CS252840B2 - Method of piperazine-1-ylergoline derivatives production - Google Patents
Method of piperazine-1-ylergoline derivatives productionInfo
- Publication number
- CS252840B2 CS252840B2 CS86329A CS32986A CS252840B2 CS 252840 B2 CS252840 B2 CS 252840B2 CS 86329 A CS86329 A CS 86329A CS 32986 A CS32986 A CS 32986A CS 252840 B2 CS252840 B2 CS 252840B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- alkyl
- sec
- independently
- ylergoline
- piperazine
- Prior art date
Links
- FYHUSGDFBMCJBD-RJPUVWTNSA-N (6ar,10ar)-9-piperazin-1-yl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline Chemical class C1CNCCN1C(CN[C@@H]1C2)C[C@@H]1C1=C3C2=CNC3=CC=C1 FYHUSGDFBMCJBD-RJPUVWTNSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 239000000164 antipsychotic agent Substances 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical compound [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858501078A GB8501078D0 (en) | 1985-01-16 | 1985-01-16 | Piperazin-1-yl-ergo-line derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS32986A2 CS32986A2 (en) | 1987-03-12 |
| CS252840B2 true CS252840B2 (en) | 1987-10-15 |
Family
ID=10572936
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS86329A CS252840B2 (en) | 1985-01-16 | 1986-01-15 | Method of piperazine-1-ylergoline derivatives production |
| CS914153A CS415391A3 (en) | 1985-01-16 | 1991-12-30 | Piperazin-1-yl-ergoline derivative, process of its preparation and a pharmaceutical which it contains |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS914153A CS415391A3 (en) | 1985-01-16 | 1991-12-30 | Piperazin-1-yl-ergoline derivative, process of its preparation and a pharmaceutical which it contains |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4728649A (enExample) |
| EP (1) | EP0197241B1 (enExample) |
| JP (1) | JPS61167686A (enExample) |
| AT (1) | ATE48999T1 (enExample) |
| AU (1) | AU581280B2 (enExample) |
| CA (1) | CA1243670A (enExample) |
| CS (2) | CS252840B2 (enExample) |
| DE (1) | DE3667789D1 (enExample) |
| DK (1) | DK16186A (enExample) |
| FI (1) | FI84825C (enExample) |
| GB (1) | GB8501078D0 (enExample) |
| GR (1) | GR860071B (enExample) |
| HK (1) | HK95890A (enExample) |
| HU (1) | HU195215B (enExample) |
| IE (1) | IE58689B1 (enExample) |
| MY (1) | MY103696A (enExample) |
| SG (1) | SG80590G (enExample) |
| SU (1) | SU1500160A3 (enExample) |
| ZA (1) | ZA86268B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2032570T3 (es) * | 1987-11-20 | 1993-02-16 | Farmitalia Carlo Erba S.R.L. | Derivados antiparkinson de ergolina. (reserva del art. 167.2 cpe). |
| GB8824744D0 (en) * | 1988-10-21 | 1988-11-30 | Erba Carlo Spa | Antiemesis ergoline derivatives |
| JPH04504582A (ja) * | 1990-01-25 | 1992-08-13 | フアルミタリア・カルロ・エルバ・エツセ・エルレ・エルレ | エルゴリン誘導体を製造する方法 |
| GB9006772D0 (en) * | 1990-03-27 | 1990-05-23 | Erba Carlo Spa | 4-piperidinyl-ergoline derivatives |
| PT628042E (pt) * | 1992-12-24 | 2002-01-30 | Pharmacia & Upjohn Spa | Derivados de ergolina serotoninergicos |
| JPH08502759A (ja) * | 1993-08-18 | 1996-03-26 | アルコン ラボラトリーズ，インコーポレイテッド | 緑内障治療用のエルゴリン誘導体の使用 |
| GB9711043D0 (en) * | 1997-05-29 | 1997-07-23 | Ciba Geigy Ag | Organic compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6818658A (enExample) * | 1968-01-18 | 1969-07-22 | ||
| CH615181A5 (en) * | 1975-05-21 | 1980-01-15 | Sandoz Ag | Process for the preparation of novel ergolene derivatives |
| AU526764B2 (en) * | 1978-09-08 | 1983-01-27 | Farmitalia Carlo Erba S.P.A. | Ergoline derivatives |
| BE879822A (fr) * | 1979-02-20 | 1980-03-03 | Erba Farmitalia | Derives de l'ergoline |
| PH21123A (en) * | 1983-04-28 | 1987-07-27 | Erba Farmitalia | Ergoline derivatives |
-
1985
- 1985-01-16 GB GB858501078A patent/GB8501078D0/en active Pending
-
1986
- 1986-01-08 US US06/817,135 patent/US4728649A/en not_active Expired - Fee Related
- 1986-01-13 FI FI860157A patent/FI84825C/fi not_active IP Right Cessation
- 1986-01-13 GR GR860071A patent/GR860071B/el unknown
- 1986-01-13 IE IE8686A patent/IE58689B1/en not_active IP Right Cessation
- 1986-01-14 CA CA000499525A patent/CA1243670A/en not_active Expired
- 1986-01-14 ZA ZA86268A patent/ZA86268B/xx unknown
- 1986-01-14 AT AT86100391T patent/ATE48999T1/de active
- 1986-01-14 DK DK16186A patent/DK16186A/da not_active Application Discontinuation
- 1986-01-14 DE DE8686100391T patent/DE3667789D1/de not_active Expired - Lifetime
- 1986-01-14 EP EP86100391A patent/EP0197241B1/en not_active Expired
- 1986-01-14 JP JP61004411A patent/JPS61167686A/ja active Granted
- 1986-01-14 AU AU52260/86A patent/AU581280B2/en not_active Ceased
- 1986-01-15 SU SU864008378A patent/SU1500160A3/ru active
- 1986-01-15 CS CS86329A patent/CS252840B2/cs unknown
- 1986-01-15 HU HU86208A patent/HU195215B/hu not_active IP Right Cessation
-
1988
- 1988-12-31 MY MYPI88001620A patent/MY103696A/en unknown
-
1990
- 1990-10-04 SG SG805/90A patent/SG80590G/en unknown
- 1990-11-15 HK HK958/90A patent/HK95890A/en not_active IP Right Cessation
-
1991
- 1991-12-30 CS CS914153A patent/CS415391A3/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI84825C (fi) | 1992-01-27 |
| SG80590G (en) | 1990-11-23 |
| US4728649A (en) | 1988-03-01 |
| CS32986A2 (en) | 1987-03-12 |
| SU1500160A3 (ru) | 1989-08-07 |
| CS415391A3 (en) | 1992-05-13 |
| ATE48999T1 (de) | 1990-01-15 |
| IE58689B1 (en) | 1993-11-03 |
| GR860071B (en) | 1986-05-14 |
| FI84825B (fi) | 1991-10-15 |
| HU195215B (en) | 1988-04-28 |
| GB8501078D0 (en) | 1985-02-20 |
| CA1243670A (en) | 1988-10-25 |
| JPS61167686A (ja) | 1986-07-29 |
| JPH0524918B2 (enExample) | 1993-04-09 |
| FI860157A7 (fi) | 1986-07-17 |
| DE3667789D1 (de) | 1990-02-01 |
| AU581280B2 (en) | 1989-02-16 |
| EP0197241B1 (en) | 1989-12-27 |
| AU5226086A (en) | 1986-07-24 |
| DK16186D0 (da) | 1986-01-14 |
| FI860157A0 (fi) | 1986-01-13 |
| MY103696A (en) | 1993-08-28 |
| DK16186A (da) | 1986-07-17 |
| ZA86268B (en) | 1986-09-24 |
| HK95890A (en) | 1990-11-23 |
| HUT40120A (en) | 1986-11-28 |
| EP0197241A1 (en) | 1986-10-15 |
| IE860086L (en) | 1986-07-16 |
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