CY1107818T1 - Hiv-1 tat, ή παραγωγα αυτου για προφυλακτικο και θεραπευτικο εμβολιασμο - Google Patents

Hiv-1 tat, ή παραγωγα αυτου για προφυλακτικο και θεραπευτικο εμβολιασμο

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Publication number
CY1107818T1
CY1107818T1 CY20071101530T CY071101530T CY1107818T1 CY 1107818 T1 CY1107818 T1 CY 1107818T1 CY 20071101530 T CY20071101530 T CY 20071101530T CY 071101530 T CY071101530 T CY 071101530T CY 1107818 T1 CY1107818 T1 CY 1107818T1
Authority
CY
Cyprus
Prior art keywords
tat
hiv
nef
gag
rev
Prior art date
Application number
CY20071101530T
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English (en)
Inventor
Barbara Ensoli
Original Assignee
Istituto Superiore di Sanità
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Istituto Superiore di Sanità filed Critical Istituto Superiore di Sanità
Publication of CY1107818T1 publication Critical patent/CY1107818T1/el

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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/46—Cellular immunotherapy
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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Abstract

Η παρούσα εφεύρεση αφορά Tat σαν το δραστικό συστατικό για ένα προφυλακτικό ή/και θεραπευτικό εμβόλιο έναντι μόλυνσης HIV, τη πρόοδο προς AIDS και την ανάπτυξη όγκων και άλλων συνδρόμων και συμπτωμάτων σε υποκείμενα μολυσμένα με HIV. To Tat είναι μία βιολογικώς δραστική μορφή είτε ως ανασυνδυασμένη πρωτεΐνη, είτε πεπτίδιο, είτε ως DNA. Ειδικότερα, η εφεύρεση αφορά ένα εμβόλιο που βασίζεται επί HIV-1 Tat σαν ανοσογόνο, που εμβολιάζεται σαν DNA ή/και ανασυνδυασμένη πρωτεΐνη ή σαν πεπτίδια, μόνα ή σε συνδυασμό με άλλα γονίδια ή ιϊκά γονιδιακά προϊόντα (Nef, Rev, Gag) ή τμήματα αυτών ή σε συνδυασμό με διάφορες άνοσο ρυθμιστικές κυτοκίνες (IL-12, IL-15) ή με το γονίδιο που κωδικοποιεί μία άνοσο ρυθμιστική κυτοκίνη ή τμήμα αυτής. Tat, Nef, Rev, Gag και άνοσο ρυθμιστικές κυτοκίνες χορηγούνται τόσο σαν ένα μίγμα ανασυνδυασμένων πρωτεϊνών, πεπτιδίων ή πρωτεϊνών σύντηξης (Tat/Nef, Tat/Rev, Tat/Gag, Tat/IL-12, Tat/IL-15) όσο ως πλασμίδιο DNA.
CY20071101530T 1997-12-01 2007-11-29 Hiv-1 tat, ή παραγωγα αυτου για προφυλακτικο και θεραπευτικο εμβολιασμο CY1107818T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97RM000743A IT1297090B1 (it) 1997-12-01 1997-12-01 Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le
EP98966601A EP1035865B1 (en) 1997-12-01 1998-11-30 Hiv-1 tat, or derivatives thereof for prophylactic and therapeutic vaccination

Publications (1)

Publication Number Publication Date
CY1107818T1 true CY1107818T1 (el) 2013-06-19

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CY20071101530T CY1107818T1 (el) 1997-12-01 2007-11-29 Hiv-1 tat, ή παραγωγα αυτου για προφυλακτικο και θεραπευτικο εμβολιασμο

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US (2) US7744896B1 (el)
EP (2) EP1698347A3 (el)
JP (1) JP2001524531A (el)
CN (1) CN1283121A (el)
AP (1) AP2000001828A0 (el)
AT (1) ATE374041T1 (el)
AU (1) AU762893B2 (el)
BR (1) BR9814725A (el)
CA (1) CA2311647C (el)
CU (1) CU20000126A7 (el)
CY (1) CY1107818T1 (el)
DE (1) DE69838486T2 (el)
DK (1) DK1035865T3 (el)
EA (1) EA004330B1 (el)
ES (1) ES2293700T3 (el)
IL (1) IL136372A0 (el)
IT (1) IT1297090B1 (el)
NZ (1) NZ505373A (el)
OA (1) OA11419A (el)
PL (1) PL341818A1 (el)
PT (1) PT1035865E (el)
TR (1) TR200001553T2 (el)
WO (1) WO1999027958A2 (el)

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WO1999027958A9 (en) 1999-09-10
EA200000596A1 (ru) 2000-12-25
OA11419A (en) 2004-04-21
AU2412699A (en) 1999-06-16
CA2311647C (en) 2013-03-19
ITRM970743A1 (it) 1999-06-01
AU762893B2 (en) 2003-07-10
NZ505373A (en) 2003-07-25
IL136372A0 (en) 2001-06-14
CA2311647A1 (en) 1999-06-10
AP2000001828A0 (en) 2000-06-30
ES2293700T3 (es) 2008-03-16
EA004330B1 (ru) 2004-04-29
EP1698347A2 (en) 2006-09-06
DK1035865T3 (da) 2008-02-04
CU20000126A7 (es) 2005-10-19
DE69838486D1 (de) 2007-11-08
EP1035865B1 (en) 2007-09-26
EP1698347A3 (en) 2006-12-20
WO1999027958A2 (en) 1999-06-10
TR200001553T2 (tr) 2000-11-21
CN1283121A (zh) 2001-02-07
IT1297090B1 (it) 1999-08-03
US8197820B2 (en) 2012-06-12
JP2001524531A (ja) 2001-12-04
US7744896B1 (en) 2010-06-29
EP1035865A2 (en) 2000-09-20
PL341818A1 (en) 2001-05-07
DE69838486T2 (de) 2008-06-26
PT1035865E (pt) 2007-12-07
US20100015087A1 (en) 2010-01-21
ATE374041T1 (de) 2007-10-15
WO1999027958A3 (en) 1999-07-22

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