CY1106274T1 - Χρηση πρωτεϊνων συντηξης των οποιων το ν-τελικο τμημα ειναι ενα παραγωγο ιρουδινης για την παραγωγη ανασυνδυασμενων πρωτεϊνων μεσω εκκρισης απο ζυμομυκητα - Google Patents
Χρηση πρωτεϊνων συντηξης των οποιων το ν-τελικο τμημα ειναι ενα παραγωγο ιρουδινης για την παραγωγη ανασυνδυασμενων πρωτεϊνων μεσω εκκρισης απο ζυμομυκηταInfo
- Publication number
- CY1106274T1 CY1106274T1 CY20061101726T CY061101726T CY1106274T1 CY 1106274 T1 CY1106274 T1 CY 1106274T1 CY 20061101726 T CY20061101726 T CY 20061101726T CY 061101726 T CY061101726 T CY 061101726T CY 1106274 T1 CY1106274 T1 CY 1106274T1
- Authority
- CY
- Cyprus
- Prior art keywords
- protein
- hirudin
- dna sequence
- production
- terminal portion
- Prior art date
Links
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical class C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title abstract 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- 108020004705 Codon Proteins 0.000 abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 102000007625 Hirudins Human genes 0.000 abstract 2
- 108010007267 Hirudins Proteins 0.000 abstract 2
- 229940006607 hirudin Drugs 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 101710188306 Protein Y Proteins 0.000 abstract 1
- -1 where m = 1-10 Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Η εφεύρεση αναφέρεται σε μία κασέτα έκφρασης της μορφής Ρx - Sx - Bn -(ZR) - Hir (AsmR) - πρωτεΐνη (Υ) - Τ, στην οποία το Ρx είναι οποιαδήποτε αλληλουχία υποκινητή DNA, επιλεγμένη με τέτοιο τρόπο ώστε να μπορούν να επιτευχθούν οι βέλτιστες αποδόσεις της πρωτεΐνης ενδιαφέροντος, Sx είναι οποιοδήποτε DNA κωδικοποιεί μία αλληλουχία σήματος ή αλληλουχία οδηγό το οποίο επιτρέπει βέλτιστες αποδόσεις, Βn είναι 1-15 κωδικόνια αμινοξέων ή ένας χημικός δεσμός, Ζ είναι το κωδικόνιο ενός αμινοξέος το οποίο επιλέχθηκε από την ομάδα η οποία περιλαμβάνει Lys και Arg, R είναι ένα κωδικόνιο Arg ή ένας χημικός δεσμός, Asm είναι ένας χημικός δεσμός ή m κωδικόνια αμινοξέων, όπου m = 1-10, Hir είναι μία αλληλουχία DNA που κωδικοποιεί για ιρουδίνη ή ένα παράγωγο ιρουδίνης, η οποία είναι τουλάχιστον 40% ομόλογη με την φυσική ιρουδίνη, η πρωτεΐνη Υ είναι μία αλληλουχία DNA που κωδικοποιεί οποιαδήποτε πρωτεΐνη η οποία μπορεί να παραχθεί σε και να εκκριθεί από ζυμομύκητα, Τ είναι μία μη μεταφρασμένη αλληλουχία DNA, η οποία είναι επωφελής στην έκφραση.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10108211A DE10108211A1 (de) | 2001-02-20 | 2001-02-20 | Verwendung von Fusionsproteinen, deren N-terminaler Anteil aus einem Hirudinderivat besteht, zur Herstellung rekombinanter Proteine über Sekretion durch Hefen |
| PCT/EP2002/001308 WO2002070722A1 (en) | 2001-02-20 | 2002-02-08 | Use of fusion proteins whose n-terminal part is a hirudin derivative for the production of recombinant proteins via secretion by yeasts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1106274T1 true CY1106274T1 (el) | 2011-10-12 |
Family
ID=7674912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061101726T CY1106274T1 (el) | 2001-02-20 | 2006-11-30 | Χρηση πρωτεϊνων συντηξης των οποιων το ν-τελικο τμημα ειναι ενα παραγωγο ιρουδινης για την παραγωγη ανασυνδυασμενων πρωτεϊνων μεσω εκκρισης απο ζυμομυκητα |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20030176673A1 (el) |
| EP (1) | EP1364032B1 (el) |
| JP (1) | JP4199543B2 (el) |
| KR (1) | KR100858833B1 (el) |
| CN (1) | CN1279171C (el) |
| AT (1) | ATE342367T1 (el) |
| AU (1) | AU2002250903B2 (el) |
| BR (1) | BR0207379A (el) |
| CA (1) | CA2439042C (el) |
| CY (1) | CY1106274T1 (el) |
| DE (2) | DE10108211A1 (el) |
| DK (1) | DK1364032T3 (el) |
| ES (1) | ES2272696T3 (el) |
| HK (1) | HK1065068A1 (el) |
| IL (2) | IL157416A0 (el) |
| MX (1) | MXPA03007116A (el) |
| NO (1) | NO331376B1 (el) |
| NZ (1) | NZ527642A (el) |
| PE (1) | PE20020857A1 (el) |
| PT (1) | PT1364032E (el) |
| WO (1) | WO2002070722A1 (el) |
| ZA (1) | ZA200305868B (el) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638618B2 (en) * | 2001-02-20 | 2009-12-29 | Sanofi-Aventis Deutschland Gmbh | Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest |
| DE102006031962A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
| DE102006031955A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
| DE102008025007A1 (de) | 2008-05-24 | 2009-11-26 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| DE102008003566A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| EP2229406B1 (de) | 2008-01-09 | 2015-04-22 | Sanofi-Aventis Deutschland GmbH | Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil |
| KR20100111682A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
| PT2349324T (pt) | 2008-10-17 | 2017-12-06 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
| PL2498802T3 (pl) | 2009-11-13 | 2015-06-30 | Sanofi Aventis Deutschland | Kompozycja farmaceutyczna zawierająca agonistę GLP-1, insulinę i metioninę |
| EP2498801B1 (de) | 2009-11-13 | 2018-01-24 | Sanofi-Aventis Deutschland GmbH | HARMAZEUTISCHE ZUSAMMENSETZUNG UMFASSEND desPro36Exendin-4(1-39)-Lys6-NH2 UND METHIONIN |
| EP2611458B1 (en) | 2010-08-30 | 2016-09-21 | Sanofi-Aventis Deutschland GmbH | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| BR112014004726A2 (pt) | 2011-08-29 | 2017-04-04 | Sanofi Aventis Deutschland | combinação farmacêutica para uso no controle glicêmico em pacientes de diabetes tipo 2 |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| EP3229828B1 (en) | 2014-12-12 | 2023-04-05 | Sanofi-Aventis Deutschland GmbH | Insulin glargine/lixisenatide fixed ratio formulation |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5705355A (en) * | 1984-03-27 | 1998-01-06 | Transgene, S.A. | Hirudin, pharmaceutical compositions comprising it and their use |
| DE3586333T2 (de) * | 1984-03-27 | 1992-12-10 | Transgene Sa | Expressionsvektoren fuer hirudin, transformierte zellen und verfahren zur herstellung von hirudin. |
| DE3738541A1 (de) * | 1987-11-13 | 1989-05-24 | Hoechst Ag | Verfahren zur isolierung und reinigung von hirudin |
| US6875589B1 (en) * | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
| GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
| DE4009268A1 (de) * | 1990-03-22 | 1991-09-26 | Consortium Elektrochem Ind | Sekretion von hirudinderivaten |
| CA2072375C (en) * | 1990-11-08 | 2000-01-11 | Satoru Misawa | Hirudin analog, method of manufacturing thereof and anti-coagulant composition, and secretion vector, transformed microorganisms containing saidvector and manufacturing method of products which is produced from said microorganism |
| FI92601C (fi) * | 1992-03-11 | 1994-12-12 | Marja Makarow | Menetelmä hyötyproteiinien erittämiseksi hiivoista |
| DE19543737A1 (de) * | 1995-11-24 | 1997-05-28 | Hoechst Ag | Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices |
| DE19544233A1 (de) * | 1995-11-28 | 1997-06-05 | Hoechst Ag | Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten |
| PT889949E (pt) * | 1996-03-13 | 2003-10-31 | Delta Biotechnology Ltd | Controlo de fermentacao |
| DE10033195A1 (de) * | 2000-07-07 | 2002-03-21 | Aventis Pharma Gmbh | Bifunktionale Fusionsproteine aus Hirudin und TAP |
| US7202059B2 (en) * | 2001-02-20 | 2007-04-10 | Sanofi-Aventis Deutschland Gmbh | Fusion proteins capable of being secreted into a fermentation medium |
-
2001
- 2001-02-20 DE DE10108211A patent/DE10108211A1/de not_active Withdrawn
-
2002
- 2002-02-06 PE PE2002000082A patent/PE20020857A1/es not_active Application Discontinuation
- 2002-02-08 EP EP02719782A patent/EP1364032B1/en not_active Expired - Lifetime
- 2002-02-08 KR KR1020037010932A patent/KR100858833B1/ko not_active IP Right Cessation
- 2002-02-08 CA CA2439042A patent/CA2439042C/en not_active Expired - Fee Related
- 2002-02-08 PT PT02719782T patent/PT1364032E/pt unknown
- 2002-02-08 ES ES02719782T patent/ES2272696T3/es not_active Expired - Lifetime
- 2002-02-08 NZ NZ527642A patent/NZ527642A/en not_active IP Right Cessation
- 2002-02-08 DK DK02719782T patent/DK1364032T3/da active
- 2002-02-08 IL IL15741602A patent/IL157416A0/xx unknown
- 2002-02-08 WO PCT/EP2002/001308 patent/WO2002070722A1/en active IP Right Grant
- 2002-02-08 DE DE60215315T patent/DE60215315T2/de not_active Expired - Lifetime
- 2002-02-08 JP JP2002570745A patent/JP4199543B2/ja not_active Expired - Fee Related
- 2002-02-08 AU AU2002250903A patent/AU2002250903B2/en not_active Ceased
- 2002-02-08 AT AT02719782T patent/ATE342367T1/de active
- 2002-02-08 BR BR0207379-0A patent/BR0207379A/pt not_active Application Discontinuation
- 2002-02-08 CN CNB028068491A patent/CN1279171C/zh not_active Expired - Fee Related
- 2002-02-08 MX MXPA03007116A patent/MXPA03007116A/es active IP Right Grant
- 2002-02-19 US US10/076,632 patent/US20030176673A1/en not_active Abandoned
-
2003
- 2003-07-30 ZA ZA2003/05868A patent/ZA200305868B/en unknown
- 2003-08-14 IL IL157416A patent/IL157416A/en not_active IP Right Cessation
- 2003-08-19 NO NO20033672A patent/NO331376B1/no not_active IP Right Cessation
-
2004
- 2004-10-14 HK HK04107931A patent/HK1065068A1/xx not_active IP Right Cessation
-
2006
- 2006-11-30 CY CY20061101726T patent/CY1106274T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1279171C (zh) | 2006-10-11 |
| KR100858833B1 (ko) | 2008-09-17 |
| BR0207379A (pt) | 2004-06-15 |
| EP1364032A1 (en) | 2003-11-26 |
| US20030176673A1 (en) | 2003-09-18 |
| NO331376B1 (no) | 2011-12-12 |
| EP1364032B1 (en) | 2006-10-11 |
| ATE342367T1 (de) | 2006-11-15 |
| DE60215315T2 (de) | 2007-05-24 |
| ZA200305868B (en) | 2005-02-23 |
| WO2002070722A1 (en) | 2002-09-12 |
| PT1364032E (pt) | 2007-01-31 |
| DE10108211A1 (de) | 2002-08-22 |
| DK1364032T3 (da) | 2007-02-19 |
| DE60215315D1 (de) | 2006-11-23 |
| NZ527642A (en) | 2005-03-24 |
| MXPA03007116A (es) | 2003-11-18 |
| CN1526021A (zh) | 2004-09-01 |
| HK1065068A1 (en) | 2005-02-08 |
| JP2004518446A (ja) | 2004-06-24 |
| IL157416A (en) | 2009-08-03 |
| NO20033672L (no) | 2003-10-17 |
| KR20030074841A (ko) | 2003-09-19 |
| PE20020857A1 (es) | 2002-11-04 |
| IL157416A0 (en) | 2004-03-28 |
| CA2439042C (en) | 2013-06-18 |
| AU2002250903B2 (en) | 2006-12-07 |
| ES2272696T3 (es) | 2007-05-01 |
| NO20033672D0 (no) | 2003-08-19 |
| JP4199543B2 (ja) | 2008-12-17 |
| CA2439042A1 (en) | 2002-09-12 |
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