CY1108414T1 - Δισκιο πολλαπλων στρωματων που περιεχει πραβαστατινη και ασπιρινη και μεθοδος - Google Patents
Δισκιο πολλαπλων στρωματων που περιεχει πραβαστατινη και ασπιρινη και μεθοδοςInfo
- Publication number
- CY1108414T1 CY1108414T1 CY20081101137T CY081101137T CY1108414T1 CY 1108414 T1 CY1108414 T1 CY 1108414T1 CY 20081101137 T CY20081101137 T CY 20081101137T CY 081101137 T CY081101137 T CY 081101137T CY 1108414 T1 CY1108414 T1 CY 1108414T1
- Authority
- CY
- Cyprus
- Prior art keywords
- aspirin
- layer containing
- probastatin
- pravastatin
- table containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Παρέχεται ένα δισκίο πολλαπλών στρωμάτων, που έχει τρία ή περισσότερα στρώματα, το οποίο είναι χρήσιμο για την ελάττωση της χοληστερίνης και την μείωση του κινδύνου ενός μυοκαρδιακού εμφράγματος, το οποίο δισκίο περιλαμβάνει ένα πρώτο στρώμα που περιέχει ασπιρίνη, ένα άλλο στρώμα που περιέχει πραβαστατίνη και ένα μεσαίο στρώμα φραγμού το οποίο περιέχει κατά προτίμηση ένα ρυθμιστικό του pΗ μέσον το οποίο διαχωρίζει το πρώτο στρώμα που περιέχει ασπιρίνη από το άλλο στρώμα που περιέχει πραβαστατινη και εμποδίζει ή ελαχιστοποιεί αλληλεπίδραση από ασπιρίνη με πραβαστατινη. Μία μέθοδος για την ελάττωση της χοληστερίνης και την μείωση του κινδύνου ενός μυοκαρδιακού εμφράγματος με χρησιμοποίηση μίας τέτοιας σύνθεσης παρέχεται επίσης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/316,424 US20040115265A1 (en) | 2002-12-11 | 2002-12-11 | Multilayered tablet containing pravastatin and aspirin and method |
EP03812825A EP1581194B1 (en) | 2002-12-11 | 2003-12-03 | Multilayered tablet containing pravastatin and aspirin and method |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108414T1 true CY1108414T1 (el) | 2014-02-12 |
Family
ID=32505946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081101137T CY1108414T1 (el) | 2002-12-11 | 2008-10-14 | Δισκιο πολλαπλων στρωματων που περιεχει πραβαστατινη και ασπιρινη και μεθοδος |
Country Status (17)
Country | Link |
---|---|
US (1) | US20040115265A1 (el) |
EP (1) | EP1581194B1 (el) |
JP (1) | JP2006511520A (el) |
AT (1) | ATE401061T1 (el) |
AU (1) | AU2003297689A1 (el) |
CY (1) | CY1108414T1 (el) |
DE (1) | DE60322264D1 (el) |
DK (1) | DK1581194T3 (el) |
ES (1) | ES2308040T3 (el) |
IS (1) | IS2877B (el) |
MY (1) | MY140947A (el) |
NO (1) | NO338696B1 (el) |
PL (1) | PL206190B1 (el) |
PT (1) | PT1581194E (el) |
SI (1) | SI1581194T1 (el) |
TW (1) | TWI361700B (el) |
WO (1) | WO2004052289A2 (el) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2316456T (pt) | 2003-04-29 | 2017-09-05 | Orexigen Therapeutics Inc | Composições para afetar a perda de peso compreendendo naltrexona e bupropion |
US8163797B2 (en) * | 2003-12-31 | 2012-04-24 | Actavis Elizabeth Llc | Method of treating with stable pravastatin formulation |
JP2008526771A (ja) * | 2004-12-30 | 2008-07-24 | ジェンザイム コーポレーション | 高リン酸血症のための亜鉛含有処置 |
US20060251722A1 (en) * | 2005-05-03 | 2006-11-09 | Novavax, Inc. | Multi-component vitamin and mineral supplement for the optimal absorption of components |
US8986669B2 (en) * | 2005-09-02 | 2015-03-24 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
WO2007056405A2 (en) * | 2005-11-08 | 2007-05-18 | Genzyme Corporation | Magnesium-containing polymers for the treatment of hyperphosphatemia |
DK2135603T3 (da) | 2005-11-22 | 2013-03-25 | Orexigen Therapeutics Inc | Sammensætninger og fremgangsmåder til øgning af insulinsensitivitet |
WO2007072060A2 (en) * | 2005-12-23 | 2007-06-28 | Cipla Limited | Particles comprising a core containing a hmg-coa reductase inhibitor and coated with a film |
ATE489079T1 (de) | 2005-12-29 | 2010-12-15 | Osmotica Kereskedelmi Es Szolgaltata Kft | Mehrschichtige tablette mit dreifacher freisetzungskombination |
US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
EP2043627A2 (en) * | 2006-07-05 | 2009-04-08 | Genzyme Corporation | Iron(ii)-containing treatments for hyperphosphatemia |
US8765178B2 (en) * | 2006-07-19 | 2014-07-01 | Watson Laboratories, Inc. | Controlled release formulations and associated methods |
CN101588795A (zh) * | 2006-11-09 | 2009-11-25 | 奥雷西根治疗公司 | 包含中间快速溶解层的分层药物制剂 |
AU2007319472B2 (en) | 2006-11-09 | 2013-01-17 | Nalpropion Pharmaceuticals Llc | Methods Of Administering Weight Loss Medications |
PL2134351T3 (pl) | 2007-03-13 | 2017-10-31 | Jds Therapeutics Llc | Sposoby i kompozycje do przedłużonego uwalniania chromu |
WO2009002867A2 (en) * | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
JP5654873B2 (ja) | 2007-10-12 | 2015-01-14 | フエリング・インターナシヨナル・センター・エス・アー | 医薬品を製造する方法 |
US20110144145A1 (en) | 2008-05-30 | 2011-06-16 | Orexigen Therapeutics, Inc. | Methods for treating visceral fat conditions |
AU2011203867B2 (en) | 2010-01-11 | 2015-12-03 | Nalpropion Pharmaceuticals Llc | Methods of providing weight loss therapy in patients with major depression |
TR201005325A2 (tr) | 2010-06-30 | 2012-01-23 | Bi̇lgi̇ç Mahmut | Atorvastatin ve aspirin içeren farmasötik formülasyonlar |
KR20120068277A (ko) * | 2010-12-17 | 2012-06-27 | 한미사이언스 주식회사 | HMG-CoA 환원효소 억제제 및 아스피린을 포함하는 약제학적 복합제제 |
US8718837B2 (en) * | 2011-01-28 | 2014-05-06 | Intouch Technologies | Interfacing with a mobile telepresence robot |
EP2858640B1 (en) | 2012-06-06 | 2020-03-25 | Nalpropion Pharmaceuticals LLC | Composition for use in a method of treating overweight and obesity in patients with high cardiovascular risk |
EP2810644A1 (en) * | 2013-06-06 | 2014-12-10 | Ferrer Internacional, S.A. | Oral formulation for the treatment of cardiovascular diseases |
GB2564295A (en) | 2016-02-11 | 2019-01-09 | Nutrition 21 Llc | Chromium containing compositions for improving health and fitness |
JP7109748B2 (ja) * | 2018-12-11 | 2022-08-01 | 日本ジェネリック株式会社 | アジルサルタンとアムロジピンベシル酸塩含有固形製剤及び固形製剤の製造方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4590183A (en) * | 1985-04-22 | 1986-05-20 | Sterling Drug Inc. | Gastric cytoprotection with sodium thiosulfate in oral administration of aspirin |
JP3172749B2 (ja) * | 1992-02-17 | 2001-06-04 | ライオン株式会社 | イブプロフェン含有製剤 |
IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
IT1264517B1 (it) * | 1993-05-31 | 1996-09-24 | Ekita Investments Nv | Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati |
FR2772615B1 (fr) * | 1997-12-23 | 2002-06-14 | Lipha | Comprime multicouche pour la liberation instantanee puis prolongee de substances actives |
US6235311B1 (en) * | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
BR9908911A (pt) * | 1998-03-19 | 2001-10-02 | Bristol Myers Squibb Co | Sistema bifásico e processo de distribuição por liberação controlada de substâncias farmacêuticas de alta solubilidade |
US6669955B2 (en) * | 2001-08-28 | 2003-12-30 | Longwood Pharmaceutical Research, Inc. | Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
-
2002
- 2002-12-11 US US10/316,424 patent/US20040115265A1/en not_active Abandoned
-
2003
- 2003-12-03 WO PCT/US2003/038774 patent/WO2004052289A2/en active Application Filing
- 2003-12-03 JP JP2004559355A patent/JP2006511520A/ja active Pending
- 2003-12-03 AT AT03812825T patent/ATE401061T1/de active
- 2003-12-03 DE DE60322264T patent/DE60322264D1/de not_active Expired - Lifetime
- 2003-12-03 SI SI200331302T patent/SI1581194T1/sl unknown
- 2003-12-03 PT PT03812825T patent/PT1581194E/pt unknown
- 2003-12-03 EP EP03812825A patent/EP1581194B1/en not_active Expired - Lifetime
- 2003-12-03 PL PL377265A patent/PL206190B1/pl unknown
- 2003-12-03 DK DK03812825T patent/DK1581194T3/da active
- 2003-12-03 AU AU2003297689A patent/AU2003297689A1/en not_active Abandoned
- 2003-12-03 ES ES03812825T patent/ES2308040T3/es not_active Expired - Lifetime
- 2003-12-08 TW TW092134590A patent/TWI361700B/zh active
- 2003-12-10 MY MYPI20034728A patent/MY140947A/en unknown
-
2005
- 2005-06-07 NO NO20052734A patent/NO338696B1/no not_active IP Right Cessation
- 2005-06-10 IS IS7889A patent/IS2877B/is unknown
-
2008
- 2008-10-14 CY CY20081101137T patent/CY1108414T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1581194B1 (en) | 2008-07-16 |
ES2308040T3 (es) | 2008-12-01 |
WO2004052289A3 (en) | 2005-03-24 |
EP1581194A4 (en) | 2006-03-15 |
NO338696B1 (no) | 2016-10-03 |
NO20052734L (no) | 2005-07-07 |
AU2003297689A8 (en) | 2004-06-30 |
WO2004052289A2 (en) | 2004-06-24 |
DK1581194T3 (da) | 2008-10-20 |
PT1581194E (pt) | 2008-09-24 |
IS2877B (is) | 2014-04-15 |
TWI361700B (en) | 2012-04-11 |
SI1581194T1 (sl) | 2008-12-31 |
IS7889A (is) | 2005-06-10 |
US20040115265A1 (en) | 2004-06-17 |
NO20052734D0 (no) | 2005-06-07 |
AU2003297689A1 (en) | 2004-06-30 |
PL377265A1 (pl) | 2006-01-23 |
MY140947A (en) | 2010-02-12 |
PL206190B1 (pl) | 2010-07-30 |
JP2006511520A (ja) | 2006-04-06 |
ATE401061T1 (de) | 2008-08-15 |
DE60322264D1 (de) | 2008-08-28 |
TW200505432A (en) | 2005-02-16 |
EP1581194A2 (en) | 2005-10-05 |
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