CS71991A2 - New squalene synthetase inhibitors - Google Patents

New squalene synthetase inhibitors Download PDF

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Publication number
CS71991A2
CS71991A2 CS91719A CS71991A CS71991A2 CS 71991 A2 CS71991 A2 CS 71991A2 CS 91719 A CS91719 A CS 91719A CS 71991 A CS71991 A CS 71991A CS 71991 A2 CS71991 A2 CS 71991A2
Authority
CS
Czechoslovakia
Prior art keywords
compound
formula
methanol
compounds
pharmaceutically acceptable
Prior art date
Application number
CS91719A
Other languages
Czech (cs)
English (en)
Inventor
James D Bergstrom
Otto D Hensens
Leeyuan Huang
Jerrold M Liesch
Janet C Onishi
Frank L Vanmiddlesworth
Original Assignee
Merck O Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/496,742 external-priority patent/US5096923A/en
Priority claimed from US07/626,071 external-priority patent/US5053425A/en
Application filed by Merck O Co filed Critical Merck O Co
Publication of CS71991A2 publication Critical patent/CS71991A2/cs

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08Bridged systems
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/145Fungal isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1085Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi
CS91719A 1990-03-21 1991-03-19 New squalene synthetase inhibitors CS71991A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49674990A 1990-03-21 1990-03-21
US49673190A 1990-03-21 1990-03-21
US07/496,742 US5096923A (en) 1990-03-21 1990-03-21 Novel squalene synthetase inhibitors
US07/626,071 US5053425A (en) 1990-03-21 1990-12-11 Novel anti-fungal compounds

Publications (1)

Publication Number Publication Date
CS71991A2 true CS71991A2 (en) 1991-11-12

Family

ID=27504381

Family Applications (1)

Application Number Title Priority Date Filing Date
CS91719A CS71991A2 (en) 1990-03-21 1991-03-19 New squalene synthetase inhibitors

Country Status (17)

Country Link
EP (1) EP0450812B1 (no)
JP (1) JPH04279589A (no)
KR (1) KR910016931A (no)
AT (1) ATE104982T1 (no)
AU (1) AU640755B2 (no)
CA (1) CA2038517A1 (no)
CS (1) CS71991A2 (no)
DE (2) DE450812T1 (no)
DK (1) DK0450812T3 (no)
ES (1) ES2052463T1 (no)
GR (1) GR920300106T1 (no)
HU (1) HUT61555A (no)
IE (1) IE910924A1 (no)
IL (1) IL97535A0 (no)
NO (1) NO911121L (no)
NZ (1) NZ237448A (no)
PT (1) PT97077A (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97251A0 (en) * 1990-03-21 1992-05-25 Merck & Co Inc Antihypercholesterolemic 2,8-dioxabicyclo(3,2,1)octane derivatives,their preparation and pharmaceutical compositions containing them
GB9100437D0 (en) * 1991-01-09 1991-02-20 Glaxo Group Ltd Chemical compounds
GB9105152D0 (en) * 1991-03-12 1991-04-24 Glaxo Group Ltd Chemical compounds
YU49292A (sh) * 1991-05-10 1995-01-31 Merck And Co.Inc. Nova jedinjenja koja snižavaju holesterol
MX9202156A (es) * 1991-05-10 1993-08-01 Merck & Co Inc Novedosos compuestos para reducir el colesterol.
US5256689A (en) * 1991-05-10 1993-10-26 Merck & Co., Inc. Cholesterol lowering compounds
US5250424A (en) * 1991-06-14 1993-10-05 Merck & Co., Inc. Processes for preparing novel squalene synthetase inhibitors
US5200342A (en) * 1991-06-14 1993-04-06 Merck & Co., Inc. Squalene synthetase inhibitors and processes therefrom
CA2071723A1 (en) * 1991-06-27 1992-12-28 Gerald F. Bills Culture of exserohilum rostratum and processes therefrom
EP0524677A1 (en) * 1991-07-16 1993-01-27 Glaxo Group Limited Cyclic ketal derivatives
US5468771A (en) * 1991-08-07 1995-11-21 Merck & Co., Inc. Cholesterol lowering compound
GB9121380D0 (en) * 1991-10-08 1991-11-20 Glaxo Group Ltd Chemical compounds
GB2261374A (en) * 1991-11-15 1993-05-19 Merck & Co Inc Inhibitors of farnesyl protein transferase as anti-cancer agents
US5252471A (en) * 1992-03-09 1993-10-12 Merck & Co., Inc. Directed biosynthesis of cholesterol lowering compounds
WO1993017557A1 (en) * 1992-03-09 1993-09-16 Merck & Co., Inc. Cholesterol lowering compounds produced by directed biosynthesis
US5294627A (en) * 1992-08-27 1994-03-15 Merck & Co., Inc. Directed biosynthesis of biologically active compounds
GB9205136D0 (en) * 1992-03-10 1992-04-22 Glaxo Group Ltd Chemical compounds
GB9205140D0 (en) * 1992-03-10 1992-04-22 Glaxo Group Ltd Chemical compounds
EP0568946A1 (en) * 1992-05-08 1993-11-10 Takeda Chemical Industries, Ltd. Compound TAN-1607A, its derivatives, their production, and use thereof
US5260215A (en) * 1992-07-20 1993-11-09 Merck & Co., Inc. Fungal microorganism ATCC 74167 capable of producing cholesterol lowering compounds
US5283256A (en) * 1992-07-22 1994-02-01 Merck & Co., Inc. Cholesterol-lowering agents
US5322855A (en) * 1992-10-19 1994-06-21 Merck & Co., Inc. Cholesterol lowering compounds
US5447717A (en) * 1993-02-25 1995-09-05 Merck & Co., Inc. Cholesterol-lowering agents
US5430055A (en) * 1994-04-08 1995-07-04 Pfizer Inc. Inhibitor of squalene synthase

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276216A (en) * 1980-07-31 1981-06-30 Ortho Pharmaceutical Corporation Synthesis of dioxabicyclo[3.2.1]octanes and oxepanes
IL97251A0 (en) * 1990-03-21 1992-05-25 Merck & Co Inc Antihypercholesterolemic 2,8-dioxabicyclo(3,2,1)octane derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0450812A1 (en) 1991-10-09
EP0450812B1 (en) 1994-04-27
NO911121D0 (no) 1991-03-20
NZ237448A (en) 1993-11-25
DE450812T1 (de) 1992-11-26
HUT61555A (en) 1993-01-28
IE910924A1 (en) 1991-09-25
KR910016931A (ko) 1991-11-05
DE69101802D1 (de) 1994-06-01
DE69101802T2 (de) 1994-10-27
AU640755B2 (en) 1993-09-02
CA2038517A1 (en) 1991-09-22
ATE104982T1 (de) 1994-05-15
JPH04279589A (ja) 1992-10-05
PT97077A (pt) 1991-11-29
ES2052463T1 (es) 1994-07-16
AU7368391A (en) 1993-01-28
HU910930D0 (en) 1991-10-28
DK0450812T3 (da) 1994-06-06
GR920300106T1 (en) 1993-02-17
NO911121L (no) 1991-09-23
IL97535A0 (en) 1992-06-21

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