CY1113205T1 - Μεθοδος για ρυθμιση ενεργοποιησης μακροφαγου - Google Patents
Μεθοδος για ρυθμιση ενεργοποιησης μακροφαγουInfo
- Publication number
- CY1113205T1 CY1113205T1 CY20121100954T CY121100954T CY1113205T1 CY 1113205 T1 CY1113205 T1 CY 1113205T1 CY 20121100954 T CY20121100954 T CY 20121100954T CY 121100954 T CY121100954 T CY 121100954T CY 1113205 T1 CY1113205 T1 CY 1113205T1
- Authority
- CY
- Cyprus
- Prior art keywords
- macrofag
- activation
- regulation
- macrophage activation
- compounds
- Prior art date
Links
- 230000004913 activation Effects 0.000 title abstract 3
- 210000002540 macrophage Anatomy 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000009091 Amyloidogenic Proteins Human genes 0.000 abstract 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 abstract 1
- 230000006933 amyloid-beta aggregation Effects 0.000 abstract 1
- 150000001449 anionic compounds Chemical class 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- -1 sulfonates Chemical class 0.000 abstract 1
- 150000003871 sulfonates Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7429598P | 1998-02-11 | 1998-02-11 | |
| US24839699A | 1999-02-10 | 1999-02-10 | |
| EP99903869A EP1054664B1 (en) | 1998-02-11 | 1999-02-11 | Method for modulating macrophage activation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113205T1 true CY1113205T1 (el) | 2016-04-13 |
Family
ID=26755484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100954T CY1113205T1 (el) | 1998-02-11 | 2012-10-16 | Μεθοδος για ρυθμιση ενεργοποιησης μακροφαγου |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1054664B1 (enExample) |
| JP (1) | JP4574845B2 (enExample) |
| AU (1) | AU2437899A (enExample) |
| CA (2) | CA2632106A1 (enExample) |
| CY (1) | CY1113205T1 (enExample) |
| DK (1) | DK1054664T3 (enExample) |
| ES (1) | ES2392391T3 (enExample) |
| IL (1) | IL137751A0 (enExample) |
| MX (2) | MXPA00007815A (enExample) |
| NZ (2) | NZ550199A (enExample) |
| PT (1) | PT1054664E (enExample) |
| WO (1) | WO1999040909A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5605938A (en) | 1991-05-31 | 1997-02-25 | Gliatech, Inc. | Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate |
| AU3726299A (en) * | 1998-05-15 | 1999-12-06 | Neurochem, Inc. | Use of amyloid inhibitors for modulating neuronal cell death |
| US6310073B1 (en) | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
| KR100822525B1 (ko) * | 1999-04-28 | 2008-04-16 | 뉴로겜 인터내셔널 리미티드 | 아밀로이드증 치료용 조성물 및 방법 |
| WO2001003680A2 (en) * | 1999-07-09 | 2001-01-18 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
| US6670399B2 (en) | 1999-12-23 | 2003-12-30 | Neurochem (International) Limited | Compounds and methods for modulating cerebral amyloid angiopathy |
| US7105336B2 (en) * | 2002-10-07 | 2006-09-12 | Biogaia Ab | Selection and use of lactic acid bacteria for reducing inflammation caused by Helicobacter |
| JP2006512417A (ja) * | 2002-12-24 | 2006-04-13 | ニューロケム (インターナショナル) リミテッド | β−アミロイド関連疾患の治療のための治療用製剤 |
| CN1753662A (zh) * | 2002-12-24 | 2006-03-29 | 神经化学(国际)有限公司 | 用于治疗β-淀粉状蛋白相关疾病的治疗制剂 |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US7253306B2 (en) | 2003-06-23 | 2007-08-07 | Neurochem (International) Limited | Pharmaceutical drug candidates and methods for preparation thereof |
| US20050142191A1 (en) * | 2003-06-23 | 2005-06-30 | Neurochem (International) Limited | Pharmaceutical formulations of amyloid inhibiting compounds |
| US7414076B2 (en) | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US7244764B2 (en) | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| MXPA05013607A (es) * | 2003-06-23 | 2006-04-06 | Neurochem Int Ltd | Candidatos de farmaco farmaceuticos mejorados y metodos para preparar los mismos. |
| CA2900876A1 (en) | 2004-12-22 | 2006-08-17 | Bhi Limited Partnership | Methods and compositions for treating amyloid-related diseases |
| TW200716088A (en) * | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
| SG10201706600VA (en) | 2005-11-30 | 2017-09-28 | Abbvie Inc | Monoclonal antibodies and uses thereof |
| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Aβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| CA2634871A1 (en) | 2005-12-22 | 2007-11-08 | Neurochem (International) Limited | Treatment of renal disorders, diabetic nephopathy and dyslipidemias |
| PT2089417E (pt) | 2006-10-12 | 2015-04-14 | Bhi Ltd Partnership | Métodos, compostos, composições e veículos para administrar o ácido 3-amino-1-propanossulfónico |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| CA2701793C (en) | 2007-10-05 | 2017-04-25 | Genentech, Inc. | Use of anti-amyloid beta antibody in ocular diseases |
| WO2010094734A2 (en) * | 2009-02-19 | 2010-08-26 | Biofocus Dpi B.V. | Methods for identifying and compounds useful for the diagnosis and treatment of diseases involving inflammation |
| MY174012A (en) * | 2009-09-17 | 2020-03-03 | Bespoke Bioscience Llc | Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury |
| EP2558494B1 (en) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta binding proteins |
| CN103179981B (zh) | 2010-07-30 | 2017-02-08 | Ac免疫有限公司 | 安全和功能性的人源化抗β‑淀粉样蛋白抗体 |
| US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| WO2016163886A2 (en) * | 2015-04-10 | 2016-10-13 | Clues2Cure International B.V. | Administration of taurine or an analog thereof for the treatment of nerve cell damage |
| CN109381452A (zh) * | 2017-08-11 | 2019-02-26 | 江西青峰药业有限公司 | 乙基硫酸类化合物的应用及其制备方法 |
| CN109381453A (zh) * | 2017-08-14 | 2019-02-26 | 江西青峰药业有限公司 | 乙基硫酸钾在制备用于预防或治疗炎症性疾病药物中的应用 |
| CN109394746A (zh) * | 2017-08-15 | 2019-03-01 | 江西青峰药业有限公司 | 乙基硫酸铵在制备用于预防或治疗炎症性疾病药物中的应用 |
| EP4514335A1 (en) | 2022-04-28 | 2025-03-05 | Alzheon, Inc. | Tramiprosate for treating apoe4-related diseases |
| KR20250110352A (ko) | 2022-12-02 | 2025-07-18 | 알제온, 인크. | 트라미프로세이트를 이용하여 신경퇴행성 장애를 치료하는 방법 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1140049A (en) * | 1977-12-22 | 1983-01-25 | Dke J.E. Helgstran | Pharmaceutical preparations from derivatives of hydroxycarbonylphosphonic acid |
| US5087618A (en) * | 1982-05-18 | 1992-02-11 | University Of Florida | Redox carriers for brain-specific drug delivery |
| US5463092A (en) * | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
| US5276059A (en) * | 1992-07-10 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of diseases associated with amyloid formation |
| US5840294A (en) * | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
| US5643562A (en) * | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
| EP1060750B1 (en) * | 1993-03-29 | 2005-12-07 | Queen's University At Kingston | Propane-1,3-disulfonic acid and its pharmaceutically acceptable salts for treating amyloidosis |
| US5869469A (en) * | 1997-08-18 | 1999-02-09 | Queen's University At Kingston | Phosphonocarboxylate compounds for treating amyloidosis |
| NZ550116A (en) * | 1997-08-18 | 2008-03-28 | Neurochem Int Ltd | Phosphono-carboxylate compounds for treating amyloidosis |
-
1999
- 1999-02-11 NZ NZ550199A patent/NZ550199A/en not_active IP Right Cessation
- 1999-02-11 PT PT99903869T patent/PT1054664E/pt unknown
- 1999-02-11 AU AU24378/99A patent/AU2437899A/en not_active Abandoned
- 1999-02-11 CA CA002632106A patent/CA2632106A1/en not_active Abandoned
- 1999-02-11 EP EP99903869A patent/EP1054664B1/en not_active Expired - Lifetime
- 1999-02-11 NZ NZ568553A patent/NZ568553A/en unknown
- 1999-02-11 CA CA002320224A patent/CA2320224C/en not_active Expired - Lifetime
- 1999-02-11 MX MXPA00007815A patent/MXPA00007815A/es active IP Right Grant
- 1999-02-11 ES ES99903869T patent/ES2392391T3/es not_active Expired - Lifetime
- 1999-02-11 DK DK99903869.8T patent/DK1054664T3/da active
- 1999-02-11 IL IL13775199A patent/IL137751A0/xx not_active IP Right Cessation
- 1999-02-11 MX MX2008014823A patent/MX2008014823A/es active IP Right Grant
- 1999-02-11 WO PCT/IB1999/000354 patent/WO1999040909A1/en not_active Ceased
- 1999-02-11 JP JP2000531161A patent/JP4574845B2/ja not_active Expired - Lifetime
-
2012
- 2012-10-16 CY CY20121100954T patent/CY1113205T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002502871A (ja) | 2002-01-29 |
| IL137751A0 (en) | 2001-10-31 |
| EP1054664B1 (en) | 2012-08-08 |
| WO1999040909A1 (en) | 1999-08-19 |
| JP4574845B2 (ja) | 2010-11-04 |
| NZ568553A (en) | 2010-02-26 |
| AU2437899A (en) | 1999-08-30 |
| EP1054664A1 (en) | 2000-11-29 |
| ES2392391T3 (es) | 2012-12-10 |
| CA2320224C (en) | 2008-08-12 |
| CA2320224A1 (en) | 1999-08-19 |
| HK1032915A1 (en) | 2001-08-10 |
| CA2632106A1 (en) | 1999-08-19 |
| MX2008014823A (es) | 2009-03-06 |
| NZ550199A (en) | 2008-07-31 |
| DK1054664T3 (da) | 2012-11-05 |
| MXPA00007815A (es) | 2002-04-24 |
| PT1054664E (pt) | 2012-11-02 |
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