WO1999019513A3 - Methods for detecting compounds which modulate the activity of an lpa receptor - Google Patents

Methods for detecting compounds which modulate the activity of an lpa receptor Download PDF

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Publication number
WO1999019513A3
WO1999019513A3 PCT/US1998/021315 US9821315W WO9919513A3 WO 1999019513 A3 WO1999019513 A3 WO 1999019513A3 US 9821315 W US9821315 W US 9821315W WO 9919513 A3 WO9919513 A3 WO 9919513A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulate
activity
methods
lpa receptor
detecting compounds
Prior art date
Application number
PCT/US1998/021315
Other languages
French (fr)
Other versions
WO1999019513A2 (en
Inventor
James Erikson
J Graham Goddard
Michael Kiefer
Original Assignee
Lxr Biotechnology Inc
James Erikson
J Graham Goddard
Michael Kiefer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lxr Biotechnology Inc, James Erikson, J Graham Goddard, Michael Kiefer filed Critical Lxr Biotechnology Inc
Priority to AU97945/98A priority Critical patent/AU9794598A/en
Publication of WO1999019513A2 publication Critical patent/WO1999019513A2/en
Publication of WO1999019513A3 publication Critical patent/WO1999019513A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides novel methods for identifying and characterizing compounds that modulate the activity of an LPA receptor.
PCT/US1998/021315 1997-10-10 1998-10-09 Methods for detecting compounds which modulate the activity of an lpa receptor WO1999019513A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU97945/98A AU9794598A (en) 1997-10-10 1998-10-09 Methods for detecting compounds which modulate the activity of an lpa receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6157297P 1997-10-10 1997-10-10
US60/061,572 1997-10-10

Publications (2)

Publication Number Publication Date
WO1999019513A2 WO1999019513A2 (en) 1999-04-22
WO1999019513A3 true WO1999019513A3 (en) 1999-08-05

Family

ID=22036653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/021315 WO1999019513A2 (en) 1997-10-10 1998-10-09 Methods for detecting compounds which modulate the activity of an lpa receptor

Country Status (2)

Country Link
AU (1) AU9794598A (en)
WO (1) WO1999019513A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037146A (en) * 1997-01-28 2000-03-14 Smithkline Beecham Corporation CDNA clone HE8CH90 that encodes a novel 7-transmembrane receptor
JP2002512016A (en) * 1998-04-23 2002-04-23 スミスクライン ビーチャム コーポレーション EDG family gene, human H218
US6380177B1 (en) 1999-06-25 2002-04-30 Atairgin Technologies, Inc. LPA analogs as agonists of the Edg2 LPA receptor
SE9902763D0 (en) * 1999-07-21 1999-07-21 Astra Pharma Inc Novel receptor
AU7057700A (en) * 1999-08-18 2001-03-13 Atairgin Technologies, Inc. Compounds which modulate the activity of an lpa receptor
GB9923890D0 (en) * 1999-10-08 1999-12-08 Pfizer Ltd Novel polypeptide
AU784543B2 (en) * 1999-11-16 2006-04-27 Pharmacia & Upjohn Company Novel G protein-coupled receptors
US20010041355A1 (en) * 2000-03-24 2001-11-15 Shyam Ramakrishnan Regulation of human nerve growth factor-related G protein-coupled receptor
WO2001073021A1 (en) * 2000-03-28 2001-10-04 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor protein and dna thereof
EP1178110A1 (en) * 2000-08-01 2002-02-06 Aventis Pharma Deutschland GmbH EDG8 receptor for sphingosine 1-phosphate , its preparation and use
MXPA02010241A (en) * 2000-04-26 2004-09-06 Aventis Pharma Gmbh Edg8 receptor, its preparation and use.
EP1149907A1 (en) * 2000-04-26 2001-10-31 Aventis Pharma Deutschland GmbH EDG8 receptor, its preparation and use
AU2001284732A1 (en) * 2000-08-04 2002-02-18 Genaissance Pharmaceuticals, Inc. Haplotypes of the edg4 gene
US7521192B2 (en) 2001-04-18 2009-04-21 Rigel Pharmaceuticals, Inc. EDG: modulators of lymphocyte activation and migration
EP1490111A2 (en) * 2001-11-30 2004-12-29 Solvay Pharmaceuticals GmbH Edg-receptor agonists for the treatment of hypertension
AU2003233119A1 (en) * 2002-05-08 2003-11-11 Neuronova Ab Modulation of neural stem cells with s1p or lpa receptor agonists
AU2003246726A1 (en) * 2002-07-31 2004-02-23 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human g-protein coupled receptor 45 (gpr45)
EP1418185A1 (en) * 2002-11-11 2004-05-12 Aventis Pharma Deutschland GmbH Use of EDG2 receptor in an animal model of heart failure
US7169612B2 (en) 2002-11-11 2007-01-30 Sanofi-Aventis Deutschland Gmbh Use of EDG2 receptor in an animal model of heart failure
EP1579866A4 (en) * 2002-12-12 2009-07-29 Takeda Pharmaceutical Novel use of edg receptors
BR112012006686B8 (en) 2009-09-25 2021-05-25 Astellas Pharma Inc substituted amide compounds, pharmaceutical compositions containing said compounds, and their use to prevent and/or treat diseases caused by Lpa
MX2013003345A (en) 2010-09-24 2013-06-24 Astellas Pharma Inc Substituted amide compound.

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021925A1 (en) * 1994-02-14 1995-08-17 American Cyanamid Company Heterologous g protein coupled receptors expressed in yeast, their fusion with g proteins and use thereof in bioassay
WO1995030012A1 (en) * 1994-04-26 1995-11-09 Cadus Pharmaceutical Corporation Functional expression of mammalian adenylyl cyclase in yeast
US5482835A (en) * 1990-09-13 1996-01-09 Duke University Methods of testing in yeast cells for agonists and antagonists of mammal G-protein coupled receptors
WO1997000952A2 (en) * 1995-06-20 1997-01-09 Incyte Pharmaceuticals, Inc. A human edg-2 receptor homolog
WO1997011159A1 (en) * 1995-09-20 1997-03-27 Molecular Geriatrics Corporation Yeast receptor and g-protein fusion protein
CA2199455A1 (en) * 1997-03-07 1998-09-07 Jerold J. M. Chun Cloned lysophosphatidic acid receptors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482835A (en) * 1990-09-13 1996-01-09 Duke University Methods of testing in yeast cells for agonists and antagonists of mammal G-protein coupled receptors
WO1995021925A1 (en) * 1994-02-14 1995-08-17 American Cyanamid Company Heterologous g protein coupled receptors expressed in yeast, their fusion with g proteins and use thereof in bioassay
WO1995030012A1 (en) * 1994-04-26 1995-11-09 Cadus Pharmaceutical Corporation Functional expression of mammalian adenylyl cyclase in yeast
WO1997000952A2 (en) * 1995-06-20 1997-01-09 Incyte Pharmaceuticals, Inc. A human edg-2 receptor homolog
WO1997011159A1 (en) * 1995-09-20 1997-03-27 Molecular Geriatrics Corporation Yeast receptor and g-protein fusion protein
CA2199455A1 (en) * 1997-03-07 1998-09-07 Jerold J. M. Chun Cloned lysophosphatidic acid receptors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AN S ET AL: "MOLECULAR CLONING OF THE HUMAN EDG2 PROTEIN AND ITS IDENTIFICATION AS A FUNCTIONAL CELLULAR RECEPTOR FOR LYSOPHOSPHATIDIC ACID", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 231, no. 3, 24 February 1997 (1997-02-24), pages 619 - 622, XP002046899 *
HECHT J H ET AL: "VENTRICULAR ZONE GENE-1 (VZG-1) ENCODES A LYSOPHOSPHATIDIC ACID RECEPTOR EXPRESSED IN NEUROGENIC REGIONS OF THE DEVELOPING CEREBRALCORTEX", THE JOURNAL OF CELL BIOLOGY, vol. 135, no. 4, 1 November 1996 (1996-11-01), pages 1071 - 1083, XP002046888 *

Also Published As

Publication number Publication date
AU9794598A (en) 1999-05-03
WO1999019513A2 (en) 1999-04-22

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