CY1114774T1 - 4- [2- (4-μεθυλφαινυλσουλφανυλ) φαινυλο]πιπεριδινη για την αγωγη του συνδρομου ευερεθιστου εντερου (ibs) - Google Patents

4- [2- (4-μεθυλφαινυλσουλφανυλ) φαινυλο]πιπεριδινη για την αγωγη του συνδρομου ευερεθιστου εντερου (ibs)

Info

Publication number
CY1114774T1
CY1114774T1 CY20141100065T CY141100065T CY1114774T1 CY 1114774 T1 CY1114774 T1 CY 1114774T1 CY 20141100065 T CY20141100065 T CY 20141100065T CY 141100065 T CY141100065 T CY 141100065T CY 1114774 T1 CY1114774 T1 CY 1114774T1
Authority
CY
Cyprus
Prior art keywords
methylphenylsulfanyl
piperidine
treatment
bowel syndrome
irritable bowel
Prior art date
Application number
CY20141100065T
Other languages
English (en)
Inventor
Silke Miller
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of CY1114774T1 publication Critical patent/CY1114774T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Η χρήση της 4-[2-(4-μεθυλφαινυλσουλφανυλ)-φαινυλο] πιπεριδίνης ή ενός φαρμακευτικά αποδεκτού άλατος αυτής για την αγωγή του συνδρόμου ευερέθιστου εντέρου.
CY20141100065T 2007-03-20 2014-01-24 4- [2- (4-μεθυλφαινυλσουλφανυλ) φαινυλο]πιπεριδινη για την αγωγη του συνδρομου ευερεθιστου εντερου (ibs) CY1114774T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200700423 2007-03-20
EP08758225.0A EP2167085B1 (en) 2007-03-20 2008-06-13 4- [2- (4-methylphenylsulfanyl) phenyl]piperidine for the treatment of irritable bowel syndrome (ibs)

Publications (1)

Publication Number Publication Date
CY1114774T1 true CY1114774T1 (el) 2016-12-14

Family

ID=39575680

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20131100146T CY1113965T1 (el) 2007-03-20 2013-02-15 4-[2-(4-μεθυλφαινυλσουλφανυλ) φαινυλ] πιπεριδινη με συνδυασμενη σεροτονινη και αναστολη της επαναπροσληψης νορεπινεφρινης για τη θεραπεια της adhd, μελαγχολιας, ανθισταμενης στην αγωγη καταθλιψης ή υπολειμματικων συμπτωματων καταθλιψης
CY20141100065T CY1114774T1 (el) 2007-03-20 2014-01-24 4- [2- (4-μεθυλφαινυλσουλφανυλ) φαινυλο]πιπεριδινη για την αγωγη του συνδρομου ευερεθιστου εντερου (ibs)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20131100146T CY1113965T1 (el) 2007-03-20 2013-02-15 4-[2-(4-μεθυλφαινυλσουλφανυλ) φαινυλ] πιπεριδινη με συνδυασμενη σεροτονινη και αναστολη της επαναπροσληψης νορεπινεφρινης για τη θεραπεια της adhd, μελαγχολιας, ανθισταμενης στην αγωγη καταθλιψης ή υπολειμματικων συμπτωματων καταθλιψης

Country Status (28)

Country Link
US (2) US20100144788A1 (el)
EP (2) EP2139479B1 (el)
JP (1) JP5388867B2 (el)
KR (1) KR20090125775A (el)
CN (2) CN101674830B (el)
AR (1) AR065798A1 (el)
AU (1) AU2008228639B2 (el)
BR (1) BRPI0808831A2 (el)
CA (1) CA2684556C (el)
CL (1) CL2008000796A1 (el)
CO (1) CO6220957A2 (el)
CY (2) CY1113965T1 (el)
DK (2) DK2139479T3 (el)
EA (1) EA017407B1 (el)
ES (2) ES2399305T3 (el)
HK (1) HK1142007A1 (el)
HR (1) HRP20130049T1 (el)
IL (1) IL200954A (el)
MX (1) MX2009009934A (el)
MY (1) MY163537A (el)
NZ (1) NZ579723A (el)
PL (2) PL2139479T3 (el)
PT (2) PT2139479E (el)
RS (2) RS52676B (el)
SI (1) SI2139479T1 (el)
TW (1) TWI432194B (el)
UA (2) UA97660C2 (el)
WO (1) WO2008113360A2 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2656057C (en) * 2006-06-16 2012-10-02 H. Lundbeck A/S Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
TWI432194B (zh) 2007-03-20 2014-04-01 Lundbeck & Co As H ４-〔２-（４-甲基苯硫基）苯基〕哌啶之新穎治療用途
JP5764327B2 (ja) * 2007-06-15 2015-08-19 ハー・ルンドベック・アクチエゼルスカベット 過敏性腸症候群（ｉｂｓ）を処置するための４−［２−（４−メチルフェニルスルファニル）フェニル］ピペリジン
TW200938194A (en) * 2007-12-14 2009-09-16 Lundbeck & Co As H Therapeutic uses of compounds having affinity to the serotonin transporter, serotonin receptors and noradrenalin transporter
WO2011136373A1 (ja) * 2010-04-30 2011-11-03 武田薬品工業株式会社 腸溶性錠剤
US9311462B1 (en) 2011-03-04 2016-04-12 Zynga Inc. Cross platform social networking authentication system
US8332488B1 (en) 2011-03-04 2012-12-11 Zynga Inc. Multi-level cache with synch
US8347322B1 (en) 2011-03-31 2013-01-01 Zynga Inc. Social network application programming interface
US10135776B1 (en) 2011-03-31 2018-11-20 Zynga Inc. Cross platform social networking messaging system
US8522137B1 (en) 2011-06-30 2013-08-27 Zynga Inc. Systems, methods, and machine readable media for social network application development using a custom markup language
JP2019524682A (ja) 2016-07-01 2019-09-05 ハー・ルンドベック・アクチエゼルスカベット 抗うつ作用の速い発現のためのボルチオキセチン投与計画

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516282A (ja) * 1998-05-22 2002-06-04 イーライ・リリー・アンド・カンパニー 難治性鬱病の処置のための組合せ治療
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
ATE406894T1 (de) * 2003-04-04 2008-09-15 Lundbeck & Co As H 4-(2-phenylsulfanyl-phenyl)-piperidin-derivate als serotonin-wiederaufnahme-hemmer
EP1635828B1 (en) * 2003-04-04 2008-04-23 H. Lundbeck A/S 4-(2-phenyloxyphenyl)-piperidine or -1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors
AR052308A1 (es) * 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
DE102006028034A1 (de) * 2006-06-14 2007-12-20 Leifheit Ag Bürste und Kehrgerät mit Bürste
CA2656057C (en) * 2006-06-16 2012-10-02 H. Lundbeck A/S Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
TWI432194B (zh) 2007-03-20 2014-04-01 Lundbeck & Co As H ４-〔２-（４-甲基苯硫基）苯基〕哌啶之新穎治療用途
TWI405588B (zh) 2007-03-20 2013-08-21 Lundbeck & Co As H ４-〔２-（４-甲苯基硫基）-苯基〕哌啶之鹽類的液體調配物
TW200938194A (en) * 2007-12-14 2009-09-16 Lundbeck & Co As H Therapeutic uses of compounds having affinity to the serotonin transporter, serotonin receptors and noradrenalin transporter

Also Published As

Publication number Publication date
MY163537A (en) 2017-09-15
NZ579723A (en) 2011-07-29
AU2008228639B2 (en) 2012-12-13
CY1113965T1 (el) 2016-07-27
CO6220957A2 (es) 2010-11-19
KR20090125775A (ko) 2009-12-07
EP2167085A1 (en) 2010-03-31
ES2445400T3 (es) 2014-03-03
WO2008113360A2 (en) 2008-09-25
UA99611C2 (ru) 2012-09-10
UA97660C2 (ru) 2012-03-12
EP2139479B1 (en) 2012-12-12
EA017407B1 (ru) 2012-12-28
MX2009009934A (es) 2009-09-24
PT2139479E (pt) 2013-02-20
SI2139479T1 (sl) 2013-04-30
PT2167085E (pt) 2014-02-17
US8507526B2 (en) 2013-08-13
CN101674830A (zh) 2010-03-17
CN101646438A (zh) 2010-02-10
BRPI0808831A2 (pt) 2014-08-26
JP5388867B2 (ja) 2014-01-15
IL200954A (en) 2014-12-31
DK2139479T3 (da) 2013-02-11
PL2167085T3 (pl) 2014-08-29
US20100137366A1 (en) 2010-06-03
TWI432194B (zh) 2014-04-01
HRP20130049T1 (hr) 2013-02-28
CN101646438B (zh) 2012-04-11
CA2684556A1 (en) 2008-09-25
DK2167085T3 (da) 2014-02-03
IL200954A0 (en) 2010-05-17
JP2010521502A (ja) 2010-06-24
HK1142007A1 (en) 2010-11-26
EP2139479A2 (en) 2010-01-06
US20100144788A1 (en) 2010-06-10
AR065798A1 (es) 2009-07-01
TW200848032A (en) 2008-12-16
WO2008113360A3 (en) 2008-11-13
EA200970871A1 (ru) 2010-04-30
EP2167085B1 (en) 2013-12-25
RS53138B (en) 2014-06-30
PL2139479T3 (pl) 2013-05-31
RS52676B (en) 2013-06-28
ES2399305T3 (es) 2013-03-27
CL2008000796A1 (es) 2008-09-26
CN101674830B (zh) 2012-05-09
AU2008228639A1 (en) 2008-09-25
CA2684556C (en) 2013-01-08

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