CY1113693T1 - Φαρμακευτικες συνθεσεις και μεθοδοι για τον εμβολιασμο κατα της διαχυτης καντιντιασης και αλλων μολυσματικων παραγοντων - Google Patents
Φαρμακευτικες συνθεσεις και μεθοδοι για τον εμβολιασμο κατα της διαχυτης καντιντιασης και αλλων μολυσματικων παραγοντωνInfo
- Publication number
- CY1113693T1 CY1113693T1 CY20121100979T CY121100979T CY1113693T1 CY 1113693 T1 CY1113693 T1 CY 1113693T1 CY 20121100979 T CY20121100979 T CY 20121100979T CY 121100979 T CY121100979 T CY 121100979T CY 1113693 T1 CY1113693 T1 CY 1113693T1
- Authority
- CY
- Cyprus
- Prior art keywords
- candida
- als
- protein family
- cell adhesion
- immunogenic
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 208000015181 infectious disease Diseases 0.000 title 1
- 230000002458 infectious effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002255 vaccination Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 230000002163 immunogen Effects 0.000 abstract 5
- 230000021164 cell adhesion Effects 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 4
- 241000222122 Candida albicans Species 0.000 abstract 3
- 230000002265 prevention Effects 0.000 abstract 3
- 229960005486 vaccine Drugs 0.000 abstract 3
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 2
- 206010007134 Candida infections Diseases 0.000 abstract 2
- 201000003984 candidiasis Diseases 0.000 abstract 2
- 241000222173 Candida parapsilosis Species 0.000 abstract 1
- 241000222178 Candida tropicalis Species 0.000 abstract 1
- 241000235645 Pichia kudriavzevii Species 0.000 abstract 1
- 206010041925 Staphylococcal infections Diseases 0.000 abstract 1
- 241000222126 [Candida] glabrata Species 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 229940095731 candida albicans Drugs 0.000 abstract 1
- 208000032343 candida glabrata infection Diseases 0.000 abstract 1
- 229940055022 candida parapsilosis Drugs 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000013210 hematogenous Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/327,197 US20070077256A1 (en) | 1999-11-19 | 2006-01-06 | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| EP07709622A EP1982190B1 (en) | 2006-01-06 | 2007-01-05 | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113693T1 true CY1113693T1 (el) | 2016-06-22 |
Family
ID=38256965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100979T CY1113693T1 (el) | 2006-01-06 | 2012-10-18 | Φαρμακευτικες συνθεσεις και μεθοδοι για τον εμβολιασμο κατα της διαχυτης καντιντιασης και αλλων μολυσματικων παραγοντων |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US20070077256A1 (enExample) |
| EP (4) | EP2532360B1 (enExample) |
| JP (3) | JP5692963B2 (enExample) |
| AU (1) | AU2007205065B2 (enExample) |
| CA (2) | CA2636277C (enExample) |
| CY (1) | CY1113693T1 (enExample) |
| DK (1) | DK1982190T3 (enExample) |
| ES (3) | ES2608354T3 (enExample) |
| PT (1) | PT1982190E (enExample) |
| WO (1) | WO2007081896A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060083750A1 (en) * | 1999-11-19 | 2006-04-20 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis |
| US20070077256A1 (en) * | 1999-11-19 | 2007-04-05 | Los Angeles Biomedical Research Institute | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| US8541008B2 (en) * | 1999-11-19 | 2013-09-24 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against candidiasis |
| RU2015122387A (ru) * | 2009-07-03 | 2015-10-27 | Лос-Анжелес Биомедикал Ресёрч Институт Эт Харбор-Укла Медикал Центер | Hyr1 в качестве мишени для активной и пассивной иммунизации против candida |
| WO2012163533A1 (en) | 2011-06-01 | 2012-12-06 | Eth Zurich | T cell epitope of candida albicans |
| CN103998056B (zh) * | 2011-07-22 | 2017-09-12 | 诺瓦蒂格姆疗法有限公司 | 用于接种抗金黄色葡萄球菌疫苗的方法和组合物 |
| EA030005B1 (ru) | 2013-03-15 | 2018-06-29 | Лос-Анджелес Биомедикал Ресерч Институт Эт Харбор-Укла Медикал Центер | Композиции и способы лечения грибковых и бактериальных патогенов |
| JP6566616B2 (ja) * | 2014-08-19 | 2019-08-28 | キヤノン株式会社 | 通信装置、その制御方法、およびプログラム |
| AU2016355236C1 (en) | 2015-11-16 | 2022-09-22 | Medincell | A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
| CN108883167A (zh) | 2016-03-09 | 2018-11-23 | 加州大学洛杉矶分校港口医学中心生物医学研究所 | 用于预防和治疗外阴阴道念珠菌病的方法和药剂盒 |
| US10308571B2 (en) * | 2017-10-11 | 2019-06-04 | Uop Llc | Process for minimizing benzene, toluene, and a recycle loop in a zero benzene aromatics complex |
| WO2019199279A1 (en) * | 2018-04-10 | 2019-10-17 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Methods of treatment for candida auris infections |
| EP3552620A1 (en) * | 2018-04-11 | 2019-10-16 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Methods of treatment for candida auris infections |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ191327A (en) | 1978-08-24 | 1981-07-13 | W B Martin | Pasteurellosis vaccine comprising antigenic material derived from the a1 and a2 serotypes of pasteurella haemolytica |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5622939A (en) | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5961970A (en) | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| WO1995031998A1 (en) | 1994-05-23 | 1995-11-30 | The Research & Development Institute, Inc. | Candida albicans adhesin as a vaccine |
| US5668263A (en) | 1994-12-16 | 1997-09-16 | Smithkline Beecham Corporation | Conserved yeast nucleic acid sequences |
| DE69520509T2 (de) | 1995-06-07 | 2001-07-12 | Pfizer Inc., New York | In ovo impfung gegen coccidiose |
| WO1997043314A2 (en) * | 1996-05-16 | 1997-11-20 | The Texas A & M University System | Collagen binding protein compositions and methods of use |
| US6747137B1 (en) | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| US6703025B1 (en) * | 1998-08-31 | 2004-03-09 | Inhibitex, Inc. | Multicomponent vaccines |
| US7067138B1 (en) | 1999-11-19 | 2006-06-27 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis |
| US20070077256A1 (en) | 1999-11-19 | 2007-04-05 | Los Angeles Biomedical Research Institute | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| US8541008B2 (en) | 1999-11-19 | 2013-09-24 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against candidiasis |
| US20060083750A1 (en) * | 1999-11-19 | 2006-04-20 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis |
| US7435871B2 (en) | 2001-11-30 | 2008-10-14 | Amgen Fremont Inc. | Transgenic animals bearing human Igλ light chain genes |
| WO2003099325A1 (en) | 2002-05-21 | 2003-12-04 | Schering-Plough Ltd. | Methods for the in vitro culture of sporozoea sp. and user thereof |
| US7241613B1 (en) | 2002-06-05 | 2007-07-10 | Oscient Pharmaceuticals Corporation | Identification of Candida cell surface proteins and their uses |
| US7723087B2 (en) * | 2002-11-12 | 2010-05-25 | The Brigham And Women's Hospital, Inc. | Nucleic acid molecules for enhanced production of a bacterial polysaccharide and methods of use thereof |
| RU2322241C2 (ru) | 2003-11-21 | 2008-04-20 | Пфайзер Продактс Инк. | Применение антибиотиков в качестве адъювантов вакцин |
| US20050287146A1 (en) * | 2003-12-19 | 2005-12-29 | Joseph Patti | Method of inhibiting Candida-related infections using donor selected or donor stimulated immunoglobulin compositions |
| GB0420466D0 (en) | 2004-09-14 | 2004-10-20 | Cassone Antonio | Anti-glucan antibodies |
| WO2006036817A2 (en) | 2004-09-24 | 2006-04-06 | Microbia, Inc. | Fungal variants and uses thereof |
| CA2489194A1 (en) | 2004-12-03 | 2006-06-03 | Guilhem Janbon | Polypeptides involved in candida biofilm formation and uses thereof |
| WO2007126813A2 (en) | 2006-03-29 | 2007-11-08 | Inhibitex, Inc. | Cross-reactive monoclonal antibodies recognizing als family proteins |
| UA109105C2 (uk) | 2006-04-17 | 2015-07-27 | Молекула нуклеїнової кислоти, що кодує істотно нетоксичний мутеїн альфа-токсину clostridium perfringens, та істотно нетоксичний мутеїн альфа-токсину clostridium perfringens | |
| WO2008147847A1 (en) | 2007-05-22 | 2008-12-04 | Baylor College Of Medicine | Immune complex vaccination as a strategy to enhance immunity in the elderly and other immune compromised populations |
| RU2525587C2 (ru) | 2008-05-29 | 2014-08-20 | Интервет Интернэшнл Б.В. | Вакцинная композиция для иммунизации животного против кокцидиоза и способ ее использования |
| US20100150942A1 (en) | 2008-12-03 | 2010-06-17 | Cantor Thomas L | Affinity purified human polyclonal antibodies and methods of making and using them |
| SI2445522T1 (sl) | 2009-06-22 | 2017-10-30 | Wyeth Llc | Imunogeni sestavki antigenov Staphylococcusa aureusa |
| RU2015122387A (ru) | 2009-07-03 | 2015-10-27 | Лос-Анжелес Биомедикал Ресёрч Институт Эт Харбор-Укла Медикал Центер | Hyr1 в качестве мишени для активной и пассивной иммунизации против candida |
| WO2012163533A1 (en) | 2011-06-01 | 2012-12-06 | Eth Zurich | T cell epitope of candida albicans |
| CN103998056B (zh) * | 2011-07-22 | 2017-09-12 | 诺瓦蒂格姆疗法有限公司 | 用于接种抗金黄色葡萄球菌疫苗的方法和组合物 |
| EP2755668A4 (en) | 2011-09-14 | 2015-07-01 | Los Angeles Biomed Res Inst | COMPOSITIONS OF HYR1 AND TREATMENT PROCEDURES THEREWITH |
| WO2014144024A1 (en) | 2013-03-15 | 2014-09-18 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Hyr1 compositions and methods for treating fungal and bacterial pathogens |
| US20160030533A1 (en) | 2013-03-15 | 2016-02-04 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Compositions and methods of treating fungal and bacterial pathogens |
| EA030005B1 (ru) | 2013-03-15 | 2018-06-29 | Лос-Анджелес Биомедикал Ресерч Институт Эт Харбор-Укла Медикал Центер | Композиции и способы лечения грибковых и бактериальных патогенов |
| GB201503812D0 (en) | 2015-03-06 | 2015-04-22 | Univ Aberdeen | Antibody molecules and uses thereof |
| CN108883167A (zh) | 2016-03-09 | 2018-11-23 | 加州大学洛杉矶分校港口医学中心生物医学研究所 | 用于预防和治疗外阴阴道念珠菌病的方法和药剂盒 |
-
2006
- 2006-01-06 US US11/327,197 patent/US20070077256A1/en not_active Abandoned
-
2007
- 2007-01-05 EP EP12001586.2A patent/EP2532360B1/en not_active Not-in-force
- 2007-01-05 CA CA2636277A patent/CA2636277C/en not_active Expired - Fee Related
- 2007-01-05 EP EP07709622A patent/EP1982190B1/en not_active Not-in-force
- 2007-01-05 CA CA2948424A patent/CA2948424A1/en not_active Abandoned
- 2007-01-05 EP EP12001595A patent/EP2532361A1/en not_active Withdrawn
- 2007-01-05 JP JP2008549598A patent/JP5692963B2/ja not_active Expired - Fee Related
- 2007-01-05 EP EP11008862.2A patent/EP2428800B1/en not_active Not-in-force
- 2007-01-05 AU AU2007205065A patent/AU2007205065B2/en not_active Ceased
- 2007-01-05 ES ES12001586.2T patent/ES2608354T3/es active Active
- 2007-01-05 WO PCT/US2007/000433 patent/WO2007081896A2/en not_active Ceased
- 2007-01-05 DK DK07709622.0T patent/DK1982190T3/da active
- 2007-01-05 PT PT07709622T patent/PT1982190E/pt unknown
- 2007-01-05 US US12/160,073 patent/US20090297562A1/en not_active Abandoned
- 2007-01-05 ES ES11008862.2T patent/ES2608309T3/es active Active
- 2007-01-05 ES ES07709622T patent/ES2391580T3/es active Active
-
2011
- 2011-01-10 US US12/987,949 patent/US20120014995A1/en not_active Abandoned
-
2012
- 2012-09-21 JP JP2012207831A patent/JP5775044B2/ja not_active Expired - Fee Related
- 2012-10-18 CY CY20121100979T patent/CY1113693T1/el unknown
-
2013
- 2013-03-05 US US13/785,835 patent/US20140037689A1/en not_active Abandoned
-
2014
- 2014-05-22 JP JP2014105980A patent/JP2014148547A/ja not_active Withdrawn
-
2016
- 2016-02-03 US US15/014,440 patent/US10300120B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007205065B2 (en) | 2013-10-31 |
| CA2636277C (en) | 2017-06-13 |
| ES2391580T3 (es) | 2012-11-28 |
| JP2009524601A (ja) | 2009-07-02 |
| AU2007205065A1 (en) | 2007-07-19 |
| JP2012255031A (ja) | 2012-12-27 |
| CA2948424A1 (en) | 2007-07-19 |
| US20140037689A1 (en) | 2014-02-06 |
| EP2428800B1 (en) | 2016-09-28 |
| EP1982190A4 (en) | 2009-12-23 |
| CA2636277A1 (en) | 2007-07-19 |
| US10300120B2 (en) | 2019-05-28 |
| EP2428800A1 (en) | 2012-03-14 |
| US20160220648A1 (en) | 2016-08-04 |
| WO2007081896A2 (en) | 2007-07-19 |
| US20070077256A1 (en) | 2007-04-05 |
| WO2007081896A3 (en) | 2007-11-22 |
| US20090297562A1 (en) | 2009-12-03 |
| EP1982190A2 (en) | 2008-10-22 |
| JP5775044B2 (ja) | 2015-09-09 |
| JP2014148547A (ja) | 2014-08-21 |
| EP2532360B1 (en) | 2016-09-28 |
| JP5692963B2 (ja) | 2015-04-01 |
| EP1982190B1 (en) | 2012-07-18 |
| EP2532360A1 (en) | 2012-12-12 |
| EP2532361A1 (en) | 2012-12-12 |
| ES2608309T3 (es) | 2017-04-07 |
| ES2608354T3 (es) | 2017-04-10 |
| US20120014995A1 (en) | 2012-01-19 |
| DK1982190T3 (da) | 2012-10-22 |
| PT1982190E (pt) | 2012-10-22 |
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