CY1108386T1 - Βελτιωμενα οστεοεπαγωγικα υλικα - Google Patents

Βελτιωμενα οστεοεπαγωγικα υλικα

Info

Publication number
CY1108386T1
CY1108386T1 CY20081101083T CY081101083T CY1108386T1 CY 1108386 T1 CY1108386 T1 CY 1108386T1 CY 20081101083 T CY20081101083 T CY 20081101083T CY 081101083 T CY081101083 T CY 081101083T CY 1108386 T1 CY1108386 T1 CY 1108386T1
Authority
CY
Cyprus
Prior art keywords
matrix material
outputs
morphogenetic protein
improved bone
protein
Prior art date
Application number
CY20081101083T
Other languages
English (en)
Inventor
Jens Pohl
Rolf Bechtold
Michael Kruse
Original Assignee
Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh filed Critical Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh
Publication of CY1108386T1 publication Critical patent/CY1108386T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Indole Compounds (AREA)
  • Prostheses (AREA)
  • Peptides Or Proteins (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)

Abstract

Η παρούσα εφεύρεση αφορά οστεοεπαγωγικά υλικά που περιλαμβάνουν υλικά μήτρας με μορφογενετική πρωτεΐνη(-ες) απορροφημένη επί εσωτερικών ή εξωτερικών επιφανειών αυτού του υλικού μήτρας, όπου το οστεοεπαγωγικό υλικό λαμβάνεται με επαφή του υλικού μήτρας και της μορφογενετικής πρωτεΐνης(-ών) κάτω από συνθήκες pΗ και ιονικής συγκέντρωσης για να διατηρείται η πρωτεΐνη σταθερή και διαλελυμένη σε ένα διάλυμα μέχρις ότου ξηραθεί και επιτρέποντας με τον τρόπο αυτό το υλικό της μήτρας να καθίσταται ομοιόμορφα επικαλυμμένο με τη μορφογενετική πρωτεΐνη(-ες).
CY20081101083T 2003-03-28 2008-09-30 Βελτιωμενα οστεοεπαγωγικα υλικα CY1108386T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03007141A EP1462126A1 (en) 2003-03-28 2003-03-28 Improved Osteoinductive Materials
EP04723595A EP1608414B1 (en) 2003-03-28 2004-03-26 Improved osteoinductive materials

Publications (1)

Publication Number Publication Date
CY1108386T1 true CY1108386T1 (el) 2014-02-12

Family

ID=32798932

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101083T CY1108386T1 (el) 2003-03-28 2008-09-30 Βελτιωμενα οστεοεπαγωγικα υλικα

Country Status (14)

Country Link
US (2) US7485617B1 (el)
EP (2) EP1462126A1 (el)
JP (1) JP4863868B2 (el)
AT (1) ATE400308T1 (el)
AU (1) AU2004224768B2 (el)
CA (1) CA2519174C (el)
CY (1) CY1108386T1 (el)
DE (1) DE602004014913D1 (el)
DK (1) DK1608414T3 (el)
ES (1) ES2305757T3 (el)
PL (1) PL1608414T3 (el)
PT (1) PT1608414E (el)
SI (1) SI1608414T1 (el)
WO (1) WO2004084965A2 (el)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
AU2003209071B2 (en) * 2002-02-08 2008-08-14 The University Of Erlangen-Nuremberg Formulation comprising bioactive agents and method of using same
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
EP1462126A1 (en) * 2003-03-28 2004-09-29 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Improved Osteoinductive Materials
EP1880731A1 (en) * 2006-07-18 2008-01-23 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Human growth and differentiation factor GDF-5
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
DE102006060958A1 (de) 2006-12-20 2008-06-26 Jennissen, Herbert P., Prof. Dr. Verfahren zur Herstellung einer Polymermatrix, daraus bestehende Implantate sowie deren Verwendung
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
ES2402672T3 (es) * 2007-01-25 2013-05-07 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Uso del GDF-5 para el mejoramiento o el mantenimiento del aspecto dérmico
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
EP2187932B1 (en) 2007-08-07 2015-01-28 DePuy Synthes Products, LLC Protein formulations comprising gdf-5 in aqueous acidic solution
DE102007051914A1 (de) * 2007-10-29 2009-05-07 Herbert Prof. Dr. Jennissen Verfahren zur Herstellung von mit Wachstumsfaktoren beladenen Partikeln sowie die so erhaltenen Partikel
CN102026619A (zh) 2008-04-14 2011-04-20 先进科技及再生医学有限责任公司 液体缓冲的gdf-5制剂
WO2010098421A1 (ja) * 2009-02-27 2010-09-02 株式会社オステオファーマ 改善された保存安定性を有する組換えヒト骨形成蛋白質
US8680182B2 (en) 2009-06-04 2014-03-25 Clemson University Research Foundation Methods for promoting the revascularization and reenervation of CNS lesions
US8609409B2 (en) 2009-06-04 2013-12-17 Clemson University Methods and compositions for cell culture platform
AU2011284657B2 (en) 2010-07-30 2013-11-14 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Drug delivery devices and growth factor formulations for accelerated wound healing
AU2011329054B2 (en) 2010-11-15 2015-05-28 Zimmer Orthobiologics, Inc. Bone void fillers
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
EP2537538A1 (en) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbable Wound Dressing
KR20170091741A (ko) 2014-12-09 2017-08-09 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 신종 상처 치료기구
US11324806B2 (en) * 2018-10-19 2022-05-10 Warsaw Orthopedic, Inc. Sustained delivery of a growth differentiation factor
CN111803718B (zh) * 2020-07-02 2022-02-25 西安交通大学医学院第二附属医院 一种抗纤维化药物缓释涂层及其制备方法
CN114432502B (zh) * 2021-12-31 2023-02-03 中山大学附属第八医院（深圳福田） 一种负载op3-4多肽、抗cxcl9抗体的水凝胶及其制备方法与应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121043A1 (de) * 1991-06-26 1993-01-07 Merck Patent Gmbh Knochenersatzmaterial mit fgf
CA2093836A1 (en) * 1992-04-24 1993-10-25 Wayne Gombotz Biodegradable tgf-.beta. delivery system for bone regeneration
CA2151486A1 (en) * 1993-01-12 1994-07-21 Arthur J. Ammann Tgf-beta formulation for inducing bone growth
JPH0788174A (ja) * 1993-09-28 1995-04-04 Yamanouchi Pharmaceut Co Ltd 骨形成用移植体
EP1074620A1 (en) * 1999-08-06 2001-02-07 HyGene AG Monomeric protein of the TGF-beta family
JPH10243996A (ja) * 1997-03-07 1998-09-14 Kagaku Gijutsu Shinko Jigyodan 硬組織石灰化促進用生体材料
EP1161201A4 (en) * 1999-02-16 2006-07-19 Zimmer Orthobiologics Inc DEVICE AND METHOD FOR REGENERATING AND RESTORING CARTILAGE DEFECTS
EP1339437B1 (en) * 2000-12-06 2004-07-28 Astra Tech AB Medical prosthetic devices and implants coated with metal hydrides and biomolecules having improved biocompatibility
AU2002308204B9 (en) * 2001-11-19 2008-06-12 Scil Technology Gmbh Device having osteoinductive and osteoconductive properties
EP1462126A1 (en) * 2003-03-28 2004-09-29 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Improved Osteoinductive Materials

Also Published As

Publication number Publication date
SI1608414T1 (sl) 2008-10-31
EP1462126A1 (en) 2004-09-29
DK1608414T3 (da) 2008-11-10
ATE400308T1 (de) 2008-07-15
JP4863868B2 (ja) 2012-01-25
WO2004084965A3 (en) 2004-11-25
US7485617B1 (en) 2009-02-03
EP1608414B1 (en) 2008-07-09
US20090155366A1 (en) 2009-06-18
AU2004224768A1 (en) 2004-10-07
PL1608414T3 (pl) 2009-02-27
JP2006521135A (ja) 2006-09-21
AU2004224768B2 (en) 2008-05-22
ES2305757T3 (es) 2008-11-01
PT1608414E (pt) 2008-10-21
DE602004014913D1 (de) 2008-08-21
US8163694B2 (en) 2012-04-24
CA2519174C (en) 2012-05-15
CA2519174A1 (en) 2004-10-07
WO2004084965A2 (en) 2004-10-07
EP1608414A2 (en) 2005-12-28

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