CY1106991T1 - Αντιπολλαπλασιαστικη δραση ολιγονουκλεοτιδιων πλουσιων σε g και μεθοδος χρησιμοποιησης αυτων για την προσδεση σε νουκλεολινη - Google Patents

Αντιπολλαπλασιαστικη δραση ολιγονουκλεοτιδιων πλουσιων σε g και μεθοδος χρησιμοποιησης αυτων για την προσδεση σε νουκλεολινη

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Publication number
CY1106991T1
CY1106991T1 CY20071101441T CY071101441T CY1106991T1 CY 1106991 T1 CY1106991 T1 CY 1106991T1 CY 20071101441 T CY20071101441 T CY 20071101441T CY 071101441 T CY071101441 T CY 071101441T CY 1106991 T1 CY1106991 T1 CY 1106991T1
Authority
CY
Cyprus
Prior art keywords
antipliplaspulating
properties
cells
nucleolin
proliferation
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Application number
CY20071101441T
Other languages
English (en)
Inventor
Donald M Miller
Paula J Bates
John O Trent
Original Assignee
Antisoma Research Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antisoma Research Limited filed Critical Antisoma Research Limited
Publication of CY1106991T1 publication Critical patent/CY1106991T1/el

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
    • C12N2310/151—Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει μία μέθοδο για την αναστολή του πολλαπλασιασμού κακοηθών και/ή υπερπλαστικών κυττάρων σε ένα υποκείμενο χορηγώντας στο υποκείμενο μία θεραπευτικώς αποτελεσματική ποσότητα ενός πλούσιου σε γουανοσίνη ολιγονουκλεοτιδίου. Η παρούσα εφεύρεση επίσης παρέχει ολιγονουκλεοτίδια που είναι ικανά να προσδένονται ειδικά σε μία ειδική κυτταρική πρωτεΐνη που είναι νουκλεολίνη και/ή έχει φύση προσομοιάζουσα νουκλεολίνη, που ενέχεται στον πολλαπλασιασμό κυττάρων, συγκεκριμένα κακοηθών και/ή υπερπλαστικών κυττάρων, και μία μέθοδο για την επιλογή τους.
CY20071101441T 1999-04-08 2007-11-08 Αντιπολλαπλασιαστικη δραση ολιγονουκλεοτιδιων πλουσιων σε g και μεθοδος χρησιμοποιησης αυτων για την προσδεση σε νουκλεολινη CY1106991T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12831699P 1999-04-08 1999-04-08
US14982399P 1999-08-19 1999-08-19
EP00921868A EP1181304B1 (en) 1999-04-08 2000-04-07 Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin

Publications (1)

Publication Number Publication Date
CY1106991T1 true CY1106991T1 (el) 2012-09-26

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CY20071101441T CY1106991T1 (el) 1999-04-08 2007-11-08 Αντιπολλαπλασιαστικη δραση ολιγονουκλεοτιδιων πλουσιων σε g και μεθοδος χρησιμοποιησης αυτων για την προσδεση σε νουκλεολινη

Country Status (12)

Country Link
US (2) US7314926B1 (el)
EP (1) EP1181304B1 (el)
JP (1) JP2002541264A (el)
AT (1) ATE375358T1 (el)
AU (1) AU775412B2 (el)
CA (1) CA2370000A1 (el)
CY (1) CY1106991T1 (el)
DE (1) DE60036700T2 (el)
DK (1) DK1181304T3 (el)
ES (1) ES2296615T3 (el)
PT (1) PT1181304E (el)
WO (1) WO2000061597A1 (el)

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WO2000061597A9 (en) 2001-11-29
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US7314926B1 (en) 2008-01-01
WO2000061597A1 (en) 2000-10-19
CA2370000A1 (en) 2000-10-19
EP1181304B1 (en) 2007-10-10
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ATE375358T1 (de) 2007-10-15
EP1181304A1 (en) 2002-02-27
ES2296615T3 (es) 2008-05-01
PT1181304E (pt) 2008-01-23
DK1181304T3 (da) 2008-02-11
AU775412B2 (en) 2004-07-29
US8648051B2 (en) 2014-02-11
US20090326047A1 (en) 2009-12-31

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