CY1112827T1 - Προφαρμακα καρβαμιδικου ακυλοξυαλκυλεστερα, μεθοδοι συνθεσης και χρηση - Google Patents

Προφαρμακα καρβαμιδικου ακυλοξυαλκυλεστερα, μεθοδοι συνθεσης και χρηση

Info

Publication number
CY1112827T1
CY1112827T1 CY20121100410T CY121100410T CY1112827T1 CY 1112827 T1 CY1112827 T1 CY 1112827T1 CY 20121100410 T CY20121100410 T CY 20121100410T CY 121100410 T CY121100410 T CY 121100410T CY 1112827 T1 CY1112827 T1 CY 1112827T1
Authority
CY
Cyprus
Prior art keywords
carbamidic
composition
methods
group
rrepresents
Prior art date
Application number
CY20121100410T
Other languages
English (en)
Inventor
Mark A Gallop
Fenmei Yao
Maria J Ludwikow
Thu Phan
Ge Peng
Original Assignee
Xenoport, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenoport, Inc. filed Critical Xenoport, Inc.
Publication of CY1112827T1 publication Critical patent/CY1112827T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Οι γνωστοποιήσεις στο παρόν σχετίζονται γενικά με προφάρμακα καρβαμιδικού ακυλοξυαλκυλεστέρα του (±)4-αμινο-3-(4-χλωροφαινυλο)βουτανοϊκού οξέος και ανάλογα αυτών, φαρμακευτικές συνθέσεις αυτών, μεθόδους παρασκευής προφαρμάκων του (±)4-αμινο-3-(4-χλωροφαινυλο)βουτανοϊκού οξέος και αναλόγων αυτών, μεθόδους χρήσης προφαρμάκων του (±)4-αμινο-3-(4-χλωροφαινυλο)βουτανοϊκού οξέος και αναλόγων αυτών, και φαρμακευτικές συνθέσεις αυτών για αντιμετώπιση ή πρόληψη κοινών νόσων και/ή διαταραχών όπως σπαστικότητα και νόσος γαστροοισοφαγικής παλινδρόμησης. Οι γνωστοποιήσεις στο παρόν επίσης σχετίζονται με προφάρμακα καρβαμιδικού ακυλοξυαλκυλεστέρα του (±)4-αμινο-3-(4-χλωροφαινυλο)βουτανοϊκού οξέος και ανάλογα αυτών τα οποία είναι κατάλληλα για στοματική χορήγηση και με παρατεταμένης αποδέσμευσης στοματικές δοσολογικές μορφές αυτών.
CY20121100410T 2003-08-20 2012-05-02 Προφαρμακα καρβαμιδικου ακυλοξυαλκυλεστερα, μεθοδοι συνθεσης και χρηση CY1112827T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49693803P 2003-08-20 2003-08-20
US60663704P 2004-08-13 2004-08-13
EP04781926A EP1660440B1 (en) 2003-08-20 2004-08-20 Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Publications (1)

Publication Number Publication Date
CY1112827T1 true CY1112827T1 (el) 2016-02-10

Family

ID=36762986

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100410T CY1112827T1 (el) 2003-08-20 2012-05-02 Προφαρμακα καρβαμιδικου ακυλοξυαλκυλεστερα, μεθοδοι συνθεσης και χρηση

Country Status (14)

Country Link
EP (1) EP1660440B1 (el)
JP (3) JP5148874B2 (el)
CN (2) CN101914040A (el)
AT (1) ATE546427T1 (el)
CA (1) CA2536257C (el)
CY (1) CY1112827T1 (el)
ES (1) ES2382000T3 (el)
HK (1) HK1090912A1 (el)
IL (1) IL173826A (el)
NO (1) NO335606B1 (el)
NZ (1) NZ545719A (el)
PL (1) PL1660440T3 (el)
RU (2) RU2423347C2 (el)
SG (1) SG145759A1 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG145759A1 (en) * 2003-08-20 2008-09-29 Xenoport Inc Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
CA2706575C (en) * 2008-01-25 2015-07-14 Xenoport, Inc. Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
JP6925080B2 (ja) * 2017-08-25 2021-08-25 ▲広▼州市恒▲諾▼康医▲薬▼科技有限公司Guangzhou Henovcom Bioscience Co., Ltd 長時間作用型ラサギリンプロドラッグ、その製造方法および用途
CN107805202A (zh) * 2017-12-01 2018-03-16 内蒙古圣氏化学股份有限公司 一种氯甲基异丙基碳酸酯连续化反应装置及方法
CN117623989A (zh) * 2022-08-29 2024-03-01 广州市恒诺康医药科技有限公司 一种mao-b抑制剂前药的多晶型及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3475065D1 (en) * 1983-06-23 1988-12-15 Merck & Co Inc (acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivatives
GB2365425A (en) * 2000-08-01 2002-02-20 Parke Davis & Co Ltd Alkyl amino acid derivatives useful as pharmaceutical agents
AU2002345664C1 (en) * 2001-06-11 2008-03-06 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
SG145759A1 (en) * 2003-08-20 2008-09-29 Xenoport Inc Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Also Published As

Publication number Publication date
EP1660440A2 (en) 2006-05-31
CA2536257A1 (en) 2005-03-03
SG145759A1 (en) 2008-09-29
IL173826A (en) 2014-07-31
RU2423347C2 (ru) 2011-07-10
JP2011256182A (ja) 2011-12-22
CN1860101A (zh) 2006-11-08
ATE546427T1 (de) 2012-03-15
EP1660440B1 (en) 2012-02-22
HK1090912A1 (en) 2007-01-05
NO20061268L (no) 2006-05-22
CA2536257C (en) 2012-01-03
JP2013006842A (ja) 2013-01-10
CN1860101B (zh) 2010-10-27
JP2007521318A (ja) 2007-08-02
CN101914040A (zh) 2010-12-15
RU2010147826A (ru) 2012-05-27
RU2006108541A (ru) 2007-09-27
ES2382000T3 (es) 2012-06-04
NO335606B1 (no) 2015-01-12
PL1660440T3 (pl) 2012-07-31
NZ545719A (en) 2010-03-26
IL173826A0 (en) 2006-07-05
JP5148874B2 (ja) 2013-02-20

Similar Documents

Publication Publication Date Title
CY1112827T1 (el) Προφαρμακα καρβαμιδικου ακυλοξυαλκυλεστερα, μεθοδοι συνθεσης και χρηση
SE0301882D0 (sv) New use I
MX2009008439A (es) Nuevos inhibidores de la replicacion del virus de hepatitis c.
SE0301886D0 (sv) New use V
TN2009000481A1 (en) Novel peptide inhibitors of hepatitis c virus replication
CY1109519T1 (el) Κεκορεσμενες και ακορεστες 3-πυριδυλο-βενζοκυκλοαλκυλομεθυλαμινες για τη θεραπεια πονων, καταθλιψεων και καταστασεων φοβου
MX2009011867A (es) Nuevos inhibidores macrociclicos de la replicacion del virus de hepatitis c.
EA200802223A1 (ru) 1,5-дифенилпиразолы ii в качестве ингибиторов hsp90
SE0301888D0 (sv) New use VII
EA200870216A1 (ru) Амидо соединения и их применение в качестве лекарственных средств
EA201000098A1 (ru) Производные хиназолинамида
EA201001669A1 (ru) Замещенные пиримидин-5-карбоксамиды 281
WO2009134616A3 (en) Novel inhibitors of hepatitis c virus replication
SG166791A1 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
NO20083005L (no) Anvendelse av benzofuserte heterocykliske sulfamidderivater for behandling av smerte
WO2009026176A3 (en) Antiinfective flavononol compounds and methods of use thereof
MY143568A (en) 11b-hsd1 inhibitors for the treatment of diabetes
MX2012003171A (es) Novedosos inhibidores macrociclicos de la replicacion del virus de hepatitis c.
NZ607580A (en) N-heteroaryl compounds
EA201100245A1 (ru) Новый холиновый сокристалл эпалрестата
EP4327886A3 (en) Pyrimido- pyridazinone compounds and use thereof
ATE451922T1 (de) Verwendung von thiazolidinon-derivaten zur behandlung von festen tumoren
AR074453A1 (es) Compuestos 4-(azacicloalquil ) benceno-1,3-diol, como inhibidores de la tirosinasa y su uso en medicina humana y tambien en cosmetica
JP2010520242A5 (el)
SE0401969D0 (sv) Piperidine derivatives