CY1109314T1 - Φαρμακευτικη συνθεση περιεχουσα σταθεροποιημενη αμορφη μορφη της υδροχλωρικης ντονεπεζιλης - Google Patents
Φαρμακευτικη συνθεση περιεχουσα σταθεροποιημενη αμορφη μορφη της υδροχλωρικης ντονεπεζιληςInfo
- Publication number
- CY1109314T1 CY1109314T1 CY20091100878T CY091100878T CY1109314T1 CY 1109314 T1 CY1109314 T1 CY 1109314T1 CY 20091100878 T CY20091100878 T CY 20091100878T CY 091100878 T CY091100878 T CY 091100878T CY 1109314 T1 CY1109314 T1 CY 1109314T1
- Authority
- CY
- Cyprus
- Prior art keywords
- donepezil
- pharmaceutical composition
- amporative
- hydrochlor
- composition contained
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σταθεροποιημένες φαρμακευτικές συνθέσεις με μία άμορφη μορφή της υδροχλωρικής 1 - βενζυλ-4-((5,6-διμεθοξυ-1-ινδανον)-2-υλ)μεθυλ-πιπεριδίνης (ντονεπεζίλη) και μέθοδο για τη σταθεροποίηση αυτής της ένωσης. Η φαρμακευτική σύνθεση παρασκευάζεται με in situ σχηματισμό υδροχλωρικής ντονεπεζίλης και φόρτωμα του λαμβανόμενου διαλύματος επί ενός μίγματος φαρμακευτικώς αποδεκτών εκδόχων. Η άμορφη μορφή της υδροχλωρικής ντονεπεζίλης σταθεροποιείται με προσθήκη ενός αναστολέα κρυστάλλωσης στο διάλυμα ή στο μίγμα των φαρμακευτικώς αποδεκτών εκδόχων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI200200155A SI21223A (sl) | 2002-06-19 | 2002-06-19 | Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom |
EP03741747A EP1513528B1 (en) | 2002-06-19 | 2003-06-18 | Pharmaceutical composition containing stabilised amorphous form of donepezil hydrochloride |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109314T1 true CY1109314T1 (el) | 2014-07-02 |
Family
ID=29778199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100878T CY1109314T1 (el) | 2002-06-19 | 2009-08-17 | Φαρμακευτικη συνθεση περιεχουσα σταθεροποιημενη αμορφη μορφη της υδροχλωρικης ντονεπεζιλης |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1513528B1 (el) |
AT (1) | ATE431739T1 (el) |
AU (1) | AU2003279102A1 (el) |
CY (1) | CY1109314T1 (el) |
DE (1) | DE60327696D1 (el) |
DK (1) | DK1513528T3 (el) |
EA (1) | EA012904B1 (el) |
ES (1) | ES2326529T3 (el) |
HR (1) | HRP20041198B1 (el) |
PL (1) | PL212584B1 (el) |
PT (1) | PT1513528E (el) |
RS (1) | RS51824B (el) |
SI (2) | SI21223A (el) |
UA (1) | UA86573C2 (el) |
WO (1) | WO2004000317A1 (el) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL150509A (en) | 2002-07-01 | 2007-07-04 | Joseph Kaspi | Pharmaceutical preparations containing donafazil hydrochloride |
IL154370A0 (en) * | 2003-02-10 | 2003-09-17 | Chemagis Ltd | Solid amorphous mixtures, processes for the preparation thereof and pharmaceutical compositions containing the same |
CA2552221A1 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Donepezil formulations |
EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
KR20070083679A (ko) | 2004-09-29 | 2007-08-24 | 케마지스 리미티드 | 약학적으로 순수한 비정질 도네페닐 염산염의 제조를 위한정제된 도네페질 말레산염의 용도 |
ATE415148T1 (de) * | 2004-10-19 | 2008-12-15 | Krka Tovarna Zdravil D D Novo | Feste pharmazeutische zusammensetzung mit donepezilhydrochlorid |
WO2006063025A1 (en) * | 2004-12-07 | 2006-06-15 | Nektar Therapeutics | Stable non-crystalline formulation comprising donepezil |
US20060122226A1 (en) | 2004-12-08 | 2006-06-08 | Itai Adin | Crystalline forms of Donepezil base |
RU2401125C2 (ru) | 2004-12-27 | 2010-10-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Способ стабилизации лекарственного средства против деменции |
JP2007015934A (ja) * | 2005-07-05 | 2007-01-25 | Meiko Shoji Kk | 温感クリーム化粧料 |
DE102005060377A1 (de) | 2005-12-16 | 2007-06-21 | Ratiopharm Gmbh | Pharmazeutische Zusammensetzung enthaltend Donepezilhydrochlorid, Tablette hieraus und Verfahren zu deren Herstellung |
EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
DE102007037932A1 (de) | 2007-08-11 | 2009-02-12 | Alfred E. Tiefenbacher Gmbh & Co.Kg | Donepezilhydrochlorid in amorpher Form enthaltende Tablette |
DE102009041839A1 (de) * | 2009-09-18 | 2011-03-24 | Dolorgiet Gmbh & Co. Kg | Donepezil-haltige Tabletten |
EP2366378A1 (en) * | 2010-03-01 | 2011-09-21 | Dexcel Pharma Technologies Ltd. | Sustained-release donepezil formulations |
WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
EP2502620A1 (en) | 2011-03-24 | 2012-09-26 | Krka Tovarna Zdravil, D.D., Novo Mesto | Solid pharmaceutical composition comprising donepezil |
WO2013135852A1 (en) | 2012-03-15 | 2013-09-19 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
CN105377235A (zh) | 2013-07-19 | 2016-03-02 | 勃林格殷格翰动物保健有限公司 | 含有防腐的醚化的环糊精衍生物的液体水性药物组合物 |
BR122019024673B1 (pt) | 2013-12-04 | 2023-04-11 | Boehringer Ingelheim Vetmedica Gmbh | Composições farmacêuticas aprimoradas de pimobendan |
EP3380079A4 (en) * | 2015-11-25 | 2019-08-21 | Patheon Development Services Inc. | AMORPHOUS DISPERSION GRANULES AND PHARMACEUTICAL FORMS FOR ORAL USE |
US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
KR102372630B1 (ko) * | 2019-05-15 | 2022-03-14 | 주식회사 대웅제약 | 고함량의 도네페질 또는 그의 염을 포함하는 경피흡수제제 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2525108B1 (fr) * | 1982-04-19 | 1989-05-12 | Elan Corp Ltd | Medicaments a haut degre de solubilite et procede pour leur obtention |
AU731282B2 (en) * | 1996-06-07 | 2001-03-29 | Eisai Co. Ltd. | Polymorphs of donepezil hydrochloride and process for production |
ES2310164T3 (es) * | 1999-02-10 | 2009-01-01 | Pfizer Products Inc. | Dispositivo de liberacion controlada por la matriz. |
CA2359945C (en) * | 1999-11-12 | 2011-04-26 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
-
2002
- 2002-06-19 SI SI200200155A patent/SI21223A/sl not_active IP Right Cessation
-
2003
- 2003-06-18 WO PCT/SI2003/000019 patent/WO2004000317A1/en not_active Application Discontinuation
- 2003-06-18 PT PT03741747T patent/PT1513528E/pt unknown
- 2003-06-18 AU AU2003279102A patent/AU2003279102A1/en not_active Abandoned
- 2003-06-18 RS YU110604A patent/RS51824B/en unknown
- 2003-06-18 EA EA200500040A patent/EA012904B1/ru not_active IP Right Cessation
- 2003-06-18 EP EP03741747A patent/EP1513528B1/en not_active Expired - Lifetime
- 2003-06-18 AT AT03741747T patent/ATE431739T1/de active
- 2003-06-18 SI SI200331643T patent/SI1513528T1/sl unknown
- 2003-06-18 DE DE60327696T patent/DE60327696D1/de not_active Expired - Lifetime
- 2003-06-18 UA UAA200500514A patent/UA86573C2/ru unknown
- 2003-06-18 PL PL372116A patent/PL212584B1/pl unknown
- 2003-06-18 ES ES03741747T patent/ES2326529T3/es not_active Expired - Lifetime
- 2003-06-18 DK DK03741747T patent/DK1513528T3/da active
-
2004
- 2004-12-17 HR HRP20041198AA patent/HRP20041198B1/hr not_active IP Right Cessation
-
2009
- 2009-08-17 CY CY20091100878T patent/CY1109314T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20041198A2 (en) | 2005-04-30 |
DK1513528T3 (da) | 2009-09-07 |
AU2003279102A1 (en) | 2004-01-06 |
PL372116A1 (en) | 2005-07-11 |
RS110604A (en) | 2007-02-05 |
EP1513528B1 (en) | 2009-05-20 |
EA012904B1 (ru) | 2010-02-26 |
PT1513528E (pt) | 2009-08-18 |
EP1513528A1 (en) | 2005-03-16 |
ES2326529T3 (es) | 2009-10-14 |
HRP20041198B1 (hr) | 2013-05-31 |
ATE431739T1 (de) | 2009-06-15 |
EA200500040A1 (ru) | 2005-06-30 |
SI1513528T1 (sl) | 2009-10-31 |
PL212584B1 (pl) | 2012-10-31 |
WO2004000317A1 (en) | 2003-12-31 |
UA86573C2 (ru) | 2009-05-12 |
DE60327696D1 (de) | 2009-07-02 |
RS51824B (en) | 2012-02-29 |
SI21223A (sl) | 2003-12-31 |
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