил)фенил] пиперидина с объединенным ингибированием повторного поглощения серотонина и норадреналина для лечения невропатической боли
TWI432194B (zh) 2007-03-20 2014-04-01 Lundbeck & Co As H ４-〔２-（４-甲基苯硫基）苯基〕哌啶之新穎治療用途
SI2167085T1 (sl) * 2007-06-15 2014-05-30 H. Lundbeck A/S 4-(2-(4-metilfenilsulfanil)fenil)piperidin za zdravljenje sindroma razdraĺ˝ljivega äśrevesja (ibs)
TW200938194A (en) * 2007-12-14 2009-09-16 Lundbeck & Co As H Therapeutic uses of compounds having affinity to the serotonin transporter, serotonin receptors and noradrenalin transporter
JP5787881B2 (ja) 2010-04-30 2015-09-30 武田薬品工業株式会社 腸溶性錠剤
US8745134B1 (en) 2011-03-04 2014-06-03 Zynga Inc. Cross social network data aggregation
US8332488B1 (en) 2011-03-04 2012-12-11 Zynga Inc. Multi-level cache with synch
US8347322B1 (en) 2011-03-31 2013-01-01 Zynga Inc. Social network application programming interface
US10135776B1 (en) 2011-03-31 2018-11-20 Zynga Inc. Cross platform social networking messaging system
US8522137B1 (en) 2011-06-30 2013-08-27 Zynga Inc. Systems, methods, and machine readable media for social network application development using a custom markup language
WO2018002115A1 (en) 2016-07-01 2018-01-04 H. Lundbeck A/S Vortioxetine dosing regimes for fast onset of antidepressant effect

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI226829B (en) * 1998-05-22 2005-01-21 Lilly Co Eli Pharmaceutical compositions for treatment of partial responders or refractory depression
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
JP4667366B2 (ja) * 2003-04-04 2011-04-13 ハー・ルンドベック・アクチエゼルスカベット セロトニン再取り込み阻害剤としての４−（２−フェニルスルファニル−フェニル）−ピペリジン誘導体
PL1635828T3 (pl) * 2003-04-04 2008-10-31 H Lundbeck As Pochodne 4-(2-fenyloksyfenylo)-piperydyny lub 1,2,3,6-tetrahydropirydyny jako inhibitory wychwytu zwrotnego serotoniny
AR052308A1 (es) * 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
DE102006028034A1 (de) * 2006-06-14 2007-12-20 Leifheit Ag Bürste und Kehrgerät mit Bürste
EA016054B1 (ru) * 2006-06-16 2012-01-30 Х. Лундбекк А/С Кристаллические формы 4-[2-(4-метилфенилсульфанил)фенил] пиперидина с объединенным ингибированием повторного поглощения серотонина и норадреналина для лечения невропатической боли
TWI432194B (zh) 2007-03-20 2014-04-01 Lundbeck & Co As H ４-〔２-（４-甲基苯硫基）苯基〕哌啶之新穎治療用途
TWI405588B (zh) 2007-03-20 2013-08-21 Lundbeck & Co As H ４-〔２-（４-甲苯基硫基）-苯基〕哌啶之鹽類的液體調配物
TW200938194A (en) * 2007-12-14 2009-09-16 Lundbeck & Co As H Therapeutic uses of compounds having affinity to the serotonin transporter, serotonin receptors and noradrenalin transporter

Also Published As

Publication number Publication date
WO2008113360A3 (en) 2008-11-13
IL200954A (en) 2014-12-31
JP2010521502A (ja) 2010-06-24
UA99611C2 (ru) 2012-09-10
RS52676B (en) 2013-06-28
KR20090125775A (ko) 2009-12-07
RS53138B (en) 2014-06-30
ES2399305T3 (es) 2013-03-27
BRPI0808831A2 (pt) 2014-08-26
DK2167085T3 (da) 2014-02-03
NZ579723A (en) 2011-07-29
EA200970871A1 (ru) 2010-04-30
HRP20130049T1 (hr) 2013-02-28
CA2684556A1 (en) 2008-09-25
US8507526B2 (en) 2013-08-13
CN101674830A (zh) 2010-03-17
CO6220957A2 (es) 2010-11-19
PT2139479E (pt) 2013-02-20
PL2139479T3 (pl) 2013-05-31
JP5388867B2 (ja) 2014-01-15
MX2009009934A (es) 2009-09-24
SI2139479T1 (sl) 2013-04-30
MY163537A (en) 2017-09-15
US20100137366A1 (en) 2010-06-03
TW200848032A (en) 2008-12-16
ES2445400T3 (es) 2014-03-03
CN101646438B (zh) 2012-04-11
DK2139479T3 (da) 2013-02-11
CL2008000796A1 (es) 2008-09-26
WO2008113360A2 (en) 2008-09-25
AU2008228639B2 (en) 2012-12-13
EP2139479B1 (en) 2012-12-12
EP2167085B1 (en) 2013-12-25
EP2167085A1 (en) 2010-03-31
TWI432194B (zh) 2014-04-01
AU2008228639A1 (en) 2008-09-25
US20100144788A1 (en) 2010-06-10
EP2139479A2 (en) 2010-01-06
CA2684556C (en) 2013-01-08
IL200954A0 (en) 2010-05-17
CN101646438A (zh) 2010-02-10
CY1114774T1 (el) 2016-12-14
PT2167085E (pt) 2014-02-17
HK1142007A1 (en) 2010-11-26
UA97660C2 (ru) 2012-03-12
EA017407B1 (ru) 2012-12-28
AR065798A1 (es) 2009-07-01
PL2167085T3 (pl) 2014-08-29
CN101674830B (zh) 2012-05-09

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