CY1108382T1 - Συνθεσεις και μεθοδοι για σταθεροποιηση βιολογικων μοριων κατα την λυοφιληση - Google Patents

Συνθεσεις και μεθοδοι για σταθεροποιηση βιολογικων μοριων κατα την λυοφιληση

Info

Publication number
CY1108382T1
CY1108382T1 CY20081101074T CY081101074T CY1108382T1 CY 1108382 T1 CY1108382 T1 CY 1108382T1 CY 20081101074 T CY20081101074 T CY 20081101074T CY 081101074 T CY081101074 T CY 081101074T CY 1108382 T1 CY1108382 T1 CY 1108382T1
Authority
CY
Cyprus
Prior art keywords
biological molecules
compositions
methods
molecules during
during lyophilization
Prior art date
Application number
CY20081101074T
Other languages
English (en)
Inventor
Irina Esikova
Sidney Wolfe
James Thomson
Hora Maninder
Original Assignee
Novartis Vaccines And Diagnostics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22611688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1108382(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Vaccines And Diagnostics, Inc. filed Critical Novartis Vaccines And Diagnostics, Inc.
Publication of CY1108382T1 publication Critical patent/CY1108382T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεση απευθύνεται σε συνθέσεις και μεθόδους για την παρασκευή βιολογικών μορίων, συγκεκριμένα MenC-CRM 197. Βιολογικά μόρια διαλυμένα σε ρυθμιστικό διάλυμα διάλυσης που περιλαμβάνει τουλάχιστον ένα άμορφο έκδοχο και τουλάχιστον ένα άμορφο ρυθμιστικό διάλυμα δείχνουν μειωμένη συσσωμάτωση και πρωτεολυτική διάσπαση.
CY20081101074T 1999-12-02 2008-09-30 Συνθεσεις και μεθοδοι για σταθεροποιηση βιολογικων μοριων κατα την λυοφιληση CY1108382T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16848699P 1999-12-02 1999-12-02
EP00992589A EP1233784B1 (en) 1999-12-02 2000-12-01 Compositions and methods for stabilizing biological molecules upon lyophilization

Publications (1)

Publication Number Publication Date
CY1108382T1 true CY1108382T1 (el) 2014-02-12

Family

ID=22611688

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101074T CY1108382T1 (el) 1999-12-02 2008-09-30 Συνθεσεις και μεθοδοι για σταθεροποιηση βιολογικων μοριων κατα την λυοφιληση

Country Status (10)

Country Link
EP (2) EP2292263A3 (el)
JP (2) JP4948731B2 (el)
AT (1) ATE400296T1 (el)
CA (1) CA2393298C (el)
CY (1) CY1108382T1 (el)
DE (1) DE60039450D1 (el)
DK (1) DK1233784T3 (el)
ES (1) ES2307553T3 (el)
PT (1) PT1233784E (el)
WO (1) WO2001041800A2 (el)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE400296T1 (de) 1999-12-02 2008-07-15 Novartis Vaccines & Diagnostic Zusammensetzungen und methoden zur stabilisierung von biologischen molekülen nach lyophilisierung
PL226184B1 (pl) 2001-01-23 2017-06-30 Aventis Pasteur Poliwalentna sprzezona szczepionka meningokokowa polisacharyd- bialko
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
WO2003009869A1 (en) * 2001-07-26 2003-02-06 Chiron Srl. Vaccines comprising aluminium adjuvants and histidine
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
US7927858B2 (en) 2002-11-01 2011-04-19 Glaxosmithkline Biologicals, S.A. Drying process
EP2172213B1 (en) 2003-01-30 2013-04-03 Novartis AG Injectable vaccines against multiple meningococcal serogroups
EP1651275A1 (en) * 2003-08-05 2006-05-03 Fuji Photo Film B.V. Use of recombinant or synthetic gelatin-like proteins as stabiliser in lyophilized pharmaceutical compositions
EP1675869B1 (en) 2003-10-23 2012-02-15 Novartis Vaccines and Diagnostics, Inc. Stabilised compositions
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
GB0409745D0 (en) 2004-04-30 2004-06-09 Chiron Srl Compositions including unconjugated carrier proteins
KR20130122810A (ko) 2005-06-27 2013-11-08 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신 제조 방법
ES2670231T3 (es) 2006-03-22 2018-05-29 Glaxosmithkline Biologicals S.A. Regímenes para inmunización con conjugados meningocócicos
US10828361B2 (en) 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
TW200806315A (en) * 2006-04-26 2008-02-01 Wyeth Corp Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
TW201009337A (en) * 2008-05-30 2010-03-01 Intervet Int Bv Analytical method to monitor vaccine potency and stability
CN104740631B (zh) * 2008-10-29 2019-04-16 阿布林克斯公司 单域抗原结合性分子的制剂
EP2346900A1 (en) 2008-10-29 2011-07-27 Wyeth LLC Methods for purification of single domain antigen binding molecules
EP2575870B1 (en) 2010-06-04 2016-12-07 Wyeth LLC Vaccine formulations
EP3246044B2 (en) 2010-08-23 2024-04-10 Wyeth LLC Stable formulations of neisseria meningitidis rlp2086 antigens
ES2864635T3 (es) 2010-09-10 2021-10-14 Wyeth Llc Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis
JP6191082B2 (ja) 2011-03-02 2017-09-06 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム より低用量の抗原および／またはアジュバントを有する混合ワクチン
EP2716661B1 (en) * 2011-06-01 2018-03-07 Xiamen University Fusion protein comprising diphtheria toxin non-toxic mutant crm197 or fragment thereof
US20150044251A1 (en) * 2011-12-23 2015-02-12 Novartis Ag Stable compositions for immunising against staphylococcus aureus
US9283270B2 (en) 2012-01-20 2016-03-15 Serum Institute Of India Ltd. Method for stabilization of biological molecules
US20150125486A1 (en) 2012-03-08 2015-05-07 Novartis Ag Adjuvanted formulations of pediatric antigens
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
MY167723A (en) 2012-03-09 2018-09-21 Pfizer Neisseria meningitidis compositions and methods thereof
WO2013181348A1 (en) * 2012-05-30 2013-12-05 The Brigham And Women's Hospital, Inc. Polysaccharide compositions and methods of use
WO2014005103A2 (en) * 2012-06-28 2014-01-03 Ansun Biopharma, Inc. Microparticle formulations for delivery to the lower and central respiratory tract and methods of manufacture
CN104487086B (zh) * 2012-07-07 2019-08-30 巴拉特生物技术国际有限公司 无动物源的不含酒精的疫苗组合物及其制备方法
AU2013311702A1 (en) 2012-09-06 2015-02-19 Novartis Ag Combination vaccines with serogroup B meningococcus and D/T/P
ES2848048T3 (es) 2012-10-03 2021-08-05 Glaxosmithkline Biologicals Sa Composiciones inmunogénicas
BR112015014250A2 (pt) 2012-12-18 2017-07-11 Glaxosmithkline Biologicals Sa método para imunizar um bebê, vacina de combinação e, kit
ES2685894T3 (es) 2013-03-08 2018-10-15 Pfizer Inc. Polipéptidos de fusión inmunogénicos
WO2015033251A2 (en) 2013-09-08 2015-03-12 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
KR20190049940A (ko) 2015-02-19 2019-05-09 화이자 인코포레이티드 나이세리아 메닌지티디스 조성물 및 그의 방법
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CA3117867A1 (en) 2018-11-06 2020-05-14 Glaxosmithkline Biologicals Sa Immunogenic compositions
GB202208089D0 (en) * 2022-06-01 2022-07-13 Glaxosmithkline Biologicals Sa Immunogenic composition

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9422096D0 (en) * 1994-11-02 1994-12-21 Biocine Spa Combined meningitis vaccine
AU716785B2 (en) * 1995-07-27 2000-03-09 Genentech Inc. Stabile isotonic lyophilized protein formulation
ATE400296T1 (de) 1999-12-02 2008-07-15 Novartis Vaccines & Diagnostic Zusammensetzungen und methoden zur stabilisierung von biologischen molekülen nach lyophilisierung

Also Published As

Publication number Publication date
JP2011137047A (ja) 2011-07-14
PT1233784E (pt) 2008-11-03
DE60039450D1 (de) 2008-08-21
WO2001041800A3 (en) 2002-01-03
ES2307553T3 (es) 2008-12-01
WO2001041800A2 (en) 2001-06-14
JP4948731B2 (ja) 2012-06-06
EP2292263A3 (en) 2011-07-27
CA2393298C (en) 2011-02-01
DK1233784T3 (da) 2008-09-01
EP1233784A2 (en) 2002-08-28
CA2393298A1 (en) 2001-06-14
ATE400296T1 (de) 2008-07-15
EP1233784B1 (en) 2008-07-09
JP2003516361A (ja) 2003-05-13
WO2001041800A9 (en) 2002-08-01
EP2292263A2 (en) 2011-03-09

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