CY1105837T1 - Hmi - συνθεση απο paclitaxel με χρησιμοποιηση διαλκυλδιχλωροσιλανιων - Google Patents

Hmi - συνθεση απο paclitaxel με χρησιμοποιηση διαλκυλδιχλωροσιλανιων

Info

Publication number
CY1105837T1
CY1105837T1 CY20061101767T CY061101767T CY1105837T1 CY 1105837 T1 CY1105837 T1 CY 1105837T1 CY 20061101767 T CY20061101767 T CY 20061101767T CY 061101767 T CY061101767 T CY 061101767T CY 1105837 T1 CY1105837 T1 CY 1105837T1
Authority
CY
Cyprus
Prior art keywords
paclitaxel
dialkyldichlorosilane
hmi
composition
apacetylbaccatin
Prior art date
Application number
CY20061101767T
Other languages
English (en)
Inventor
Purushotham Vemishetti
Francis S. Gibson
John L. Dillon, Jr.
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1105837T1 publication Critical patent/CY1105837T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Silicon Polymers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paper (AREA)

Abstract

Μια μέθοδος για την σύνθεση του Paclitaxel από 10-απακετυλβακκατίνη-ΙΙΙ η οποία προστατεύεται στην 7-θέση με μία προστατευτική ομάδα από διαλκυλαλκοξυσιλύλιο που έχει τον τύπο –Si(R)2(OR’).
CY20061101767T 1999-05-28 2006-12-08 Hmi - συνθεση απο paclitaxel με χρησιμοποιηση διαλκυλδιχλωροσιλανιων CY1105837T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13655999P 1999-05-28 1999-05-28
PCT/US2000/013639 WO2000073293A1 (en) 1999-05-28 2000-05-18 Semi-synthesis of paclitaxel using dialkyldichlorosilanes

Publications (1)

Publication Number Publication Date
CY1105837T1 true CY1105837T1 (el) 2011-02-02

Family

ID=22473365

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101767T CY1105837T1 (el) 1999-05-28 2006-12-08 Hmi - συνθεση απο paclitaxel με χρησιμοποιηση διαλκυλδιχλωροσιλανιων

Country Status (18)

Country Link
US (1) US6242614B1 (el)
EP (1) EP1183250B1 (el)
JP (1) JP2003502290A (el)
KR (1) KR100603877B1 (el)
AT (1) ATE342260T1 (el)
AU (1) AU776216B2 (el)
CA (1) CA2375253A1 (el)
CY (1) CY1105837T1 (el)
DE (1) DE60031269T2 (el)
DK (1) DK1183250T3 (el)
ES (1) ES2273698T3 (el)
HK (1) HK1042301A1 (el)
HU (1) HUP0201266A3 (el)
IL (1) IL145869A (el)
MX (1) MXPA01012177A (el)
PT (1) PT1183250E (el)
TW (1) TW593300B (el)
WO (1) WO2000073293A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ298333B6 (cs) * 2005-09-26 2007-08-29 Zentiva, A. S Zpusob prípravy 7-trialkylsilylbaccatinu III
GB0701523D0 (en) * 2007-01-26 2007-03-07 Chatham Biotec Ltd Semi-synthetic process for the preparation of taxane derivatives
EP2183234A4 (en) * 2007-08-22 2012-02-29 Canada Inc 6570763 PROCESS FOR CONVERTING 9-DIHYDRO-13-ACETYLBACCATIN III IN DOCETAXEL OR PACLITAXEL
US20090292131A1 (en) * 2008-05-07 2009-11-26 Ladislav Cvak Processes for preparation of taxanes and intermediates thereof
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
US9375484B2 (en) * 2011-05-31 2016-06-28 Regents Of The University Of Minnesota Taxane silicate prodrugs and nanoparticles
KR101378537B1 (ko) 2011-09-30 2014-03-28 주식회사 삼양바이오팜 10-디아세틸파클리탁셀로부터 파클리탁셀을 제조하는 방법
CN103145654A (zh) * 2013-04-12 2013-06-12 江苏斯威森生物医药工程研究中心有限公司 一种多西他赛的半合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
ATE258171T1 (de) 1991-09-23 2004-02-15 Univ Florida State Metallalkoxide
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
CA2155304C (en) * 1993-02-05 2010-07-20 Charles Swindell Syntheses of paclitaxel, analogs and intermediates with variable a-ring side chains
US6005120A (en) * 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
JPH1192468A (ja) * 1997-09-17 1999-04-06 Yakult Honsha Co Ltd 新規なタキサン誘導体
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
US6136988A (en) * 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same
JP4502338B2 (ja) * 1999-09-17 2010-07-14 株式会社横浜国際バイオ研究所 タキソイド化合物の製造法

Also Published As

Publication number Publication date
KR100603877B1 (ko) 2006-07-25
MXPA01012177A (es) 2002-07-22
ATE342260T1 (de) 2006-11-15
US6242614B1 (en) 2001-06-05
EP1183250B1 (en) 2006-10-11
WO2000073293A1 (en) 2000-12-07
CA2375253A1 (en) 2000-12-07
IL145869A (en) 2005-07-25
TW593300B (en) 2004-06-21
DE60031269T2 (de) 2007-05-31
IL145869A0 (en) 2002-07-25
PT1183250E (pt) 2006-12-29
AU5140800A (en) 2000-12-18
HUP0201266A2 (en) 2002-08-28
HK1042301A1 (en) 2002-08-09
KR20020032426A (ko) 2002-05-03
ES2273698T3 (es) 2007-05-16
EP1183250A1 (en) 2002-03-06
HUP0201266A3 (en) 2005-02-28
JP2003502290A (ja) 2003-01-21
EP1183250A4 (en) 2002-11-13
AU776216B2 (en) 2004-09-02
DK1183250T3 (da) 2007-01-08
DE60031269D1 (de) 2006-11-23

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