CY1106089T1 - Σκευασματα για τοπικη εφαρμογη ουσιων που δρουν ως αντιανδρογονα - Google Patents
Σκευασματα για τοπικη εφαρμογη ουσιων που δρουν ως αντιανδρογοναInfo
- Publication number
- CY1106089T1 CY1106089T1 CY20061100695T CY061100695T CY1106089T1 CY 1106089 T1 CY1106089 T1 CY 1106089T1 CY 20061100695 T CY20061100695 T CY 20061100695T CY 061100695 T CY061100695 T CY 061100695T CY 1106089 T1 CY1106089 T1 CY 1106089T1
- Authority
- CY
- Cyprus
- Prior art keywords
- androgens
- preparation
- topical application
- substances acting
- treatment
- Prior art date
Links
- 239000000126 substance Substances 0.000 title abstract 2
- 239000000051 antiandrogen Substances 0.000 title 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- 201000004384 Alopecia Diseases 0.000 abstract 2
- 206010068168 androgenetic alopecia Diseases 0.000 abstract 2
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 206010039792 Seborrhoea Diseases 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 201000002996 androgenic alopecia Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 230000003779 hair growth Effects 0.000 abstract 1
- 239000004014 plasticizer Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000008742 seborrheic dermatitis Diseases 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
Abstract
Σκεύασμα που περιέχει τουλάχιστον μια φυσιολογικά συμβατή ουσία σχηματισμού μεμβράνης, τουλάχιστον έναν φυσιολογικά συμβατό διαλύτη, τουλάχιστον έναν πλαστικοποιητή και μια ένωση του τύπου (I) είναι κατάλληλη για τη θεραπεία της ανδρογόνου αλωπεκίας, του δασυτριχισμού των γυναικών ανδρικού τύπου, δηλ. για την αποφυγή της ανεπιθύμητης τριχοφυΐας και τη θεραπεία σμηγματόρροιας και της ακμής και περαιτέρω μπορεί να χρησιμοποιηθεί στη βιομηχανία καλλυντικών.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1998148856 DE19848856A1 (de) | 1998-10-23 | 1998-10-23 | Zubereitungen zur topischen Applikation von antiandrogen wirksamen Subsatanzen |
DE1999100749 DE19900749A1 (de) | 1999-01-12 | 1999-01-12 | Zubereitungen zur topischen Applikation von antiandrogen wirksamen Substanzen |
PCT/EP1999/007660 WO2000024366A1 (de) | 1998-10-23 | 1999-10-12 | Zubereitungen zur topischen applikation von antiandrogen wirksamen substanzen |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106089T1 true CY1106089T1 (el) | 2011-06-08 |
Family
ID=26049702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100695T CY1106089T1 (el) | 1998-10-23 | 2006-06-01 | Σκευασματα για τοπικη εφαρμογη ουσιων που δρουν ως αντιανδρογονα |
Country Status (13)
Country | Link |
---|---|
US (6) | US20030083322A1 (el) |
EP (1) | EP1123082B1 (el) |
JP (1) | JP5162064B2 (el) |
AT (1) | ATE318578T1 (el) |
AU (1) | AU755165B2 (el) |
CA (1) | CA2347907C (el) |
CY (1) | CY1106089T1 (el) |
DE (1) | DE59913181D1 (el) |
DK (1) | DK1123082T3 (el) |
ES (1) | ES2258342T3 (el) |
IL (2) | IL142598A0 (el) |
PT (1) | PT1123082E (el) |
WO (1) | WO2000024366A1 (el) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6509334B1 (en) * | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
JP2004504336A (ja) * | 2000-07-26 | 2004-02-12 | コグニス・フランス・ソシエテ・アノニム | 体毛成長を抑制する相乗活性混合物 |
EP1515725A4 (en) * | 2002-06-25 | 2005-09-21 | Wyeth Corp | USE OF CYCLOTHIOCARBAMATE DERIVATIVES IN THE TREATMENT OF HORMONE-RELATED ILLNESSES |
CA2489813A1 (en) * | 2002-06-25 | 2003-12-31 | Wyeth | Use of thio-oxindole derivatives in treatment of hormone-related conditions |
KR20050012831A (ko) * | 2002-06-25 | 2005-02-02 | 와이어쓰 | 피부 질환을 치료하는 데 있어서의 티오-옥스인돌유도체의 용도 |
MXPA04012420A (es) * | 2002-06-25 | 2005-04-19 | Wyeth Corp | Derivados de ciclotiocabamativa como moduladores de rp y uso de los mismos para tratamiento de trastornos de la piel. |
DE202004000552U1 (de) * | 2004-01-15 | 2004-04-01 | Ivoclar Vivadent Ag | Mittel zum Bleichen von Zähnen |
AU2005209045B2 (en) * | 2004-01-30 | 2011-02-24 | Ace Aps | Use of ACE inhibitors and/or angiotensin II receptor antagonists for the improving and/or maintaining the skin tone and for the treatment of skin ageing |
EP1789031A2 (en) * | 2004-08-18 | 2007-05-30 | Ace ApS | Cosmetic and pharmaceutical compositions comprising ace inhibitors and/or angiotensin ii receptor antagonists |
CN105287484A (zh) | 2007-11-30 | 2016-02-03 | 盖尔德马研究及发展公司 | 含有萘甲酸衍生物、过氧化苯甲酰和成膜剂的组合物 |
EP2153836A1 (en) * | 2008-08-04 | 2010-02-17 | Polichem S.A. | Film-forming liquid formulations for drug release to hair and scalp |
WO2010069519A1 (en) * | 2008-12-18 | 2010-06-24 | Merz Pharma Gmbh & Co. Kgaa | Topical compositions comprising at least one active ingredient poorly soluble in water and biopolymers such as hyaluronic acid with a pka-value between 5-7 |
US20150313829A1 (en) * | 2012-11-26 | 2015-11-05 | Roberto Queiroga Lautner | Topical formulations for the prevention and treatment of alopecia and inhibition of hair growth |
DE102013226048A1 (de) * | 2013-12-16 | 2015-06-18 | Henkel Ag & Co. Kgaa | Stylingspray mit Volumeneffekt |
IT201900000484A1 (it) * | 2019-04-23 | 2020-10-23 | Neilos S R L | Composizione per il trattamento dei disordini a carico dell’apparato uro-genitale femminile |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5514672A (en) * | 1981-02-17 | 1996-05-07 | Bazzano; Gail S. | Use of retinoids and compositions containing same for hair growth |
US5541220A (en) * | 1984-03-07 | 1996-07-30 | Ismail; Roshdy | Agents for the treatment and protection of the skin |
US4946870A (en) * | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives |
JPH082774B2 (ja) * | 1987-02-05 | 1996-01-17 | 株式会社資生堂 | 〔ベンゾ−1,2,4−チアジアジン〕−1−ジオキシド誘導体溶解組成物 |
US5160737A (en) * | 1988-05-03 | 1992-11-03 | Perio Products Ltd. | Liquid polymer composition, and method of use |
JP2733980B2 (ja) * | 1988-08-26 | 1998-03-30 | 大正製薬株式会社 | 養毛組成物 |
USRE35956E (en) * | 1991-01-09 | 1998-11-10 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
US5411981A (en) * | 1991-01-09 | 1995-05-02 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
FR2693461B1 (fr) * | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
AU659861B2 (en) * | 1991-09-10 | 1995-06-01 | Sansho Seiyaku Co., Ltd. | Preparation for promoting hair growth |
GB9210768D0 (en) * | 1992-05-20 | 1992-07-08 | Unilever Plc | Cosmetic composition |
GB9210756D0 (en) * | 1992-05-20 | 1992-07-08 | Unilever Plc | Cosmetic composition |
US5417984A (en) * | 1992-12-14 | 1995-05-23 | Biocontrol, Inc. | Low crystallinity cellulose excipients |
WO1994013257A1 (en) * | 1992-12-16 | 1994-06-23 | Creative Products Resource Associates, Ltd. | Occlusive/semi-occlusive lotion for treatment of a skin disease or disorder |
FR2706126B1 (fr) * | 1993-06-08 | 1995-07-21 | Oreal | Composition cosmétique contenant un pseudo-latex ayant des propriétés de rémanence. |
TW521073B (en) * | 1994-01-05 | 2003-02-21 | Hoechst Marion Roussel Inc | New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them |
FR2716110B1 (fr) * | 1994-02-16 | 1996-04-05 | Roussel Uclaf | Compositions cosmétiques ou pharmaceutiques comprenant des liposomes. |
FR2719216B1 (fr) * | 1994-05-02 | 1996-05-31 | Oreal | Composition pour le traitement et la protection des cheveux à base de céramides et de polymères de Vinylpyrrolidone. |
JPH09512562A (ja) * | 1994-05-05 | 1997-12-16 | メルク フロスト カナダ インコーポレーテツド | 局所性ポリマー薬物供給システム |
JPH0812529A (ja) * | 1994-06-23 | 1996-01-16 | Riken Health Kk | 透明養毛・育毛剤 |
ES2168392T3 (es) * | 1994-12-02 | 2002-06-16 | Kao Corp | Derivados de flavanonol y compuesto estimulante para la nutricion y crecimiento del cabello que los contiene. |
FR2729664A1 (fr) * | 1995-01-20 | 1996-07-26 | Cird Galderma | Composes bicycliques-aromatiques a forte activite biologique compositions pharmaceutiques et cosmetiques les contenant et utilisations |
FR2741342B1 (fr) * | 1995-11-22 | 1998-02-06 | Roussel Uclaf | Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques |
FR2742749B1 (fr) * | 1995-12-22 | 1998-02-06 | Roussel Uclaf | Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques |
FR2751965B1 (fr) * | 1996-08-01 | 1998-11-27 | Oreal | Nouveaux composes de la famille des aryl-2,4-dioxo-oxazolidines |
US5916910A (en) * | 1997-06-04 | 1999-06-29 | Medinox, Inc. | Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore |
EP0966246A1 (de) * | 1997-08-28 | 1999-12-29 | Wella Aktiengesellschaft | Zwei-komponenten kosmetisches pflegemittel |
FR2770842B1 (fr) * | 1997-11-13 | 1999-12-17 | Oreal | Nouveaux composes derives de n-aryl 2-hydroxy alkylamides |
-
1999
- 1999-10-12 DE DE59913181T patent/DE59913181D1/de not_active Expired - Lifetime
- 1999-10-12 AU AU10359/00A patent/AU755165B2/en not_active Expired
- 1999-10-12 DK DK99953787T patent/DK1123082T3/da active
- 1999-10-12 WO PCT/EP1999/007660 patent/WO2000024366A1/de active IP Right Grant
- 1999-10-12 ES ES99953787T patent/ES2258342T3/es not_active Expired - Lifetime
- 1999-10-12 EP EP99953787A patent/EP1123082B1/de not_active Expired - Lifetime
- 1999-10-12 IL IL14259899A patent/IL142598A0/xx active IP Right Grant
- 1999-10-12 JP JP2000577977A patent/JP5162064B2/ja not_active Expired - Lifetime
- 1999-10-12 AT AT99953787T patent/ATE318578T1/de active
- 1999-10-12 CA CA002347907A patent/CA2347907C/en not_active Expired - Lifetime
- 1999-10-12 PT PT99953787T patent/PT1123082E/pt unknown
- 1999-10-22 US US09/425,742 patent/US20030083322A1/en not_active Abandoned
-
2001
- 2001-04-15 IL IL142598A patent/IL142598A/en not_active IP Right Cessation
-
2003
- 2003-09-29 US US10/671,545 patent/US20050175647A1/en not_active Abandoned
-
2006
- 2006-06-01 CY CY20061100695T patent/CY1106089T1/el unknown
-
2008
- 2008-11-20 US US12/292,521 patent/US20090093487A1/en not_active Abandoned
-
2010
- 2010-11-17 US US12/948,619 patent/US20110065763A1/en not_active Abandoned
-
2012
- 2012-03-30 US US13/436,545 patent/US20120277235A1/en not_active Abandoned
-
2013
- 2013-06-12 US US13/916,488 patent/US20140142124A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL142598A0 (en) | 2002-03-10 |
EP1123082B1 (de) | 2006-03-01 |
US20090093487A1 (en) | 2009-04-09 |
PT1123082E (pt) | 2006-06-30 |
US20050175647A1 (en) | 2005-08-11 |
JP5162064B2 (ja) | 2013-03-13 |
EP1123082A1 (de) | 2001-08-16 |
JP2002528401A (ja) | 2002-09-03 |
AU755165B2 (en) | 2002-12-05 |
US20030083322A1 (en) | 2003-05-01 |
AU1035900A (en) | 2000-05-15 |
US20140142124A1 (en) | 2014-05-22 |
ES2258342T3 (es) | 2006-08-16 |
ATE318578T1 (de) | 2006-03-15 |
DE59913181D1 (de) | 2006-04-27 |
US20110065763A1 (en) | 2011-03-17 |
WO2000024366A1 (de) | 2000-05-04 |
CA2347907A1 (en) | 2000-05-04 |
DK1123082T3 (da) | 2006-06-26 |
IL142598A (en) | 2006-04-10 |
US20120277235A1 (en) | 2012-11-01 |
CA2347907C (en) | 2009-12-08 |
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