CY1108773T1 - 7-υδροξυεπιανδροστερονη που εχει νευροπροστατευτικη δραση - Google Patents

7-υδροξυεπιανδροστερονη που εχει νευροπροστατευτικη δραση

Info

Publication number
CY1108773T1
CY1108773T1 CY20081101165T CY081101165T CY1108773T1 CY 1108773 T1 CY1108773 T1 CY 1108773T1 CY 20081101165 T CY20081101165 T CY 20081101165T CY 081101165 T CY081101165 T CY 081101165T CY 1108773 T1 CY1108773 T1 CY 1108773T1
Authority
CY
Cyprus
Prior art keywords
hydroxyapiandrosterone
neuroprotective action
neuroprotective
action
hydroxyepiandrosterone
Prior art date
Application number
CY20081101165T
Other languages
English (en)
Inventor
Ashley Ker Pringle
Lars Eric Sundstrom
Ernst Wülfert
Original Assignee
Hunter-Fleming Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hunter-Fleming Limited filed Critical Hunter-Fleming Limited
Publication of CY1108773T1 publication Critical patent/CY1108773T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η 7-Υδροξυεπιανδροστερόνη μπορεί να χρησιμοποιηθεί για προστασία έναντι της οξείας ή της χρόνιας νευρωνικής βλάβης.
CY20081101165T 2000-06-29 2008-10-20 7-υδροξυεπιανδροστερονη που εχει νευροπροστατευτικη δραση CY1108773T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0016022A GB2363983A (en) 2000-06-29 2000-06-29 Protection against neuronal damage using 7-hydroxyepiandrosterone
EP01945494A EP1294382B1 (en) 2000-06-29 2001-06-29 7-hydroxyepiandrosterone having neuroprotective activity

Publications (1)

Publication Number Publication Date
CY1108773T1 true CY1108773T1 (el) 2014-04-09

Family

ID=9894707

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101165T CY1108773T1 (el) 2000-06-29 2008-10-20 7-υδροξυεπιανδροστερονη που εχει νευροπροστατευτικη δραση

Country Status (24)

Country Link
US (2) US7718639B2 (el)
EP (1) EP1294382B1 (el)
JP (1) JP4942905B2 (el)
KR (1) KR100786284B1 (el)
CN (1) CN100459980C (el)
AT (1) ATE401897T1 (el)
AU (2) AU6770901A (el)
CA (1) CA2414584C (el)
CY (1) CY1108773T1 (el)
CZ (1) CZ299676B6 (el)
DE (1) DE60134979D1 (el)
DK (1) DK1294382T3 (el)
ES (1) ES2310182T3 (el)
GB (1) GB2363983A (el)
HK (1) HK1052300B (el)
HU (1) HU227152B1 (el)
IL (2) IL153541A0 (el)
NO (1) NO327959B1 (el)
PL (1) PL200699B1 (el)
PT (1) PT1294382E (el)
RU (1) RU2307654C2 (el)
SI (1) SI1294382T1 (el)
WO (1) WO2002000225A1 (el)
ZA (1) ZA200300085B (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2363984A (en) * 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 3-hydroxy-7 -hydroxy steroids and 3-oxo-7 -hydroxy steroids
GB2378898A (en) * 2001-08-14 2003-02-26 Hunter Fleming Ltd Prophylactic and therapeutic use of hydroxysteroids
WO2004019953A1 (en) * 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment methods
GB0409498D0 (en) * 2004-04-28 2004-06-02 Hunter Fleming Ltd Transdermal steroid formulation
RU2458065C2 (ru) * 2006-11-21 2012-08-10 Юмекрайн Аб Новые стероидные соединения, обладающие повышенной растворимостью в воде и устойчивостью к метаболизму, и способы их приготовления
GB0623971D0 (en) * 2006-11-30 2007-01-10 Hunter Fleming Ltd Modulation of prostaglandin/cyclooxygenase metabolic pathways
AU2007327011A1 (en) 2006-11-30 2008-06-05 Hunter-Fleming Limited Modulation of prostaglandin/cyclooxygenase metabolic pathways

Family Cites Families (33)

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YU243975A (en) 1974-10-14 1982-06-30 Schering Ag Process for obtaining 7-hydroxyestradiols
US5707983A (en) 1990-08-29 1998-01-13 Humanetics Corporation Treatment of alzheimer's disease and modulation of immune system with Δ5-androstenes
US5292730A (en) * 1990-08-29 1994-03-08 Humanetics Corporation Modulation of immune system with Δ5-androstenes
US5212167A (en) * 1991-09-12 1993-05-18 Trustees Of Boston University Modulation of receptor-mediated ion transport
FR2696934B1 (fr) * 1992-10-20 1995-06-02 Conservatoire Nal Arts Metiers Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir.
US5846963A (en) 1995-06-07 1998-12-08 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
EP0688220B1 (en) 1993-03-09 2004-11-24 University of Utah Research Foundation Use of dhea and derivatives thereof for the manufacture of a medicament for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5387583A (en) * 1993-04-20 1995-02-07 Loria; Roger M. Compositions containing corticosteroids or analogues thereof and corticosteroid buffering effective amounts of 5-androstene 3B, 17B or 5-androstene 3B, 7B, 17B triol or analogues thereof
US5877169A (en) 1993-11-05 1999-03-02 University Of Florida Research Foundation, Inc. Methods of treatment of ischemic damage
US5554601A (en) 1993-11-05 1996-09-10 University Of Florida Methods for neuroprotection
US5976850A (en) 1994-10-19 1999-11-02 University Of Edinburgh Hippocampus-associated proteins; DNA sequences coding therefor and uses thereof
US5556847A (en) * 1994-10-27 1996-09-17 Duquesne University Of The Holy Ghost Methods of effecting memory enhancement mediated by steroid sulfatase inhibitors
GEP20012530B (en) 1995-06-06 2001-09-25 Cocensys Inc Neuroactive Steroids of the Androstane and Pregnane Series
JP4313435B2 (ja) 1995-07-24 2009-08-12 トラスティーズ オブ ボストン ユニバーシティー プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制
GB2317826B (en) * 1995-08-29 1999-12-15 Univ Edinburgh Regulation of intracellular glucocorticoid concentrations
US5985242A (en) 1995-10-27 1999-11-16 Praecis Pharmaceuticals, Inc. Modulators of β-amyloid peptide aggregation comprising D-amino acids
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FR2760362B1 (fr) 1997-03-10 2000-08-11 Vitasterol Utilisation cosmetique ou dermatologique de steroides 7-hydroxyles
WO1998043647A1 (en) * 1997-03-28 1998-10-08 Massachusetts Institute Of Technology, Inc. Regulation of amyloid precursor protein (app) expression by estrogenic compounds
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WO1999015179A1 (en) 1997-09-25 1999-04-01 Regents Of The University Of Minnesota Methods of limiting apoptosis of cells
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JP2004515446A (ja) * 1997-11-24 2004-05-27 ユニバーシティ・オブ・フロリダ・リサーチ・ファンデーション・インコーポレーテッド テストステロン阻害剤及びニューロンの保護のためのその用途
GB9726569D0 (en) 1997-12-16 1998-02-11 Univ Southampton Neuroprotective agents
WO1999052532A1 (en) * 1998-04-14 1999-10-21 Pharmadigm, Inc. Method for reducing central nervous system impairment
FR2786102B1 (fr) * 1998-11-20 2001-02-16 Monique Vincens Utilisation de sulfate de dehydroepiandrosterone pour augmenter le nombre de recepteurs nmda chez un mammifere
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DK1226155T3 (da) 1999-11-02 2007-09-10 Bayer Schering Pharma Ag 18-nor-steroider som selektivt virksomme östrogener
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GB2363984A (en) * 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 3-hydroxy-7 -hydroxy steroids and 3-oxo-7 -hydroxy steroids
EP1557166A1 (en) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders

Also Published As

Publication number Publication date
CA2414584A1 (en) 2002-01-03
PL200699B1 (pl) 2009-01-30
CN1440290A (zh) 2003-09-03
ES2310182T3 (es) 2009-01-01
NO20026243D0 (no) 2002-12-27
KR20030034113A (ko) 2003-05-01
AU2001267709B2 (en) 2005-07-28
EP1294382A1 (en) 2003-03-26
AU6770901A (en) 2002-01-08
GB2363983A (en) 2002-01-16
HUP0301134A2 (hu) 2003-08-28
PL359108A1 (en) 2004-08-23
CZ200377A3 (cs) 2003-06-18
SI1294382T1 (sl) 2009-02-28
ZA200300085B (en) 2004-04-21
DE60134979D1 (de) 2008-09-04
IL153541A0 (en) 2003-07-06
HUP0301134A3 (en) 2006-06-28
JP4942905B2 (ja) 2012-05-30
US7718639B2 (en) 2010-05-18
IL153541A (en) 2008-03-20
CZ299676B6 (cs) 2008-10-15
DK1294382T3 (da) 2008-11-24
JP2004501196A (ja) 2004-01-15
GB0016022D0 (en) 2000-08-23
KR100786284B1 (ko) 2007-12-18
RU2003102437A (ru) 2005-01-27
HK1052300A1 (en) 2003-09-11
US20100173883A1 (en) 2010-07-08
HU227152B1 (en) 2010-08-30
NO20026243L (no) 2003-02-27
ATE401897T1 (de) 2008-08-15
PT1294382E (pt) 2008-10-21
WO2002000225A1 (en) 2002-01-03
NO327959B1 (no) 2009-10-26
RU2307654C2 (ru) 2007-10-10
CA2414584C (en) 2009-10-27
US20030166626A1 (en) 2003-09-04
CN100459980C (zh) 2009-02-11
HK1052300B (zh) 2009-01-30
EP1294382B1 (en) 2008-07-23

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