CS249576B1 - 6-purinyl n-(2-chlorethyl)carbamate and thiocarbamate and method of their production - Google Patents

6-purinyl n-(2-chlorethyl)carbamate and thiocarbamate and method of their production Download PDF

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Publication number
CS249576B1
CS249576B1 CS8410291A CS1029184A CS249576B1 CS 249576 B1 CS249576 B1 CS 249576B1 CS 8410291 A CS8410291 A CS 8410291A CS 1029184 A CS1029184 A CS 1029184A CS 249576 B1 CS249576 B1 CS 249576B1
Authority
CS
Czechoslovakia
Prior art keywords
animals
tumor
purinyl
chloroethyl
dose
Prior art date
Application number
CS8410291A
Other languages
Czech (cs)
English (en)
Other versions
CS1029184A1 (en
Inventor
Antonin Cerny
Jiri Krepelka
Milan Melka
Milan Miko
Stanislava Pokorna
Irena Kejhova
Ruzena Reichlova
Marta Beitova
Jaroslava Grimova
Original Assignee
Antonin Cerny
Jiri Krepelka
Milan Melka
Milan Miko
Stanislava Pokorna
Irena Kejhova
Ruzena Reichlova
Marta Beitova
Jaroslava Grimova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antonin Cerny, Jiri Krepelka, Milan Melka, Milan Miko, Stanislava Pokorna, Irena Kejhova, Ruzena Reichlova, Marta Beitova, Jaroslava Grimova filed Critical Antonin Cerny
Priority to CS8410291A priority Critical patent/CS249576B1/cs
Publication of CS1029184A1 publication Critical patent/CS1029184A1/cs
Priority to CA000497510A priority patent/CA1260935A/en
Priority to EP85309296A priority patent/EP0186454B1/de
Priority to FI855089A priority patent/FI82246C/fi
Priority to JP60285848A priority patent/JPS61186382A/ja
Priority to US06/812,139 priority patent/US4720497A/en
Publication of CS249576B1 publication Critical patent/CS249576B1/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS8410291A 1984-12-22 1984-12-22 6-purinyl n-(2-chlorethyl)carbamate and thiocarbamate and method of their production CS249576B1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CS8410291A CS249576B1 (en) 1984-12-22 1984-12-22 6-purinyl n-(2-chlorethyl)carbamate and thiocarbamate and method of their production
CA000497510A CA1260935A (en) 1984-12-22 1985-12-12 6-purinyl n-(2-chlorethyl) carbamate and thiocarbamate and a process for their preparation
EP85309296A EP0186454B1 (de) 1984-12-22 1985-12-19 6-Purinyl-N-(2-chlorethyl)carbamat und -thiocarbamat, Verfahren zu ihrer Herstellung und ihre Verwendung
FI855089A FI82246C (fi) 1984-12-22 1985-12-19 Foerfarande foer framstaellning av ett farmakologiskt aktiva 6-purinyl-n-/2-kloretyl/karbamat eller tiokarbamat.
JP60285848A JPS61186382A (ja) 1984-12-22 1985-12-20 ６−プリニルｎ−（２−クロロエチル）カルバメ−ト及びチオカルバメ−ト、及びそれらの製法
US06/812,139 US4720497A (en) 1984-12-22 1985-12-23 6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS8410291A CS249576B1 (en) 1984-12-22 1984-12-22 6-purinyl n-(2-chlorethyl)carbamate and thiocarbamate and method of their production

Publications (2)

Publication Number Publication Date
CS1029184A1 CS1029184A1 (en) 1985-08-15
CS249576B1 true CS249576B1 (en) 1987-04-16

Family

ID=5448550

Family Applications (1)

Application Number Title Priority Date Filing Date
CS8410291A CS249576B1 (en) 1984-12-22 1984-12-22 6-purinyl n-(2-chlorethyl)carbamate and thiocarbamate and method of their production

Country Status (6)

Country Link
US (1) US4720497A (de)
EP (1) EP0186454B1 (de)
JP (1) JPS61186382A (de)
CA (1) CA1260935A (de)
CS (1) CS249576B1 (de)
FI (1) FI82246C (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS249576B1 (en) * 1984-12-22 1987-04-16 Antonin Cerny 6-purinyl n-(2-chlorethyl)carbamate and thiocarbamate and method of their production
US6866797B1 (en) 2000-08-03 2005-03-15 Bj Services Company Corrosion inhibitors and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH501652A (de) * 1966-07-01 1971-01-15 Spofa Vereinigte Pharma Werke Verfahren zur Herstellung von N-( -(6-Purinylthio)-valeryl)-aminosäureestern
GR75219B (de) * 1980-04-21 1984-07-13 Merck & Co Inc
CS249576B1 (en) * 1984-12-22 1987-04-16 Antonin Cerny 6-purinyl n-(2-chlorethyl)carbamate and thiocarbamate and method of their production

Also Published As

Publication number Publication date
FI855089A (fi) 1986-06-23
FI855089A0 (fi) 1985-12-19
FI82246C (fi) 1991-02-11
JPH0586791B2 (de) 1993-12-14
EP0186454A3 (en) 1989-03-08
CS1029184A1 (en) 1985-08-15
EP0186454A2 (de) 1986-07-02
CA1260935A (en) 1989-09-26
EP0186454B1 (de) 1992-04-08
JPS61186382A (ja) 1986-08-20
US4720497A (en) 1988-01-19
FI82246B (fi) 1990-10-31

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