CY1109400T1 - Αναστολεις μεταλλοπρωτεϊνασης μητρας - Google Patents

Αναστολεις μεταλλοπρωτεϊνασης μητρας

Info

Publication number
CY1109400T1
CY1109400T1 CY20091100090T CY091100090T CY1109400T1 CY 1109400 T1 CY1109400 T1 CY 1109400T1 CY 20091100090 T CY20091100090 T CY 20091100090T CY 091100090 T CY091100090 T CY 091100090T CY 1109400 T1 CY1109400 T1 CY 1109400T1
Authority
CY
Cyprus
Prior art keywords
alkyl
alkylaryl
cor
optionally substituted
bond
Prior art date
Application number
CY20091100090T
Other languages
English (en)
Inventor
Simon Gaines
Ian Peter Holmes
Stephen Lewis Martin
Stephen Paul Watson
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of CY1109400T1 publication Critical patent/CY1109400T1/el

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035Isoindoles, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Soft Magnetic Materials (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Περιγράφονται ενώσεις του τύπου (I): στον οποίο: το Α παριστάνει δεσμό, C1-6αλκύλιο ή CΗ&ίδια, CΗ-C1-4αλκύλιο, το Β παριστάνει δεσμό, Ο, S, SO, S02, CO, CR7R8, C02R14, CONR14R15, N(COR14)(COR15), N(S02R14)(COR15) ή NR14R15, το D παριστάνει δεσμό, ή C1-6αλκύλιο, το Ε παριστάνει υποκατεστημένο αρύλιο ή υποκατεστημένο ή μη υποκατεστημένο ετεροαρύλιο, το Q παριστάνει προαιρετικώς υποκατεστημένο 5- ή 6-μελή δακτύλιο αρυλίου ή ετεροαρυλίου, το Χ παριστάνει Ο, S, SO, S02, CO, CNR5, CNOR5, CNNR5R6, NR11 ή CR7R8, το Υ παριστάνει CR50R11, CR5SR11, NOR5, CR5NR6R11, SO, S02, CO, CNR5, CNOR5 ή CS, τα R1 και R1' το καθένα ανεξαρτήτως παριστάνει Η, C1-6αλκύλιο ή C1-4αλκυλαρύλιο, το R2 παριστάνει C02R12, CH20R12 ή CONR12R13, CONR120R13, NR12COR13, SR12, ΡΟ(ΟΗ)2, PONHR12 ή SONHR12, το R3 παριστάνει Η, C1-6αλκύλιο ή C1-4αλκυλαρύλιο, το R4 παριστάνει προαιρετικώς υποκατεστημένο αρύλιο ή ετεροαρύλιο, το Ζ παριστάνει δεσμό, CH2, Ο, S, SO, S02, NR5, OCR5R6, CR9R10O ή τα Ζ, R4 και Q σχηματίζουν μαζί μια προαιρετικώς υποκατεστημένη συμπυκνωμένη τρικυκλική ομάδα, τα R5 και R6 το καθένα ανεξαρτήτως παριστάνουν Η, C1-6αλκύλιο ή C1-4αλκυλαρύλιο, τα R7 και R8 το καθένα ανεξαρτήτως παριστάνουν Η, αλογονο, C1-6αλκύλιο ή C1-4αλκυλαρύλιο, τα R9 και R10 το καθένα ανεξαρτήτως παριστάνει Η, C1-6αλκύλιο προαιρετικώς υποκατεστημένο με αλογονο, κυανό, OR11 ή NR6R11, C1-4 αλκυλαρύλιο προαιρετικώς υποκατεστημένο με αλογονο, κυανο, OR11 ή NR6R11, OR11 ή, μαζί με το Ν με το οποίο συνδέονται, τα R9 και R10 σχηματίζουν ετεροκυκλική ομάδα, το R11 παριστάνει Η, C-16 αλκύλιο, C1-4 αλκυλαρύλιο ή COR5, τα R12 και R13 το καθένα ανεξαρτήτως παριστάνουν Η, C1-3 αλκύλιο, C1-3 αλκυλαρύλιο ή C1-3 αλκυλετεροαρύλιο ή, μαζί με την ομάδα με την οποία συνδέονται, τα R12 και R13 σχηματίζουν ένα ετεροκυκλικό δακτύλιο, τα R14 και R15 παριστάνουν το καθένα ανεξαρτήτως Η, C1-6 αλκύλιο, C1-4 αλκυλαρύλιο ή C1-4 αλκυλετεραρύλιο ή μαζί με την ομάδα με την οποία συνδέονται τα R14 και R15 σχηματίζουν ετεροκυκλική ή συμπυκνωμένη ετεροκυκλική ομάδα, και τα φυσιολογικώς λειτουργικά παράγωγα τους, μέθοδοι για την παρασκευή τους, φαρμακευτικές τυποποιήσεις που τις
CY20091100090T 2003-09-13 2009-01-27 Αναστολεις μεταλλοπρωτεϊνασης μητρας CY1109400T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0321538.1A GB0321538D0 (en) 2003-09-13 2003-09-13 Therapeutically useful compounds
EP04765231A EP1663970B1 (en) 2003-09-13 2004-09-10 Matrix metalloproteinase inhibitors

Publications (1)

Publication Number Publication Date
CY1109400T1 true CY1109400T1 (el) 2014-07-02

Family

ID=29227079

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CY20091100090T CY1109400T1 (el) 2003-09-13 2009-01-27 Αναστολεις μεταλλοπρωτεϊνασης μητρας

Country Status (29)

Country Link
US (3) US7601729B2 (el)
EP (3) EP2295408A1 (el)
JP (3) JP2007505081A (el)
KR (3) KR20130079628A (el)
CN (1) CN1849306B (el)
AT (2) ATE502922T1 (el)
AU (1) AU2004272280C1 (el)
BR (1) BRPI0413791A (el)
CA (1) CA2538315C (el)
CY (1) CY1109400T1 (el)
DE (2) DE602004017622D1 (el)
DK (1) DK1663970T3 (el)
ES (2) ES2362954T3 (el)
GB (1) GB0321538D0 (el)
HK (1) HK1092141A1 (el)
HR (1) HRP20080668T3 (el)
IL (1) IL173305A (el)
IS (2) IS2622B (el)
MA (1) MA28039A1 (el)
MX (1) MXPA06002458A (el)
NO (1) NO20060540L (el)
NZ (2) NZ545211A (el)
PL (1) PL1663970T3 (el)
PT (1) PT1663970E (el)
RU (2) RU2370488C2 (el)
SG (1) SG145685A1 (el)
SI (1) SI1663970T1 (el)
WO (1) WO2005026120A1 (el)
ZA (1) ZA200602070B (el)

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Publication number Priority date Publication date Assignee Title
GB0321538D0 (en) * 2003-09-13 2003-10-15 Glaxo Group Ltd Therapeutically useful compounds
EP1856063B1 (en) * 2005-02-22 2012-01-25 Ranbaxy Laboratories Limited 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases
EA016567B1 (ru) 2006-08-22 2012-05-30 Ранбакси Лабораториз Лимитед Ингибиторы матриксных металлопротеиназ
AU2013200728B2 (en) * 2006-08-22 2014-12-18 Sun Pharmaceutical Industries Limited Matrix metalloproteinase inhibitors
EP2520561B1 (en) 2007-06-08 2016-02-10 MannKind Corporation IRE-1A Inhibitors
FR2949463B1 (fr) * 2009-08-26 2011-09-16 Commissariat Energie Atomique Inhibiteurs de mmp
BR112013002370A2 (pt) 2010-07-30 2017-06-20 Ranbaxy Laboratories Ltd composto, composição farmacêutica e processo de preparação de um composto
JP2013540754A (ja) 2010-09-24 2013-11-07 ランバクシー ラボラトリーズ リミテッド マトリックスメタロプロテイナーゼ阻害剤
WO2014083229A1 (es) 2012-11-28 2014-06-05 Administración General De La Comunidad Autónoma De Euskadi Uso de inhibidores de metaloproteasas en el tratamiento de enfermedades hepáticas poliquísticas
SI3413892T1 (sl) 2016-02-12 2022-06-30 Cytokinetics, Incorporated Tetrahidroizokinolinski derivati
CN110769866B (zh) * 2017-06-13 2022-07-29 爱惜康有限责任公司 具有可控愈合的外科缝合器

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GB0319069D0 (en) 2003-08-14 2003-09-17 Glaxo Group Ltd Therapeutically useful compounds
GB0321538D0 (en) 2003-09-13 2003-10-15 Glaxo Group Ltd Therapeutically useful compounds
EP1856063B1 (en) 2005-02-22 2012-01-25 Ranbaxy Laboratories Limited 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases
EA016567B1 (ru) 2006-08-22 2012-05-30 Ранбакси Лабораториз Лимитед Ингибиторы матриксных металлопротеиназ

Also Published As

Publication number Publication date
MXPA06002458A (es) 2006-06-20
IS2622B (is) 2010-05-15
ATE413384T1 (de) 2008-11-15
PL1663970T3 (pl) 2009-04-30
CA2538315C (en) 2014-04-08
US20060293353A1 (en) 2006-12-28
JP2007505081A (ja) 2007-03-08
US20090082377A1 (en) 2009-03-26
BRPI0413791A (pt) 2006-11-07
MA28039A1 (fr) 2006-07-03
IL173305A (en) 2011-01-31
IS8843A (is) 2009-08-19
NO20060540L (no) 2006-04-04
AU2004272280C1 (en) 2011-10-27
GB0321538D0 (en) 2003-10-15
CN1849306B (zh) 2014-01-29
CA2538315A1 (en) 2005-03-24
JP2011231118A (ja) 2011-11-17
EP1663970A1 (en) 2006-06-07
JP2012107031A (ja) 2012-06-07
AU2004272280A1 (en) 2005-03-24
US7601729B2 (en) 2009-10-13
ES2362954T3 (es) 2011-07-15
US8263602B2 (en) 2012-09-11
NZ573479A (en) 2010-09-30
ATE502922T1 (de) 2011-04-15
DE602004031991D1 (de) 2011-05-05
EP2042488B1 (en) 2011-03-23
IS8268A (is) 2006-01-26
EP2042488A1 (en) 2009-04-01
DE602004017622D1 (de) 2008-12-18
EP2295408A1 (en) 2011-03-16
US8343986B2 (en) 2013-01-01
KR20130079628A (ko) 2013-07-10
WO2005026120A1 (en) 2005-03-24
EP1663970B1 (en) 2008-11-05
RU2008146479A (ru) 2010-06-20
AU2004272280B2 (en) 2011-04-21
ZA200602070B (en) 2007-05-30
RU2370488C2 (ru) 2009-10-20
HRP20080668T3 (en) 2009-02-28
HK1092141A1 (en) 2007-02-02
SI1663970T1 (sl) 2009-04-30
PT1663970E (pt) 2009-01-09
IL173305A0 (en) 2006-06-11
CN1849306A (zh) 2006-10-18
SG145685A1 (en) 2008-09-29
US20100029699A1 (en) 2010-02-04
RU2006106850A (ru) 2007-10-20
DK1663970T3 (da) 2009-01-12
NZ545211A (en) 2009-01-31
KR20060120648A (ko) 2006-11-27
KR20120007566A (ko) 2012-01-20
ES2314436T3 (es) 2009-03-16

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