CS729587A2 - Method of tertiary alkylsubstituted naphthyridine and quinoline carboxylic acids production - Google Patents

Method of tertiary alkylsubstituted naphthyridine and quinoline carboxylic acids production

Info

Publication number
CS729587A2
CS729587A2 CS877295A CS729587A CS729587A2 CS 729587 A2 CS729587 A2 CS 729587A2 CS 877295 A CS877295 A CS 877295A CS 729587 A CS729587 A CS 729587A CS 729587 A2 CS729587 A2 CS 729587A2
Authority
CS
Czechoslovakia
Prior art keywords
alkylsubstituted
naphthyridine
tertiary
carboxylic acids
quinoline carboxylic
Prior art date
Application number
CS877295A
Other languages
English (en)
Other versions
CS270597B2 (en
Inventor
Abraham Weber
Daniel Bouzard
Munior Essiz
Cesare Pierre Di
Jean-Pierre Jacquet
Philippe Remuzon
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to CS887400A priority Critical patent/CS270598B2/cs
Publication of CS729587A2 publication Critical patent/CS729587A2/cs
Publication of CS270597B2 publication Critical patent/CS270597B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CS877295A 1986-10-08 1987-10-08 Method of tertiary alkylsubstituted naphthyridine and quinoline carboxylic acids production CS270597B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS887400A CS270598B2 (en) 1986-10-08 1988-11-10 Method of 1-tertiary alkylsubstituted naphthyridine and quinoline carboxylic acids preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91675286A 1986-10-08 1986-10-08
US9923187A 1987-09-25 1987-09-25

Publications (2)

Publication Number Publication Date
CS729587A2 true CS729587A2 (en) 1989-11-14
CS270597B2 CS270597B2 (en) 1990-07-12

Family

ID=26795810

Family Applications (1)

Application Number Title Priority Date Filing Date
CS877295A CS270597B2 (en) 1986-10-08 1987-10-08 Method of tertiary alkylsubstituted naphthyridine and quinoline carboxylic acids production

Country Status (10)

Country Link
EP (1) EP0266576A3 (cs)
CN (1) CN87106925A (cs)
CS (1) CS270597B2 (cs)
IE (1) IE872696L (cs)
IL (1) IL84105A0 (cs)
NZ (1) NZ222047A (cs)
OA (1) OA08688A (cs)
PL (2) PL156484B1 (cs)
PT (1) PT85886B (cs)
YU (2) YU46079B (cs)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
US4859776A (en) * 1988-03-11 1989-08-22 Abbott Laboratories (S)-7-(3-aminopyrrolidin-1-yl)-1-(ortho, para-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid and method for its preparation
EP0997466A1 (en) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
FI901201A7 (fi) * 1989-03-13 1990-09-14 Bristol Myers Squibb Co Antibakteeriset 5-substituoidut 1,4-dihydro-4-oksonaftyridiini-3-karboksylaattijohdannaiset ja niiden valmistus
DE3910920A1 (de) * 1989-04-05 1990-10-11 Bayer Ag Enantiomerenreine 7-(3-amino-1-pyrrolidinyl)-chinolon- und -naphthyridoncarbonsaeuren
WO1991016327A1 (en) 1990-04-18 1991-10-31 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactams
JPH06509792A (ja) * 1991-01-14 1994-11-02 ハンミ藥品工業株式會社 新規なキノロン化合物及びその製造方法
AU1161492A (en) * 1991-01-14 1992-08-17 Hanmi Pharmaceutical Co., Ltd. Novel quinolone compounds and processes for preparation thereof
KR940014395A (ko) * 1992-12-09 1994-07-18 강박광 신규한 퀴놀론 유도체 및 그의 제조방법
KR0148277B1 (ko) * 1993-01-18 1998-11-02 채영복 신규한 플루오르퀴놀론계 유도체 및 그의 제조방법
WO1994025464A1 (en) * 1993-04-24 1994-11-10 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
DK0688772T3 (da) * 1994-06-16 1999-11-01 Lg Chemical Ltd Quinolincarboxylsyrederivater med 7-(4-aminomethyl-3-oxim)-pyrrolidinsubstituenter og fremgangsmåde til deres fremstilling
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
US6316488B1 (en) * 1999-06-17 2001-11-13 Merck & Co., Inc. Antibiotic compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
SE0003795D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Pharmaceutically useful compounds
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
WO2003031441A1 (en) * 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
EP1620098B1 (en) 2003-04-30 2008-06-11 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
DE602004015158D1 (de) 2003-12-18 2008-08-28 Morphochem Ag Komb Chemie Oxazolidinon-chinolon hybrid antibiotika
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
US7935725B2 (en) 2007-10-31 2011-05-03 Janssen Pharmaceutica Nv Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase
RS53081B (sr) 2008-04-11 2014-06-30 Janssen Pharmaceutica N.V. Thiazolopiridin-2-iloksi-fenil i amini thiazolopiridin-2-iloksi fenila kao modulatori leukotrien a4 hidrolaze
EP2430019B1 (en) 2009-05-14 2013-09-18 Janssen Pharmaceutica, N.V. Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase
ES2383857B1 (es) * 2010-11-23 2013-05-13 Consejo Superior De Investigaciones Científicas (Csic) Haptenos e inmunoreactivos y su uso en la obtención de anticuerpos de familia e inmunoensayos para quinolonas

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH408036A (de) * 1960-02-17 1966-02-28 Lepetit Spa Verfahren zur Herstellung von 3,8-Diazabicyclo-(3,2,1)-octan-2,4-dionen
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
GB2093018B (en) * 1979-08-22 1984-09-12 Kyorin Seiyaku Kk 6,8-difluoro-quinoline carboxylic acid derivatives
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4578473A (en) * 1985-04-15 1986-03-25 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents

Also Published As

Publication number Publication date
YU46079B (sh) 1992-12-21
PT85886A (en) 1987-11-01
PL268098A1 (en) 1988-09-01
YU46112B (sh) 1992-12-21
IL84105A0 (en) 1988-03-31
PT85886B (pt) 1990-07-31
CS270597B2 (en) 1990-07-12
OA08688A (fr) 1989-03-31
CN87106925A (zh) 1988-09-14
PL156484B1 (en) 1992-03-31
NZ222047A (en) 1991-01-29
YU186887A (en) 1988-12-31
EP0266576A2 (en) 1988-05-11
EP0266576A3 (en) 1989-03-22
PL154473B1 (en) 1991-08-30
YU131088A (en) 1988-12-31
IE872696L (en) 1988-04-08

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