CS255890B2 - Process for preparing new racemic and optical active derivatives of 9-or 11-nitroapovincaminic acid - Google Patents

Process for preparing new racemic and optical active derivatives of 9-or 11-nitroapovincaminic acid Download PDF

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Publication number
CS255890B2
CS255890B2 CS855187A CS518785A CS255890B2 CS 255890 B2 CS255890 B2 CS 255890B2 CS 855187 A CS855187 A CS 855187A CS 518785 A CS518785 A CS 518785A CS 255890 B2 CS255890 B2 CS 255890B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
group
acid
nitroapovincaminic
optionally
Prior art date
Application number
CS855187A
Other languages
Czech (cs)
English (en)
Other versions
CS518785A2 (en
Inventor
Andras Vedres
Csaba Szantay
Istvan Moldvai
Bela Stefko
Dora Groo
Ergon Karpati
Bela Kiss
Eva Palosi
Miklos Riesz
Zsolt Szombathelyi
Laszlo Szporny
Maria Zajer
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of CS518785A2 publication Critical patent/CS518785A2/cs
Publication of CS255890B2 publication Critical patent/CS255890B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS855187A 1984-07-11 1985-07-11 Process for preparing new racemic and optical active derivatives of 9-or 11-nitroapovincaminic acid CS255890B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU842704A HU191938B (en) 1984-07-11 1984-07-11 Process for production of new derivatives of 9 and 11 nitro-apovincamin acid

Publications (2)

Publication Number Publication Date
CS518785A2 CS518785A2 (en) 1987-07-16
CS255890B2 true CS255890B2 (en) 1988-03-15

Family

ID=10960721

Family Applications (1)

Application Number Title Priority Date Filing Date
CS855187A CS255890B2 (en) 1984-07-11 1985-07-11 Process for preparing new racemic and optical active derivatives of 9-or 11-nitroapovincaminic acid

Country Status (25)

Country Link
US (1) US4810709A (xx)
EP (1) EP0174459B1 (xx)
JP (1) JPS6136285A (xx)
KR (1) KR910010081B1 (xx)
AR (1) AR246262A1 (xx)
AT (1) ATE49208T1 (xx)
AU (1) AU576877B2 (xx)
CA (1) CA1266659A (xx)
CS (1) CS255890B2 (xx)
DD (1) DD236095A5 (xx)
DE (1) DE3575137D1 (xx)
DK (1) DK318085A (xx)
ES (1) ES8604222A1 (xx)
FI (1) FI852751L (xx)
GR (1) GR851725B (xx)
HU (1) HU191938B (xx)
IL (1) IL75776A (xx)
NO (1) NO166322C (xx)
NZ (1) NZ212712A (xx)
PH (1) PH24338A (xx)
PL (1) PL145330B1 (xx)
PT (1) PT80800B (xx)
SU (1) SU1440347A3 (xx)
YU (1) YU115485A (xx)
ZA (1) ZA855244B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191693B (en) * 1984-07-11 1987-03-30 Richter Gedeon Vegyeszet Process for production of derivatives of 9-or-11 substituated apovincamin acid
HU191694B (en) * 1984-07-11 1987-03-30 Richter Gedeon Vegyeszet Process for production of new derivatives of amineburnan carbonic acid
HU193772B (en) * 1985-06-12 1987-11-30 Richter Gedeon Vegyeszet Process for producing new nitro-bis-indole derivatives
CA2238488A1 (en) * 1994-07-07 1997-06-05 Hiroyoshi Hidaka Apovincaminic acid derivatives and drugs containing the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790837A (fr) * 1971-11-03 1973-02-15 Richter Gedeon Vegeon Vegyesze Nouveaux esters alcaloides utiles comme vasodilatateurs cerebraux et leur procede de preparation
FR2176516B1 (xx) * 1972-03-22 1975-03-14 Synthelabo
FR2228479B1 (xx) * 1973-05-07 1976-05-14 Synthelabo
FI751840A (xx) * 1974-09-24 1976-03-25 Synthelabo
FR2287227A1 (fr) * 1974-10-10 1976-05-07 Synthelabo Nouveaux nitriles, leurs sels, leur preparation et les medicaments qui en contiennent
FR2342980A1 (fr) * 1976-03-01 1977-09-30 Omnium Chimique Sa Procede de preparation de 9 et 11-aminoapovincamines dextrogyres, de 9 et 11-aminoapovincamines levogyres, de 9 et 11-aminoapovincamines racemiques et nouveaux derives de l'apovincamine
HU192013B (en) * 1984-04-25 1987-04-28 Richter Gedeon Vegyeszet Process for production of new aporincavinol esther derivatives
HU191694B (en) * 1984-07-11 1987-03-30 Richter Gedeon Vegyeszet Process for production of new derivatives of amineburnan carbonic acid

Also Published As

Publication number Publication date
HUT38100A (en) 1986-04-28
AU576877B2 (en) 1988-09-08
DK318085A (da) 1986-01-12
PH24338A (en) 1990-06-13
IL75776A0 (en) 1985-11-29
DK318085D0 (da) 1985-07-11
AR246262A1 (es) 1994-07-29
EP0174459B1 (de) 1990-01-03
ES545117A0 (es) 1986-01-16
FI852751L (fi) 1986-01-12
FI852751A0 (fi) 1985-07-11
CA1266659A (en) 1990-03-13
PT80800B (pt) 1987-09-18
KR860001112A (ko) 1986-02-22
ATE49208T1 (de) 1990-01-15
NO852796L (no) 1986-01-13
AU4477185A (en) 1986-01-16
PL254497A1 (en) 1986-10-21
DE3575137D1 (de) 1990-02-08
NZ212712A (en) 1988-10-28
PL145330B1 (en) 1988-09-30
PT80800A (en) 1985-08-01
ES8604222A1 (es) 1986-01-16
HU191938B (en) 1987-04-28
GR851725B (xx) 1985-11-26
NO166322B (no) 1991-03-25
JPS6136285A (ja) 1986-02-20
IL75776A (en) 1989-07-31
KR910010081B1 (ko) 1991-12-14
EP0174459A1 (de) 1986-03-19
YU115485A (en) 1988-06-30
US4810709A (en) 1989-03-07
DD236095A5 (de) 1986-05-28
CS518785A2 (en) 1987-07-16
NO166322C (no) 1991-07-03
ZA855244B (en) 1986-02-26
SU1440347A3 (ru) 1988-11-23

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