CY1106437T1 - Κατασταλτικα κυτταρα για την προληψη και θepαπεια των ανοσοαποκρισεων σε μεταμοσχευση - Google Patents
Κατασταλτικα κυτταρα για την προληψη και θepαπεια των ανοσοαποκρισεων σε μεταμοσχευσηInfo
- Publication number
- CY1106437T1 CY1106437T1 CY20061100708T CY061100708T CY1106437T1 CY 1106437 T1 CY1106437 T1 CY 1106437T1 CY 20061100708 T CY20061100708 T CY 20061100708T CY 061100708 T CY061100708 T CY 061100708T CY 1106437 T1 CY1106437 T1 CY 1106437T1
- Authority
- CY
- Cyprus
- Prior art keywords
- transplantation
- treatment
- prevention
- suppressor
- immune responses
- Prior art date
Links
- 238000002054 transplantation Methods 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 3
- 230000028993 immune response Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000009329 Graft vs Host Disease Diseases 0.000 abstract 1
- 208000024908 graft versus host disease Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
- C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Μέθοδος για την ελάττωση μιας ανοσοαπόκρισης σε μόσχευμα εντός λήπτη με θεραπεία του εν λόγω λήπτη με μια ποσότητα κατασταλτικών κυττάρων Τ αποτελεσματική ώστε να ελαττώνει ή να παρεμποδίζει την απόρριψη του μοσχεύματος από τον ξενιστή. Τα κατασταλτικά κύτταρα Τ μπορούν να χορηγούνται πριν, ταυτοχρόνως ή μετά το μόσχευμα. Αποκαλύπτεται επίσης μια μέθοδος πρόκλησης ανοσοαπόκρισης από ξένο ιστό έναντι του ξενιστή, δηλαδή της νόσου του μοσχεύματος έναντι του ξενιστή, με θεραπεία με κατασταλτικά κύτταρα Τ.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/415,627 US6685936B2 (en) | 1999-10-12 | 1999-10-12 | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
PCT/US2000/028011 WO2001026470A1 (en) | 1999-10-12 | 2000-10-10 | Suppressor cells for prevention and treatment of immune responses in transplantation |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106437T1 true CY1106437T1 (el) | 2011-10-12 |
Family
ID=23646488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100708T CY1106437T1 (el) | 1999-10-12 | 2006-06-02 | Κατασταλτικα κυτταρα για την προληψη και θepαπεια των ανοσοαποκρισεων σε μεταμοσχευση |
Country Status (12)
Country | Link |
---|---|
US (2) | US6685936B2 (el) |
EP (1) | EP1220611B1 (el) |
JP (1) | JP2003511398A (el) |
AT (1) | ATE319312T1 (el) |
AU (1) | AU775647B2 (el) |
CA (1) | CA2382737A1 (el) |
CY (1) | CY1106437T1 (el) |
DE (1) | DE60026561T2 (el) |
DK (1) | DK1220611T3 (el) |
ES (1) | ES2261250T3 (el) |
PT (1) | PT1220611E (el) |
WO (1) | WO2001026470A1 (el) |
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HUE052516T2 (hu) | 2013-04-12 | 2021-05-28 | Houston Methodist Hospital | Szervek javítása transzplantációhoz |
CN105793411B (zh) | 2013-11-16 | 2018-04-17 | 泰尔茂比司特公司 | 生物反应器中的细胞扩增 |
JP6783143B2 (ja) | 2014-03-25 | 2020-11-11 | テルモ ビーシーティー、インコーポレーテッド | 培地の受動的補充 |
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IL99864A (en) * | 1990-10-31 | 2000-11-21 | Autoimmune Inc | Compositions for suppressing transplant rejection in mammals which contain tissue donor derived MHC antigens |
US5733542A (en) * | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
ES2173085T3 (es) * | 1991-11-05 | 2002-10-16 | Univ Leland Stanford Junior | Celulas supresoras y progenitoras. |
US5738852A (en) * | 1993-04-20 | 1998-04-14 | Solis Therapeutics, Inc. | Methods of enhancing antigen-specific T cell responses |
US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
WO1999047163A2 (en) * | 1998-03-18 | 1999-09-23 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
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1999
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-
2000
- 2000-05-01 US US09/563,768 patent/US6281012B1/en not_active Expired - Lifetime
- 2000-10-10 JP JP2001529270A patent/JP2003511398A/ja active Pending
- 2000-10-10 DE DE60026561T patent/DE60026561T2/de not_active Expired - Lifetime
- 2000-10-10 WO PCT/US2000/028011 patent/WO2001026470A1/en active IP Right Grant
- 2000-10-10 PT PT00972063T patent/PT1220611E/pt unknown
- 2000-10-10 CA CA002382737A patent/CA2382737A1/en not_active Abandoned
- 2000-10-10 ES ES00972063T patent/ES2261250T3/es not_active Expired - Lifetime
- 2000-10-10 EP EP00972063A patent/EP1220611B1/en not_active Expired - Lifetime
- 2000-10-10 AT AT00972063T patent/ATE319312T1/de active
- 2000-10-10 DK DK00972063T patent/DK1220611T3/da active
- 2000-10-10 AU AU10778/01A patent/AU775647B2/en not_active Expired
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2006
- 2006-06-02 CY CY20061100708T patent/CY1106437T1/el unknown
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EP1220611A4 (en) | 2004-12-22 |
WO2001026470A1 (en) | 2001-04-19 |
EP1220611A1 (en) | 2002-07-10 |
ATE319312T1 (de) | 2006-03-15 |
CA2382737A1 (en) | 2001-04-19 |
US6281012B1 (en) | 2001-08-28 |
ES2261250T3 (es) | 2006-11-16 |
DE60026561T2 (de) | 2007-03-15 |
DE60026561D1 (de) | 2006-05-04 |
PT1220611E (pt) | 2006-07-31 |
AU1077801A (en) | 2001-04-23 |
EP1220611B1 (en) | 2006-03-08 |
DK1220611T3 (da) | 2006-07-10 |
US6685936B2 (en) | 2004-02-03 |
JP2003511398A (ja) | 2003-03-25 |
AU775647B2 (en) | 2004-08-12 |
US20020034504A1 (en) | 2002-03-21 |
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