CY1113378T1 - Καινοτομος χρηση των αντισωματων αντι il-1bhta - Google Patents
Καινοτομος χρηση των αντισωματων αντι il-1bhtaInfo
- Publication number
- CY1113378T1 CY1113378T1 CY20121100867T CY121100867T CY1113378T1 CY 1113378 T1 CY1113378 T1 CY 1113378T1 CY 20121100867 T CY20121100867 T CY 20121100867T CY 121100867 T CY121100867 T CY 121100867T CY 1113378 T1 CY1113378 T1 CY 1113378T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- rheumatoid arthritis
- receptor
- antibodies
- disrupt
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/246—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Η παρούσα περιγραφή αναφέρεται στη χρήση ενώσεων που διακόπτουν τη σύνδεση του συνδέτη IL-1β με τον IL-1 υποδοχέα (στο παρόν αναφερόμενες ως «Ενώσεις IL-1 βήτα»), όπως είναι μικρές μοριακές ενώσεις που διακόπτουν την αλληλεπίδραση του συνδέτη IL-1β με τον υποδοχέα IL-1, αντισώματα έναντι της IL-1β ή αντισώματα έναντι των υποδοχέων IL-1, π.χ. μόρια που προσδένουν την IL-1 β που περιγράφηκαν στο παρόν, π.χ. ενώσεις που προσδένουν την IL-1β ή τους υποδοχείς της IL-1, και/ή RNA ενώσεις που ελαττώνουν είτε τους συνδέτες IL-1β ή τα επίπεδα των πρωτεϊνικών υποδοχέων της IL-1, για την αντιμετώπιση και/ή τη πρόληψη των αυτό-φλεγμονωδών συνδρόμων, π.χ. της νεανικής ρευματοειδούς αρθρίτιδας ή του συνδρόμου ρευματοειδούς αρθρίτιδας των ενηλίκων και σε μεθόδους αντιμετώπισης και/ή πρόληψης των αυτό-φλεγμονωδών συνδρόμων, π.χ. της νεανικής ρευματοειδούς αρθρίτιδας ή του συνδρόμου της ρευματοειδούς αρθρίτιδας των ενηλίκων, στα θηλαστικά, συγκεκριμένα στους ανθρώπους.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73043505P | 2005-10-26 | 2005-10-26 | |
US74212505P | 2005-12-02 | 2005-12-02 | |
EP06826560A EP1940465B1 (en) | 2005-10-26 | 2006-10-24 | Novel use of anti il-1beta antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113378T1 true CY1113378T1 (el) | 2015-11-04 |
Family
ID=37806690
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100867T CY1113378T1 (el) | 2005-10-26 | 2012-09-24 | Καινοτομος χρηση των αντισωματων αντι il-1bhta |
CY2013046C CY2013046I1 (el) | 2005-10-26 | 2013-12-13 | Καινοτομος χρηση των αντισωματων αντι il-1bhta |
CY20181100301T CY1120018T1 (el) | 2005-10-26 | 2018-03-12 | Θεραπεια του οικογενους μεσογειακου πυρετου με αντι-il-1b αντισωματα |
CY2018018C CY2018018I2 (el) | 2005-10-26 | 2018-06-12 | Θεραπεια του οικογενους μεσογειακου πυρετου με αντι-il-1b αντισωματα |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY2013046C CY2013046I1 (el) | 2005-10-26 | 2013-12-13 | Καινοτομος χρηση των αντισωματων αντι il-1bhta |
CY20181100301T CY1120018T1 (el) | 2005-10-26 | 2018-03-12 | Θεραπεια του οικογενους μεσογειακου πυρετου με αντι-il-1b αντισωματα |
CY2018018C CY2018018I2 (el) | 2005-10-26 | 2018-06-12 | Θεραπεια του οικογενους μεσογειακου πυρετου με αντι-il-1b αντισωματα |
Country Status (29)
Country | Link |
---|---|
US (8) | US8105587B2 (el) |
EP (5) | EP2848258B1 (el) |
JP (4) | JP2009513645A (el) |
KR (3) | KR101518064B1 (el) |
CN (2) | CN102861332A (el) |
AU (1) | AU2006306280B2 (el) |
BR (1) | BRPI0617830B8 (el) |
CA (3) | CA2898369C (el) |
CY (4) | CY1113378T1 (el) |
DK (2) | DK1940465T3 (el) |
ES (3) | ES2389110T3 (el) |
HK (3) | HK1121041A1 (el) |
HU (2) | HUE036973T2 (el) |
IL (4) | IL190545A (el) |
JO (2) | JO2826B1 (el) |
LT (3) | LT2848258T (el) |
LU (2) | LU92326I2 (el) |
MA (1) | MA29919B1 (el) |
NO (2) | NO345888B1 (el) |
NZ (1) | NZ567222A (el) |
PH (2) | PH12013501287B1 (el) |
PL (2) | PL1940465T3 (el) |
PT (2) | PT2848258T (el) |
RU (2) | RU2468817C2 (el) |
SI (2) | SI1940465T1 (el) |
TN (1) | TNSN08189A1 (el) |
TR (1) | TR201802449T4 (el) |
TW (3) | TWI537003B (el) |
WO (1) | WO2007050607A2 (el) |
Families Citing this family (20)
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LT2848258T (lt) | 2005-10-26 | 2018-02-26 | Novartis Ag | Šeiminės viduržemio jūros karštligės gydymas su anti-il-1 beta antikūnais |
EP3406263A1 (en) * | 2007-05-29 | 2018-11-28 | Novartis AG | New indications for anti-il-1beta therapy |
AU2012203932B2 (en) * | 2007-05-29 | 2014-04-24 | Novartis Ag | New indications for anti-IL-I-beta therapy |
PT2293816E (pt) * | 2008-06-06 | 2013-02-13 | Xoma Technology Ltd | Métodos para o tratamento da artrite reumatoide |
EP2196476A1 (en) | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
US8911722B2 (en) | 2009-09-14 | 2014-12-16 | The Regents Of The University Of Colorado, A Body Corporate | Modulation of yeast-based immunotherapy products and responses |
CN102655880A (zh) * | 2009-10-15 | 2012-09-05 | 雅培制药有限公司 | Il-1结合蛋白 |
PE20130205A1 (es) * | 2010-05-14 | 2013-03-24 | Abbvie Inc | Proteinas de union a il-1 |
US8853365B2 (en) * | 2010-12-21 | 2014-10-07 | Abbvie Inc. | Dual variable domain immunnoglobulins and uses thereof |
BR112013028808A2 (pt) | 2011-05-10 | 2016-09-06 | Nestec Sa | métodos de caracterização de perfil de atividade de doença para a gestão de terapia personalizada |
EP3426775A1 (en) | 2016-03-10 | 2019-01-16 | Novartis AG | Chemically modified messenger rna's |
CA3064529C (en) | 2017-05-31 | 2021-12-14 | Prometheus Biosciences, Inc. | Methods for assessing mucosal healing in crohn's disease patients |
WO2018235056A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | IL-1BETA BINDING ANTIBODIES FOR USE IN THE TREATMENT OF CANCER |
EP3790576A1 (en) | 2018-05-09 | 2021-03-17 | Novartis Ag | Use of canakinumab |
KR20210107730A (ko) | 2018-12-21 | 2021-09-01 | 노파르티스 아게 | 골수 형성이상 증후군의 치료 또는 예방에서의 il-1 베타 항체의 용도 |
US20220025036A1 (en) | 2018-12-21 | 2022-01-27 | Novartis Ag | Use of il-1beta binding antibodies |
WO2020128620A1 (en) | 2018-12-21 | 2020-06-25 | Novartis Ag | Use of il-1beta binding antibodies |
WO2020128637A1 (en) | 2018-12-21 | 2020-06-25 | Novartis Ag | Use of il-1 binding antibodies in the treatment of a msi-h cancer |
TWI793503B (zh) * | 2020-01-20 | 2023-02-21 | 美商美國禮來大藥廠 | 抗IL-1β抗體 |
WO2023132698A1 (ko) * | 2022-01-10 | 2023-07-13 | (주)지아이이노베이션 | 글루카곤-유사 펩타이드-1 및 인터루킨-1 수용체 길항제를 포함하는 퇴행성 뇌질환 예방 또는 치료용 약학 조성물 |
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EP1883427A4 (en) | 2005-01-20 | 2010-04-21 | Univ Rochester | COMPOSITIONS AND METHODS FOR STUDYING AND TREATING INFLAMMATORY DISEASES AND DISORDERS |
BRPI0609040B1 (pt) | 2005-03-18 | 2018-07-31 | Microbia, Inc. | Fungo recombinante do gênero yarrowia, método de produção de um carotenóide e método de preparo de um aditivo alimentício ou ração contendo um carotenóide |
KR101502920B1 (ko) | 2005-06-21 | 2015-03-17 | 조마 (유에스) 엘엘씨 | IL-1β 결합성 항체 및 그의 단편 |
LT2848258T (lt) | 2005-10-26 | 2018-02-26 | Novartis Ag | Šeiminės viduržemio jūros karštligės gydymas su anti-il-1 beta antikūnais |
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