CY1110836T1 - Χρηση anti-cd40 αντισωματων ανταγωνιστων για θεραπευτικη αγωγη χρονιας λεμφοκυτταρικης λευχαιμιας - Google Patents

Χρηση anti-cd40 αντισωματων ανταγωνιστων για θεραπευτικη αγωγη χρονιας λεμφοκυτταρικης λευχαιμιας

Info

Publication number
CY1110836T1
CY1110836T1 CY20101100928T CY101100928T CY1110836T1 CY 1110836 T1 CY1110836 T1 CY 1110836T1 CY 20101100928 T CY20101100928 T CY 20101100928T CY 101100928 T CY101100928 T CY 101100928T CY 1110836 T1 CY1110836 T1 CY 1110836T1
Authority
CY
Cyprus
Prior art keywords
antigen
lymphocytic leukemia
binding fragment
antibody
therapeutic treatment
Prior art date
Application number
CY20101100928T
Other languages
Greek (el)
English (en)
Inventor
Li Long
Mohammad Luqman
Asha Yabannavar
Isabel Zaror
Sharon Lea Aukerman
Original Assignee
Novartis Vaccines And Diagnostics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines And Diagnostics, Inc. filed Critical Novartis Vaccines And Diagnostics, Inc.
Publication of CY1110836T1 publication Critical patent/CY1110836T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CY20101100928T 2003-11-04 2010-10-18 Χρηση anti-cd40 αντισωματων ανταγωνιστων για θεραπευτικη αγωγη χρονιας λεμφοκυτταρικης λευχαιμιας CY1110836T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US51733703P 2003-11-04 2003-11-04
US52557903P 2003-11-26 2003-11-26
US56571004P 2004-04-27 2004-04-27
US61179404P 2004-09-21 2004-09-21
EP04810417A EP1682177B8 (en) 2003-11-04 2004-11-04 Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemia

Publications (1)

Publication Number Publication Date
CY1110836T1 true CY1110836T1 (el) 2015-06-10

Family

ID=34577850

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100928T CY1110836T1 (el) 2003-11-04 2010-10-18 Χρηση anti-cd40 αντισωματων ανταγωνιστων για θεραπευτικη αγωγη χρονιας λεμφοκυτταρικης λευχαιμιας

Country Status (16)

Country Link
US (1) US20070110754A1 (https=)
EP (2) EP2243491A1 (https=)
JP (2) JP4765037B2 (https=)
KR (1) KR20070028295A (https=)
CN (1) CN1929862B (https=)
AT (1) ATE474598T1 (https=)
AU (1) AU2004287480B2 (https=)
CA (1) CA2544364A1 (https=)
CY (1) CY1110836T1 (https=)
DE (1) DE602004028270D1 (https=)
DK (1) DK1682177T3 (https=)
IL (1) IL175393A0 (https=)
PL (1) PL1682177T3 (https=)
PT (1) PT1682177E (https=)
SI (1) SI1682177T1 (https=)
WO (1) WO2005044304A2 (https=)

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Also Published As

Publication number Publication date
CN1929862B (zh) 2012-02-15
US20070110754A1 (en) 2007-05-17
DE602004028270D1 (de) 2010-09-02
EP1682177A2 (en) 2006-07-26
JP2011116760A (ja) 2011-06-16
DK1682177T3 (da) 2010-11-01
WO2005044304A2 (en) 2005-05-19
PT1682177E (pt) 2010-11-29
CA2544364A1 (en) 2005-05-19
HK1095269A1 (en) 2007-05-04
WO2005044304A3 (en) 2005-08-25
CN1929862A (zh) 2007-03-14
EP1682177B1 (en) 2010-07-21
IL175393A0 (en) 2006-09-05
EP1682177B8 (en) 2010-09-01
KR20070028295A (ko) 2007-03-12
EP2243491A1 (en) 2010-10-27
AU2004287480A1 (en) 2005-05-19
AU2004287480B2 (en) 2011-09-15
ATE474598T1 (de) 2010-08-15
PL1682177T3 (pl) 2011-03-31
JP4765037B2 (ja) 2011-09-07
SI1682177T1 (sl) 2010-12-31
JP2007510664A (ja) 2007-04-26

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