CY1108511T1 - Θεραπευτικες παραλλαγες της λιποπρωτεϊνικης λιπασης (lpl) - Google Patents
Θεραπευτικες παραλλαγες της λιποπρωτεϊνικης λιπασης (lpl)Info
- Publication number
- CY1108511T1 CY1108511T1 CY20081101305T CY081101305T CY1108511T1 CY 1108511 T1 CY1108511 T1 CY 1108511T1 CY 20081101305 T CY20081101305 T CY 20081101305T CY 081101305 T CY081101305 T CY 081101305T CY 1108511 T1 CY1108511 T1 CY 1108511T1
- Authority
- CY
- Cyprus
- Prior art keywords
- lpl
- therapeutic
- variations
- lipoprotein fat
- lipoprotein
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 102000004895 Lipoproteins Human genes 0.000 title 1
- 108090001030 Lipoproteins Proteins 0.000 title 1
- 108010013563 Lipoprotein Lipase Proteins 0.000 abstract 4
- 102100022119 Lipoprotein lipase Human genes 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 108010023302 HDL Cholesterol Proteins 0.000 abstract 1
- 102000043296 Lipoprotein lipases Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 201000011110 familial lipoprotein lipase deficiency Diseases 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01034—Lipoprotein lipase (3.1.1.34)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99202048 | 1999-06-24 | ||
| EP20000943499 EP1200117B1 (en) | 1999-06-24 | 2000-06-23 | Lipoprotein lipase (lpl) variant therapeutics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1108511T1 true CY1108511T1 (el) | 2014-04-09 |
Family
ID=8240356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20081101305T CY1108511T1 (el) | 1999-06-24 | 2008-11-13 | Θεραπευτικες παραλλαγες της λιποπρωτεϊνικης λιπασης (lpl) |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110201673A1 (enExample) |
| EP (1) | EP1200117B1 (enExample) |
| JP (1) | JP5095894B2 (enExample) |
| AT (1) | ATE404217T1 (enExample) |
| AU (1) | AU5799200A (enExample) |
| CA (1) | CA2370081C (enExample) |
| CY (1) | CY1108511T1 (enExample) |
| DE (1) | DE60039880D1 (enExample) |
| DK (1) | DK1200117T3 (enExample) |
| ES (1) | ES2311464T3 (enExample) |
| PT (1) | PT1200117E (enExample) |
| WO (1) | WO2001000220A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005015687D1 (de) * | 2004-03-02 | 2009-09-10 | Cellectar Inc | Phospholipid-analoga für die behandlung von krebs |
| ES2306163T3 (es) * | 2004-06-21 | 2008-11-01 | Amsterdam Molecular Therapeutics B.V. | Tratamiento de esteatohepatitis no alcoholica (nash). |
| PT3272872T (pt) | 2005-10-20 | 2020-06-26 | Uniqure Ip Bv | Vetores aav melhorados produzidos em células de insetos |
| WO2007148971A2 (en) | 2006-06-21 | 2007-12-27 | Amsterdam Molecular Therapeutics B.V. | Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav in insect cells |
| HUE029744T2 (en) | 2007-07-26 | 2017-04-28 | Uniqure Ip Bv | Baculoviral vectors comprising repeated coding sequences with differential codon biases |
| WO2009030254A1 (en) * | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| EP2432497A1 (en) * | 2009-05-18 | 2012-03-28 | Amsterdam Molecular Therapeutics (AMT) IP B.V. | Use of lipoprotein lipase (lpl) in therapy |
| DK3708192T3 (da) | 2009-06-12 | 2023-11-06 | Cellectar Inc | Etherphospholipidforbindelser til behandling af cancer og billeddannelse og detektering af cancerstamceller |
| EP2545165B1 (en) | 2010-03-11 | 2020-07-29 | uniQure IP B.V. | Mutated rep encoding sequences for use in aav production |
| WO2011122950A1 (en) | 2010-04-01 | 2011-10-06 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Monomeric duplex aav vectors |
| SG10201604810UA (en) | 2012-02-07 | 2016-08-30 | Global Bio Therapeutics Inc | Compartmentalized method of nucleic acid delivery and compositions and uses thereof |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| WO2015137802A1 (en) | 2014-03-10 | 2015-09-17 | Uniqure Ip B.V. | Further improved aav vectors produced in insect cells |
| MA41035A (fr) * | 2014-08-19 | 2017-08-15 | Shire Human Genetic Therapies | Lipoprotéine lipase pour le traitement d'affections liées à une hypertriglycéridémie, y compris la pancréatite aiguë |
| EP3458106A4 (en) * | 2016-05-18 | 2020-03-18 | Modernatx, Inc. | POLYNUCLEOTIDS FOR CODING LIPOPROTEIN LIPASE FOR TREATING HYPERLIPIDEMIA |
| CA3045551A1 (en) | 2016-12-16 | 2018-06-21 | Uniqure Ip B.V. | Immunoadsorption |
| US11452749B2 (en) | 2017-07-10 | 2022-09-27 | Uniqure Ip B.V. | Means and methods for AAV gene therapy in humans |
| WO2019016349A1 (en) | 2017-07-20 | 2019-01-24 | Uniqure Ip B.V. | PRODUCTION OF ENHANCED VAA CAPSIDS IN INSECT CELLS |
| CN111527201A (zh) | 2017-12-29 | 2020-08-11 | 优尼科Ip有限公司 | 修饰的病毒载体及其制备和使用方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU695618B2 (en) * | 1994-04-11 | 1998-08-20 | Baylor College Of Medicine | Compositions and methods for gene therapy to treat disease |
| US5658729A (en) * | 1994-10-11 | 1997-08-19 | The University Of British Columbia | Method, reagent and kit for evaluating susceptibility to premature atherosclerosis |
-
2000
- 2000-06-23 CA CA2370081A patent/CA2370081C/en not_active Expired - Fee Related
- 2000-06-23 AT AT00943499T patent/ATE404217T1/de active
- 2000-06-23 DE DE60039880T patent/DE60039880D1/de not_active Expired - Lifetime
- 2000-06-23 PT PT00943499T patent/PT1200117E/pt unknown
- 2000-06-23 ES ES00943499T patent/ES2311464T3/es not_active Expired - Lifetime
- 2000-06-23 WO PCT/CA2000/000762 patent/WO2001000220A2/en not_active Ceased
- 2000-06-23 EP EP20000943499 patent/EP1200117B1/en not_active Expired - Lifetime
- 2000-06-23 JP JP2001505929A patent/JP5095894B2/ja not_active Expired - Fee Related
- 2000-06-23 AU AU57992/00A patent/AU5799200A/en not_active Abandoned
- 2000-06-23 DK DK00943499T patent/DK1200117T3/da active
-
2008
- 2008-11-13 CY CY20081101305T patent/CY1108511T1/el unknown
-
2010
- 2010-10-05 US US12/898,684 patent/US20110201673A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU5799200A (en) | 2001-01-31 |
| DE60039880D1 (en) | 2008-09-25 |
| JP2003503355A (ja) | 2003-01-28 |
| DK1200117T3 (da) | 2008-11-17 |
| JP5095894B2 (ja) | 2012-12-12 |
| WO2001000220A2 (en) | 2001-01-04 |
| EP1200117A2 (en) | 2002-05-02 |
| WO2001000220A3 (en) | 2001-07-12 |
| CA2370081A1 (en) | 2001-01-04 |
| CA2370081C (en) | 2014-06-03 |
| US20110201673A1 (en) | 2011-08-18 |
| PT1200117E (pt) | 2008-11-26 |
| EP1200117B1 (en) | 2008-08-13 |
| ES2311464T3 (es) | 2009-02-16 |
| ATE404217T1 (de) | 2008-08-15 |
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