CY1107083T1 - Συνδετηρες για ρυθμιση της εκφρασης εξωγενων γονιδιων μεσω συμπλοκου υποδοχεα εκδυζονης - Google Patents

Συνδετηρες για ρυθμιση της εκφρασης εξωγενων γονιδιων μεσω συμπλοκου υποδοχεα εκδυζονης

Info

Publication number
CY1107083T1
CY1107083T1 CY20071101577T CY071101577T CY1107083T1 CY 1107083 T1 CY1107083 T1 CY 1107083T1 CY 20071101577 T CY20071101577 T CY 20071101577T CY 071101577 T CY071101577 T CY 071101577T CY 1107083 T1 CY1107083 T1 CY 1107083T1
Authority
CY
Cyprus
Prior art keywords
gene expression
receptors
connectors
response element
ligand
Prior art date
Application number
CY20071101577T
Other languages
English (en)
Inventor
Glenn Richard Carlson
Dean Ervin Cress
Tarlochan Singh Dhadialla
Robert Eugene Hormann
Dat Phat Le
Original Assignee
Intrexon Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corporation filed Critical Intrexon Corporation
Publication of CY1107083T1 publication Critical patent/CY1107083T1/el

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18Ethylenedioxybenzenes, not substituted on the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση αυτή αφορά μία βελτιωμένη μέθοδο για ρύθμιση έκφρασης εξωγενούς γονιδίου όπου ένα σύμπλοκο υποδοχέα εκδυζόνης που περιλαμβάνει : ένα πεδίο σύνδεσης DNA, πεδίο σύνδεσης συνδετήρα, πεδίο μετενεργοποίησης και ένας συνδετήρας φέρεται σε επαφή με ένα DNA κατασκεύασμα που περιλαμβάνει : το εξωγενές γονίδιο και ένα στοιχείο απόκρισης όπου το εξωγενές γονίδιο είναι κάτω από τον έλεγχο του στοιχείου απόκρισης και σύνδεση του πεδίου σύνδεσης DNA προς το στοιχείο απόκρισης παρουσία του συνδετήρα έχει σαν αποτέλεσμα ενεργοποίηση ή καταστολή του γονιδίου. Η βελτίωση βασίζεται σε μία ομάδα επιλογής μη-στεροειδών συνδετήρων που δείχνουν βελτιωμένη δραστικότητα έναντι γνωστών συνδετήρων.
CY20071101577T 1998-06-17 2007-12-12 Συνδετηρες για ρυθμιση της εκφρασης εξωγενων γονιδιων μεσω συμπλοκου υποδοχεα εκδυζονης CY1107083T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8954698P 1998-06-17 1998-06-17
US09/315,451 US6258603B1 (en) 1998-06-17 1999-05-02 Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
EP99304444A EP0965644B1 (en) 1998-06-17 1999-06-08 Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex

Publications (1)

Publication Number Publication Date
CY1107083T1 true CY1107083T1 (el) 2012-10-24

Family

ID=26780689

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101577T CY1107083T1 (el) 1998-06-17 2007-12-12 Συνδετηρες για ρυθμιση της εκφρασης εξωγενων γονιδιων μεσω συμπλοκου υποδοχεα εκδυζονης

Country Status (14)

Country Link
US (2) US6258603B1 (el)
EP (1) EP0965644B1 (el)
JP (1) JP4537512B2 (el)
KR (1) KR100563143B1 (el)
CN (1) CN1296480C (el)
AT (1) ATE378414T1 (el)
AU (1) AU765306B2 (el)
BR (1) BR9902283A (el)
CY (1) CY1107083T1 (el)
DE (1) DE69937519T2 (el)
DK (1) DK0965644T3 (el)
ES (1) ES2296370T3 (el)
PT (1) PT965644E (el)
TW (1) TWI224109B (el)

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Also Published As

Publication number Publication date
ATE378414T1 (de) 2007-11-15
KR100563143B1 (ko) 2006-03-22
BR9902283A (pt) 2000-05-02
DK0965644T3 (da) 2008-01-28
ES2296370T3 (es) 2008-04-16
EP0965644A3 (en) 2004-01-07
US6258603B1 (en) 2001-07-10
KR20000006256A (ko) 2000-01-25
CN1296480C (zh) 2007-01-24
EP0965644A2 (en) 1999-12-22
AU3390099A (en) 2000-02-10
EP0965644B1 (en) 2007-11-14
JP2000037189A (ja) 2000-02-08
TWI224109B (en) 2004-11-21
JP4537512B2 (ja) 2010-09-01
DE69937519D1 (de) 2007-12-27
PT965644E (pt) 2007-12-03
US20010044151A1 (en) 2001-11-22
DE69937519T2 (de) 2008-09-04
CN1251389A (zh) 2000-04-26
AU765306B2 (en) 2003-09-18

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