BRPI0418463A - métodos de inibir expressão de stat3 humano, de induzir apoptose em células de carcinoma do pulmão, e de inibir crescimento de tumor de linfoma de células t, tumor alcl, e tumor mieloma múltiplo em um animal - Google Patents

métodos de inibir expressão de stat3 humano, de induzir apoptose em células de carcinoma do pulmão, e de inibir crescimento de tumor de linfoma de células t, tumor alcl, e tumor mieloma múltiplo em um animal

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Publication number
BRPI0418463A
BRPI0418463A BRPI0418463-7A BRPI0418463A BRPI0418463A BR PI0418463 A BRPI0418463 A BR PI0418463A BR PI0418463 A BRPI0418463 A BR PI0418463A BR PI0418463 A BRPI0418463 A BR PI0418463A
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Brazil
Prior art keywords
tumor
inhibiting
methods
cell lymphoma
lung carcinoma
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BRPI0418463-7A
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English (en)
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James G Karras
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Isis Pharmaceuticals Inc
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Publication of BRPI0418463A publication Critical patent/BRPI0418463A/pt

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Abstract

MéTODOS DE INIBIR EXPRESSãO DE STAT3 HUMANO, DE INDUZIR APOPTOSE EM CéLULAS DE CARCINOMA DO PULMãO, E DE INIBIR CRESCIMENTO DE TUMOS DE LINFOMA DE CéLULAS T, TUMOR ALCL, E TUMOR MIELOMA MúLTIPLO EM UM ANIMAL Proporciona-se compostos, composições e métodos para inibir a expressão de STAT3 humano. As composições compreendem oligonucleotídeos anti-sentido alvejados para ácidos nucleicos codificando STAT3. Proporciona-se métodos de uso destes oligonucleotídeos para inibição da expressãp de STAT3 e para a promoção de apoptose. Proporciona-se também métodos para tratamento de doenças, particularmente doenças inflamatórias e cânceres, associadas com superexpressão ou ativação constitutiva de STAT3 ou apoptose insuficiente.
BRPI0418463-7A 2004-02-06 2004-09-30 métodos de inibir expressão de stat3 humano, de induzir apoptose em células de carcinoma do pulmão, e de inibir crescimento de tumor de linfoma de células t, tumor alcl, e tumor mieloma múltiplo em um animal BRPI0418463A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/773,678 US7098192B2 (en) 1999-04-08 2004-02-06 Antisense oligonucleotide modulation of STAT3 expression
PCT/US2004/032130 WO2005083124A1 (en) 2004-02-06 2004-09-30 Antisense oligonucleotide modulation of stat3 expression

Publications (1)

Publication Number Publication Date
BRPI0418463A true BRPI0418463A (pt) 2007-06-05

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BRPI0418463-7A BRPI0418463A (pt) 2004-02-06 2004-09-30 métodos de inibir expressão de stat3 humano, de induzir apoptose em células de carcinoma do pulmão, e de inibir crescimento de tumor de linfoma de células t, tumor alcl, e tumor mieloma múltiplo em um animal

Country Status (10)

Country Link
US (5) US7098192B2 (pt)
EP (3) EP2468865B1 (pt)
JP (2) JP2007523074A (pt)
KR (1) KR100809166B1 (pt)
CN (1) CN1914335A (pt)
AU (2) AU2004316504B9 (pt)
BR (1) BRPI0418463A (pt)
CA (1) CA2555245C (pt)
ES (1) ES2521599T3 (pt)
WO (1) WO2005083124A1 (pt)

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