CY1110274T1 - Ανασυνδυαστικα μορια mhc χρησιμα για τον χειρισμο των αντιγονου-ειδικων τ-κυτταρων - Google Patents

Ανασυνδυαστικα μορια mhc χρησιμα για τον χειρισμο των αντιγονου-ειδικων τ-κυτταρων

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Publication number
CY1110274T1
CY1110274T1 CY20091100324T CY091100324T CY1110274T1 CY 1110274 T1 CY1110274 T1 CY 1110274T1 CY 20091100324 T CY20091100324 T CY 20091100324T CY 091100324 T CY091100324 T CY 091100324T CY 1110274 T1 CY1110274 T1 CY 1110274T1
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Cyprus
Prior art keywords
cells
antigen
specific
mhc
polypeptides
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CY20091100324T
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English (en)
Inventor
Gregory G Burrows
Arthur A Vanderbark
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Oregon Health And Science University
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Publication of CY1110274T1 publication Critical patent/CY1110274T1/el

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Πολυπεπτίδια MHC δύο πεδίων χρήσιμα για τον χειρισμό των ειδικών αντιγόνου Τ-κυττάρων αποκαλύπτονται. Αυτά τα πολυπεπτίδια περιλαμβάνουν τα βασισμένα σε MHC κατηγορίας II μόρια που περιλαμβάνουν ομοιοπολικά συνδεδεμένα πεδία β1 και α1, και τα βασισμένα σε MHC κατηγορίας I μόρια που περιλαμβάνουν ομοιοπολικά συνδεδεμένα πεδία α1 και α2. Αυτά τα πολυπεπτίδια μπορούν επίσης να περιλαμβάνουν ομοιοπολικά συνδεδεμένους αντιγονικούς καθοριστικές, τοξικά τμήματα, ή/και ανιχνεύσιμες σημάνσεις. Τα αποκαλυπτόμενα πολυπεπτίδια μπορούν να χρησιμοποιηθούν για να στοχοθετήσουν ειδικά αντιγόνου Τ-κύτταρα, και είναι χρήσιμα, μεταξύ άλλων, για να ανιχνεύουν και να καθαρίζουν τα ειδικά αντιγόνου Τ-κύτταρα, για να προκαλούν ή να ενεργοποιούν τα Τ-κύτταρα, και για να υποβάλλουν σε θεραπεία παθήσεις μεσολαβούμενες από τα ειδικά αντιγόνου Τ-κύτταρα.
CY20091100324T 1997-09-16 2009-03-23 Ανασυνδυαστικα μορια mhc χρησιμα για τον χειρισμο των αντιγονου-ειδικων τ-κυτταρων CY1110274T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6455297P 1997-09-16 1997-09-16
US6455597P 1997-10-10 1997-10-10
EP98946814A EP1017721B1 (en) 1997-09-16 1998-09-15 Recombinant mhc molecules useful for manipulation of antigen-specific t-cells

Publications (1)

Publication Number Publication Date
CY1110274T1 true CY1110274T1 (el) 2015-01-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100324T CY1110274T1 (el) 1997-09-16 2009-03-23 Ανασυνδυαστικα μορια mhc χρησιμα για τον χειρισμο των αντιγονου-ειδικων τ-κυτταρων

Country Status (12)

Country Link
US (4) US6270772B1 (el)
EP (1) EP1017721B1 (el)
JP (1) JP4485679B2 (el)
AT (1) ATE423789T1 (el)
AU (1) AU741130B2 (el)
CA (1) CA2302779C (el)
CY (1) CY1110274T1 (el)
DE (1) DE69840600D1 (el)
DK (1) DK1017721T3 (el)
ES (1) ES2323098T3 (el)
PT (1) PT1017721E (el)
WO (1) WO1999014236A1 (el)

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ATE423789T1 (de) 2009-03-15
WO1999014236A1 (en) 1999-03-25
DK1017721T3 (da) 2009-04-20
JP4485679B2 (ja) 2010-06-23
JP2001516571A (ja) 2001-10-02
ES2323098T3 (es) 2009-07-06
US7265218B2 (en) 2007-09-04
DE69840600D1 (de) 2009-04-09
AU9375098A (en) 1999-04-05
US20080064859A1 (en) 2008-03-13
AU741130B2 (en) 2001-11-22
EP1017721B1 (en) 2009-02-25
EP1017721A4 (en) 2003-04-09
US6270772B1 (en) 2001-08-07
EP1017721A1 (en) 2000-07-12
US20020176864A1 (en) 2002-11-28
US6815171B2 (en) 2004-11-09
CA2302779A1 (en) 1999-03-25
US20050074853A1 (en) 2005-04-07
PT1017721E (pt) 2009-05-07
CA2302779C (en) 2010-02-02

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