CU20140145A7 - Vacuna de proteína quimérica contra la neumonía causada por streptococcus pneumoniae - Google Patents

Vacuna de proteína quimérica contra la neumonía causada por streptococcus pneumoniae

Info

Publication number
CU20140145A7
CU20140145A7 CU2014000145A CU20140145A CU20140145A7 CU 20140145 A7 CU20140145 A7 CU 20140145A7 CU 2014000145 A CU2014000145 A CU 2014000145A CU 20140145 A CU20140145 A CU 20140145A CU 20140145 A7 CU20140145 A7 CU 20140145A7
Authority
CU
Cuba
Prior art keywords
streptococcus pneumoniae
pneumoniae
chemeric
vaccine
vaccine against
Prior art date
Application number
CU2014000145A
Other languages
English (en)
Other versions
CU24238B1 (es
Inventor
Aleksandr Nikolaevich Suvorov
Llya Vladimirovich Dukhovlinov
Anton Losifovich Orlov
Evgenii Jakovlevich Baiguzin
Original Assignee
Epitope Ltd Epitope Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epitope Ltd Epitope Ltd filed Critical Epitope Ltd Epitope Ltd
Publication of CU20140145A7 publication Critical patent/CU20140145A7/es
Publication of CU24238B1 publication Critical patent/CU24238B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

El problema a resolver: ausencia de una vacuna eficiente segura para la profilaxis y el tratamiento de enfermedades causadas por Streptococcus pneumoniae (S.pneumoniae) capaz de proporcionar defensa contra todas las cepas de S.pneumoniae (ausencia de una vacuna universal contra neumococos). La solución: Se da la vacuna basada en la proteína quimérica que consiste en epítopos inmunogénicos de proteínas conservadoras de Streptococcus pneumoniae: PspA, Spr1895, y PsaA, así como también los componentes de la flagellina (FliC1, FliC2) que funciona como un adyuvante seguro, y en consecuencia las proteínas o los péptidos homólogos a aquellos no menos que el 60% se sus secuencias de aminoácidos, conectadas a través de uniones flexibles. Se muestran seguridad, eficacia y ambos efectos preventivos y terapéuticos.
CUP2014000145A 2012-06-22 2013-06-21 Vacuna de proteína quimérica contra la neumonía causada por streptococcus pneumoniae CU24238B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2012126328/15A RU2510281C2 (ru) 2012-06-22 2012-06-22 ВАКЦИНА ПРОТИВ ПНЕВМОНИИ, ВЫЗЫВАЕМОЙ Streptococcus pneumoniae, НА ОСНОВЕ ГИБРИДНОГО БЕЛКА
PCT/RU2013/000525 WO2013191591A1 (en) 2012-06-22 2013-06-21 Chimeric protein vaccine against pneumonia caused by streptococcus pneumoniae

Publications (2)

Publication Number Publication Date
CU20140145A7 true CU20140145A7 (es) 2015-04-29
CU24238B1 CU24238B1 (es) 2017-02-02

Family

ID=49769080

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2014000145A CU24238B1 (es) 2012-06-22 2013-06-21 Vacuna de proteína quimérica contra la neumonía causada por streptococcus pneumoniae

Country Status (13)

Country Link
US (1) US9345757B2 (es)
EP (1) EP2863944B1 (es)
JP (1) JP6195089B2 (es)
KR (1) KR20150034192A (es)
CN (1) CN104470538B (es)
BR (1) BR112014032135A2 (es)
CU (1) CU24238B1 (es)
EA (1) EA027981B1 (es)
HK (1) HK1208632A1 (es)
MX (1) MX355642B (es)
RU (1) RU2510281C2 (es)
UA (1) UA116634C2 (es)
WO (1) WO2013191591A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104844712B (zh) * 2015-04-03 2019-06-28 长春百克生物科技股份公司 肺炎链球菌蛋白抗原及其制备方法和应用
RU2591809C1 (ru) * 2015-07-21 2016-07-20 Андрей Дмитриевич Протасов Способ активации факторов противовирусной защиты у пациентов с хронической обструктивной болезнью легких
RU2627602C2 (ru) * 2015-12-29 2017-08-09 Федеральное бюджетное учреждение науки Государственный научный центр прикладной микробиологии и биотехнологии (ФБУН ГНЦ ПМБ) Способ получения химерного рекомбинантного белка fliC:pagN
CA3044112A1 (en) 2016-12-03 2018-06-07 The Uab Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a
EP3661546B1 (en) * 2017-08-03 2023-12-13 Intervet International B.V. A vaccine for protection against streptococcus suis
RU2687488C1 (ru) * 2018-07-12 2019-05-14 Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский и технологический институт биологической промышленности" ФГБНУ ВНИТИБП Формолвакцина полиштаммная против пневмоний телят стрептококковой этиологии
RU2720614C9 (ru) * 2020-04-23 2021-02-09 федеральное государственное бюджетное учреждение «Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи» Министерства здравоохранения Российской Федерации Иммунобиологическое средство и способ его использования для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936252B2 (en) 1998-07-27 2005-08-30 Microbial Technics Limited Streptococcus pneumoniae proteins and nucleic acid molecules
CA2379327A1 (en) * 1999-06-10 2000-12-21 Uab Research Foundation Pneumococcal surface protein combination vaccine
GB0022742D0 (en) * 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
WO2002083855A2 (en) 2001-04-16 2002-10-24 Wyeth Holdings Corporation Novel streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
EP2314719A1 (en) 2003-04-15 2011-04-27 Intercell AG S. pneumoniae antigens
EP1477802A1 (en) 2003-05-16 2004-11-17 Erasmus Universiteit Rotterdam Method for selecting and producing vaccine components and vaccines based thereon
EP2371843B1 (en) 2005-05-19 2014-09-17 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Functional epitopes of streptococcus pneumoniae psaA antigen and uses thereof
AR058707A1 (es) * 2005-12-22 2008-02-20 Glaxosmithkline Biolog Sa Vacuna, procedimiento para fabricarla y su uso
SI2300609T1 (sl) * 2008-06-25 2014-04-30 Inserm Institut National De La Sante Et De La Recherche Medicale Nove imunoadjuvantne spojine na osnovi flagelina in njihova uporaba
WO2010045620A1 (en) * 2008-10-17 2010-04-22 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae
US8003112B2 (en) 2009-04-16 2011-08-23 Howard University Meningococcal and pneumococcal conjugate vaccine and method of using same
US20120135037A1 (en) * 2009-06-01 2012-05-31 Mizel Steven B Flagellin fusion proteins and conjugates comprising pneumococcus antigens and methods of using the same

Also Published As

Publication number Publication date
WO2013191591A9 (en) 2014-02-13
JP2015521618A (ja) 2015-07-30
JP6195089B2 (ja) 2017-09-20
MX355642B (es) 2018-04-25
HK1208632A1 (en) 2016-03-11
EP2863944A4 (en) 2016-05-11
US20150174230A1 (en) 2015-06-25
BR112014032135A2 (pt) 2017-08-01
RU2012126328A (ru) 2013-12-27
EP2863944A1 (en) 2015-04-29
WO2013191591A1 (en) 2013-12-27
EP2863944B1 (en) 2018-12-19
EA027981B1 (ru) 2017-09-29
WO2013191591A4 (en) 2014-04-03
CN104470538B (zh) 2017-12-22
KR20150034192A (ko) 2015-04-02
MX2014016049A (es) 2015-07-06
US9345757B2 (en) 2016-05-24
EA201590078A1 (ru) 2015-06-30
CN104470538A (zh) 2015-03-25
RU2510281C2 (ru) 2014-03-27
UA116634C2 (uk) 2018-04-25
CU24238B1 (es) 2017-02-02

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